CXCR3 (C-X-C motif chemokine receptor 3) - Rat Genome Database

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Gene: CXCR3 (C-X-C motif chemokine receptor 3) Homo sapiens
Analyze
Symbol: CXCR3
Name: C-X-C motif chemokine receptor 3
RGD ID: 1350447
HGNC Page HGNC
Description: Enables C-X-C chemokine binding activity and signaling receptor activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of angiogenesis; and regulation of apoptotic process. Located in plasma membrane. Implicated in asthma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C chemokine receptor type 3; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine (C-X-C) receptor 3; chemokine receptor 3; CKR-L2; CMKAR3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; interferon-inducible protein 10 receptor; IP-10 receptor; IP10 receptor; IP10-R; Mig receptor; Mig-R; MigR
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX71,615,916 - 71,618,511 (-)EnsemblGRCh38hg38GRCh38
GRCh38X71,615,913 - 71,618,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,835,769 - 70,838,361 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

References - curated
1. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
2. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
3. Cheong HS, etal., Biochem Biophys Res Commun. 2005 Sep 9;334(4):1219-25.
4. Fadel SA, etal., Eur J Immunol. 2008 Dec;38(12):3376-87.
5. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
6. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
7. Gao JM, etal., Chin Med Sci J. 2006 Sep;21(3):152-6.
8. Garcia G, etal., Allergy. 2007 Feb;62(2):170-7.
9. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
10. GOA_HUMAN data from the GO Consortium
11. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
12. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
13. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
14. Honeth G, etal., Exp Cell Res. 2006 May 1;312(8):1265-76. Epub 2006 Jan 23.
15. Hosomi S, etal., Clin Exp Immunol. 2011 Feb;163(2):215-24. doi: 10.1111/j.1365-2249.2010.04290.x. Epub 2010 Nov 19.
16. Jiang D, etal., J Clin Invest. 2004 Jul;114(2):291-9.
17. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
18. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
19. Komatsu K, etal., Curr Eye Res. 2008 Sep;33(9):736-49. doi: 10.1080/02713680802344716.
20. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
21. Kurashima K, etal., Respirology. 2006 Mar;11(2):152-7.
22. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
23. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
24. Marchese A, etal., Genomics 1995 Sep 20;29(2):335-44.
25. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
26. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
27. Mohan K, etal., Eur J Immunol. 2005 Jun;35(6):1702-11.
28. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
29. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
30. RGD automated import pipeline for gene-chemical interactions
31. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
32. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
33. Sporici R and Issekutz TB, Eur J Immunol. 2010 Oct;40(10):2751-61.
34. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
35. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
36. Suzaki Y, etal., Eur Respir J. 2008 Apr;31(4):783-9. Epub 2007 Dec 19.
37. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
38. Thomas SY, etal., J Immunol. 2007 Aug 1;179(3):1901-12.
39. Walser TC, etal., Cancer Res. 2006 Aug 1;66(15):7701-7.
40. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
41. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
Additional References at PubMed
PMID:2834384   PMID:9064356   PMID:9419219   PMID:9466968   PMID:9625760   PMID:9660793   PMID:10233762   PMID:10393705   PMID:10627472   PMID:10666479   PMID:10741397   PMID:10900358  
PMID:10903743   PMID:10903763   PMID:10942362   PMID:11134180   PMID:11160352   PMID:11196695   PMID:11554781   PMID:11559369   PMID:11714650   PMID:11739530   PMID:11966764   PMID:11990865  
PMID:12016104   PMID:12055238   PMID:12070001   PMID:12270371   PMID:12356205   PMID:12425561   PMID:12444109   PMID:12445801   PMID:12477932   PMID:12517959   PMID:12571234   PMID:12688353  
PMID:12750173   PMID:12782716   PMID:12819030   PMID:12884299   PMID:12919091   PMID:12953097   PMID:12960247   PMID:12960302   PMID:14618028   PMID:14630801   PMID:14657006   PMID:14742268  
PMID:15126579   PMID:15150261   PMID:15155273   PMID:15181567   PMID:15265234   PMID:15273303   PMID:15328188   PMID:15489334   PMID:15501397   PMID:15518810   PMID:15528361   PMID:15578697  
PMID:15687242   PMID:15713799   PMID:15725351   PMID:15808644   PMID:15856455   PMID:15879427   PMID:15885315   PMID:16033640   PMID:16034118   PMID:16127166   PMID:16243485   PMID:16339779  
