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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationISORGD:13148496480464CTDIndomethacin affects the localization of TJP1 protein

PMID:23668856
decreases expressionISORGD:13148496480464CTDIndomethacin results in decreased expression of TJP1 mRNA

PMID:23668856
multiple interactionsISORGD:13148496480464CTDQuercetin inhibits the reaction [Indomethacin affects the localization of TJP1 protein], Quercetin inhibits the reaction [Indomethacin results in decreased expression of TJP1 mRNA]

PMID:23668856
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.