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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDHexachlorocyclohexane affects the localization of TJP1 protein

PMID:15194225
multiple interactionsEXP 6480464CTDHexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein]

PMID:15194225
affects localizationISORGD:13148506480464CTDHexachlorocyclohexane affects the localization of TJP1 protein

PMID:11532877
decreases expressionISORGD:13148506480464CTDHexachlorocyclohexane results in decreased expression of TJP1 protein

PMID:11532877
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.