Cxcr3 (C-X-C motif chemokine receptor 3) - Rat Genome Database

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Gene: Cxcr3 (C-X-C motif chemokine receptor 3) Rattus norvegicus
Analyze
Symbol: Cxcr3
Name: C-X-C motif chemokine receptor 3
RGD ID: 621528
Description: Enables C-X-C chemokine receptor activity. Involved in T cell chemotaxis; calcium-mediated signaling; and positive regulation of cytosolic calcium ion concentration. Located in external side of plasma membrane. Used to study dilated cardiomyopathy; high grade glioma; myocarditis; and renovascular hypertension. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-X-C chemokine receptor type 3; chemokine (C-X-C motif) receptor 3; CXC-R3; CXCR-3; G protein-coupled receptor 9; Gpr9; interferon-inducible protein 10 receptor; IP-10 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,884,293 - 70,886,944 (-)NCBIGRCr8
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,844,318 - 66,846,969 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,327,657 - 68,330,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,827,868 - 71,830,519 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,388,981 - 69,391,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,794,276 - 89,796,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,867,709 - 89,870,360 (-)NCBI
CeleraX67,199,203 - 67,201,854 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asperentin  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Brevianamide A  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
ceric oxide  (EXP)
CGP 52608  (ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
cyproterone acetate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
digoxin  (ISO)
diuron  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GSK-J4  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methyl methanesulfonate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-nitrosodiethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
pevonedistat  (ISO)
phenethyl caffeate  (EXP)
PhIP  (ISO)
pioglitazone  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sterigmatocystin  (ISO)
taurine  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
external side of plasma membrane  (IBA,IDA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
2. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
3. CXCR3 polymorphisms associated with risk of asthma. Cheong HS, etal., Biochem Biophys Res Commun. 2005 Sep 9;334(4):1219-25.
4. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Fadel SA, etal., Eur J Immunol. 2008 Dec;38(12):3376-87.
5. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
6. Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
7. CXC chemokine receptor 3 modulates bleomycin-induced pulmonary injury via involving inflammatory process. Gao JM, etal., Chin Med Sci J. 2006 Sep;21(3):152-6.
8. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Garcia G, etal., Allergy. 2007 Feb;62(2):170-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
11. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
12. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
13. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
14. Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma. Honeth G, etal., Exp Cell Res. 2006 May 1;312(8):1265-76. Epub 2006 Jan 23.
15. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Hosomi S, etal., Clin Exp Immunol. 2011 Feb;163(2):215-24. doi: 10.1111/j.1365-2249.2010.04290.x. Epub 2010 Nov 19.
16. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. Jiang D, etal., J Clin Invest. 2004 Jul;114(2):291-9.
17. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
18. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
19. Pathogenesis of herpetic stromal keratitis in CCR5- and/or CXCR3-deficient mice. Komatsu K, etal., Curr Eye Res. 2008 Sep;33(9):736-49. doi: 10.1080/02713680802344716.
20. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
21. Asthma severity is associated with an increase in both blood CXCR3+ and CCR4+ T cells. Kurashima K, etal., Respirology. 2006 Mar;11(2):152-7.
22. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
23. Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
24. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
25. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Mohan K, etal., Eur J Immunol. 2005 Jun;35(6):1702-11.
28. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
31. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
32. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
36. Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
37. CXCR3 blockade inhibits T-cell migration into the CNS during EAE and prevents development of adoptively transferred, but not actively induced, disease. Sporici R and Issekutz TB, Eur J Immunol. 2010 Oct;40(10):2751-61.
38. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
39. Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
40. A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Suzaki Y, etal., Eur Respir J. 2008 Apr;31(4):783-9. Epub 2007 Dec 19.
41. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
42. Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway. Thomas SY, etal., J Immunol. 2007 Aug 1;179(3):1901-12.
43. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Verge GM, etal., Eur J Neurosci 2004 Sep;20(5):1150-60.
44. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Walser TC, etal., Cancer Res. 2006 Aug 1;66(15):7701-7.
45. Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
46. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
Additional References at PubMed
PMID:11554781   PMID:12477932   PMID:12782716   PMID:15489334   PMID:15789559   PMID:16670343   PMID:19008373   PMID:19703720   PMID:21515370   PMID:22675496   PMID:23170857   PMID:23620790  
PMID:25281485   PMID:26572542   PMID:26835911   PMID:28046003   PMID:30448292   PMID:32782146  


