RGD Reference Report - Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia. - Rat Genome Database

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Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia.

Authors: Takahashi, H  Nagai, N  Urano, T 
Citation: Takahashi H, etal., Neurosci Lett. 2005 Jun 10-17;381(1-2):189-93. Epub 2005 Mar 2.
RGD ID: 1580875
Pubmed: PMID:15882815   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2005.02.031   (Journal Full-text)

We studied the possible involvement of the tissue plasminogen activator (t-PA)/plasmin system on both delayed neuronal death in the hippocampus and the associated enhancement of locomotor activity in rats, after transient forebrain ischemia induced by a four-vessel occlusion (FVO). Seven days after FVO, locomotor activity was abnormally increased and, after 10 days, pyramidal cells were degraded in the CA1 region of the hippocampus. FVO increased the t-PA antigen level and its activity in the hippocampus, which peaked at 4 h. Both the enhanced locomotor activity and the degradation of pyramidal cells were significantly suppressed by intracerebroventricular injection of aprotinin, a plasmin inhibitor, at 4 h but not during FVO. These results suggest the importance of the t-PA/plasmin cascade during the early pathological stages of delayed neuronal death in the hippocampus following transient forebrain ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transient cerebral ischemia  ISOPlat (Rattus norvegicus)1580875; 1580875Protein:increased expression and increased activity:hippocampus (rat)RGD 
transient cerebral ischemia  IEP 1580875Protein:increased expression and increased activity:hippocampus (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plat  (plasminogen activator, tissue type)

Genes (Mus musculus)
Plat  (plasminogen activator, tissue)

Genes (Homo sapiens)
PLAT  (plasminogen activator, tissue type)


Additional Information