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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:131923
Term: salubrinal
Definition: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).
Chemical ID: MESH:C496827
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13148506480464CTDsalubrinal inhibits the reaction [Cyclosporine results in decreased expression of TJP1 protein]

PMID:22155090
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.