PLAT (plasminogen activator, tissue type) - Rat Genome Database

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Gene: PLAT (plasminogen activator, tissue type) Pan paniscus
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Symbol: PLAT
Name: plasminogen activator, tissue type
RGD ID: 11884387
Description: ENCODES a protein that exhibits phosphoprotein binding (ortholog); serine-type endopeptidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); cellular response to luteinizing hormone stimulus (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute promyelocytic leukemia (ortholog); Acute Traumatic Coagulopathy (ortholog); FOUND IN apical part of cell (ortholog); cell surface (ortholog); collagen-containing extracellular matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: tissue-type plasminogen activator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute promyelocytic leukemia  (ISO)
Acute Traumatic Coagulopathy  (ISO)
Airway Obstruction  (ISO)
allergic contact dermatitis  (ISO)
amphetamine abuse  (ISO)
angioedema  (ISO)
antiphospholipid syndrome  (ISO)
aphasia  (ISO)
Arterial Occlusive Diseases  (ISO)
Arterial Thrombosis  (ISO)
atherosclerosis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
Back Pain  (ISO)
Bacteremia  (ISO)
blood coagulation disease  (ISO)
brain edema  (ISO)
brain infarction  (ISO)
brain ischemia  (ISO)
Burns  (ISO)
cardiac tamponade  (ISO)
Cardiogenic Shock  (ISO)
Carotid Artery Injuries  (ISO)
Central Nervous System Viral Diseases  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesterol embolism  (ISO)
Chronic Hepatitis  (ISO)
congestive heart failure  (ISO)
coronary thrombosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disseminated intravascular coagulation  (ISO)
Embolism  (ISO)
Embolism and Thrombosis  (ISO)
Endotoxemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
factor VIII deficiency  (ISO)
Femur Head Necrosis  (ISO)
gestational diabetes  (ISO)
Hematoma, Epidural, Spinal  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Henoch-Schoenlein purpura  (ISO)
hypertension  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
IMMUNODEFICIENCY 15  (ISO)
Intracranial Embolism and Thrombosis  (ISO)
Intracranial Hemorrhages  (ISO)
intracranial thrombosis  (ISO)
intracranial vasospasm  (ISO)
lactic acidosis  (ISO)
leukopenia  (ISO)
Low Back Pain  (ISO)
meningoencephalitis  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
myocardial infarction  (ISO)
Nerve Degeneration  (ISO)
Neurologic Manifestations  (ISO)
Noonan syndrome  (ISO)
obesity  (ISO)
pancreatic adenocarcinoma  (ISO)
Paresis  (ISO)
pericardial effusion  (ISO)
peritonitis  (ISO)
pulmonary embolism  (ISO)
Reperfusion Injury  (ISO)
respiratory failure  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spinal Cord Compression  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
Subdural Hematoma  (ISO)
thrombocytopenia  (ISO)
Thromboembolism  (ISO)
thrombophilia due to decreased release of PLAT  (ISO)
thrombosis  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Venous Thromboembolism  (ISO)
Venous Thrombosis  (ISO)
Ventricular Dysfunction, Left  (ISO)
von Willebrand's disease 1  (ISO)
Wounds and Injuries  (ISO)

References

Genomics

Comparative Map Data
PLAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1838,864,918 - 38,897,776 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBIMhudiblu_PPA_v0panPan3
PLAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl842,174,718 - 42,207,709 (-)EnsemblGRCh38hg38GRCh38
GRCh38842,174,718 - 42,207,565 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,032,236 - 42,065,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,151,393 - 42,184,351 (-)NCBINCBI36hg18NCBI36
Build 34842,151,911 - 42,184,351NCBI
Celera840,981,190 - 41,014,147 (-)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,559,713 - 40,592,984 (-)NCBIHuRef
CHM1_1842,080,535 - 42,113,811 (-)NCBICHM1_1
Plat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,247,655 - 23,272,864 (+)NCBIGRCm39mm39
GRCm39 Ensembl823,247,743 - 23,272,860 (+)Ensembl
GRCm38822,757,722 - 22,782,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,757,727 - 22,782,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37823,868,216 - 23,893,320 (+)NCBIGRCm37mm9NCBIm37
MGSCv36824,223,313 - 24,248,389 (+)NCBImm8
Celera824,247,228 - 24,272,480 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Plat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21669,240,582 - 69,265,177 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1674,098,260 - 74,122,889 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01674,098,263 - 74,122,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01673,730,256 - 73,754,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,711,323 - 73,736,328 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11673,711,587 - 73,736,593 (-)NCBI
Celera1667,134,451 - 67,159,047 (-)NCBICelera
RH 3.4 Map16644.8RGD
Cytogenetic Map16q12.5NCBI
Plat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536730,981 - 756,394 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955536730,962 - 754,333 (+)NCBIChiLan1.0ChiLan1.0
PLAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,469,590 - 23,496,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,974,129 - 24,000,506 (+)NCBI
ROS_Cfam_1.01625,217,768 - 25,244,182 (+)NCBI
UMICH_Zoey_3.11623,588,653 - 23,615,286 (+)NCBI
UNSW_CanFamBas_1.01624,152,407 - 24,178,867 (+)NCBI
UU_Cfam_GSD_1.01624,203,090 - 24,229,785 (+)NCBI
Plat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,519,711 - 46,546,290 (+)NCBI
SpeTri2.0NW_004936785476,200 - 503,371 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,195,602 - 11,224,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,195,599 - 11,223,821 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,168,730 - 13,197,126 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,164,391 - 40,196,627 (-)NCBI
ChlSab1.1 Ensembl840,163,891 - 40,196,555 (-)Ensembl
Vero_WHO_p1.0NW_0236660521,590,000 - 1,622,258 (+)NCBI
Plat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247801,014,429 - 1,063,636 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000015970   ⟹   ENSPPAP00000003463
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000015977   ⟹   ENSPPAP00000003467
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,864,918 - 38,897,779 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000016021   ⟹   ENSPPAP00000003472
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,865,678 - 38,882,718 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000016023   ⟹   ENSPPAP00000003473
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,865,678 - 38,882,718 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000016025   ⟹   ENSPPAP00000003475
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl838,865,678 - 38,882,718 (-)Ensembl
RefSeq Acc Id: XM_008976915   ⟹   XP_008975163
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1838,864,918 - 38,897,775 (-)NCBI
Mhudiblu_PPA_v0841,419,415 - 41,451,951 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008976916   ⟹   XP_008975164
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1838,864,918 - 38,897,776 (-)NCBI
Mhudiblu_PPA_v0841,419,415 - 41,451,950 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008975163 (Get FASTA)   NCBI Sequence Viewer  
  XP_008975164 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008975164   ⟸   XM_008976916
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008975163   ⟸   XM_008976915
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000003463   ⟸   ENSPPAT00000015970
RefSeq Acc Id: ENSPPAP00000003467   ⟸   ENSPPAT00000015977
RefSeq Acc Id: ENSPPAP00000003472   ⟸   ENSPPAT00000016021
RefSeq Acc Id: ENSPPAP00000003473   ⟸   ENSPPAT00000016023
RefSeq Acc Id: ENSPPAP00000003475   ⟸   ENSPPAT00000016025


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000014440 Ensembl, ENTREZGENE
NCBI Gene PLAT ENTREZGENE