Sgk2 (serum/glucocorticoid regulated kinase 2)

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Gene: Sgk2 (serum/glucocorticoid regulated kinase 2) Rattus norvegicus

Analyze

Symbol:

Sgk2

Name:

serum/glucocorticoid regulated kinase 2

RGD ID:

620232

Description:

Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2); INTERACTS WITH 2,4,6-trinitrotoluene; 2-amino-4,6-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

serine/threonine-protein kinase Sgk2; serum/glucocorticoid-regulated kinase 2; SGK2, serine/threonine kinase 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGK2 (serum/glucocorticoid regulated kinase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGK2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SGK2 (serum/glucocorticoid regulated kinase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sgk2 (serum/glucocorticoid regulated kinase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sgk2a (serum/glucocorticoid regulated kinase 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPK2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sgk-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	SCH9	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	155,452,311 - 155,477,655 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,951,255 - 163,976,603 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	161,694,860 - 161,720,202 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	153,778,278 - 153,794,932 (+)	NCBI
Celera	3	150,301,782 - 150,326,821 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal cancer (ISO)

Experimental Liver Cirrhosis (ISO)

visual epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrotoluene (EXP)

2-amino-4,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

ampicillin (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atorvastatin calcium (ISO)

azoxystrobin (ISO)

barium(0) (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-naphthoflavone (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

buta-1,3-diene (ISO)

captan (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

clothianidin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

fenofibrate (ISO)

fluvastatin (ISO)

glucose (ISO)

glutathione (EXP)

GW 4064 (ISO)

hydrogen peroxide (ISO)

isotretinoin (ISO)

Licochalcone B (ISO)

menadione (ISO)

metformin (EXP)

methylmercury chloride (ISO)

N-methylformamide (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

ouabain (ISO)

paracetamol (EXP,ISO)

paraquat (EXP,ISO)

PCB138 (EXP)

phenobarbital (ISO)

picoxystrobin (ISO)

pirinixic acid (ISO)

potassium atom (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

quinolin-8-ol (ISO)

rifampicin (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

simvastatin (ISO)

sodium arsenite (ISO)

streptozocin (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

tremolite asbestos (ISO)

troglitazone (EXP,ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IBA)

peptidyl-serine phosphorylation (IBA)

protein phosphorylation (IEA)

Cellular Component

cellular_component (ND)

cytoplasm (IEA)

nucleoplasm (IEA,ISO)

Molecular Function

ATP binding (IEA)

potassium channel regulator activity (IBA,ISO,ISS)

protein binding (ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12397388	PMID:15057822	PMID:19447520	PMID:20926631

Genomics

Comparative Map Data

Sgk2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	155,452,311 - 155,477,655 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,951,255 - 163,976,603 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	161,694,860 - 161,720,202 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	153,778,278 - 153,794,932 (+)	NCBI
Celera	3	150,301,782 - 150,326,821 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

SGK2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	43,559,027 - 43,585,627 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	43,558,968 - 43,588,237 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	42,187,667 - 42,214,267 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	41,621,100 - 41,647,687 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	41,621,099 - 41,647,686	NCBI
Celera	20	38,895,152 - 38,921,737 (+)	NCBI		Celera
Cytogenetic Map	20	q13.12	NCBI
HuRef	20	38,923,264 - 38,950,126 (+)	NCBI		HuRef
CHM1_1	20	42,091,437 - 42,118,025 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	45,292,229 - 45,318,829 (+)	NCBI		T2T-CHM13v2.0

Sgk2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	162,829,249 - 162,856,059 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	162,829,250 - 162,856,047 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	162,987,327 - 163,014,139 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	162,987,330 - 163,014,127 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	162,813,217 - 162,839,863 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	162,678,987 - 162,705,568 (+)	NCBI		MGSCv36	mm8
Celera	2	168,934,488 - 168,961,119 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI

Sgk2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	13,581,145 - 13,625,320 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	13,581,145 - 13,625,320 (-)	NCBI	ChiLan1.0	ChiLan1.0

