Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase) Rattus norvegicus
Analyze
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Description: Exhibits several functions, including glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; peptidyl-cysteine S-nitrosylase activity; and protein homodimerization activity. Involved in several processes, including gluconeogenesis; negative regulation of vascular associated smooth muscle cell apoptotic process; and peptidyl-cysteine S-trans-nitrosylation. Localizes to several cellular components, including the cytosol; glutamatergic synapse; and postsynaptic density, intracellular component. Used to study Alzheimer's disease and middle cerebral artery infarction. Biomarker of brain disease (multiple); diabetic retinopathy; obesity; oral squamous cell carcinoma; and rheumatic heart disease. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase); PARTICIPATES IN gluconeogenesis pathway; electron transport chain pathway; Fanconi syndrome pathway; INTERACTS WITH (-)-selegiline; (RS)-amphetamine; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 38 kDa BFA-dependent ADP-ribosylation substrate; BARS-38; Gapd; peptidyl-cysteine S-nitrosylase GAPDH
Orthologs:
Homo sapiens (human) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Canis lupus familiaris (dog) : LOC100688969 (glyceraldehyde-3-phosphate dehydrogenase-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Sus scrofa (pig) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
more info ...
Related Pseudogenes: Gapdh-ps1   Gapdh-ps2   LOC100361351   LOC689831  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04157,676,336 - 157,680,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,693,580 - 224,697,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,282,215 - 161,286,090 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1962,857,154 - 62,857,964 (+)NCBI
Celera4146,699,388 - 146,703,263 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gapdh
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2661
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.