PMID:16368892   PMID:16455991   PMID:16456020   PMID:16679918   PMID:16733654   PMID:16787707   PMID:16806233   PMID:16847335   PMID:16861617   PMID:16930533   PMID:16934957   PMID:17018607  
PMID:17142783   PMID:17142784   PMID:17251291   PMID:17339184   PMID:17363734   PMID:17457216   PMID:17560677   PMID:17615381   PMID:17666357   PMID:17703412   PMID:17912012   PMID:17947699  
PMID:18037659   PMID:18174362   PMID:18240029   PMID:18280341   PMID:18291705   PMID:18375741   PMID:18453591   PMID:18485912   PMID:18497951   PMID:18616679   PMID:18689270   PMID:18729739  
PMID:18761554   PMID:18798334   PMID:18832436   PMID:18962861   PMID:19106589   PMID:19134328   PMID:19258923   PMID:19344719   PMID:19380511   PMID:19539215   PMID:19641142   PMID:19703720  
PMID:19734217   PMID:19735481   PMID:19758167   PMID:19767105   PMID:19800124   PMID:20041963   PMID:20047517   PMID:20059481   PMID:20079227   PMID:20096889   PMID:20164417   PMID:20185576  
PMID:20203286   PMID:20228225   PMID:20237496   PMID:20377416   PMID:20379873   PMID:20429924   PMID:20485444   PMID:20503287   PMID:20529825   PMID:20733031   PMID:20848514   PMID:20855888  
PMID:20856926   PMID:20980681   PMID:21051441   PMID:21091908   PMID:21148743   PMID:21255008   PMID:21274647   PMID:21303425   PMID:21357438   PMID:21426802   PMID:21538345   PMID:21645215  
PMID:21739422   PMID:21811993   PMID:21873635   PMID:21962843   PMID:22079021   PMID:22111598   PMID:22236567   PMID:22262158   PMID:22369302   PMID:22392992   PMID:22401929   PMID:22675496  
PMID:22685032   PMID:22689289   PMID:22792160   PMID:22796894   PMID:22798340   PMID:22936405   PMID:23121557   PMID:23158864   PMID:23170857   PMID:23179902   PMID:23298254   PMID:23333304  
PMID:23600831   PMID:23643635   PMID:23773308   PMID:23994383   PMID:24124129   PMID:24129241   PMID:24135023   PMID:24318111   PMID:24366869   PMID:24489825   PMID:24526602   PMID:24530757  
PMID:24586509   PMID:24715380   PMID:24890729   PMID:24907118   PMID:24999582   PMID:25013801   PMID:25178112   PMID:25232565   PMID:25275127   PMID:25514189   PMID:25527046   PMID:25537642  
PMID:25663474   PMID:25760840   PMID:25768944   PMID:25858769   PMID:26037167   PMID:26164305   PMID:26209629   PMID:26275313   PMID:26339376   PMID:26394162   PMID:26434630   PMID:26506526  
PMID:26589908   PMID:26732675   PMID:26801009   PMID:26823797   PMID:26831417   PMID:26871637   PMID:26883105   PMID:26965295   PMID:27273823   PMID:27297979   PMID:27339056   PMID:27390897  
PMID:27412416   PMID:27461521   PMID:27470388   PMID:27565063   PMID:27872865   PMID:28111710   PMID:28206670   PMID:28392462   PMID:28465448   PMID:28498408   PMID:28686641   PMID:28701399  
PMID:28829757   PMID:28869080   PMID:28927891   PMID:28945356   PMID:29054054   PMID:29116188   PMID:29119926   PMID:29153094   PMID:29266971   PMID:29286143   PMID:29384425   PMID:29440351  
PMID:29762848   PMID:30092218   PMID:30302818   PMID:30359318   PMID:30401786   PMID:30467622   PMID:30481563   PMID:30728405   PMID:30779709   PMID:30957556   PMID:31073998   PMID:31097717  
PMID:31173051   PMID:31173052   PMID:31209409   PMID:31232926   PMID:31300682   PMID:31412247   PMID:31437604   PMID:31831069   PMID:31839046   PMID:32035061   PMID:32037509   PMID:32296183  
PMID:32503584   PMID:32512633   PMID:32802894   PMID:32943658   PMID:33152118   PMID:33187013   PMID:33197439   PMID:33202536   PMID:33208100   PMID:33224143   PMID:33253709   PMID:33337555  
PMID:33378361   PMID:33441425   PMID:33446393   PMID:33493514   PMID:33640906   PMID:33775870  


Genomics

Comparative Map Data
CXCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX71,615,916 - 71,618,511 (-)EnsemblGRCh38hg38GRCh38
GRCh38X71,615,913 - 71,618,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,835,769 - 70,838,361 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
Cxcr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,775,141 - 100,777,753 (-)NCBIGRCm39mm39
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)Ensembl
GRCm38X101,731,535 - 101,734,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,926,875 - 98,929,486 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X97,934,255 - 97,936,866 (-)NCBImm8
CeleraX88,649,308 - 88,651,919 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.58NCBI
Cxcr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX66,844,318 - 66,846,969 (-)Ensembl
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,794,276 - 89,796,927 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,867,709 - 89,870,360 (-)NCBI
CeleraX67,199,203 - 67,201,854 (-)NCBICelera
Cytogenetic MapXq22NCBI
Cxcr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,148,879 - 11,152,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,148,928 - 11,152,313 (-)NCBIChiLan1.0ChiLan1.0
CXCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X70,933,160 - 70,935,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,933,160 - 70,935,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X60,880,759 - 60,883,355 (-)NCBIMhudiblu_PPA_v0panPan3
CXCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,882,433 - 55,884,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBI
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBI
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBI
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBI
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBI
Cxcr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,283,637 - 46,307,589 (+)NCBI
SpeTri2.0NW_00493676266,636 - 69,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,592,038 - 57,595,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,592,032 - 57,595,706 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X65,033,696 - 65,037,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,430,723 - 61,433,777 (-)NCBI
ChlSab1.1 EnsemblX61,430,725 - 61,433,386 (-)Ensembl
Vero_WHO_p1.0NW_0236660653,300,128 - 3,302,726 (-)NCBI
Cxcr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249031,958,323 - 1,961,789 (-)NCBI

Position Markers
RH47042  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X70,835,836 - 70,835,978UniSTSGRCh37
Build 36X70,752,561 - 70,752,703RGDNCBI36
CeleraX71,188,076 - 71,188,218RGD
Cytogenetic MapXq13UniSTS
HuRefX64,650,738 - 64,650,881UniSTS
GeneMap99-GB4 RH MapX231.8UniSTS
PMC135988P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X70,836,314 - 70,836,728UniSTSGRCh37
Build 36X70,753,039 - 70,753,453RGDNCBI36
CeleraX71,188,554 - 71,188,968RGD
Cytogenetic MapXq13UniSTS
HuRefX64,651,217 - 64,651,631UniSTS
PMC198541P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X70,836,319 - 70,836,719UniSTSGRCh37
Build 36X70,753,044 - 70,753,444RGDNCBI36
CeleraX71,188,559 - 71,188,959RGD
Cytogenetic MapXq13UniSTS
HuRefX64,651,222 - 64,651,622UniSTS
STS-X95876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X70,835,965 - 70,836,191UniSTSGRCh37
Build 36X70,752,690 - 70,752,916RGDNCBI36
CeleraX71,188,205 - 71,188,431RGD
Cytogenetic MapXq13UniSTS
HuRefX64,650,868 - 64,651,094UniSTS
GeneMap99-GB4 RH MapX238.28UniSTS
NCBI RH MapX379.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:868
Count of miRNA genes:423
Interacting mature miRNAs:446
Transcripts:ENST00000373691, ENST00000373693
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 87 80 29 6 683 6 10 1 11 33 52
Low 946 932 898 258 1094 158 469 151 180 178 612 1165 101 409 190 2 2
Below cutoff 1244 1611 734 318 99 257 3027 1594 2491 177 653 215 64 771 2042

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001142797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005262256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005262257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB032735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF469635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL590763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY242128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ834242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC461701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X95876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z79783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373691   ⟹   ENSP00000362795
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 EnsemblX71,615,916 - 71,618,510 (-)Ensembl
RefSeq Acc Id: ENST00000373693   ⟹   ENSP00000362797
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 EnsemblX71,615,919 - 71,618,511 (-)Ensembl
RefSeq Acc Id: NM_001142797   ⟹   NP_001136269
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,919 - 71,618,511 (-)NCBI
GRCh37X70,835,766 - 70,838,367 (-)ENTREZGENE
HuRefX64,650,668 - 64,653,542 (-)ENTREZGENE
CHM1_1X70,728,177 - 70,730,778 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001504   ⟹   NP_001495
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,919 - 71,618,511 (-)NCBI
GRCh37X70,835,766 - 70,838,367 (-)ENTREZGENE
Build 36X70,752,491 - 70,755,092 (-)NCBI Archive
HuRefX64,650,668 - 64,653,542 (-)ENTREZGENE
CHM1_1X70,728,177 - 70,730,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005262256   ⟹   XP_005262313
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,913 - 71,618,511 (-)NCBI
GRCh37X70,835,766 - 70,838,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005262257   ⟹   XP_005262314
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,913 - 71,618,511 (-)NCBI
GRCh37X70,835,766 - 70,838,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017029435   ⟹   XP_016884924
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,913 - 71,618,348 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017029436   ⟹   XP_016884925
