RGD Reference Report - CXC chemokine receptor 3 modulates bleomycin-induced pulmonary injury via involving inflammatory process. - Rat Genome Database

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CXC chemokine receptor 3 modulates bleomycin-induced pulmonary injury via involving inflammatory process.

Authors: Gao, JM  Lu, B  Guo, ZJ 
Citation: Gao JM, etal., Chin Med Sci J. 2006 Sep;21(3):152-6.
RGD ID: 5135486
Pubmed: PMID:17086735   (View Abstract at PubMed)

OBJECTIVE: To investigate the role of CXC chemokine receptor 3 (CXCR3) in bleomycin-induced lung injury by using CXCR3 gene deficient mice. METHODS: Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C57BL/6 wide type mice were challenged by injection of bleomycin via trachea. Lung tissue was stained with HE method. Airway resistance was measured. Bronchoalveolar lavage (BAL) was performed using phosphate buffered saline twice, cell number and differentials were counted by Diff-Quick staining. Interleukin (IL)4, IL-5, IL-12p40, and interfon-y in BAL fluid and lung homogenate were measured by enzyme-linked immunosorbent assay. Unpaired t test was explored to compare the difference between two groups. RESULTS: On day 7 after bleomycin injection via trachea, CXCR3 knockout mice were protected from bleomycin-induced lung injury as evidenced by fewer accumulation of inflammatory cells in the airway and lung interstitium compared with their wild type littermates (P < 0.05). Airway resistance was also lower in CXCR3 knockout mice compared with wild type mice (P < 0.01). Significantly lower level of inflammatory cytokines release, including the altered production of IL-4 and IL-5 both in BAL fluid and lung tissue was seen in CXCR3 knockout mice than in wild type mice (both P<0.05). CONCLUSION: CXCR3 signaling promotes inflammatory cells recruiting and initiates inflammatory cytokines cascade following endotracheal bleomycin administration, indicating that CXCR3 might be a therapeutic target for pulmonary injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Lung Injury  ISOCxcr3 (Mus musculus)5135486; 5135486 RGD 
Lung Injury  IMP 5135486 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcr3  (C-X-C motif chemokine receptor 3)

Genes (Mus musculus)
Cxcr3  (C-X-C motif chemokine receptor 3)

Genes (Homo sapiens)
CXCR3  (C-X-C motif chemokine receptor 3)


Additional Information