F2rl2 (coagulation factor II (thrombin) receptor-like 2) - Rat Genome Database

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Gene: F2rl2 (coagulation factor II (thrombin) receptor-like 2) Rattus norvegicus
Analyze
Symbol: F2rl2
Name: coagulation factor II (thrombin) receptor-like 2
RGD ID: 620871
Description: Predicted to enable several functions, including enzyme activator activity; ion channel regulator activity; and proteinase-activated receptor activity. Involved in response to wounding. Predicted to be located in apical plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human F2RL2 (coagulation factor II thrombin receptor like 2); PARTICIPATES IN insulin signaling pathway; protease mediated signaling via protease-activated receptor 3; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coagulation factor II receptor-like 2; PAR-3; PAR3; protease-activated receptor 3; proteinase-activated receptor 3; thrombin receptor-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,972,054 - 26,977,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,972,054 - 26,977,098 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx234,011,700 - 34,016,699 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0232,111,806 - 32,116,807 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0226,928,439 - 26,933,433 (+)NCBIRnor_WKY
Rnor_6.0226,240,385 - 26,245,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,240,385 - 26,245,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,371,780 - 45,376,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,073,852 - 26,078,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,994,220 - 25,998,987 (+)NCBI
Celera223,033,959 - 23,038,978 (+)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cross Talk Pathways Between Coagulation and Inflammation. Foley JH and Conway EM, Circ Res. 2016 Apr 29;118(9):1392-408. doi: 10.1161/CIRCRESAHA.116.306853.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Increase of prothrombin-mRNA after global cerebral ischemia in rats, with constant expression of protease nexin-1 and protease-activated receptors. Riek-Burchardt M, etal., Neurosci Lett 2002 Aug 30;329(2):181-4.
11. Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush. Rohatgi T, etal., J Neurosci Res 2003 Jul 15;73(2):246-54.
12. Transient focal ischemia in rat brain differentially regulates mRNA expression of protease-activated receptors 1 to 4. Rohatgi T, etal., J Neurosci Res 2004 Jan 15;75(2):273-9.
Additional References at PubMed
PMID:1299297   PMID:16403464   PMID:16458856   PMID:16892058   PMID:17136598  


Genomics

Comparative Map Data
F2rl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2226,972,054 - 26,977,098 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,972,054 - 26,977,098 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx234,011,700 - 34,016,699 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0232,111,806 - 32,116,807 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0226,928,439 - 26,933,433 (+)NCBIRnor_WKY
Rnor_6.0226,240,385 - 26,245,533 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl226,240,385 - 26,245,533 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0245,371,780 - 45,376,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4226,073,852 - 26,078,618 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,994,220 - 25,998,987 (+)NCBI
Celera223,033,959 - 23,038,978 (+)NCBICelera
Cytogenetic Map2q12NCBI
F2RL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,615,482 - 76,623,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl576,615,482 - 76,623,413 (-)EnsemblGRCh38hg38GRCh38
GRCh37575,911,307 - 75,919,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36575,947,063 - 75,954,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 34575,947,063 - 75,954,996NCBI
Celera571,805,260 - 71,813,193 (-)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,119,015 - 71,126,968 (-)NCBIHuRef
CHM1_1575,344,295 - 75,352,247 (-)NCBICHM1_1
T2T-CHM13v2.0577,097,223 - 77,105,145 (-)NCBIT2T-CHM13v2.0
F2rl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,833,428 - 95,839,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,833,361 - 95,839,247 (+)EnsemblGRCm39 Ensembl
GRCm381395,696,920 - 95,702,768 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,696,853 - 95,702,739 (+)EnsemblGRCm38mm10GRCm38
MGSCv371396,466,875 - 96,472,723 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,797,656 - 96,803,438 (+)NCBIMGSCv36mm8
Celera1399,313,808 - 99,319,652 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1350.38NCBI
F2rl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,246,333 - 24,254,887 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542524,246,333 - 24,254,887 (+)NCBIChiLan1.0ChiLan1.0
F2RL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1539,297,424 - 39,305,370 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl539,297,424 - 39,305,370 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0538,680,372 - 38,688,509 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
F2RL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,967,278 - 29,974,316 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,967,312 - 29,972,872 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,206,044 - 31,213,084 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,891,456 - 29,898,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,891,199 - 29,898,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,822,502 - 29,829,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,802,374 - 29,809,212 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0330,172,976 - 30,180,016 (+)NCBIUU_Cfam_GSD_1.0
F2rl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,515,607 - 190,522,114 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549337,024 - 342,948 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936549336,871 - 342,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F2RL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,535,676 - 85,541,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,534,188 - 85,542,062 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,181,035 - 87,188,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
F2RL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1470,887,979 - 70,895,419 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl470,886,113 - 70,895,113 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604919,720,145 - 19,727,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F2rl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,073,656 - 1,077,635 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,073,481 - 1,078,207 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in F2rl2
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000024292
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat

Markers in Region
F2rl2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,975,969 - 26,976,089 (+)MAPPERmRatBN7.2
Rnor_6.0226,244,405 - 26,244,524NCBIRnor6.0
Rnor_5.0245,375,800 - 45,375,919UniSTSRnor5.0
Celera223,037,850 - 23,037,969UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 4 3 4 1
Low 3 21 37 29 16 29 1 1 25 16 21 11 1
Below cutoff 22 6 6 6 7 9 41 19 17 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024292   ⟹   ENSRNOP00000024292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,972,054 - 26,977,098 (+)Ensembl
Rnor_6.0 Ensembl226,240,385 - 26,245,533 (+)Ensembl
RefSeq Acc Id: NM_053313   ⟹   NP_445765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2226,972,054 - 26,977,098 (+)NCBI
Rnor_6.0226,240,385 - 26,245,533 (+)NCBI
Rnor_5.0245,371,780 - 45,376,928 (+)NCBI
RGSC_v3.4226,073,852 - 26,078,618 (+)RGD
Celera223,033,959 - 23,038,978 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL26789 (Get FASTA)   NCBI Sequence Viewer  
  EDM10105 (Get FASTA)   NCBI Sequence Viewer  
  Q920E1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445765   ⟸   NM_053313
- Peptide Label: precursor
- UniProtKB: Q920E1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024292   ⟸   ENSRNOT00000024292
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920E1-F1-model_v2 AlphaFold Q920E1 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691078
Promoter ID:EPDNEW_R1603
Type:initiation region
Name:F2rl2_1
Description:coagulation factor II receptor-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0226,240,363 - 26,240,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620871 AgrOrtholog
BioCyc Gene G2FUF-54799 BioCyc
Ensembl Genes ENSRNOG00000018054 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024292 ENTREZGENE
  ENSRNOP00000024292.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024292 ENTREZGENE
  ENSRNOT00000024292.3 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_act_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protea_act_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29636 UniProtKB/Swiss-Prot
NCBI Gene 29636 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen F2rl2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEASEAR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LPU1_RAT UniProtKB/TrEMBL
  PAR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 F2rl2  coagulation factor II (thrombin) receptor-like 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 F2rl2  coagulation factor II (thrombin) receptor-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL