Efna2 (ephrin A2) - Rat Genome Database

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Gene: Efna2 (ephrin A2) Rattus norvegicus
Analyze
Symbol: Efna2
Name: ephrin A2
RGD ID: 620389
Description: Predicted to enable ephrin receptor binding activity. Involved in axon guidance and olfactory bulb development. Located in neuromuscular junction and perikaryon. Orthologous to human EFNA2 (ephrin A2); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ephrin A-2; ephrin A-2 precursor; ephrin-A2; LOC314624
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,167,091 - 10,177,719 (-)NCBIGRCr8
mRatBN7.279,515,635 - 9,528,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,516,429 - 9,527,061 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,399,367 - 12,410,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,274,704 - 14,285,362 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,135,824 - 12,146,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,382,636 - 12,393,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,382,636 - 12,393,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,552,532 - 12,563,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,028,432 - 11,039,064 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,030,443 - 11,030,724 (-)NCBI
Celera77,692,874 - 7,702,935 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of Eph receptors in skeletal muscle and their localization at the neuromuscular junction. Lai KO, etal., Mol Cell Neurosci. 2001 Jun;17(6):1034-47.
3. Distinct expression patterns of eph receptors and ephrins relate to the structural organization of the adult rat peripheral vestibular system. Matsunaga T, etal., Eur J Neurosci 2000 May;12(5):1599-616.
4. Expression and function of the Eph A receptors and their ligands ephrins A in the rat thymus. Munoz JJ, etal., J Immunol 2002 Jul 1;169(1):177-84.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system. St John JA, etal., Brain Res Dev Brain Res 2002 Sep 20;138(1):1-14.
10. The role of ephrins and Eph receptors in cancer. Surawska H, etal., Cytokine Growth Factor Rev 2004 Dec;15(6):419-33.
11. EphA5 and ephrin-A2 expression during optic nerve regeneration: a 'two-edged sword'. Symonds AC, etal., Eur J Neurosci. 2007 Feb;25(3):744-52.
Additional References at PubMed
PMID:9053851   PMID:14667581   PMID:19299512   PMID:22147308  


Genomics

Comparative Map Data
Efna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,167,091 - 10,177,719 (-)NCBIGRCr8
mRatBN7.279,515,635 - 9,528,071 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,516,429 - 9,527,061 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,399,367 - 12,410,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,274,704 - 14,285,362 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,135,824 - 12,146,446 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,382,636 - 12,393,266 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,382,636 - 12,393,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,552,532 - 12,563,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,028,432 - 11,039,064 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,030,443 - 11,030,724 (-)NCBI
Celera77,692,874 - 7,702,935 (-)NCBICelera
Cytogenetic Map7q11NCBI
EFNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,284,227 - 1,301,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,285,873 - 1,301,431 (+)EnsemblGRCh38hg38GRCh38
GRCh37191,285,872 - 1,301,430 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,237,168 - 1,250,944 (+)NCBINCBI36Build 36hg18NCBI36
Build 34191,237,167 - 1,250,944NCBI
Celera191,220,457 - 1,234,238 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,070,235 - 1,076,114 (+)NCBIHuRef
CHM1_1191,286,249 - 1,301,508 (+)NCBICHM1_1
T2T-CHM13v2.0191,253,481 - 1,270,685 (+)NCBIT2T-CHM13v2.0
Efna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,015,316 - 80,025,844 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,015,316 - 80,025,844 (+)EnsemblGRCm39 Ensembl
GRCm381080,179,482 - 80,190,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,179,482 - 80,190,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,642,227 - 79,652,755 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,582,611 - 79,592,774 (+)NCBIMGSCv36mm8
Celera1081,194,340 - 81,204,868 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Efna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,614,791 - 6,627,287 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,614,828 - 6,627,287 (-)NCBIChiLan1.0ChiLan1.0
EFNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,629,433 - 5,644,680 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,866,226 - 4,882,529 (+)NCBINHGRI_mPanPan1
EFNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2057,304,872 - 57,317,195 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,243,472 - 58,257,099 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,243,472 - 58,257,443 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,299,140 - 57,312,931 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,780,042 - 57,792,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,980,959 - 57,995,187 (-)NCBIUU_Cfam_GSD_1.0
Efna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,177,009 - 217,186,441 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588648,336 - 657,785 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588648,336 - 657,768 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,165,193 - 77,179,246 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,165,187 - 77,179,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,849,811 - 77,863,280 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EFNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,054,382 - 1,069,544 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,054,483 - 1,068,232 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660817,793,189 - 7,808,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Efna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,380,554 - 7,393,376 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,380,675 - 7,393,322 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Efna2
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:127
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000021709
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 55 12 23
Low 2 29 21 10 13 10 19 16 14 10
Below cutoff 1 14 25 20 6 20 8 11 7 4 1 8

Sequence


RefSeq Acc Id: ENSRNOT00000021709   ⟹   ENSRNOP00000021709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,516,429 - 9,527,061 (-)Ensembl
Rnor_6.0 Ensembl712,382,636 - 12,393,266 (-)Ensembl
RefSeq Acc Id: NM_001168670   ⟹   NP_001162141
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,167,091 - 10,177,719 (-)NCBI
mRatBN7.279,516,429 - 9,527,061 (-)NCBI
Rnor_6.0712,382,636 - 12,393,266 (-)NCBI
Rnor_5.0712,552,532 - 12,563,371 (-)NCBI
RGSC_v3.4711,028,432 - 11,039,064 (-)RGD
Celera77,692,874 - 7,702,935 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001162141 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD33515 (Get FASTA)   NCBI Sequence Viewer  
  EDL89311 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021709
  ENSRNOP00000021709.4
RefSeq Acc Id: NP_001162141   ⟸   NM_001168670
- Peptide Label: precursor
- UniProtKB: F1MA19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021709   ⟸   ENSRNOT00000021709
Protein Domains
Ephrin RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MA19-F1-model_v2 AlphaFold F1MA19 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620389 AgrOrtholog
BioCyc Gene G2FUF-34922 BioCyc
Ensembl Genes ENSRNOG00000016203 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021709 ENTREZGENE
  ENSRNOT00000021709.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/TrEMBL
InterPro Cupredoxin UniProtKB/TrEMBL
  Ephrin UniProtKB/TrEMBL
  Ephrin UniProtKB/TrEMBL
  Ephrin-A_Ecto UniProtKB/TrEMBL
  Ephrin_CS UniProtKB/TrEMBL
KEGG Report rno:84358 UniProtKB/TrEMBL
NCBI Gene 84358 ENTREZGENE
PANTHER Ephrin UniProtKB/TrEMBL
  EPHRIN-A2 UniProtKB/TrEMBL
Pfam Ephrin UniProtKB/TrEMBL
PhenoGen Efna2 PhenoGen
PRINTS EPHRIN UniProtKB/TrEMBL
PROSITE EPHRIN UniProtKB/TrEMBL
  EPHRIN_RBD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016203 RatGTEx
Superfamily-SCOP Cupredoxin UniProtKB/TrEMBL
UniProt A6K8P1_RAT UniProtKB/TrEMBL
  F1MA19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-27 Efna2  ephrin A2  Efna2_predicted  ephrin A2 (predicted)  Data merged from RGD:1305946 737654 APPROVED
2005-01-20 Efna2  ephrin A2    ephrin A-2 precursor  Name updated 1299863 APPROVED
2005-01-12 Efna2_predicted  ephrin A2 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Efna2  ephrin A-2 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed by primary olfactory axons during the embryonic formation of the olfactory nerve 634733
gene_process may be involved in axon guidance, neuron-target interactions, regional compartmentalization, and synaptic functions in nervous systems 1300471