Akap8 (A-kinase anchoring protein 8) - Rat Genome Database
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Gene: Akap8 (A-kinase anchoring protein 8) Rattus norvegicus
Analyze
Symbol: Akap8
Name: A-kinase anchoring protein 8
RGD ID: 620832
Description: Exhibits double-stranded DNA binding activity; protein kinase A regulatory subunit binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of tumor necrosis factor production; and regulation of histone modification. Localizes to Golgi apparatus; mitochondrion; and nuclear matrix. Orthologous to human AKAP8 (A-kinase anchoring protein 8); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; AKAP 95; AKAP-8; Akap95
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2711,316,224 - 11,332,523 (-)NCBI
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0714,323,298 - 14,339,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0714,477,683 - 14,493,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,873,303 - 12,889,333 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1712,873,301 - 12,889,308 (-)NCBI
Celera79,427,350 - 9,443,479 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12082153   PMID:12477932   PMID:15878851   PMID:16751186   PMID:16980585   PMID:17911601   PMID:19073898   PMID:19531803   PMID:19946888   PMID:22130794   PMID:22658674   PMID:22681889  
PMID:26683827  


Genomics

Comparative Map Data
Akap8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2711,316,224 - 11,332,523 (-)NCBI
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0714,323,298 - 14,339,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0714,477,683 - 14,493,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4712,873,303 - 12,889,333 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1712,873,301 - 12,889,308 (-)NCBI
Celera79,427,350 - 9,443,479 (-)NCBICelera
Cytogenetic Map7q11NCBI
AKAP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1915,353,385 - 15,379,815 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1915,353,385 - 15,379,798 (-)EnsemblGRCh38hg38GRCh38
GRCh381915,353,385 - 15,379,787 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371915,464,196 - 15,490,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,325,335 - 15,351,603 (-)NCBINCBI36hg18NCBI36
Build 341915,325,335 - 15,351,603NCBI
Celera1915,359,984 - 15,386,240 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1915,032,304 - 15,058,582 (-)NCBIHuRef
CHM1_11915,463,860 - 15,490,252 (-)NCBICHM1_1
Akap8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,522,646 - 32,540,212 (-)NCBIGRCm39mm39
GRCm39 Ensembl1732,522,646 - 32,540,212 (-)Ensembl
GRCm381732,303,672 - 32,321,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,303,672 - 32,321,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371732,440,621 - 32,458,098 (-)NCBIGRCm37mm9NCBIm37
MGSCv361732,035,284 - 32,052,761 (-)NCBImm8
Celera1733,224,515 - 33,241,992 (-)NCBICelera
Cytogenetic Map17B1NCBI
Akap8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,874,746 - 7,892,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,874,655 - 7,893,209 (+)NCBIChiLan1.0ChiLan1.0
AKAP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11915,872,536 - 15,897,661 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1915,872,536 - 15,897,661 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01914,888,201 - 14,912,739 (-)NCBIMhudiblu_PPA_v0panPan3
AKAP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2046,800,872 - 46,817,397 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12046,800,917 - 46,817,397 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Akap8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365965,123,988 - 5,142,326 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl262,222,249 - 62,241,611 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1262,222,060 - 62,241,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2261,797,360 - 61,817,852 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,965,014 - 13,987,586 (-)NCBI
Akap8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249012,452,506 - 2,471,714 (-)NCBI

Position Markers
RH133817  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0714,340,317 - 14,340,498NCBIRnor6.0
Rnor_5.0714,494,413 - 14,494,594UniSTSRnor5.0
RGSC_v3.4712,889,797 - 12,889,978UniSTSRGSC3.4
Celera79,443,943 - 9,444,124UniSTS
Cytogenetic Map7q11UniSTS
RH124529  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0714,324,455 - 14,324,665NCBIRnor6.0
Rnor_5.0714,478,840 - 14,479,050UniSTSRnor5.0
RGSC_v3.4712,874,458 - 12,874,668UniSTSRGSC3.4
Celera79,428,505 - 9,428,715UniSTS
Cytogenetic Map7q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)72920071124838025Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7591147750911477Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7595196950951969Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7975804554758045Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)71164710256647102Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71232846767193263Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)712328467106995532Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71268785067801690Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71395217958952179Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:425
Count of miRNA genes:236
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000008827
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 54 38 19 38 2 2 74 35 41 11 2
Low 5 3 3 3 6 9 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008827   ⟹   ENSRNOP00000008827
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl714,324,104 - 14,351,918 (-)Ensembl
RefSeq Acc Id: NM_053855   ⟹   NP_446307
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2711,316,226 - 11,332,356 (-)NCBI
Rnor_6.0714,323,300 - 14,339,853 (-)NCBI
Rnor_5.0714,477,683 - 14,493,949 (-)NCBI
RGSC_v3.4712,873,303 - 12,889,333 (-)RGD
Celera79,427,350 - 9,443,479 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241047   ⟹   XP_006241109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2711,316,224 - 11,332,085 (-)NCBI
Rnor_6.0714,323,298 - 14,339,565 (-)NCBI
Rnor_5.0714,477,683 - 14,493,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594573   ⟹   XP_017450062
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2711,316,224 - 11,332,437 (-)NCBI
Rnor_6.0714,323,298 - 14,339,953 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594574   ⟹   XP_017450063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2711,316,224 - 11,332,086 (-)NCBI
Rnor_6.0714,323,298 - 14,339,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078250   ⟹   XP_038934178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2711,324,623 - 11,332,523 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446307   ⟸   NM_053855
- UniProtKB: Q63014 (UniProtKB/Swiss-Prot),   B2GV93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241109   ⟸   XM_006241047
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017450062   ⟸   XM_017594573
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017450063   ⟸   XM_017594574
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000008827   ⟸   ENSRNOT00000008827
RefSeq Acc Id: XP_038934178   ⟸   XM_039078250
- Peptide Label: isoform X3
Protein Domains
C2H2 AKAP95-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620832 AgrOrtholog
Ensembl Genes ENSRNOG00000006559 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008827 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008827 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7317962 IMAGE-MGC_LOAD
  IMAGE:7380301 IMAGE-MGC_LOAD
InterPro AKAP95 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_C2H2_AKAP95 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116633 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109394 IMAGE-MGC_LOAD
  MGC:188279 IMAGE-MGC_LOAD
NCBI Gene 116633 ENTREZGENE
PANTHER PTHR12190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AKAP95 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Akap8 PhenoGen
PROSITE ZF_C2H2_AKAP95 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt AKAP8_RAT UniProtKB/Swiss-Prot
  B2GV93 ENTREZGENE, UniProtKB/TrEMBL
  Q5EB69_RAT UniProtKB/TrEMBL
  Q63014 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap8  A-kinase anchoring protein 8  Akap8  A kinase (PRKA) anchor protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Akap8  A kinase (PRKA) anchor protein 8    A kinase anchor protein 8  Name updated 1299863 APPROVED
2002-08-07 Akap8  A kinase anchor protein 8      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (pka type II) 724707