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# | Reference Title | Reference Citation |
1. | Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. | Advani RH, etal., J Clin Oncol. 2013 Jan 1;31(1):88-94. doi: 10.1200/JCO.2012.42.7906. Epub 2012 Oct 8. |
2. | Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. | Angst D, etal., J Med Chem. 2020 May 28;63(10):5102-5118. doi: 10.1021/acs.jmedchem.9b01916. Epub 2020 Mar 4. |
3. | Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer. | Basile D, etal., Cancers (Basel). 2019 Jun 24;11(6). pii: cancers11060880. doi: 10.3390/cancers11060880. |
4. | BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining. | Bi KW, etal., Front Oncol. 2020 Apr 15;10:424. doi: 10.3389/fonc.2020.00424. eCollection 2020. |
5. | Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model. | Chu Y, etal., Oncoimmunology. 2018 Oct 11;8(1):e1512455. doi: 10.1080/2162402X.2018.1512455. eCollection 2019. |
6. | Bruton tyrosine kinase gene mutations in Argentina. | Danielian S, etal., Hum Mutat. 2003 Apr;21(4):451. |
7. | Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fc epsilon RI signaling in the RBL-2H3 cell line. | Dauvillier S, etal., J Immunol. 2002 Sep 1;169(5):2274-83. doi: 10.4049/jimmunol.169.5.2274. |
8. | Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia. | de Porto AP, etal., Mol Med. 2019 Jan 15;25(1):3. doi: 10.1186/s10020-018-0069-7. |
9. | Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis. | de Porto APNA, etal., Thromb Haemost. 2019 Jun;119(6):930-940. doi: 10.1055/s-0039-1681046. Epub 2019 Mar 14. |
10. | Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. | de Weers M, etal., Hum Mol Genet. 1994 Jan;3(1):161-6. |
11. | Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. | Florence JM, etal., Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L52-L58. doi: 10.1152/ajplung.00047.2018. Epub 2018 Mar 8. |
12. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
13. | p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma. | Giordano F, etal., J Exp Clin Cancer Res. 2019 Jun 14;38(1):260. doi: 10.1186/s13046-019-1199-7. |
14. | Evaluation of Experimental Infection with L. ( L.) Amazonensis in X-Linked Immunodeficient Mice. | Gonzaga WFKM, etal., J Parasitol. 2017 Dec;103(6):708-717. doi: 10.1645/16-145. Epub 2017 Aug 7. |
15. | Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). | Heinonen JE, etal., FEBS Lett. 2002 Sep 11;527(1-3):274-8. |
16. | Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide. | Huang W, etal., J Allergy Clin Immunol. 2016 Apr;137(4):1197-205. doi: 10.1016/j.jaci.2015.08.056. Epub 2015 Nov 12. |
17. | The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. | Köprülü AD, etal., PLoS One. 2013;8(3):e60476. doi: 10.1371/journal.pone.0060476. Epub 2013 Mar 27. |
18. | BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers. | Lavitrano M, etal., J Pathol. 2020 Feb;250(2):134-147. doi: 10.1002/path.5347. Epub 2019 Dec 2. |
19. | Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. | Lindvall JM, etal., Immunol Rev 2005 Feb;203:200-15. |
20. | Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma. | Lionakis MS, etal., Cancer Cell. 2017 Jun 12;31(6):833-843.e5. doi: 10.1016/j.ccell.2017.04.012. Epub 2017 May 25. |
21. | Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. | Liu L, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):154-63. doi: 10.1124/jpet.111.181545. Epub 2011 Apr 26. |
22. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
23. | Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase. | Moore ML, etal., J Virol. 2004 Jun;78(11):5584-90. doi: 10.1128/JVI.78.11.5584-5590.2004. |
24. | Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK. | Ng YY, etal., Leukemia. 2010 Sep;24(9):1617-30. doi: 10.1038/leu.2010.140. Epub 2010 Jun 24. |
25. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
26. | A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion. | Pinschewer DD, etal., Eur J Immunol. 1999 Sep;29(9):2981-7. doi: 10.1002/(SICI)1521-4141(199909)29:09<2981::AID-IMMU2981>3.0.CO;2-Y. |
27. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
28. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
29. | SMPDB Annotation Import Pipeline | Pipeline to import SMPDB annotations from SMPDB into RGD |
30. | PKC-interacting proteins: from function to pharmacology. | Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35. |
31. | Purification of a major tyrosine kinase from RBL-2H3 cells phosphorylating Fc epsilon RI gamma-cytoplasmic domain and identification as the Btk tyrosine kinase. | Price DJ, etal., Biochim Biophys Acta. 1995 Mar 16;1265(2-3):133-42. |
32. | Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. | Rawlings DJ, etal., Science. 1993 Jul 16;261(5119):358-61. |
33. | GOA pipeline | RGD automated data pipeline |
34. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
35. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
36. | B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. | Riccio LGC, etal., Hum Reprod. 2019 Jul 8;34(7):1225-1234. doi: 10.1093/humrep/dez071. |
37. | Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. | Roschewski M, etal., Sci Immunol. 2020 Jun 5;5(48). pii: 5/48/eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5. |
38. | Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma. | Sagiv-Barfi I, etal., Blood. 2015 Mar 26;125(13):2079-86. doi: 10.1182/blood-2014-08-593137. Epub 2015 Feb 6. |
39. | Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages. | Shahan TA, etal., J Biol Chem. 2000 Apr 7;275(14):10175-81. |
40. | Development and pharmacological validation of novel methods of B cell activation in rat whole blood. | Shin J, etal., J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:61-7. doi: 10.1016/j.vascn.2014.12.006. Epub 2014 Dec 26. |
41. | Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. | Stricker R, etal., Biochim Biophys Acta 2003 Sep 23;1651(1-2):102-15. |
42. | Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. | Strijbis K, etal., PLoS One. 2014 Nov 7;9(11):e112472. doi: 10.1371/journal.pone.0112472. eCollection 2014. |
43. | X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans Infection. | Szymczak WA, etal., mBio. 2013 Jul 2;4(4). pii: mBio.00265-13. doi: 10.1128/mBio.00265-13. |
44. | Identification of the bruton tyrosine kinase (BTK) gene mutations in 20 Australian families with X-linked agammaglobulinemia (XLA). | Velickovic M, etal., Hum Mutat. 2004 Apr;23(4):398-9. |
45. | Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model. | