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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plat
Name: plasminogen activator, tissue type
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Platmultiple interactionsISOPlat (Mus musculus)6480464CTD[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PLAT mRNAPMID:30529165
Platmultiple interactionsISOPLAT (Homo sapiens)6480464CTD[N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride co-treated with PLAT protein] inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of VCAM1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [PLAT protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased degradation of CDH5 protein]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [PLAT protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased degradation of TJP1 protein]]; PLAT protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased degradation of CDH5 protein]; PLAT protein promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased degradation of TJP1 protein]PMID:23876515 PMID:29651748
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