Fmo3 (flavin containing dimethylaniline monoxygenase 3) - Rat Genome Database

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Gene: Fmo3 (flavin containing dimethylaniline monoxygenase 3) Rattus norvegicus
Analyze
Symbol: Fmo3
Name: flavin containing dimethylaniline monoxygenase 3
RGD ID: 619761
Description: Enables N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3); PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; flavin-containing monooxygenase 3; FMO 3; hepatic flavin-containing monooxygenase 3; MGC93304; trimethylamine monooxygenase
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Bp329
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,838,899 - 77,868,869 (-)NCBIGRCr8
mRatBN7.21375,309,367 - 75,334,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,309,374 - 75,328,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,887,467 - 77,905,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,188,007 - 79,206,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,447,880 - 76,466,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,837,420 - 80,862,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
almotriptan  (ISO)
amitriptyline  (ISO)
amitriptylinoxide  (ISO)
ammonium chloride  (EXP)
ANTU  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzydamine  (ISO)
beta-D-glucan  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
C60 fullerene  (EXP)
carbon nanotube  (ISO)
chloroprene  (EXP)
cholic acid  (ISO)
choline  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
graphene oxide  (ISO)
Heliotrine  (ISO)
hexane  (EXP)
imipramine oxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methimazole  (EXP,ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N,N-dimethyltryptamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Olivacine  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perazine  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
ranitidine  (ISO)
retinyl acetate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiourea  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trimethylamine  (EXP,ISO)
trovafloxacin  (EXP)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. Dolan C, etal., BMC Med Genet. 2005 Dec 2;6:41.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases. Krause RJ, etal., Chem Res Toxicol. 2006 Dec;19(12):1643-9.
5. Cloning, sequencing, tissue distribution, and heterologous expression of rat flavin-containing monooxygenase 3. Lattard V, etal., Arch Biochem Biophys 2001 Jul 1;391(1):30-40.
6. Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Lattard V, etal., Biochem Pharmacol 2002 Apr 15;63(8):1453-64.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes. Novick RM and Elfarra AA, Drug Metab Dispos. 2008 Dec;36(12):2468-74. Epub 2008 Sep 5.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication. Treacy EP, etal., Hum Mol Genet. 1998 May;7(5):839-45.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19307449  


Genomics

Comparative Map Data
Fmo3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81377,838,899 - 77,868,869 (-)NCBIGRCr8
mRatBN7.21375,309,367 - 75,334,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1375,309,374 - 75,328,028 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1377,887,467 - 77,905,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01379,188,007 - 79,206,312 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01376,447,880 - 76,466,015 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1380,837,420 - 80,862,963 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
FMO3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,090,905 - 171,117,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,090,901 - 171,117,819 (+)EnsemblGRCh38hg38GRCh38
GRCh371171,060,046 - 171,086,959 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,326,660 - 169,353,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,791,693 - 167,818,617NCBI
Celera1144,169,885 - 144,196,864 (+)NCBICelera
Cytogenetic Map1q24.3NCBI
HuRef1142,283,384 - 142,310,544 (+)NCBIHuRef
CHM1_11172,482,298 - 172,509,155 (+)NCBICHM1_1
T2T-CHM13v2.01170,447,248 - 170,474,197 (+)NCBIT2T-CHM13v2.0
Fmo3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,781,368 - 162,812,097 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,781,369 - 162,812,097 (-)EnsemblGRCm39 Ensembl
GRCm381162,953,799 - 162,984,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,953,800 - 162,984,528 (-)EnsemblGRCm38mm10GRCm38
MGSCv371164,883,931 - 164,914,622 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361164,790,475 - 164,821,166 (-)NCBIMGSCv36mm8
Celera1165,392,349 - 165,424,291 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.34NCBI
FMO3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2178,639,381 - 78,665,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1178,313,659 - 78,339,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,583,570 - 146,611,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11150,298,957 - 150,325,850 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1150,298,957 - 150,325,850 (+)Ensemblpanpan1.1panPan2
FMO3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1727,720,420 - 27,745,522 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl727,720,420 - 27,845,626 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,247,890 - 27,272,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0727,522,170 - 27,547,286 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl727,522,170 - 27,547,286 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1727,372,307 - 27,397,410 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0727,407,132 - 27,432,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0727,649,342 - 27,674,458 (-)NCBIUU_Cfam_GSD_1.0
FMO3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl963,757,964 - 63,777,279 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1963,757,928 - 63,777,075 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2970,033,981 - 70,053,802 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMO3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12557,971,737 - 57,995,850 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2557,969,234 - 57,995,613 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605559,615,621 - 59,640,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fmo3
376 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:11
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000004864
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
BI283117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21375,309,872 - 75,310,025 (+)MAPPERmRatBN7.2
Rnor_6.01380,837,924 - 80,838,076NCBIRnor6.0
Rnor_5.01385,732,323 - 85,732,475UniSTSRnor5.0
RGSC_v3.41378,659,466 - 78,659,618UniSTSRGSC3.4
Celera1375,050,438 - 75,050,590UniSTS
Cytogenetic Map13q22UniSTS
AI169813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21375,316,994 - 75,317,104 (+)MAPPERmRatBN7.2
Rnor_6.01380,845,046 - 80,845,155NCBIRnor6.0
Rnor_5.01385,739,445 - 85,739,554UniSTSRnor5.0
RGSC_v3.41378,666,588 - 78,666,697UniSTSRGSC3.4
Celera1375,057,560 - 75,057,669UniSTS
RH 3.4 Map13473.6UniSTS
Cytogenetic Map13q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 22 17 17 21 1 10
Low 2 22 15 6 17 6 8 11 27 8 31 1 8
Below cutoff 16 14 12 2 12 21 4 2

