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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:64090
Term: tert-butyl hydroperoxide
Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.
Chemical ID: MESH:D020122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDtert-Butylhydroperoxide affects the localization of TJP1 protein

PMID:16716901
multiple interactionsEXP 6480464CTD1, 2-bis(2-aminophenoxy)ethane N, N, N', N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein], 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein], Bucladesine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein], Go 6976 inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein], Staurosporine inhibits the reaction [tert-Butylhydroperoxide affects the localization of TJP1 protein]

PMID:16716901
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.