Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Zonula occludens-1, occludin, and E-cadherin protein expression in biliary tract cancers.

Authors: Nemeth, Z  Szasz, AM  Somoracz, A  Tatrai, P  Nemeth, J  Gyorffy, H  Szijarto, A  Kupcsulik, P  Kiss, A  Schaff, Z 
Citation: Nemeth Z, etal., Pathol Oncol Res. 2009 Sep;15(3):533-9. Epub .
Pubmed: (View Article at PubMed) PMID:19184677
DOI: Full-text: DOI:10.1007/s12253-009-9150-4

The incidence of cholangiocarcinomas originating from intrahepatic and extrahepatic bile ducts, as well as of gallbladder carcinoma is increasing worldwide. The malignant transformation of biliary epithelia involves profound alterations of proteins in the intercellular junctions, among others zonula occludens-1 (ZO-1), occludin, and E-cadherin. Each plays important role in the maintenance of epithelial cell polarity and regulation of cell growth and differentiation. Our aim was to investigate ZO-1, occludin, and E-cadherin immunohistochemical reactions in tissue microarray blocks containing 57 normal and 62 neoplastic biliary tract samples. We demonstrated that the tight junction components ZO-1, occludin, and E-cadherin are downregulated in carcinomas arising from various compartments of the biliary tract (normal intrahepatic and extrahepatic bile ducts, gallbladder) as compared with their normal sites of origin. These results were confirmed by discriminant analysis yielding clear separation of the three normal sample groups from carcinomas in the corresponding locations.

Annotation

Disease Annotations
Objects Annotated

Additional Information

 
RGD Object Information
RGD ID: 2325030
Created: 2010-05-19
Species: All species
Last Modified: 2010-05-19
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.