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Gene: Btk (Bruton tyrosine kinase) Rattus norvegicus
Symbol: Btk
Name: Bruton tyrosine kinase
RGD ID: 1359683
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Localizes to perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in X-linked agammaglobulinemia; agammaglobulinemia; isolated growth hormone deficiency type III; and mantle cell lymphoma. Orthologous to human BTK (Bruton tyrosine kinase); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH acetamide; acrylamide; bisphenol A.
Type: protein-coding
Also known as: Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK
Homo sapiens (human) : BTK (Bruton tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Btk (Bruton agammaglobulinemia tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btk (Bruton tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BTK (Bruton tyrosine kinase)
Canis lupus familiaris (dog) : BTK (Bruton tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btk (Bruton tyrosine kinase)
Sus scrofa (pig) : BTK (Bruton tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : BTK (Bruton tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Btk (Bruton tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Btk
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359683
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.