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Gene: Tjp1 (tight junction protein 1) Rattus norvegicus
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Symbol: Tjp1
Name: tight junction protein 1
Description: Exhibits protein C-terminus binding activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of vascular permeability; and response to ethanol. Localizes to the bicellular tight junction; cytoplasm; and gap junction. Biomarker of brain disease (multiple); cholestasis; peptic esophagitis; perinatal necrotizing enterocolitis; and uveitis. Orthologous to human TJP1 (tight junction protein 1); PARTICIPATES IN E-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-carnitine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: tight junction protein ZO-1; ZO-1; zona occludens 1; zona occludens protein 1; zonula occludens protein 1
Orthologs:
Homo sapiens (human) : TJP1 (tight junction protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Tjp1 (tight junction protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tjp1 (tight junction protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TJP1 (tight junction protein 1)
Canis lupus familiaris (dog) : TJP1 (tight junction protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tjp1 (tight junction protein 1)
Sus scrofa (pig) : TJP1 (tight junction protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01126,146,489 - 126,515,359 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01127,243,076 - 127,607,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41119,684,774 - 119,750,532 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11119,763,121 - 119,845,891 (-)NCBI
Celera1111,069,963 - 111,134,894 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Tjp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1306305
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.