RGD Reference Report - Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. - Rat Genome Database
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Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia.

Authors: Zhao, G  Reynolds, JN  Flavin, MP 
Citation: Zhao G, etal., Neuroreport. 2003 Sep 15;14(13):1689-92.
RGD ID: 1580876
Pubmed: (View Article at PubMed) PMID:14512838
DOI: Full-text: DOI:10.1097/01.wnr.0000087729.58565.b6

Altered tPA expression may influence the fate of neurons after cerebral ischemia. We determined the changes in tPA and plasminogen activator inhibitor (PAI-1) expression in adult rat brain after transient middle cerebral artery (MCA) occlusion. Immunohistology revealed tPA staining in ipsilateral but not contralateral cortex and striatum 6 h after occlusion. This pattern was maintained at 24 h. Staining data was supported by Western blot data which showed no tPA protein in contralateral cortex at 3 h but abundant protein in ipsilateral cortex which increased further at 6 h and 24 h. In contrast there was prominent PAI-1 immunostaining and protein expression in control tissue after MCA occlusion but it diminished progressively at 3, 6 and 24 h in the lesioned cortex.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Plat  (plasminogen activator, tissue type)
Serpine1  (serpin family E member 1)

Genes (Mus musculus)
Plat  (plasminogen activator, tissue)
Serpine1  (serine (or cysteine) peptidase inhibitor, clade E, member 1)

Genes (Homo sapiens)
PLAT  (plasminogen activator, tissue type)
SERPINE1  (serpin family E member 1)


Additional Information