Cox4i1 (cytochrome c oxidase subunit 4i1) - Rat Genome Database

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Gene: Cox4i1 (cytochrome c oxidase subunit 4i1) Rattus norvegicus
Analyze
Symbol: Cox4i1
Name: cytochrome c oxidase subunit 4i1
RGD ID: 68374
Description: Involved in response to nutrient. Predicted to be located in cytosol; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of mitochondrial respiratory chain complex IV. Biomarker of protein-energy malnutrition. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX IV-1; Cox4; Cox4a; cytochrome c oxidase polypeptide IV; cytochrome c oxidase subunit 4 isoform 1, mitochondrial; cytochrome c oxidase subunit IV; cytochrome c oxidase subunit IV isoform 1; cytochrome c oxidase subunit IVa; cytochrome c oxidase, subunit 4a; cytochrome c oxidase, subunit IV; cytochrome c oxidase, subunit IVa; MGC105470
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21948,721,680 - 48,727,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,721,199 - 48,727,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1955,516,046 - 55,522,295 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,196,685 - 56,202,925 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,411,393 - 58,417,603 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,245,958 - 54,252,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,245,950 - 54,252,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01964,965,282 - 64,971,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,023,960 - 51,030,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11951,028,840 - 51,035,081 (+)NCBI
Celera1947,973,554 - 47,979,795 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-nitropropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (EXP)
AM-251  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
capsaicin  (EXP)
CCCP  (ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ebselen  (ISO)
Erythropoietin  (ISO)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
glucose  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (EXP)
ivermectin  (ISO)
L-ethionine  (EXP)
limonene  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
melatonin  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
Mitotane  (ISO)
monocrotophos  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nitric oxide  (ISO)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sodium hydrogensulfite  (EXP)
sodium nitrate  (ISO)
sulfur dioxide  (EXP)
T-2 toxin  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate by complex IV of rat mitochondria. Brookes PS and Baggott JE, Biochemistry 2002 Apr 30;41(17):5633-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Nucleotide sequence of cDNA encoding subunit IV of cytochrome c oxidase from fetal rat liver. Gopalan G, etal., Nucleic Acids Res 1989 Jun 12;17(11):4376.
5. Nucleotide sequence of cDNA for rat brain and liver cytochrome c oxidase subunit IV. Goto Y, etal., Nucleic Acids Res 1989 Apr 11;17(7):2851.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function. Kumar V, etal., Sci Rep. 2019 Sep 11;9(1):13170. doi: 10.1038/s41598-019-49666-0.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Undernutrition during suckling in rats elevates plasma adiponectin and its receptor in skeletal muscle regardless of diet composition: a protective effect? Prior LJ, etal., Int J Obes (Lond). 2008 Aug 26.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The rat cytochrome c oxidase subunit IV gene family: tissue-specific and hormonal differences in subunit IV and cytochrome c mRNA expression. Virbasius JV and Scarpulla RC, Nucleic Acids Res 1990 Nov 25;18(22):6581-6.
15. Structural organization of the rat cytochrome c oxidase subunit IV gene. Yamada M, etal., J Biol Chem 1990 May 5;265(13):7687-92.
Additional References at PubMed
PMID:2165254   PMID:7601105   PMID:11940593   PMID:12270909   PMID:12477932   PMID:12506326   PMID:12865426   PMID:12910269   PMID:14651853   PMID:15489334   PMID:15565177   PMID:16103131  
PMID:17923681   PMID:18408135   PMID:18614015   PMID:19393246   PMID:19946888   PMID:20833797   PMID:20959514   PMID:21416482   PMID:22396533   PMID:22555453   PMID:22773120   PMID:22783020  
PMID:23376485   PMID:23818984   PMID:24610532   PMID:25002582   PMID:26746385   PMID:26767982   PMID:28161363   PMID:28376086   PMID:29476059   PMID:31505169  


Genomics

Comparative Map Data
Cox4i1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21948,721,680 - 48,727,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1948,721,199 - 48,727,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1955,516,046 - 55,522,295 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01956,196,685 - 56,202,925 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01958,411,393 - 58,417,603 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01954,245,958 - 54,252,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1954,245,950 - 54,252,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01964,965,282 - 64,971,577 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,023,960 - 51,030,200 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11951,028,840 - 51,035,081 (+)NCBI
Celera1947,973,554 - 47,979,795 (+)NCBICelera
Cytogenetic Map19q12NCBI
COX4I1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,799,695 - 85,807,068 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1685,798,633 - 85,807,068 (+)EnsemblGRCh38hg38GRCh38
GRCh371685,833,301 - 85,840,674 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361684,390,697 - 84,398,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 341684,390,696 - 84,398,109NCBI
Celera1670,136,278 - 70,143,686 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1671,574,688 - 71,582,119 (+)NCBIHuRef
CHM1_11687,244,717 - 87,252,148 (+)NCBICHM1_1
T2T-CHM13v2.01691,865,215 - 91,872,584 (+)NCBIT2T-CHM13v2.0
Cox4i1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,394,964 - 121,400,948 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8121,394,961 - 121,400,946 (+)EnsemblGRCm39 Ensembl
GRCm388120,668,225 - 120,674,209 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8120,668,222 - 120,674,207 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,192,190 - 123,198,109 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368123,554,281 - 123,572,260 (+)NCBIMGSCv36mm8
Celera8124,884,148 - 124,890,066 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map869.99NCBI
LOC102020379
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541884,988 - 890,890 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955541885,824 - 890,824 (+)NCBIChiLan1.0ChiLan1.0
LOC100969890
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan116101,467,899 - 101,475,288 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01666,467,259 - 66,474,652 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11685,805,595 - 85,812,851 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1685,805,611 - 85,812,851 (+)Ensemblpanpan1.1panPan2
COX4I1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,883,730 - 66,891,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,883,732 - 66,891,500 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,899,917 - 66,907,747 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0567,112,369 - 67,120,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl567,112,369 - 67,148,247 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1567,133,830 - 67,141,650 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0566,967,910 - 66,975,726 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0567,382,851 - 67,390,678 (-)NCBIUU_Cfam_GSD_1.0
LOC101971634
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934926,937,176 - 26,943,452 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366412,690,176 - 2,695,387 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366412,690,723 - 2,695,230 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX4I1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl63,131,019 - 3,137,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.163,131,017 - 3,137,619 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.263,453,560 - 3,458,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233412
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,207,509 - 71,214,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl571,206,941 - 71,215,034 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660474,523,156 - 4,530,607 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101705610
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247462,187,492 - 2,194,040 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247462,187,443 - 2,193,874 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cox4i1
34 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir338rno-miR-338-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19020050

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000024033
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
RH127425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,726,678 - 48,727,766 (+)MAPPERmRatBN7.2
Rnor_6.01954,250,957 - 54,252,044NCBIRnor6.0
Rnor_5.01964,970,334 - 64,971,421UniSTSRnor5.0
RGSC_v3.41951,028,959 - 51,030,046UniSTSRGSC3.4
Celera389,339,647 - 89,339,855UniSTS
Celera1947,978,554 - 47,979,641UniSTS
RH 3.4 Map81190.8UniSTS
Cytogenetic Map19q12UniSTS
RH125550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,726,164 - 48,726,275 (+)MAPPERmRatBN7.2
mRatBN7.2390,275,747 - 90,275,796 (+)MAPPERmRatBN7.2
Rnor_6.0393,832,685 - 93,832,794NCBIRnor6.0
Rnor_6.01954,250,443 - 54,250,553NCBIRnor6.0
Rnor_5.01964,969,820 - 64,969,930UniSTSRnor5.0
RGSC_v3.41951,028,445 - 51,028,555UniSTSRGSC3.4
RGSC_v3.4389,170,772 - 89,170,882UniSTSRGSC3.4
Celera389,339,868 - 89,339,978UniSTS
Celera1947,978,040 - 47,978,150UniSTS
Cytogenetic Map3q32UniSTS
Cytogenetic Map19q12UniSTS
Cox4a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21948,726,724 - 48,727,833 (+)MAPPERmRatBN7.2
Rnor_6.01954,251,003 - 54,252,111NCBIRnor6.0
Rnor_5.01964,970,380 - 64,971,488UniSTSRnor5.0
RGSC_v3.41951,029,005 - 51,030,113UniSTSRGSC3.4
Celera1947,978,600 - 47,979,708UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 21 3 6 9 1
Medium 1 22 57 41 19 41 8 8 68 26 40 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024033   ⟹   ENSRNOP00000024033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,721,729 - 48,727,921 (+)Ensembl
Rnor_6.0 Ensembl1954,245,950 - 54,252,225 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094964   ⟹   ENSRNOP00000097525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,725,129 - 48,727,921 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107199   ⟹   ENSRNOP00000082380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1948,721,199 - 48,727,921 (+)Ensembl
RefSeq Acc Id: NM_017202   ⟹   NP_058898
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21948,721,680 - 48,727,920 (+)NCBI
Rnor_6.01954,245,958 - 54,252,198 (+)NCBI
Rnor_5.01964,965,282 - 64,971,577 (+)NCBI
RGSC_v3.41951,023,960 - 51,030,200 (+)RGD
Celera1947,973,554 - 47,979,795 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058898   ⟸   NM_017202
- Peptide Label: precursor
- UniProtKB: P10888 (UniProtKB/Swiss-Prot),   A6IZM8 (UniProtKB/TrEMBL),   A0A8L2QCS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024033   ⟸   ENSRNOT00000024033
RefSeq Acc Id: ENSRNOP00000097525   ⟸   ENSRNOT00000094964
RefSeq Acc Id: ENSRNOP00000082380   ⟸   ENSRNOT00000107199

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10888-F1-model_v2 AlphaFold P10888 1-169 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68374 AgrOrtholog
BioCyc Gene G2FUF-5473 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
Ensembl Genes ENSRNOG00000017817 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024033.4 UniProtKB/TrEMBL
  ENSRNOP00000082380.1 UniProtKB/TrEMBL
  ENSRNOP00000097525.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024033.6 UniProtKB/TrEMBL
  ENSRNOT00000094964.1 UniProtKB/TrEMBL
  ENSRNOT00000107199.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.442.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317602 IMAGE-MGC_LOAD
InterPro Cyt_c_oxidase_su4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29445 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105470 IMAGE-MGC_LOAD
NCBI Gene 29445 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10707 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COX4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cox4i1 PhenoGen
PRINTS CYTCOXIDASE4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81406 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZUV1_RAT UniProtKB/TrEMBL
  A0A8I6ARH0_RAT UniProtKB/TrEMBL
  A0A8L2QCS6 ENTREZGENE, UniProtKB/TrEMBL
  A6IZM8 ENTREZGENE, UniProtKB/TrEMBL
  COX41_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox4i1  cytochrome c oxidase subunit 4i1  Cox4i1  cytochrome c oxidase subunit IV isoform 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cox4i1  cytochrome c oxidase subunit IV isoform 1  Cox4a  cytochrome c oxidase, subunit 4a  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cox4a  cytochrome c oxidase, subunit 4a      Name updated 70584 APPROVED
2001-12-12 Cox4a  cytochrome c oxidase, subunit IVa      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues 632600
gene_transcript 5' region contains multiple transcription start sites mapped to within an approximately 50 bp region and a GC-rich promoter lacking typical CCAAT or TATAA sequences 632600