Sequence


RefSeq Acc Id: ENSRNOT00000004864   ⟹   ENSRNOP00000004864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1375,309,374 - 75,328,028 (-)Ensembl
Rnor_6.0 Ensembl1380,837,420 - 80,862,963 (-)Ensembl
RefSeq Acc Id: NM_053433   ⟹   NP_445885
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,843,148 - 77,861,412 (-)NCBI
mRatBN7.21375,309,920 - 75,328,184 (-)NCBI
Rnor_6.01380,837,971 - 80,856,214 (-)NCBI
Rnor_5.01385,732,370 - 85,750,452 (-)NCBI
RGSC_v3.41378,659,513 - 78,678,524 (-)RGD
Celera1375,050,485 - 75,068,979 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091127   ⟹   XP_038947055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,838,899 - 77,868,143 (-)NCBI
mRatBN7.21375,309,367 - 75,334,915 (-)NCBI
RefSeq Acc Id: XM_039091128   ⟹   XP_038947056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,838,899 - 77,868,127 (-)NCBI
mRatBN7.21375,309,367 - 75,334,799 (-)NCBI
RefSeq Acc Id: XM_063272651   ⟹   XP_063128721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81377,838,899 - 77,868,869 (-)NCBI
RefSeq Acc Id: NP_445885   ⟸   NM_053433
- UniProtKB: Q5PQV6 (UniProtKB/Swiss-Prot),   Q9EQ76 (UniProtKB/Swiss-Prot),   A0A0G2JSI0 (UniProtKB/TrEMBL),   A6IDB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004864   ⟸   ENSRNOT00000004864
RefSeq Acc Id: XP_038947055   ⟸   XM_039091127
- Peptide Label: isoform X1
- UniProtKB: Q9EQ76 (UniProtKB/Swiss-Prot),   Q5PQV6 (UniProtKB/Swiss-Prot),   A0A0G2JSI0 (UniProtKB/TrEMBL),   A6IDB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947056   ⟸   XM_039091128
- Peptide Label: isoform X1
- UniProtKB: Q9EQ76 (UniProtKB/Swiss-Prot),   Q5PQV6 (UniProtKB/Swiss-Prot),   A0A0G2JSI0 (UniProtKB/TrEMBL),   A6IDB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128721   ⟸   XM_063272651
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQ76-F1-model_v2 AlphaFold Q9EQ76 1-531 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698945
Promoter ID:EPDNEW_R9470
Type:multiple initiation site
Name:Fmo3_1
Description:flavin containing monooxygenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9471  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,856,043 - 80,856,103EPDNEW
RGD ID:13698946
Promoter ID:EPDNEW_R9471
Type:single initiation site
Name:Fmo3_2
Description:flavin containing monooxygenase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9470  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01380,862,893 - 80,862,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619761 AgrOrtholog
BioCyc Gene G2FUF-17634 BioCyc
Ensembl Genes ENSRNOG00000003620 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004864.6 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7129948 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavin_mOase_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84493 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93304 IMAGE-MGC_LOAD
NCBI Gene 84493 ENTREZGENE
PANTHER DIMETHYLANILINE MONOOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIMETHYLANILINE MONOOXYGENASE [N-OXIDE-FORMING] 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FMO-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FMO3 RGD
PhenoGen Fmo3 PhenoGen
PIRSF FMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FMOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMOXYGENASE3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003620 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSI0 ENTREZGENE, UniProtKB/TrEMBL
  A6IDB5 ENTREZGENE, UniProtKB/TrEMBL
  FMO3_RAT UniProtKB/Swiss-Prot
  Q5PQV6 ENTREZGENE
  Q9EQ76 ENTREZGENE
UniProt Secondary Q5PQV6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-09 Fmo3  flavin containing dimethylaniline monoxygenase 3  Fmo3  flavin containing monooxygenase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Fmo3  flavin containing monooxygenase 3    flavin-containing monooxygenase 3  Name updated 1299863 APPROVED
2002-08-07 Fmo3  flavin-containing monooxygenase 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is gender specific 632684
gene_protein 531 amino-acid protein which has the NADPH- and FAD-binding sites and a hydrophobic carboxyl terminus 632683
gene_regulation in female rats, expression in kidney is strongly increased as a function of age while expression in liver is unaffected by age 632684