Tkt (transketolase) - Rat Genome Database

Name: Tkt
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Tkt (transketolase) Rattus norvegicus

Analyze

Symbol:

Tkt

Name:

transketolase

RGD ID:

621036

Description:

Enables cation binding activity; monosaccharide binding activity; and transketolase activity. Involved in pentose-phosphate shunt, non-oxidative branch. Located in endoplasmic reticulum membrane and peroxisome. Orthologous to human TKT (transketolase); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - non-oxidative phase; ribose 5-phosphate isomerase deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TKT (transketolase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tkt (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tkt (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TKT (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TKT (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tkt (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TKT (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TKT (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tkt (transketolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GRB10 (growth factor receptor bound protein 10)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TKT (transketolase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tkt (transketolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tkta (transketolase a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5103	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TKL1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TKL2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tkt-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8036	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tkt	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	5,723,764 - 5,748,702 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	5,723,762 - 5,748,698 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	5,735,981 - 5,760,697 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	6,881,435 - 6,906,151 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	5,734,559 - 5,759,275 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	6,609,670 - 6,634,608 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	6,609,668 - 6,634,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,543,529 - 6,568,467 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	5,908,759 - 5,933,695 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	5,908,756 - 5,933,689 (+)	NCBI
Celera	16	9,440,328 - 9,465,209 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

carcinoma (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

Hypoxia (ISO)

Neoplasm Invasiveness (ISO)

Short Stature, Developmental Delay, and Congenital Heart Defects (ISO)

Wernicke encephalopathy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP,ISO)

2-acetamidofluorene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

7,12-dimethyltetraphene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

astaxanthin (ISO)

atrazine (ISO)

Augmentin (ISO)

azoxystrobin (EXP)

benfotiamine (EXP,ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

buspirone (EXP)

butan-1-ol (ISO)

butyric acid (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlormequat chloride (EXP)

chloropicrin (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

cisplatin (ISO)

clavulanic acid (ISO)

cobalt dichloride (ISO)

cocaine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (EXP)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

felbamate (EXP)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gabapentin (EXP)

genistein (ISO)

gentamycin (EXP)

glyphosate (EXP)

gold atom (ISO)

gold(0) (ISO)

hydroquinone (ISO)

imidacloprid (EXP)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

ketoconazole (EXP)

L-methionine (ISO)

lead(II) chloride (ISO)

levofloxacin (EXP)

lithium atom (EXP)

lithium hydride (EXP)

mercury dibromide (ISO)

methapyrilene (EXP,ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

morphine (EXP)

N-methyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

p-chloromercuribenzoic acid (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

phenethyl caffeate (EXP)

phenobarbital (EXP)

phenylmercury acetate (ISO)

phenytoin (EXP)

PhIP (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (EXP,ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

streptozocin (EXP)

sunitinib (ISO)

T-2 toxin (EXP)

tetrachloromethane (EXP)

thiabendazole (EXP)

thimerosal (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

trovafloxacin (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vitamin E (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glyceraldehyde-3-phosphate biosynthetic process (IEA,ISO)

pentose-phosphate shunt (IDA,IEA,ISO)

pentose-phosphate shunt, non-oxidative branch (IBA,IDA)

regulation of growth (IEA,ISO)

xylulose 5-phosphate biosynthetic process (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

endoplasmic reticulum membrane (IBA,IDA)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

peroxisome (IDA)

Molecular Function

calcium ion binding (IEA,ISO)

carbohydrate binding (IDA)

magnesium ion binding (IDA,IEA,ISO)

metal ion binding (IEA)

monosaccharide binding (IDA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

thiamine pyrophosphate binding (IBA,IDA)

transferase activity (IEA)

transketolase activity (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pentose phosphate pathway (IDA,IEA,ISO)

pentose phosphate pathway - non-oxidative phase (IDA,TAS)

ribose 5-phosphate isomerase deficiency pathway (ISO)

