CXCR3 (C-X-C motif chemokine receptor 3) - Rat Genome Database

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Gene: CXCR3 (C-X-C motif chemokine receptor 3) Canis lupus familiaris
Analyze
Symbol: CXCR3
Name: C-X-C motif chemokine receptor 3
RGD ID: 12362937
Description: ENCODES a protein that exhibits C-X-C chemokine binding (ortholog); C-X-C chemokine receptor activity (ortholog); signaling receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); calcium-mediated signaling (ortholog); G protein-coupled receptor signaling pathway (ortholog); ASSOCIATED WITH allergic disease (ortholog); alopecia areata (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C chemokine receptor type 3; chemokine (C-X-C motif) receptor 3; interferon-inducible protein 10 receptor; IP-10 receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,882,433 - 55,884,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,851,193 - 56,853,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CXCR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,882,433 - 55,884,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX56,851,193 - 56,853,833 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBIUU_Cfam_GSD_1.0
CXCR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,615,919 - 71,618,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,615,916 - 71,618,511 (-)EnsemblGRCh38hg38GRCh38
GRCh37X70,835,769 - 70,838,361 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,752,491 - 70,755,092 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X70,618,787 - 70,621,388NCBI
CeleraX71,188,006 - 71,190,607 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,650,668 - 64,653,542 (-)NCBIHuRef
CHM1_1X70,728,177 - 70,730,778 (-)NCBICHM1_1
T2T-CHM13v2.0X70,049,169 - 70,051,938 (-)NCBIT2T-CHM13v2.0
Cxcr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,775,141 - 100,777,753 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,775,141 - 100,777,875 (-)EnsemblGRCm39 Ensembl
GRCm38X101,731,535 - 101,734,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,731,535 - 101,734,269 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X98,926,875 - 98,929,486 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X97,934,255 - 97,936,866 (-)NCBIMGSCv36mm8
CeleraX88,649,308 - 88,651,919 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX44.58NCBI
Cxcr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,884,293 - 70,886,944 (-)NCBIGRCr8
mRatBN7.2X66,844,318 - 66,846,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,844,318 - 66,846,969 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX68,327,657 - 68,330,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,827,868 - 71,830,519 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X69,388,981 - 69,391,632 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,614,346 - 71,616,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,614,346 - 71,616,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X72,463,681 - 72,466,332 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,794,276 - 89,796,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X89,867,709 - 89,870,360 (-)NCBI
CeleraX67,199,203 - 67,201,854 (-)NCBICelera
Cytogenetic MapXq22NCBI
Cxcr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,148,879 - 11,152,596 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,148,928 - 11,152,313 (-)NCBIChiLan1.0ChiLan1.0
CXCR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X71,288,407 - 71,292,821 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X71,293,832 - 71,296,427 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,880,759 - 60,883,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,933,160 - 70,935,756 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,933,160 - 70,935,756 (-)Ensemblpanpan1.1panPan2
Cxcr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,283,637 - 46,307,589 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493676266,636 - 69,373 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493676266,636 - 69,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,592,038 - 57,595,692 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,592,032 - 57,595,706 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X65,033,696 - 65,037,066 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CXCR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,430,723 - 61,433,777 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX61,430,725 - 61,433,386 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660653,300,128 - 3,302,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cxcr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,958,698 - 1,961,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249031,958,323 - 1,961,789 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CXCR3
5 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 5 4 1 6 1 5 7 2
Below cutoff 5 18 5 5 1 2 9 2 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027154   ⟹   ENSCAFP00000025254
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX55,882,433 - 55,884,582 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845033811   ⟹   ENSCAFP00845026459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX56,851,193 - 56,853,833 (-)Ensembl
RefSeq Acc Id: NM_001011887   ⟹   NP_001011887
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X55,882,433 - 55,884,582 (-)NCBI
Dog10K_Boxer_TashaX46,709,139 - 46,711,288 (-)NCBI
ROS_Cfam_1.0X56,851,684 - 56,853,833 (-)NCBI
UMICH_Zoey_3.1X54,818,992 - 54,821,141 (-)NCBI
UNSW_CanFamBas_1.0X56,150,994 - 56,153,143 (-)NCBI
UU_Cfam_GSD_1.0X56,078,430 - 56,080,579 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001011887 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD86855 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000025254.4
  ENSCAFP00030013545.1
  ENSCAFP00040016901.1
  ENSCAFP00845026459
  ENSCAFP00845026459.1
GenBank Protein Q5KSK8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001011887   ⟸   NM_001011887
- UniProtKB: Q5KSK8 (UniProtKB/Swiss-Prot),   A0A8C0L577 (UniProtKB/TrEMBL),   A0A8C0YUK9 (UniProtKB/TrEMBL),   A0A8I3NXJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000025254   ⟸   ENSCAFT00000027154
RefSeq Acc Id: ENSCAFP00845026459   ⟸   ENSCAFT00845033811
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017146 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008447 UniProtKB/TrEMBL
  ENSCAFG00040010508 UniProtKB/TrEMBL
  ENSCAFG00845019157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027154.5 UniProtKB/TrEMBL
  ENSCAFT00030015547.1 UniProtKB/TrEMBL
  ENSCAFT00040019468.1 UniProtKB/TrEMBL
  ENSCAFT00845033811 ENTREZGENE
  ENSCAFT00845033811.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_CXCR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:491952 UniProtKB/TrEMBL
NCBI Gene CXCR3 ENTREZGENE
PANTHER C-X-C CHEMOKINE RECEPTOR TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CCCHEMOKINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXCCHMKINER3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0L577 ENTREZGENE
  A0A8C0YUK9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NXJ3 ENTREZGENE, UniProtKB/TrEMBL
  CXCR3_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:39750 ENTREZGENE