SGK2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	20	40,992,171 - 41,018,587 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	40,997,536 - 41,018,587 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	20	39,897,338 - 39,924,767 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SGK2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	31,272,395 - 31,294,409 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	31,272,493 - 31,294,195 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	30,916,070 - 30,938,174 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	31,986,104 - 32,001,288 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	31,980,261 - 32,001,114 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	31,243,810 - 31,265,914 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	31,355,174 - 31,377,248 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	31,895,633 - 31,917,764 (+)	NCBI		UU_Cfam_GSD_1.0

Sgk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	180,280,673 - 180,302,503 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	3,008,161 - 3,024,218 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936530	3,007,934 - 3,025,552 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGK2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	46,188,265 - 46,208,804 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	46,188,160 - 46,208,807 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	51,626,067 - 51,649,666 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGK2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	20,217,768 - 20,245,675 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	20,218,420 - 20,246,186 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	68,961,022 - 68,988,744 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgk2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	10,726,486 - 10,752,235 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	10,727,125 - 10,749,060 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sgk2
405 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	541
Count of miRNA genes:	281
Interacting mature miRNAs:	361
Transcripts:	ENSRNOT00000041688
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat

Markers in Region

RH140959

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,669,089 - 151,669,271 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,385,453 - 159,385,634	NCBI	Rnor6.0
Rnor_5.0	3	165,581,526 - 165,581,707	UniSTS	Rnor5.0
RGSC_v3.4	3	153,889,721 - 153,889,902	UniSTS	RGSC3.4
Celera	3	150,326,431 - 150,326,612	UniSTS
RH 3.4 Map	3	1388.3	UniSTS
Cytogenetic Map	3	q42	UniSTS

AA891709

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,654,302 - 151,654,514 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,371,555 - 159,371,766	NCBI	Rnor6.0
Rnor_5.0	3	165,567,628 - 165,567,839	UniSTS	Rnor5.0
RGSC_v3.4	3	153,874,936 - 153,875,147	UniSTS	RGSC3.4
Celera	3	150,311,646 - 150,311,857	UniSTS
RH 3.4 Map	3	1389.0	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		22	22		22				23
Low	2		24	19	2	19			27	8	7	10
Below cutoff		1	10		8		4	5	8	4	23	1	4

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_134463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF361756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000041688 ⟹ ENSRNOP00000040718

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	151,651,515 - 151,669,480 (+)	Ensembl
Rnor_6.0 Ensembl	3	159,368,273 - 159,384,775 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095429 ⟹ ENSRNOP00000090611

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108319 ⟹ ENSRNOP00000081213

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	151,644,102 - 151,669,480 (+)	Ensembl

RefSeq Acc Id:

NM_134463 ⟹ NP_604458

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	151,644,102 - 151,669,480 (+)	NCBI
Rnor_6.0	3	159,361,313 - 159,385,843 (+)	NCBI
Rnor_5.0	3	165,557,662 - 165,581,916 (+)	NCBI
RGSC_v3.4	3	153,849,825 - 153,890,111 (+)	RGD
Celera	3	150,301,782 - 150,326,821 (+)	RGD

Sequence:

show sequence

CAGCTGTCCGGGAGCCAGTGGTACAGCAACCACGGTGATTCAGTCCAGCAGTTAATTAGTAACC
GGAAGGTCTCGAAGCTGGCTGTCAGCTGGCAGGGCTGGGAGGCTGGACCTGTGCTGGTTTGAGA
GTCAGGCGAGTGGGTGACAGGTCACTCCTGCTTAGGAAGGTTGTAGGGTGAGTCAGGATTGGGT
TTCAGGTCAGAAGGACGGTGCAAAGGGAGAGAACCTTTATTCTCCAGGACCTGCGCTGGAACCT
GGGGGTTTCCAGGGAGAAATGGTGACCCCGTGGGAACAGAGGTCTCCCATCCCATCCTAAGCTG
CTGGATCCTGCGTGACATCACCAGTCCCCTCGCTGCTGCCACTGTTGGAAGCTCTGAGCTCTGT
GCTGGGGGCACCAGGCACTGACACTTGGCTCTTGTTGAGAGAACAGTGAGAGTCTCTCTTGTCC
ACGGCCTGTGCTCCGCTCCAACTGCTGCATCTCCCAGAGGCTCTGCTCTGCCCAGGCTGCATAG
AGCCTATCAGATCATAGCTACAGAATGGCCTCCAGCCCAGTTGGAGTTCCTAGCCCCCAGCCCT
CTAGGGCCAATGGGAACATCAACCTGGGGCCATCAGCCAACCCAAATGCCCGACCCACAGACTT
TGATTTCCTCAAAGTCATTGGCAAAGGGAACTATGGGAAGGTCCTACTGGCCAAGCGCAAGTCA
GACGGAGCCTTCTATGCCGTGAAGGTGCTGCAGAAGAAGTCCATCTTAAAAAACAAAGAGCAGA
GCCACATCATGGCAGAACGCAACGTGCTACTGAAGAACGTGCGGCACCCCTTCCTTGTGGGCCT
GCGCTACTCCTTCCAGACCCCAGAGAAGCTCTACTTTGTGCTTGACTATGTCAACGGGGGAGAG
CTTTTCTTCCATCTCCAGCGGGAACACAGGTTCCTGGAGCCCCGGGCCCGGTTCTACACGGCAG
AGGTGGCAAGCGCCATCGGTTATCTTCACTCTCTCAACATCATCTACAGAGACCTGAAGCCAGA
AAACATTCTCTTGGACTGCCAGGGTCACGTGGTACTGACAGATTTCGGCCTTTGCAAGGAATGT
GTAGAGCCCGAGGAGACCACATCCACCTTCTGCGGCACCCCTGAGTACTTGGCTCCAGAAGTCC
TTCGTAAAGAGCCTTACGATCGAGCAGTCGACTGGTGGTGCTTAGGGGCCGTTCTCTACGAGAT
GCTGCACGGCCTGCCCCCCTTCTTCAACACAGATGTGGCCCAGATGTATGAGAACATTTTGCAT
CAGCCGCTACAGATCCCTGGAGGCCGGACAGTGGCTGCCTGTGACCTCCTGCAGGGTCTTCTCC
ACAAGGACCAGAGGCAGCGGCTGGGCTCCAAGGAAGACTTTCTCGACATAAAGAACCACATGTT
CTTCAGTCCCATAAATTGGGATGATCTGTACCACAAGAGGCTGACTCCACCCTTCAACCCAAAC
GTGGAGGGACCCGCTGACTTGAAACACTTTGACCCAGAGTTCACCCAGGAGGCTGTGTCCAAGT
CCATTGGCTGCACCCCTGACACCATGTCCAGCAGTTCTGGGGCCTCAAGTGCATTCCTCGGATT
CTCCTATGCACAGGATGATGATGACATCTTGGACTCTTGAGAGCCAAGTGCTTGGAAAGCCACC
AAGCCCAGCTGGGACCTGCAGGAACTACCTTCTGCTGCACTAAGACACGACGAGTCCCGAAGAA
GTCAGATGCAGTAGCTCAGGGAAGAGGGGAGCATTTTCCATCCCATAAAAGAACGGTGAAGGGT
TCAGGCTGGCTGACTAGGCTCCCGAGTACCCAGCCGTCTGCGGTTGAGACTTGCCCTTCTTGAG
AAATGACTTCTGTGCTTGGTTTTTCATTTTTGGTTTTGTTTGTTGTTGCTGAGGCTGTGACAAA
GTATGCAAGAAAAGTAATGTAAAGAATATCTATTTGGGCTCACAGTTTCAGAAGGTTCAGCCCA
TAGTTGGCTGATCCATTGCTGTGGTCTTTAGCCGAAGTTGAGTCATCTTGCTGGAAGGAGTGAC
TTACCCTATGCCTAGCAGGAAACAGAAACTGAGTCTGGGTTGGGAATAAGATACCTTCTGATAA
GATATTTCTGAGTGACCCACTCCCTTCCAGTGGGGCCAATGTCCTAGTTATCACCTCTCCGTGC
TATAAAATTACAAATCTGTGAATGGACTAACTTGCTGAGGAAGCCTGAGCCCCTCCCTCATTGC
ATAGTGATCCAATCAGTTACGAAAGGCCTTATCAGCTGAACACCACAACCTTCAGAAAACACTT
CAGATCAGAAGCACGATGGCTTTGAATATTGGGTTACGAGACCACAAAGTGGCCTGCTGGTCAC
TTTTGTGTTCTAAGCAAGAGAAAAGGAGGAACGGGACAGAAGTGGGTTGCCCGGAAGCCCGGTC
TGGTGGCTTCCTTTAGTGTGTCATAAATTCTCCAGCTCTACTGGAATAGAGCCTGGGCACAAGC
TACCTCTCTTAGTAAGAGGGTTCGAATGCTGAGGGAGAGGGGAGAATGTGGCGGAGGCGACCGG
CACTCTGGGAGAGGACCTCTTGGTAGCTGGATTTTTATTTCTGTGTATAAATTGATGAAATGTA
GTGAGCCTGTCATGTGTTGCCTTCGGTTTCACATTGCTCTGTGGGTGGTGTCTTTGTTTGAGGT
GGCATTAAACACACTGGATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_604458	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAL91351	(Get FASTA)	NCBI Sequence Viewer
	EDL96598	(Get FASTA)	NCBI Sequence Viewer
	Q8R4U9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_604458 ⟸ NM_134463

