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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306305
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tjp1
Name: tight junction protein 1
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13148496480464CTDSB 203580 inhibits the reaction [clopidogrel results in decreased expression of TJP1 protein]

PMID:23220562
multiple interactionsISORGD:13148506480464CTDSB 203580 inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein]

PMID:23761298
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.