Gene: Fmo3 (flavin containing monooxygenase 3) Rattus norvegicus
Analyze
Symbol: Fmo3
Name: flavin containing monooxygenase 3
Description: ENCODES a protein that exhibits amino acid binding; N,N-dimethylaniline monooxygenase activity; NADP binding; INVOLVED IN drug metabolic process; PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); familial adenomatous polyposis (ortholog); hypertension (ortholog); FOUND IN intracellular membrane-bounded organelle; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits N,N-dimethylaniline monooxygenase activity, NADP binding activity, and amino acid binding activity; involved in drug metabolic process; localizes to the intracellular membrane-bounded organelle; orthologous to human FMO3 (flavin containing monooxygenase 3).
Merged Description: Exhibits N,N-dimethylaniline monooxygenase activity, NADP binding activity, and amino acid binding activity; involved in drug metabolic process; localizes to the intracellular membrane-bounded organelle; orthologous to human FMO3 (flavin containing monooxygenase 3); PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin-containing monooxygenase 3; FMO 3; hepatic flavin-containing monooxygenase 3; MGC93304; trimethylamine monooxygenase
Orthologs:
Homo sapiens (human) : FMO3 (flavin containing monooxygenase 3)  HGNC  Alliance
Mus musculus (house mouse) : Fmo3 (flavin containing monooxygenase 3)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : FMO3 (flavin containing monooxygenase 3)
Canis lupus familiaris (dog) : FMO3 (flavin containing monooxygenase 3)
Sus scrofa (pig) : FMO3 (flavin containing monooxygenase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Fmo3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619761
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.