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,615,913 - 71,618,515 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001495   ⟸   NM_001504
- Peptide Label: isoform 1
- UniProtKB: P49682 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001136269   ⟸   NM_001142797
- Peptide Label: isoform 2
- UniProtKB: P49682 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005262314   ⟸   XM_005262257
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005262313   ⟸   XM_005262256
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016884925   ⟸   XM_017029436
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016884924   ⟸   XM_017029435
- Peptide Label: isoform X1
- UniProtKB: P49682 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000362795   ⟸   ENST00000373691
RefSeq Acc Id: ENSP00000362797   ⟸   ENST00000373693
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6808591
Promoter ID:HG_KWN:67208
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000373687,   NM_001504,   OTTHUMT00000081854
Position:
Human AssemblyChrPosition (strand)Source
Build 36X70,754,966 - 70,756,047 (-)MPROMDB
RGD ID:13627434
Promoter ID:EPDNEW_H28992
Type:initiation region
Name:CXCR3_1
Description:C-X-C motif chemokine receptor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X71,618,511 - 71,618,571EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x3 copy number gain See cases [RCV000133911] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:3092486-155699618)x2 copy number gain See cases [RCV000050889] ChrX:3092486..155699618 [GRCh38]
ChrX:3010527..154929279 [GRCh37]
ChrX:3020527..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x3 copy number gain See cases [RCV000050810] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x1 copy number loss See cases [RCV000050811] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000050699] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss Global developmental delay [RCV000050386]|See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000050697] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp11.21-q28(chrX:57372584-155996431)x1 copy number loss See cases [RCV000051665] ChrX:57372584..155996431 [GRCh38]
ChrX:57399017..155226096 [GRCh37]
ChrX:57415742..154879290 [NCBI36]
ChrX:Xp11.21-q28
pathogenic
GRCh38/hg38 Xq11.1-28(chrX:63279794-155939524)x1 copy number loss See cases [RCV000051666] ChrX:63279794..155939524 [GRCh38]
ChrX:62499671..155169188 [GRCh37]
ChrX:62416396..154822382 [NCBI36]
ChrX:Xq11.1-28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2790845-155699618)x3 copy number gain See cases [RCV000052359] ChrX:2790845..155699618 [GRCh38]
ChrX:2708886..154929279 [GRCh37]
ChrX:2718886..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:237659-156022362)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|See cases [RCV000052327] ChrX:237659..156022362 [GRCh38]
ChrX:154326..155252027 [GRCh37]
ChrX:94326..154905221 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:27245-155996431)x3 copy number gain See cases [RCV000052324] ChrX:27245..155996431 [GRCh38]
ChrX:77245..155226096 [GRCh37]
ChrX:17245..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xq12-21.1(chrX:67621041-76868590)x2 copy number gain See cases [RCV000052416] ChrX:67621041..76868590 [GRCh38]
ChrX:66840883..76009501 [GRCh37]
ChrX:66757608..76005403 [NCBI36]
ChrX:Xq12-21.1
pathogenic
GRCh38/hg38 Xq12-13.3(chrX:68382004-75243150)x2 copy number gain See cases [RCV000052417] ChrX:68382004..75243150 [GRCh38]
ChrX:67601846..74462985 [GRCh37]
ChrX:67518571..74379710 [NCBI36]
ChrX:Xq12-13.3
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40704-156022362)x3 copy number gain See cases [RCV000052325] ChrX:40704..156022362 [GRCh38]
ChrX:90704..155252027 [GRCh37]
ChrX:30704..154905221 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26101-155999293)x3 copy number gain See cases [RCV000052322] ChrX:26101..155999293 [GRCh38]
ChrX:76101..155228958 [GRCh37]
ChrX:16101..154882152 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss Global developmental delay [RCV000052986]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|Intellectual functioning disability [RCV000052988]|Global developmental delay [RCV000052989]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q22.1(chrX:675360-100368517)x1 copy number loss See cases [RCV000053005] ChrX:675360..100368517 [GRCh38]
ChrX:636095..99623515 [GRCh37]
ChrX:556095..99510171 [NCBI36]
ChrX:Xp22.33-q22.1
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss Hypoplastic left heart [RCV000052982]|See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain Global developmental delay [RCV000052984]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022826)x4 copy number gain See cases [RCV000133654] ChrX:10679..156022826 [GRCh38]
ChrX:60679..155252491 [GRCh37]
ChrX:679..154905685 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-155978689)x1 copy number loss See cases [RCV000133792] ChrX:10701..155978689 [GRCh38]
ChrX:60701..155208354 [GRCh37]
ChrX:701..154861548 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:4245..154882152 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-155999253)x3 copy number gain See cases [RCV000134564] ChrX:20297..155999253 [GRCh38]
ChrX:70297..155228918 [GRCh37]
ChrX:10297..154882112 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xq11.1-21.1(chrX:62712219-78605009)x3 copy number gain See cases [RCV000134569] ChrX:62712219..78605009 [GRCh38]
ChrX:61931689..77860506 [GRCh37]
ChrX:61848414..77747162 [NCBI36]
ChrX:Xq11.1-21.1
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x1 copy number loss See cases [RCV000133947] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xq11.1-28(chrX:62712230-155978888)x3 copy number gain See cases [RCV000134025] ChrX:62712230..155978888 [GRCh38]
ChrX:61931700..155208553 [GRCh37]
ChrX:61848425..154861747 [NCBI36]
ChrX:Xq11.1-28
pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:37076284-156016920)x1 copy number loss See cases [RCV000135300] ChrX:37076284..156016920 [GRCh38]
ChrX:37094357..155246585 [GRCh37]
ChrX:37004278..154899779 [NCBI36]
ChrX:Xp21.1-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156026127)x1 copy number loss See cases [RCV000135321] ChrX:20297..156026127 [GRCh38]
ChrX:70297..155255792 [GRCh37]
ChrX:10297..154908986 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp11.22-q21.31(chrX:53985575-92203108)x1 copy number loss See cases [RCV000135306] ChrX:53985575..92203108 [GRCh38]
ChrX:54012008..91458107 [GRCh37]
ChrX:54028733..91344763 [NCBI36]
ChrX:Xp11.22-q21.31
pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:36237706-156022206)x1 copy number loss See cases [RCV000135552] ChrX:36237706..156022206 [GRCh38]
ChrX:36255823..155251871 [GRCh37]
ChrX:36165744..154905065 [NCBI36]
ChrX:Xp21.1-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40904-155998166)x1 copy number loss See cases [RCV000136478] ChrX:40904..155998166 [GRCh38]
ChrX:90904..155227831 [GRCh37]
ChrX:30904..154881025 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x1 copy number loss See cases [RCV000136097] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q25(chrX:10701-128393708) copy number loss See cases [RCV000136094] ChrX:10701..128393708 [GRCh38]
ChrX:60701..127527686 [GRCh37]
ChrX:701..127355367 [NCBI36]
ChrX:Xp22.33-q25
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10001-156030895)x1 copy number loss See cases [RCV000136005] ChrX:10001..156030895 [GRCh38]
ChrX:60001..155260560 [GRCh37]
ChrX:1..154913754 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q13.3(chrX:10679-76420505)x3 copy number gain See cases [RCV000137137] ChrX:10679..76420505 [GRCh38]
ChrX:60679..75640898 [GRCh37]
ChrX:679..75557302 [NCBI36]
ChrX:Xp22.33-q13.3
pathogenic|likely benign
GRCh38/hg38 Xp22.33-q28(chrX:2765636-155522304)x3 copy number gain See cases [RCV000136791] ChrX:2765636..155522304 [GRCh38]
ChrX:2683677..154751965 [GRCh37]
ChrX:2693677..154405159 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2782275-155611794)x2 copy number gain See cases [RCV000136841] ChrX:2782275..155611794 [GRCh38]
ChrX:2700316..154785891 [GRCh37]
ChrX:2710316..154494649 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xq11.1-28(chrX:62561604-156003242)x3 copy number gain See cases [RCV000137553] ChrX:62561604..156003242 [GRCh38]
ChrX:61781074..155232907 [GRCh37]
ChrX:61697799..154886101 [NCBI36]
ChrX:Xq11.1-28
pathogenic
GRCh38/hg38 Xp11.23-q22.1(chrX:49100536-102174742)x1 copy number loss See cases [RCV000137414] ChrX:49100536..102174742 [GRCh38]
ChrX:48957474..101429714 [GRCh37]
ChrX:48844418..101316370 [NCBI36]
ChrX:Xp11.23-q22.1
pathogenic|likely benign
GRCh38/hg38 Xp22.33-q22.3(chrX:10701-106113403)x1 copy number loss See cases [RCV000137886] ChrX:10701..106113403 [GRCh38]
ChrX:60701..105357395 [GRCh37]
ChrX:701..105244051 [NCBI36]
ChrX:Xp22.33-q22.3
pathogenic
GRCh38/hg38 Xp22.2-q27.3(chrX:13020141-143473520)x1 copy number loss See cases [RCV000138678] ChrX:13020141..143473520 [GRCh38]
ChrX:13038260..142561303 [GRCh37]
ChrX:12948181..142388969 [NCBI36]
ChrX:Xp22.2-q27.3
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:1085618-155699644)x1 copy number loss See cases [RCV000139278] ChrX:1085618..155699644 [GRCh38]
ChrX:1118268..154929305 [GRCh37]
ChrX:1038268..154582499 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xq11.1-28(chrX:62712219-156003242)x3 copy number gain See cases [RCV000139416] ChrX:62712219..156003242 [GRCh38]
ChrX:61931689..155232907 [GRCh37]
ChrX:61848414..154886101 [NCBI36]
ChrX:Xq11.1-28
pathogenic|likely benign
GRCh38/hg38 Xp22.33-q21.31(chrX:10701-88318651)x1 copy number loss See cases [RCV000139352] ChrX:10701..88318651 [GRCh38]
ChrX:60701..87573652 [GRCh37]
ChrX:701..87460308 [NCBI36]
ChrX:Xp22.33-q21.31
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004181)x3 copy number gain See cases [RCV000139888] ChrX:251880..156004181 [GRCh38]
ChrX:168547..155233846 [GRCh37]
ChrX:108547..154887040 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2299223-155992188)x3 copy number gain See cases [RCV000141400] ChrX:2299223..155992188 [GRCh38]
ChrX:2217264..155221853 [GRCh37]
ChrX:2227264..154875047 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156016920)x3 copy number gain See cases [RCV000141401] ChrX:20297..156016920 [GRCh38]
ChrX:70297..155246585 [GRCh37]
ChrX:10297..154899779 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x4 copy number gain See cases [RCV000140786] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x1 copy number loss See cases [RCV000140787] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic|conflicting data from submitters
GRCh38/hg38 Xp11.22-q24(chrX:50289384-119297604) copy number loss See cases [RCV000141742] ChrX:50289384..119297604 [GRCh38]
ChrX:50032384..118431567 [GRCh37]
ChrX:50049124..118315595 [NCBI36]
ChrX:Xp11.22-q24
pathogenic
GRCh38/hg38 Xq12-21.1(chrX:66445907-78172208)x3 copy number gain See cases [RCV000142336] ChrX:66445907..78172208 [GRCh38]
ChrX:65665749..77427705 [GRCh37]
ChrX:65582474..77314361 [NCBI36]
ChrX:Xq12-21.1
pathogenic
GRCh38/hg38 Xp22.33-q24(chrX:251879-118847157)x3 copy number gain See cases [RCV000142134] ChrX:251879..118847157 [GRCh38]
ChrX:168546..117981120 [GRCh37]
ChrX:108546..117865148 [NCBI36]
ChrX:Xp22.33-q24
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x3 copy number gain See cases [RCV000142625] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp11.22-q28(chrX:53144751-156003242)x1 copy number loss See cases [RCV000143349] ChrX:53144751..156003242 [GRCh38]
ChrX:53321095..155232907 [GRCh37]
ChrX:53190658..154886101 [NCBI36]
ChrX:Xp11.22-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x1 copy number loss See cases [RCV000143441] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:108546..154886925 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x3 copy number gain See cases [RCV000143433] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x3 copy number gain See cases [RCV000143219] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:108547..154886925 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp11.21-q13.3(chrX:56431359-76557419)x1 copy number loss See cases [RCV000143131] ChrX:56431359..76557419 [GRCh38]
ChrX:56457792..75777827 [GRCh37]
ChrX:56474517..75694231 [NCBI36]
ChrX:Xp11.21-q13.3
pathogenic
GRCh38/hg38 Xq13.1(chrX:71071787-71777197)x2 copy number gain See cases [RCV000143302] ChrX:71071787..71777197 [GRCh38]
ChrX:70291637..70997047 [GRCh37]
ChrX:70208362..70913772 [NCBI36]
ChrX:Xq13.1
uncertain significance
GRCh38/hg38 Xq13.1(chrX:71022322-71682982)x2 copy number gain See cases [RCV000143525] ChrX:71022322..71682982 [GRCh38]
ChrX:70242172..70902832 [GRCh37]
ChrX:70158897..70819557 [NCBI36]
ChrX:Xq13.1
uncertain significance
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000148135] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000148141] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xq11.1-28(chrX:62063537-155246643)x3 copy number gain See cases [RCV000240143] ChrX:62063537..155246643 [GRCh37]
ChrX:Xq11.1-28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155246643)x3 copy number gain See cases [RCV000240122] ChrX:71267..155246643 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155250222)x3 copy number gain See cases [RCV000239843] ChrX:176426..155250222 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255839)x1 copy number loss See cases [RCV000239832] ChrX:71267..155255839 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.2-q28(chrX:13147668-155250222)x3 copy number gain See cases [RCV000239798] ChrX:13147668..155250222 [GRCh37]
ChrX:Xp22.2-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155234036)x2 copy number gain See cases [RCV000239874] ChrX:71267..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255839)x3 copy number gain See cases [RCV000239934] ChrX:70297..155255839 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.3-q21.1(chrX:44734936-79676121)x3 copy number gain See cases [RCV000240019] ChrX:44734936..79676121 [GRCh37]
ChrX:Xp11.3-q21.1
pathogenic
GRCh37/hg19 Xp11.21-q21.1(chrX:55240087-78225374)x1 copy number loss See cases [RCV000511311] ChrX:55240087..78225374 [GRCh37]
ChrX:Xp11.21-q21.1
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x2 copy number gain See cases [RCV000240106] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246271)x3 copy number gain See cases [RCV000239989] ChrX:60701..155246271 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155224766)x1 copy number loss See cases [RCV000239902] ChrX:71267..155224766 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
NC_000023.10:g.36649710_136649711del100000002insG indel Heterotaxy, visceral, 1, X-linked [RCV000754886] ChrX:36649710..136649711 [GRCh37]
ChrX:Xp21.1-q26.3
pathogenic
GRCh37/hg19 Xq11.1-28(chrX:62063537-155250222)x3 copy number gain See cases [RCV000240148] ChrX:62063537..155250222 [GRCh37]
ChrX:Xq11.1-28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2707626-155250222)x2 copy number gain See cases [RCV000240541] ChrX:2707626..155250222 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155236656)x3 copy number gain See cases [RCV000240552] ChrX:176426..155236656 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:225816-155234036)x2 copy number gain See cases [RCV000240464] ChrX:225816..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x3 copy number gain See cases [RCV000240314] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.2-q25(chrX:11692290-121187337)x2 copy number gain not provided [RCV000488046] ChrX:11692290..121187337 [GRCh37]
ChrX:Xp22.2-q25
uncertain significance
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792) copy number loss See cases [RCV000449461] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-154930047)x3 copy number gain See cases [RCV000449437] ChrX:168546..154930047 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x3 copy number gain See cases [RCV000449330] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:318707-155224707)x1 copy number loss See cases [RCV000446667] ChrX:318707..155224707 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain See cases [RCV000446932] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.1-q28(chrX:58140271-155046703)x3 copy number gain See cases [RCV000446151] ChrX:58140271..155046703 [GRCh37]
ChrX:Xp11.1-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155196888)x3 copy number gain See cases [RCV000446310] ChrX:168546..155196888 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155081533)x3 copy number gain See cases [RCV000447253] ChrX:168546..155081533 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246225)x3 copy number gain See cases [RCV000446270] ChrX:60701..155246225 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255792)x1 copy number loss See cases [RCV000446197] ChrX:71267..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xq13.1-28(chrX:68701338-155233731)x3 copy number gain See cases [RCV000446471] ChrX:68701338..155233731 [GRCh37]
ChrX:Xq13.1-28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2703632-155233731)x1 copy number loss See cases [RCV000446712] ChrX:2703632..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168566-155233731)x1 copy number loss See cases [RCV000445720] ChrX:168566..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:553069-155233731)x1 copy number loss See cases [RCV000446026] ChrX:553069..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792)x4 copy number gain See cases [RCV000448034] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155246585)x1 copy number loss See cases [RCV000448652] ChrX:70297..155246585 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:55532799-150239235)x1 copy number loss See cases [RCV000448870] ChrX:55532799..150239235 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss See cases [RCV000448393] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q13.3(chrX:168546-74549686) copy number loss See cases [RCV000512142] ChrX:168546..74549686 [GRCh37]
ChrX:Xp22.33-q13.3
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168547-151304063)x1 copy number loss See cases [RCV000510382] ChrX:168547..151304063 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q23(chrX:168547-112474026)x1 copy number loss See cases [RCV000510419] ChrX:168547..112474026 [GRCh37]
ChrX:Xp22.33-q23
pathogenic
GRCh37/hg19 Xp21.2-q28(chrX:31088082-155233731)x1 copy number loss See cases [RCV000511413] ChrX:31088082..155233731 [GRCh37]
ChrX:Xp21.2-q28
pathogenic|uncertain significance
GRCh37/hg19 Xp21.1-q22.1(chrX:37521774-98488534)x1 copy number loss See cases [RCV000512026] ChrX:37521774..98488534 [GRCh37]
ChrX:Xp21.1-q22.1
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168547-155233731) copy number gain See cases [RCV000512020] ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xq13.1(chrX:70287671-70997047)x3 copy number gain See cases [RCV000511625] ChrX:70287671..70997047 [GRCh37]
ChrX:Xq13.1
uncertain significance
GRCh37/hg19 Xp11.21-q28(chrX:55000501-155230750)x3 copy number gain See cases [RCV000511787] ChrX:55000501..155230750 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:57511767-155233731)x3 copy number gain See cases [RCV000510826] ChrX:57511767..155233731 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:56457791-155233731)x3 copy number gain See cases [RCV000511307] ChrX:56457791..155233731 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