transaldolase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase.	Abedinia M, etal., Biochem Biophys Res Commun 1992 Mar 31;183(3):1159-66.
2.	In situ localization of transketolase activity in epithelial cells of different rat tissues and subcellularly in liver parenchymal cells.	Boren J, etal., J Histochem Cytochem. 2006 Feb;54(2):191-9. Epub 2005 Aug 22.
3.	The pentose phosphate pathway in the endoplasmic reticulum.	Bublitz C and Steavenson S, J Biol Chem. 1988 Sep 15;263(26):12849-53.
4.	The interdependence of glycolytic and pentose cycle intermediates in ad libitum fed rats.	Casazza JP and Veech RL, J Biol Chem. 1986 Jan 15;261(2):690-8.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
15.	Properties and functions of the thiamin diphosphate dependent enzyme transketolase.	Schenk G, etal., Int J Biochem Cell Biol. 1998 Dec;30(12):1297-318.
16.	Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology.	Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
17.	A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis.	Veech RL Proc Natl Acad Sci U S A. 2003 May 13;100(10):5578-80. Epub 2003 Apr 29.

Additional References at PubMed

PMID:8419340	PMID:9357955	PMID:9611778	PMID:12167708	PMID:17634366	PMID:19056867	PMID:19190083	PMID:20458337	PMID:20667822	PMID:22871113	PMID:23376485	PMID:23533145
PMID:25028661	PMID:33450132

Genomics

Comparative Map Data

Tkt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	5,723,764 - 5,748,702 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	5,723,762 - 5,748,698 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	5,735,981 - 5,760,697 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	6,881,435 - 6,906,151 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	5,734,559 - 5,759,275 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	6,609,670 - 6,634,608 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	6,609,668 - 6,634,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,543,529 - 6,568,467 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	5,908,759 - 5,933,695 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	5,908,756 - 5,933,689 (+)	NCBI
Celera	16	9,440,328 - 9,465,209 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

TKT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	53,224,712 - 53,256,022 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	53,224,712 - 53,256,052 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	53,258,728 - 53,290,038 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	53,234,704 - 53,264,998 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	53,234,705 - 53,264,998	NCBI
Celera	3	53,225,747 - 53,257,192 (-)	NCBI		Celera
Cytogenetic Map	3	p21.1	NCBI
HuRef	3	53,308,475 - 53,339,480 (-)	NCBI		HuRef
CHM1_1	3	53,210,297 - 53,241,712 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	53,257,622 - 53,288,998 (-)	NCBI		T2T-CHM13v2.0

Tkt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	30,271,088 - 30,296,681 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	30,270,316 - 30,296,677 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	30,549,131 - 30,574,724 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	30,548,359 - 30,574,720 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	31,362,335 - 31,387,908 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	29,378,158 - 29,403,731 (+)	NCBI		MGSCv36	mm8
Celera	14	26,805,317 - 26,830,435 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	18.79	NCBI

Tkt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	3,178,830 - 3,193,345 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	3,178,830 - 3,193,241 (-)	NCBI	ChiLan1.0	ChiLan1.0

TKT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	53,212,734 - 53,257,204 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	53,168,426 - 53,199,003 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	54,389,549 - 54,420,704 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	54,389,549 - 54,420,704 (-)	Ensembl	panpan1.1		panPan2

TKT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	36,690,540 - 36,705,980 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	36,681,531 - 36,742,199 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	36,617,359 - 36,642,352 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	36,959,138 - 36,984,142 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	36,958,981 - 36,984,141 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	36,395,903 - 36,420,888 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	36,757,580 - 36,782,577 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	36,972,262 - 36,997,252 (+)	NCBI		UU_Cfam_GSD_1.0

Tkt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	170,812,273 - 170,840,216 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	3,950,920 - 3,978,672 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936473	3,950,846 - 3,978,778 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TKT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	35,348,915 - 35,377,587 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	35,348,921 - 35,377,518 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	38,418,457 - 38,447,124 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TKT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	14,620,340 - 14,650,694 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	14,620,287 - 14,650,655 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	152,245,198 - 152,275,549 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tkt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	3,989,299 - 4,014,269 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624822	3,989,292 - 4,014,150 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tkt
199 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	30
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000021862
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat

Markers in Region

BE117994

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	5,747,569 - 5,747,727 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	6,633,476 - 6,633,633	NCBI	Rnor6.0
Rnor_5.0	16	6,567,335 - 6,567,492	UniSTS	Rnor5.0
RGSC_v3.4	16	5,932,565 - 5,932,722	UniSTS	RGSC3.4
Celera	16	9,441,301 - 9,441,458	UniSTS
RH 3.4 Map	16	33.2	UniSTS
Cytogenetic Map	16	p16	UniSTS

TKT

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	5,744,917 - 5,745,156 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	6,630,824 - 6,631,062	NCBI	Rnor6.0
Rnor_5.0	16	6,564,683 - 6,564,921	UniSTS	Rnor5.0
RGSC_v3.4	16	5,929,913 - 5,930,151	UniSTS	RGSC3.4
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	6	8	74	35	41	11	6
Low							2	3					2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006252661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ232736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U09256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000021862 ⟹ ENSRNOP00000021862

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	5,723,762 - 5,748,689 (+)	Ensembl
Rnor_6.0 Ensembl	16	6,609,668 - 6,634,595 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000113496 ⟹ ENSRNOP00000095976

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	5,724,393 - 5,748,698 (+)	Ensembl

RefSeq Acc Id:

NM_022592 ⟹ NP_072114

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	5,723,764 - 5,748,700 (+)	NCBI
Rnor_6.0	16	6,609,670 - 6,634,606 (+)	NCBI
Rnor_5.0	16	6,543,529 - 6,568,467 (+)	NCBI
RGSC_v3.4	16	5,908,759 - 5,933,695 (+)	RGD
Celera	16	9,440,328 - 9,465,209 (-)	RGD

Sequence:

show sequence

GAATTCGGGAATGTCATGGATCCAGTGAGACAGATCCAGTGCGACCGTGAAGGCAAACGCTTTC
CGTTCCTCTCAGCTCCACCAGCTTCCACGTCCTCGCCCGACCGCGCCATGGAGGGTTACCATAA
GCCAGATCAGCAGAAGCTCCAGGCCCTGAAGGACACAGCCAATCGCCTGCGCATCAGCTCCATC
CAGGCCACCACCGCGGCAGGCTCGGGACACCCCACATCATGCTGCAGCGCTGCCGAGATCATGG
CTGTCCTGTTTTTCCATACCATGCGCTACAAGGCCCTGGATCCCCGAAACCCTCACAATGATCG
CTTTGTGCTCTCCAAGGGCCATGCAGCTCCCATCTTATATGCAGTCTGGGCTGAAGCTGGCTTC
CTGCCTGAGGCAGAGCTGCTGAACCTGAGGAAAATCAGCTCTGACTTGGATGGGCATCCTGTCC
CGAAACAAGCCTTCACCGATGTGGCCACTGGCTCCCTGGGCCAGGGGCTGGGAGCTGCGTGCGG
GATGGCATACACAGGCAAATACTTCGACAAAGCCAGCTACCGAGTCTATTGCATGCTGGGAGAC
GGGGAGGTGTCCGAGGGCTCCGTTTGGGAGGCCATGGCCTTCGCTGGAATTTACAAGCTGGACA
ACCTCGTTGCCATTTTTGACATCAACCGTCTGGGCCAGAGCGACCCAGCCCCGCTGCAGCACCA
AGTGGACGTCTACCAGAAGCGCTGTGAGGCCTTTGGCTGGCACGCCATCATCGTGGATGGGCAC
AGTGTGGAGGAGCTGTGCAAGGCCTTTGGTCAGGCCAAGCACCAACCAACAGCCATCATTGCCA
AGACCTTCAAGGGCCGCGGGATCACAGGGATTGAAGACAAGGAGGCGTGGCATGGGAAGCCCCT
CCCCAAAAACATGGCTGAGCAGATTATCCAGGAGATTTACAGCCAGGTTCAGAGCAAAAAGAAG
ATCCTCGCCACGCCCCCTCAGGAGGATGCCCCTTCCGTGGACATTGCCAACATCCGAATGCCTA
CCCCACCCAACTACAAAGTGGGGGACAAGATAGCCACACGGAAAGCCTATGGATTGGCCCTTGC
CAAGCTGGGCCACGCCAGTGACCGCATCATCGCCCTGGATGGAGACACCAAAAATTCCACCTTC
TCAGAGCTCTTCAAAAAGGAGCACCCAGACCGTTTCATCGAGTGCTACATTGCTGAGCAGAACA
TGGTGAGCATTGCTGTGGGCTGTGCCACACGTGACAGGACAGTGCCCTTCTGCAGCACTTTTGC
GGCCTTCTTCACACGCGCCTTCGACCAGATCCGCATGGCCGCCATCTCCGAGAGCAACATCAAC
CTTTGTGGCTCCCACTGCGGCGTGTCCATTGGGGAAGACGGGCCCTCGCAGATGGCCCTGGAAG
ACCTGGCCATGTTTCGGTCGGTCCCTATGTCCACCGTCTTTTACCCAAGTGATGGAGTTGCCAC
AGAGAAGGCAGTGGAATTAGCAGCCAATACAAAGGGCATCTGCTTCATTCGGACCAGCCGCCCA
GAAAATGCCATTATCTATAGCAACAACGAGGATTTCCAGGTTGGCCAAGCCAAGGTGGTCCTGA
AGAGCAAGGACGACCAAGTGACAGTGATCGGGGCTGGCGTAACTCTGCACGAGGCTCTGGCTGC
TGCAGAGATGTTGAAGAAAGAGAAGATCGGTGTCCGTGTACTGGACCCCTTCACCATCAAGCCC
CTGGACAAAAAGCTCATTCTCGACTGTGCCAGAGCAACCAAAGGCAGGATCCTCACCGTGGAGG
ACCACTACTATGAAGGTGGCATAGGCGAGGCAGTATCTGCTGTGGTAGTGGGCGAACCTGGAGT
CACAGTCACTCGCCTGGCGGTCAGCCAAGTACCACGAAGTGGGAAGCCAGCTGAGCTGCTGAAG
ATGTTTGGTATTGACAAAGACGCCATTGTGCAAGCTGTGAAGGGCCTTGTCACCAAGGGCTAGG
AAGGACATGGGATGCCGGGTGGGTGAACTACACATTCCAGGGATGTTCTGGCAAAGGTGCTCAA
GGGTGTACCGAGTGGAAAGGTAAATATATGTTTTGAGAAAAACCGAATTC

hide sequence

RefSeq Acc Id:

XM_006252661 ⟹ XP_006252723

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	5,724,347 - 5,748,702 (+)	NCBI
Rnor_6.0	16	6,610,253 - 6,634,608 (+)	NCBI
Rnor_5.0	16	6,543,529 - 6,568,467 (+)	NCBI

Sequence:

show sequence

TGATCCGCCCCCATGGGCGGGTCCTAAGGTGTCTTAACGCGCCCGCCCGCAGCACCGGGCCTCG
GTCACTGCCGGTCGCTTCCTGAGCCTCCTCTGGCTCTGTGTCTCTGTCCTCAGCTTCCACGTCC
TCGCCCGACCGCGCCATGGAGGGTTACCATAAGCCAGATCAGCAGAAGCTCCAGGCCCTGAAGG
ACACAGCCAATCGCCTGCGCATCAGCTCCATCCAGGCCACCACCGCGGCAGGCTCGGGACACCC
CACATCATGCTGCAGCGCTGCCGAGATCATGGCTGTCCTGTTTTTCCATACCATGCGCTACAAG
GCCCTGGATCCCCGAAACCCTCACAATGATCGCTTTGTGCTCTCCAAGGGCCATGCAGCTCCCA
TCTTATATGCAGTCTGGGCTGAAGCTGGCTTCCTGCCTGAGGCAGAGCTGCTGAACCTGAGGAA
AATCAGCTCTGACTTGGATGGGCATCCTGTCCCGAAACAAGCCTTCACCGATGTGGCCACTGGC
TCCCTGGGCCAGGGGCTGGGAGCTGCGTGCGGGATGGCATACACAGGCAAATACTTCGACAAAG
CCAGCTACCGAGTCTATTGCATGCTGGGAGACGGGGAGGTGTCCGAGGGCTCCGTTTGGGAGGC
CATGGCCTTCGCTGGAATTTACAAGCTGGACAACCTCGTTGCCATTTTTGACATCAACCGTCTG
GGCCAGAGCGACCCAGCCCCGCTGCAGCACCAAGTGGACGTCTACCAGAAGCGCTGTGAGGCCT
TTGGCTGGCATGCCATCATCGTGGATGGGCACAGTGTGGAGGAGCTGTGCAAGGCCTTTGGTCA
GGCCAAGCACCAACCAACAGCCATCATTGCCAAGACCTTCAAGGGCCGCGGGATCACAGGGATT
GAAGACAAGGAGGCGTGGCATGGGAAGCCCCTCCCCAAAAACATGGCTGAGCAGATTATCCAGG
AGATTTACAGCCAGGTTCAGAGCAAAAAGAAGATCCTCGCCACGCCCCCTCAGGAGGATGCCCC
TTCCGTGGACATTGCCAACATCCGAATGCCTACCCCACCCAACTACAAAGTGGGGGACAAGATA
GCCACACGGAAAGCCTATGGATTGGCCCTTGCCAAGCTGGGCCACGCCAGTGACCGCATCATCG
CCCTGGATGGAGACACCAAAAATTCCACCTTCTCAGAGCTCTTCAAAAAGGAGCACCCAGACCG
TTTCATCGAGTGCTACATTGCTGAGCAGAACATGGTGAGCATTGCTGTGGGCTGTGCCACACGT
GACAGGACAGTGCCCTTCTGCAGCACTTTTGCGGCCTTCTTCACACGCGCCTTCGACCAGATCC
GCATGGCCGCCATCTCCGAGAGCAACATCAACCTCTGTGGCTCCCATTGCGGCGTGTCCATTGG
GGAAGACGGGCCCTCGCAGATGGCCCTGGAAGACCTGGCCATGTTTCGGTCGGTCCCTATGTCC
ACCGTCTTTTACCCAAGTGATGGAGTTGCCACAGAGAAGGCAGTGGAATTAGCAGCCAATACAA
AGGGCATCTGCTTCATTCGGACCAGCCGCCCAGAAAATGCCATTATCTATAGCAACAACGAGGA
TTTCCAGGTTGGCCAAGCCAAGGTGGTCCTGAAGAGCAAGGACGACCAAGTGACGGTGATCGGG
GCTGGCGTAACTCTGCACGAGGCTCTGGCTGCTGCAGAGATGTTGAAGAAAGAGAAGATCGGCG
TCCGTGTACTGGACCCCTTCACCATCAAGCCCCTGGACAAAAAGCTCATTCTCGACTGTGCCAG
AGCAACCAAAGGCAGGATCCTCACCGTGGAGGACCACTACTATGAAGGTGGCATAGGCGAGGCA
GTATCTGCTGCGGTAGTGGGCGAACCTGGAGTCACAGTCACTCGCCTGGCGGTCAGCCAAGTAC
CACGAAGTGGGAAGCCAGCTGAGCTGCTGAAGATGTTTGGTATTGACAAAGACGCCATTGTGCA
AGCTGTGAAGGGCCTTGTCACCAAGGGCTAGGAAGGACATGGGATGCCGGGTGGGTGAACTACA
CATTCCAGGGATGTTCTGGCAAAGGTGCTCAAGGGTGTACCGAGTGGAAAGGTAAATATATGTT
TTGAGAAAAAAATTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_072114	(Get FASTA)	NCBI Sequence Viewer
	XP_006252723	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA18026	(Get FASTA)	NCBI Sequence Viewer
	EDL88991	(Get FASTA)	NCBI Sequence Viewer
	EDL88992	(Get FASTA)	NCBI Sequence Viewer
	EDL88993	(Get FASTA)	NCBI Sequence Viewer
	EDL88994	(Get FASTA)	NCBI Sequence Viewer
	EDL88995	(Get FASTA)	NCBI Sequence Viewer
	P50137	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_072114 ⟸ NM_022592

- UniProtKB:

A6KG34 (UniProtKB/TrEMBL), G3V826 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDPVRQIQCDREGKRFPFLSAPPASTSSPDRAMEGYHKPDQQKLQALKDTANRLRISSIQATTA
AGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLPEAE
LLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCMLGDGEVSE
GSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQVDVYQKRCEAFGWHAIIVDGHSVEEL
CKAFGQAKHQPTAIIAKTFKGRGITGIEDKEAWHGKPLPKNMAEQIIQEIYSQVQSKKKILATP
PQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYGLALAKLGHASDRIIALDGDTKNSTFSELFK
KEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSH
CGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAEMLKKEKIGVRVLDPFTIKPLDKKL
ILDCARATKGRILTVEDHYYEGGIGEAVSAVVVGEPGVTVTRLAVSQVPRSGKPAELLKMFGID
KDAIVQAVKGLVTKG

hide sequence

RefSeq Acc Id:	XP_006252723 ⟸ XM_006252661
- Peptide Label:	isoform X1
- UniProtKB:	P50137 (UniProtKB/Swiss-Prot), A6KG36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEGYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPR NPHNDRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQG LGAACGMAYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDP APLQHQVDVYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGIEDKEA WHGKPLPKNMAEQIIQEIYSQVQSKKKILATPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKA YGLALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVP FCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYP SDGVATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTL HEALAAAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAAV VGEPGVTVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLVTKG hide sequence

RefSeq Acc Id:

ENSRNOP00000021862 ⟸ ENSRNOT00000021862

RefSeq Acc Id:

ENSRNOP00000095976 ⟸ ENSRNOT00000113496

Protein Domains

Transketolase signature Transketolase-like pyrimidine-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50137-F1-model_v2	AlphaFold	P50137	1-623	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621036	AgrOrtholog
BioCyc Gene	G2FUF-12189	BioCyc
BioCyc Pathway	NONOXIPENT-PWY [pentose phosphate pathway (non-oxidative branch) I]	BioCyc
Ensembl Genes	ENSRNOG00000016064	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000021862	ENTREZGENE
	ENSRNOP00000021862.4	UniProtKB/TrEMBL
	ENSRNOP00000095976	ENTREZGENE
	ENSRNOP00000095976.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021862	ENTREZGENE
	ENSRNOT00000021862.7	UniProtKB/TrEMBL
	ENSRNOT00000113496	ENTREZGENE
	ENSRNOT00000113496.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.920	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.970	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	THDP-binding	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketo_C/PFOR_II	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase-like_Pyr-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:64524	UniProtKB/Swiss-Prot
NCBI Gene	64524	ENTREZGENE
PANTHER	TRANSKETOLASE	UniProtKB/Swiss-Prot
	TRANSKETOLASE	UniProtKB/Swiss-Prot
	TRANSKETOLASE	UniProtKB/TrEMBL
	TRANSKETOLASE	UniProtKB/TrEMBL
Pfam	Transket_pyr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tkt	PhenoGen
PROSITE	TRANSKETOLASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TRANSKETOLASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Transket_pyr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52518	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52922	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AQ92_RAT	UniProtKB/TrEMBL
	A6KG34	ENTREZGENE, UniProtKB/TrEMBL
	A6KG35_RAT	UniProtKB/TrEMBL
	A6KG36	ENTREZGENE, UniProtKB/TrEMBL
	A6KG37_RAT	UniProtKB/TrEMBL
	A6KG38_RAT	UniProtKB/TrEMBL
	G3V826	ENTREZGENE, UniProtKB/TrEMBL
	P50137	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-01-20	Tkt	transketolase			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Tkt	transketolase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)