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Gene: Gapdh (glyceraldehyde-3-phosphate dehydrogenase) Rattus norvegicus
Symbol: Gapdh
Name: glyceraldehyde-3-phosphate dehydrogenase
Description: Exhibits several functions, including glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; identical protein binding activity; and peptidyl-cysteine S-nitrosylase activity. Involved in several processes, including gluconeogenesis; negative regulation of vascular associated smooth muscle cell apoptotic process; and peptidyl-cysteine S-trans-nitrosylation. Localizes to several cellular components, including glutamatergic synapse; microtubule cytoskeleton; and postsynaptic density, intracellular component. Used to study Alzheimer's disease and middle cerebral artery infarction. Biomarker of several diseases, including brain glioma; diabetic retinopathy; obesity; oral squamous cell carcinoma; and rheumatic heart disease. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase); PARTICIPATES IN gluconeogenesis pathway; electron transport chain pathway; Fanconi syndrome pathway; INTERACTS WITH (-)-selegiline; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: 38 kDa BFA-dependent ADP-ribosylation substrate; BARS-38; Gapd; peptidyl-cysteine S-nitrosylase GAPDH
Homo sapiens (human) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Canis lupus familiaris (dog) : LOC100688969 (glyceraldehyde-3-phosphate dehydrogenase-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
Sus scrofa (pig) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Chlorocebus sabaeus (African green monkey) : GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Heterocephalus glaber (naked mole-rat) : Gapdh (glyceraldehyde-3-phosphate dehydrogenase)
more info ...
Related Pseudogenes: Gapdh-ps1   Gapdh-ps2   LOC100361351   LOC689831  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04157,676,336 - 157,680,322 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,676,595 - 157,679,962 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04224,693,580 - 224,697,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44161,282,215 - 161,286,090 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1962,857,154 - 62,857,964 (+)NCBI
Celera4146,699,388 - 146,703,263 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gapdh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2661
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.