Single allele duplication Syndromic X-linked intellectual disability Lubs type [RCV000768455] ChrX:15323210..153542100 [GRCh37]
ChrX:Xp22.2-q28
pathogenic
GRCh37/hg19 Xq13.1(chrX:70287671-70997047)x2 copy number gain See cases [RCV000512522] ChrX:70287671..70997047 [GRCh37]
ChrX:Xq13.1
uncertain significance
GRCh37/hg19 Xp11.21-q28(chrX:57415659-155233731)x3 copy number gain See cases [RCV000512173] ChrX:57415659..155233731 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp22.31-q21.31(chrX:7841947-90815333)x1,2 copy number gain not provided [RCV000684261] ChrX:7841947..90815333 [GRCh37]
ChrX:Xp22.31-q21.31
pathogenic
GRCh37/hg19 Xp11.23-q13.2(chrX:48115450-73424191)x1 copy number loss not provided [RCV000753535] ChrX:48115450..73424191 [GRCh37]
ChrX:Xp11.23-q13.2
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:181779-155171702)x1 copy number loss not provided [RCV000753278] ChrX:181779..155171702 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x3 copy number gain not provided [RCV000753272] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
Single allele duplication Autistic disorder of childhood onset [RCV000754365] ChrX:1..156040895 [GRCh38]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x1 copy number loss not provided [RCV000753271] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155254881)x2 copy number gain not provided [RCV000753277] ChrX:60814..155254881 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155236712)x2 copy number gain not provided [RCV000753276] ChrX:60814..155236712 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xq11.1-28(chrX:61694576-155254881)x1 copy number loss not provided [RCV000753556] ChrX:61694576..155254881 [GRCh37]
ChrX:Xq11.1-28
pathogenic
NM_001504.2(CXCR3):c.13-31A>T single nucleotide variant not provided [RCV000949119] ChrX:71617490 [GRCh38]
ChrX:70837340 [GRCh37]
ChrX:Xq13.1
benign
46,Y,inv(X)(p21.1q13.3) inversion Elevated serum creatine phosphokinase [RCV000856573] ChrX:32196272..75245806 [GRCh37]
ChrX:Xp21.1-q13.3
likely pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss not provided [RCV000848828] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.4-q21.32(chrX:40572613-92796528)x1 copy number loss not provided [RCV000845670] ChrX:40572613..92796528 [GRCh37]
ChrX:Xp11.4-q21.32
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain not provided [RCV000846039] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.1-q28(chrX:58455352-155233731)x1 copy number loss not provided [RCV000846274] ChrX:58455352..155233731 [GRCh37]
ChrX:Xp11.1-q28
pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:54941868-155233731)x1 copy number loss not provided [RCV000848218] ChrX:54941868..155233731 [GRCh37]
ChrX:Xp11.21-q28
uncertain significance
NM_001504.2(CXCR3):c.711C>T (p.His237=) single nucleotide variant not provided [RCV000933771] ChrX:71616761 [GRCh38]
ChrX:70836611 [GRCh37]
ChrX:Xq13.1
likely benign
GRCh37/hg19 Xp11.21-q28(chrX:55507789-155198481)x3 copy number gain See cases [RCV001263024] ChrX:55507789..155198481 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp11.21-q28(chrX:56469080-155233731)x3 copy number gain not provided [RCV001281359] ChrX:56469080..155233731 [GRCh37]
ChrX:Xp11.21-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60000-155234966)x1 copy number loss not provided [RCV001537933] ChrX:60000..155234966 [GRCh37]
ChrX:Xp22.33-q28
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4540 AgrOrtholog
COSMIC CXCR3 COSMIC
Ensembl Genes ENSG00000186810 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000362795 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000362797 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373691 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000373693 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000186810 GTEx
HGNC ID HGNC:4540 ENTREZGENE
Human Proteome Map CXCR3 Human Proteome Map
InterPro Chemokine_CXCR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2833 UniProtKB/Swiss-Prot
NCBI Gene 2833 ENTREZGENE
OMIM 300574 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35049 PharmGKB
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXCCHMKINER3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z3W5_HUMAN UniProtKB/TrEMBL
  A0A0S2Z3W9_HUMAN UniProtKB/TrEMBL
  A0A510GJR7_HUMAN UniProtKB/TrEMBL
  CXCR3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2R982 UniProtKB/Swiss-Prot
  O15185 UniProtKB/Swiss-Prot
  Q7Z710 UniProtKB/Swiss-Prot
  Q9P2T4 UniProtKB/Swiss-Prot
  Q9P2T5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CXCR3  C-X-C motif chemokine receptor 3    chemokine (C-X-C motif) receptor 3  Symbol and/or name change 5135510 APPROVED