GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Plat | decreases response to substance | EXP | | 6480464 | CTD | PLAT protein mutant form results in decreased susceptibility to Valproic Acid | PMID:23378038 | Plat | increases activity | EXP | | 6480464 | CTD | Valproic Acid results in increased activity of PLAT protein | PMID:23378038 | Plat | multiple interactions | EXP | | 6480464 | CTD | [Valproic Acid results in decreased activity of SERPINE1 protein] which results in increased activity of PLAT protein; pyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]; SERPINE1 protein inhibits the reaction [Valproic Acid results in increased activity of PLAT protein] | PMID:23378038 | Plat | decreases response to substance | ISO | Plat (Mus musculus) | 6480464 | CTD | PLAT gene mutant form results in decreased susceptibility to Valproic Acid | PMID:23378038 | Plat | increases expression | ISO | PLAT (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased expression of PLAT mRNA | PMID:24383497 PMID:24935251 PMID:26272509 PMID:28001369 | Plat | multiple interactions | ISO | PLAT (Homo sapiens) | 6480464 | CTD | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA | PMID:27188386 | | ||||||||||||||||||||||
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