RGD Reference Report - Nan fang yi ke da xue xue bao = Journal of Southern Medical University - Rat Genome Database

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Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Authors: Liu, BY  Jian, YL  Zhong, M  Yu, YH  Wang, Q  Zhang, J 
Citation: Liu BY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jan;27(1):35-7.
RGD ID: 2311668
Pubmed: PMID:17259140   (View Abstract at PubMed)

OBJECTIVE: To study the clinical implications of changes of coagulation function and fibrinolytic system in patients with gestational diabetes mellitus (GDM). METHODS: Twenty non-pregnant women, 20 with normal pregnancy and 46 with GDM were enrolled in this study for examinations of platelet alpha-granule membrane protein (GMP-140), Von Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI). RESULTS: vWF, GMP-140, PLG, D-dimer, PAI were obviously elevated while t-PA was lower in GDM patients as compared with the measurement in non-pregnant women and women with normal pregnancy (P<0.01). AT-III and ProC measurement showed no significant differences between GDM patients and women of the other two groups. CONCLUSION: GDM patients may have elevated platelet activation and fibrinolyic activity as well as vascular endothelial injuries, and antenatal assessment of the coagulation function can be of value for prevention and treatment of GDM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
gestational diabetes  IEP 2311668 RGD 
gestational diabetes  ISOPLAT (Homo sapiens)2311668; 2311668 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Plat  (plasminogen activator, tissue type)

Genes (Mus musculus)
Plat  (plasminogen activator, tissue)

Genes (Homo sapiens)
PLAT  (plasminogen activator, tissue type)


Additional Information