Genomics

Comparative Map Data
Cxcr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,884,293 - 70,886,944 (-)NCBIGRCr8
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,844,318 - 66,846,969 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,327,657 - 68,330,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,827,868 - 71,830,519 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,388,981 - 69,391,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,794,276 - 89,796,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,867,709 - 89,870,360 (-)NCBI
CeleraX67,199,203 - 67,201,854 (-)NCBICelera
Cytogenetic MapXq22NCBI
CXCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,615,919 - 71,618,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,615,916 - 71,618,511 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,835,769 - 70,838,361 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
T2T-CHM13v2.0X70,049,169 - 70,051,938 (-)NCBIT2T-CHM13v2.0
Cxcr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,775,141 - 100,777,753 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)EnsemblGRCm39 Ensembl
GRCm38X101,731,535 - 101,734,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,926,875 - 98,929,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,934,255 - 97,936,866 (-)NCBIMGSCv36mm8
CeleraX88,649,308 - 88,651,919 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.58NCBI
Cxcr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,148,879 - 11,152,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,148,928 - 11,152,313 (-)NCBIChiLan1.0ChiLan1.0
CXCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X71,288,407 - 71,292,821 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X71,293,832 - 71,296,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,880,759 - 60,883,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,933,160 - 70,935,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,933,160 - 70,935,756 (-)Ensemblpanpan1.1panPan2
CXCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,882,433 - 55,884,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,851,193 - 56,853,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBIUU_Cfam_GSD_1.0
Cxcr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,283,637 - 46,307,589 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493676266,636 - 69,373 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493676266,636 - 69,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,592,038 - 57,595,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,592,032 - 57,595,706 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X65,033,696 - 65,037,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,430,723 - 61,433,777 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,430,725 - 61,433,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660653,300,128 - 3,302,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,958,698 - 1,961,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,958,323 - 1,961,789 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cxcr3
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000004406
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH133060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,844,370 - 66,844,587 (+)MAPPERmRatBN7.2
Rnor_6.0X71,614,399 - 71,614,615NCBIRnor6.0
Rnor_5.0X72,463,734 - 72,463,950UniSTSRnor5.0
RGSC_v3.4X89,794,329 - 89,794,545UniSTSRGSC3.4
CeleraX67,199,256 - 67,199,472UniSTS
Cytogenetic MapXq31UniSTS
RH142674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,845,740 - 66,846,829 (+)MAPPERmRatBN7.2
Rnor_6.0X71,615,769 - 71,616,857NCBIRnor6.0
Rnor_5.0X72,465,104 - 72,466,192UniSTSRnor5.0
RGSC_v3.4X89,795,699 - 89,796,787UniSTSRGSC3.4
CeleraX67,200,626 - 67,201,714UniSTS
Cytogenetic MapXq31UniSTS
PMC127682P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,845,359 - 66,845,813 (+)MAPPERmRatBN7.2
Rnor_6.0X71,615,388 - 71,615,841NCBIRnor6.0
Rnor_5.0X72,464,723 - 72,465,176UniSTSRnor5.0
RGSC_v3.4X89,795,318 - 89,795,771UniSTSRGSC3.4
CeleraX67,200,245 - 67,200,698UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 37 64 90 90 59 25 59 6 197 82 45 41 56 31

Sequence


Ensembl Acc Id: ENSRNOT00000004406   ⟹   ENSRNOP00000004406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,844,319 - 66,846,969 (-)Ensembl
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076210   ⟹   ENSRNOP00000067897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,615,761 - 71,616,900 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100739   ⟹   ENSRNOP00000083118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX66,844,318 - 66,846,809 (-)Ensembl
RefSeq Acc Id: NM_053415   ⟹   NP_445867
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,884,293 - 70,886,944 (-)NCBI
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBI
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBI
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBI
RGSC_v3.4X89,794,276 - 89,796,927 (-)RGD
CeleraX67,199,203 - 67,201,854 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445867 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF76982 (Get FASTA)   NCBI Sequence Viewer  
  AAH91136 (Get FASTA)   NCBI Sequence Viewer  
  EDL95884 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004406.3
GenBank Protein Q9JII9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445867   ⟸   NM_053415
- UniProtKB: Q9JII9 (UniProtKB/Swiss-Prot),   A6IQC9 (UniProtKB/TrEMBL),   A0A8I5ZZB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004406   ⟸   ENSRNOT00000004406
Ensembl Acc Id: ENSRNOP00000067897   ⟸   ENSRNOT00000076210
Ensembl Acc Id: ENSRNOP00000083118   ⟸   ENSRNOT00000100739
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JII9-F1-model_v2 AlphaFold Q9JII9 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701884
Promoter ID:EPDNEW_R12404
Type:multiple initiation site
Name:Cxcr3_1
Description:C-X-C motif chemokine receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,616,909 - 71,616,969EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621528 AgrOrtholog
BioCyc Gene G2FUF-2089 BioCyc
Ensembl Genes ENSRNOG00000003305 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004406.6 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7376065 IMAGE-MGC_LOAD
InterPro Chemokine_CXCR3 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR1 UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:84475 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108640 IMAGE-MGC_LOAD
NCBI Gene 84475 ENTREZGENE
PANTHER C-X-C CHEMOKINE RECEPTOR TYPE 3 UniProtKB/Swiss-Prot
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Cxcr3 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot
  CXCCHMKINER3 UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003305 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A8I5ZZB3 ENTREZGENE, UniProtKB/TrEMBL
  A6IQC9 ENTREZGENE, UniProtKB/TrEMBL
  CXCR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Cxcr3  C-X-C motif chemokine receptor 3  Cxcr3  chemokine (C-X-C motif) receptor 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cxcr3  chemokine (C-X-C motif) receptor 3  Gpr9  G protein-coupled receptor 9  Symbol and Name updated 1299863 APPROVED
2002-08-07 Gpr9  G protein-coupled receptor 9      Symbol and Name status set to provisional 70820 PROVISIONAL