- UniProtKB:

Q8R4U9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASSPVGVPSPQPSRANGNINLGPSANPNARPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVK
VLQKKSILKNKEQSHIMAERNVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE
HRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTS
TFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGG
RTVAACDLLQGLLHKDQRQRLGSKEDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADLK
HFDPEFTQEAVSKSIGCTPDTMSSSSGASSAFLGFSYAQDDDDILDS

hide sequence

RefSeq Acc Id:

ENSRNOP00000040718 ⟸ ENSRNOT00000041688

RefSeq Acc Id:

ENSRNOP00000090611 ⟸ ENSRNOT00000095429

RefSeq Acc Id:

ENSRNOP00000081213 ⟸ ENSRNOT00000108319

Protein Domains

AGC-kinase C-terminal Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R4U9-F1-model_v2	AlphaFold	Q8R4U9	1-367	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620232	AgrOrtholog
BioCyc Gene	G2FUF-46926	BioCyc
Ensembl Genes	ENSRNOG00000033573	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000040718.5	UniProtKB/TrEMBL
	ENSRNOP00000081213	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000090611.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000041688.6	UniProtKB/TrEMBL
	ENSRNOT00000095429.1	UniProtKB/TrEMBL
	ENSRNOT00000108319	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	AGC-kinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171497	UniProtKB/Swiss-Prot
NCBI Gene	171497	ENTREZGENE
Pfam	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sgk2	PhenoGen
PROSITE	AGC_KINASE_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	S_TK_X	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A9X9_RAT	UniProtKB/TrEMBL
	Q8R4U9	ENTREZGENE
	R9PXX7_RAT	UniProtKB/TrEMBL
	SGK2_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-02	Sgk2	serum/glucocorticoid regulated kinase 2	Sgk2	SGK2, serine/threonine kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-05-12	Sgk2	SGK2, serine/threonine kinase 2	Sgk2	serum/glucocorticoid regulated kinase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Sgk2	serum/glucocorticoid regulated kinase 2			Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Sgk2	serum/glucocorticoid regulated kinase 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD