Cxcr3 (chemokine (C-X-C motif) receptor 3) - Rat Genome Database

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Gene: Cxcr3 (chemokine (C-X-C motif) receptor 3) Mus musculus
Symbol: Cxcr3
Name: chemokine (C-X-C motif) receptor 3
RGD ID: 733057
Description: Predicted to enable chemokine binding activity and chemokine receptor activity. Predicted to be involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of angiogenesis; and regulation of apoptotic process. Predicted to act upstream of or within angiogenesis and signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CXCR3 (C-X-C motif chemokine receptor 3).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-X-C chemokine receptor type 3; Cd183; chemokine (C-X-C) receptor 3; Cmka; Cmkar3; CXC-R3; Cxcr; CXCR-3; interferon-inducible protein 10 receptor; IP-10 receptor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X100,775,141 - 100,777,753 (-)NCBIGRCm39mm39
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)Ensembl
GRCm38X101,731,535 - 101,734,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,926,875 - 98,929,486 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X97,934,255 - 97,936,866 (-)NCBImm8
CeleraX88,649,308 - 88,651,919 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.58NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component


References - curated
# Reference Title Reference Citation
1. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. Agostini C, etal., J Immunol. 1998 Dec 1;161(11):6413-20.
2. Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. Belperio JA, etal., J Immunol. 2002 Jul 15;169(2):1037-49.
3. CXCR3 polymorphisms associated with risk of asthma. Cheong HS, etal., Biochem Biophys Res Commun. 2005 Sep 9;334(4):1219-25.
4. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Fadel SA, etal., Eur J Immunol. 2008 Dec;38(12):3376-87.
5. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. Feferman T, etal., J Immunol. 2005 May 1;174(9):5324-31.
6. Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3. Feferman T, etal., J Neuroimmunol. 2009 Apr 30;209(1-2):87-95. Epub 2009 Feb 20.
7. CXC chemokine receptor 3 modulates bleomycin-induced pulmonary injury via involving inflammatory process. Gao JM, etal., Chin Med Sci J. 2006 Sep;21(3):152-6.
8. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Garcia G, etal., Allergy. 2007 Feb;62(2):170-7.
9. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
10. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. Grumelli S, etal., PLoS Med. 2004 Oct;1(1):e8. Epub 2004 Oct 19.
11. Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. Hartl D, etal., J Immunol. 2008 Dec 1;181(11):8053-67.
12. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. Hildebrandt GC, etal., J Immunol. 2004 Aug 1;173(3):2050-9.
13. Chemokine-directed migration of tumor-inhibitory neural progenitor cells towards an intracranially growing glioma. Honeth G, etal., Exp Cell Res. 2006 May 1;312(8):1265-76. Epub 2006 Jan 23.
14. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Hosomi S, etal., Clin Exp Immunol. 2011 Feb;163(2):215-24. doi: 10.1111/j.1365-2249.2010.04290.x. Epub 2010 Nov 19.
15. Regulation of pulmonary fibrosis by chemokine receptor CXCR3. Jiang D, etal., J Clin Invest. 2004 Jul;114(2):291-9.
16. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Kawamura A, etal., Circ J. 2003 Oct;67(10):851-4.
17. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Kelsen SG, etal., Am J Respir Crit Care Med. 2009 May 1;179(9):799-805. Epub 2009 Feb 12.
18. Pathogenesis of herpetic stromal keratitis in CCR5- and/or CXCR3-deficient mice. Komatsu K, etal., Curr Eye Res. 2008 Sep;33(9):736-49. doi: 10.1080/02713680802344716.
19. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. Kremlev SG, etal., J Neurosci Res. 2007 Aug 15;85(11):2450-9.
20. Asthma severity is associated with an increase in both blood CXCR3+ and CCR4+ T cells. Kurashima K, etal., Respirology. 2006 Mar;11(2):152-7.
21. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Lindell DM, etal., Eur J Immunol. 2008 Aug;38(8):2168-79.
22. Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats. Liu Z, etal., Transplant Proc. 2008 Jun;40(5):1300-2.
23. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. Matsumoto Y, etal., J Immunol. 2004 Sep 1;173(5):3535-41.
24. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. Medoff BD, etal., J Immunol. 2006 Jun 1;176(11):7087-95.
25. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
26. MGDs mouse GO annotations MGD data from the GO Consortium
28. CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Mohan K, etal., Eur J Immunol. 2005 Jun;35(6):1702-11.
29. Chemokine production during hypersensitivity pneumonitis. Nance S, etal., Eur J Immunol. 2004 Mar;34(3):677-85.
30. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
31. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Rabquer BJ, etal., Arthritis Res Ther. 2011 Feb 8;13(1):R18.
32. Mouse MP Annotation Import Pipeline RGD automated import pipeline
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants. Roe MF, etal., Pediatr Allergy Immunol. 2011 Mar;22(2):229-34. doi: 10.1111/j.1399-3038.2010.01032.x.
35. Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Shiozawa F, etal., Arthritis Res Ther. 2004;6(1):R78-R86. Epub 2003 Nov 19.
36. CXCR3 blockade inhibits T-cell migration into the CNS during EAE and prevents development of adoptively transferred, but not actively induced, disease. Sporici R and Issekutz TB, Eur J Immunol. 2010 Oct;40(10):2751-61.
37. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Steinmetz OM, etal., Am J Physiol Renal Physiol. 2007 Feb;292(2):F876-87. Epub 2006 Oct 24.
38. Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation. Sterclova M, etal., Exp Lung Res. 2009 Aug;35(6):514-23.
39. A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Suzaki Y, etal., Eur Respir J. 2008 Apr;31(4):783-9. Epub 2007 Dec 19.
40. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. Tang PC, etal., FASEB J. 2005 Sep;19(11):1528-30. Epub 2005 Jul 12.
41. Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway. Thomas SY, etal., J Immunol. 2007 Aug 1;179(3):1901-12.
42. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. Verge GM, etal., Eur J Neurosci 2004 Sep;20(5):1150-60.
43. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Walser TC, etal., Cancer Res. 2006 Aug 1;66(15):7701-7.
44. Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Wang X, etal., Mol Pharmacol 2000 Jun;57(6):1190-8.
45. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Widney DP, etal., Infect Immun. 2005 Jan;73(1):485-93.
Additional References at PubMed
PMID:9653165   PMID:9790904   PMID:10556837   PMID:10571666   PMID:11085753   PMID:11907075   PMID:12415259   PMID:12444109   PMID:12477932   PMID:12538721   PMID:12773510   PMID:14515277  
PMID:14662890   PMID:14725563   PMID:15009431   PMID:15081247   PMID:15096537   PMID:15152045   PMID:15240757   PMID:15368305   PMID:15456824   PMID:15489334   PMID:15531883   PMID:15668916  
PMID:15708587   PMID:15718500   PMID:15833359   PMID:15994833   PMID:16034118   PMID:16061736   PMID:16147979   PMID:16368781   PMID:16479546   PMID:16493069   PMID:16547260   PMID:16547278  
PMID:16585565   PMID:16585592   PMID:16602821   PMID:16849496   PMID:16849497   PMID:16941672   PMID:16977602   PMID:17056513   PMID:17175228   PMID:17175273   PMID:17237422   PMID:17325167  
PMID:17442962   PMID:17471442   PMID:17529983   PMID:17534845   PMID:17538187   PMID:17589343   PMID:17600132   PMID:17671396   PMID:17689697   PMID:17709491   PMID:17724202   PMID:17991878  
PMID:18056393   PMID:18174362   PMID:18178862   PMID:18250476   PMID:18347198   PMID:18347328   PMID:18354195   PMID:18383042   PMID:18422759   PMID:18439102   PMID:18453591   PMID:18485912  
PMID:18582406   PMID:18588860   PMID:18606672   PMID:18617426   PMID:18622291   PMID:18624307   PMID:18658026   PMID:18716926   PMID:18802063   PMID:18832436   PMID:18838544   PMID:18842729  
PMID:18922917   PMID:19006696   PMID:19008373   PMID:19017990   PMID:19026162   PMID:19087279   PMID:19115931   PMID:19129260   PMID:19140218   PMID:19152649   PMID:19187771   PMID:19276169  
PMID:19302742   PMID:19305396   PMID:19344719   PMID:19412181   PMID:19433855   PMID:19470579   PMID:19494319   PMID:19587047   PMID:19620294   PMID:19675161   PMID:19734208   PMID:19734217  
PMID:19898495   PMID:20042666   PMID:20050195   PMID:20061409   PMID:20082289   PMID:20185576   PMID:20203286   PMID:20484822   PMID:20579746   PMID:20713880   PMID:20733031   PMID:20844481  
PMID:20856926   PMID:20980681   PMID:21051441   PMID:21285915   PMID:21441449   PMID:21478401   PMID:21507985   PMID:21518789   PMID:21518913   PMID:21555535   PMID:21573156   PMID:21636553  
PMID:21647407   PMID:21734014   PMID:21788406   PMID:21788409   PMID:21789162   PMID:21873635   PMID:21925471   PMID:21939519   PMID:21962843   PMID:22079985   PMID:22086849   PMID:22116822  
PMID:22135342   PMID:22160305   PMID:22162905   PMID:22277947   PMID:22287719   PMID:22358057   PMID:22407917   PMID:22408007   PMID:22421969   PMID:22430509   PMID:22431569   PMID:22479586  
PMID:22487925   PMID:22494799   PMID:22495297   PMID:22796894   PMID:22906987   PMID:23065152   PMID:23071286   PMID:23123063   PMID:23248310   PMID:23271706   PMID:23326300   PMID:23334413  
PMID:23338236   PMID:23352234   PMID:23434930   PMID:23455510   PMID:23520491   PMID:23583952   PMID:23620790   PMID:23643685   PMID:23656737   PMID:23873018   PMID:23940275   PMID:23994549  
PMID:24124129   PMID:24130498   PMID:24223818   PMID:24227783   PMID:24238342   PMID:24366614   PMID:24390137   PMID:24523323   PMID:24552747   PMID:24591373   PMID:24679047   PMID:24700244  
PMID:24700550   PMID:24812325   PMID:24891401   PMID:24920792   PMID:24930935   PMID:24992040   PMID:25049334   PMID:25466888   PMID:25500888   PMID:25643352   PMID:25706747   PMID:25751061  
PMID:25769612   PMID:25946021   PMID:26025380   PMID:26075911   PMID:26109379   PMID:26394162   PMID:26426795   PMID:26438594   PMID:26448323   PMID:26475448   PMID:26485767   PMID:26525288  
PMID:26732675   PMID:26831100   PMID:26921107   PMID:27068264   PMID:27096319   PMID:27325565   PMID:27349927   PMID:27412416   PMID:27465528   PMID:27565063   PMID:27569211   PMID:27614845  
PMID:27663205   PMID:27727269   PMID:27861803   PMID:27870968   PMID:27886644   PMID:27960090   PMID:28100749   PMID:28108560   PMID:28116674   PMID:28129932   PMID:28215986   PMID:28358049  
PMID:28401489   PMID:28423310   PMID:28468883   PMID:28724396   PMID:28755808   PMID:28827285   PMID:28860493   PMID:29088306   PMID:29164113   PMID:29187588   PMID:29281764   PMID:29288198  
PMID:29798841   PMID:29972776   PMID:30139297   PMID:30401786   PMID:30481563   PMID:30552021   PMID:30707456   PMID:30723095   PMID:30779709   PMID:30811982   PMID:30915078   PMID:31097342  
PMID:31253729   PMID:31278374   PMID:31291583   PMID:31399281   PMID:31631836   PMID:31676770   PMID:31747599   PMID:31980603   PMID:32111837   PMID:32398421   PMID:32402278   PMID:32424367  
PMID:32485165   PMID:32574175   PMID:32587467   PMID:32596454   PMID:32661363   PMID:32901029   PMID:32973802   PMID:33026833   PMID:33357452   PMID:33415536   PMID:33510341   PMID:33548597  
PMID:33649580   PMID:34080653   PMID:34099640   PMID:34117110   PMID:34314390   PMID:34328416   PMID:34380032   PMID:34433033   PMID:34533228   PMID:34655920   PMID:34847356   PMID:35126348  
PMID:35361750   PMID:35503658   PMID:35604176  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X100,775,141 - 100,777,753 (-)NCBIGRCm39mm39
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)Ensembl
GRCm38X101,731,535 - 101,734,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,926,875 - 98,929,486 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X97,934,255 - 97,936,866 (-)NCBImm8
CeleraX88,649,308 - 88,651,919 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.58NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X71,615,919 - 71,618,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX71,615,916 - 71,618,511 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,835,769 - 70,838,361 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
T2T-CHM13v2.0X70,049,169 - 70,051,761 (-)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX66,844,318 - 66,846,969 (-)Ensembl
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,794,276 - 89,796,927 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,867,709 - 89,870,360 (-)NCBI
CeleraX67,199,203 - 67,201,854 (-)NCBICelera
Cytogenetic MapXq22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495547511,148,879 - 11,152,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,148,928 - 11,152,313 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1X70,933,160 - 70,935,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,933,160 - 70,935,756 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X60,880,759 - 60,883,355 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X55,882,433 - 55,884,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBI
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBI
ROS_Cfam_1.0 EnsemblX56,851,193 - 56,853,833 (-)Ensembl
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBI
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBI
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X46,283,637 - 46,307,589 (+)NCBI
SpeTri2.0NW_00493676266,636 - 69,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX57,592,038 - 57,595,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,592,032 - 57,595,706 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X65,033,696 - 65,037,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X61,430,723 - 61,433,777 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,430,725 - 61,433,386 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660653,300,128 - 3,302,726 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046249031,958,698 - 1,961,763 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249031,958,323 - 1,961,789 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,731,826 - 101,731,947UniSTSGRCm38
MGSCv37X98,927,165 - 98,927,286UniSTSGRCm37
CeleraX88,649,598 - 88,649,719UniSTS
Cytogenetic MapXDUniSTS
cM MapX41.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,731,869 - 101,731,959UniSTSGRCm38
MGSCv37X98,927,208 - 98,927,298UniSTSGRCm37
CeleraX88,649,641 - 88,649,731UniSTS
Cytogenetic MapXDUniSTS
cM MapX41.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,732,582 - 101,733,035UniSTSGRCm38
MGSCv37X98,927,921 - 98,928,374UniSTSGRCm37
CeleraX88,650,354 - 88,650,807UniSTS
Cytogenetic MapXDUniSTS
cM MapX41.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X101,732,963 - 101,734,066UniSTSGRCm38
MGSCv37X98,928,302 - 98,929,405UniSTSGRCm37
CeleraX88,650,735 - 88,651,838UniSTS
Cytogenetic MapXDUniSTS
cM MapX41.0UniSTS

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
4141665Mhysq2_mmale hybrid sterility QTL 2 (mouse)Not determined71453852139203212Mouse
12879918Shm4_msperm head morphology 4 (mouse)X72072050102062720Mouse
1357500Mdmsc6_mmodifier of muscularity 6 (mouse)Not determinedX75306671109306758Mouse
1302054Gct4_mgranulosa cell tumorigenesis 4 (mouse)Not determinedX76124336102062720Mouse
11075102Modc2_mmodifier of Odc2 (mouse)X80189914114190059Mouse
4141803Lmr30_mleishmaniasis resistance 30 (mouse)Not determined85062606119062720Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:127
Interacting mature miRNAs:130
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000056614   ⟹   ENSMUSP00000052444
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)Ensembl
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)Ensembl
RefSeq Acc Id: NM_009910   ⟹   NP_034040
RefSeq Status: REVIEWED
Mouse AssemblyChrPosition (strand)Source
GRCm39X100,775,141 - 100,777,753 (-)NCBI
GRCm38X101,731,535 - 101,734,147 (-)NCBI
MGSCv37X98,926,875 - 98,929,486 (-)RGD
CeleraX88,649,308 - 88,651,919 (-)RGD
Protein Sequences
Protein RefSeqs NP_034040 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40163 (Get FASTA)   NCBI Sequence Viewer  
  AAH96626 (Get FASTA)   NCBI Sequence Viewer  
  BAA34045 (Get FASTA)   NCBI Sequence Viewer  
  EDL14135 (Get FASTA)   NCBI Sequence Viewer  
  O88410 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034040   ⟸   NM_009910
- UniProtKB: O88410 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000052444   ⟸   ENSMUST00000056614

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88410-F1-model_v2 AlphaFold O88410 1-367 view protein structure

RGD ID:6845580
Promoter ID:MM_KWN:61344
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv36X98,929,246 - 98,929,746 (-)MPROMDB
RGD ID:13681088
Promoter ID:EPDNEW_M24693
Type:initiation region
Description:Mus musculus chemokine (C-X-C motif) receptor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X101,734,133 - 101,734,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277207 AgrOrtholog
Ensembl Genes ENSMUSG00000050232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000052444 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056614 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Chemokine_CXCR3 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:12766 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Cxcr3 PhenoGen
  CXCCHMKINER3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt Secondary Q4V9Y6 UniProtKB/Swiss-Prot
  Q9QWN6 UniProtKB/Swiss-Prot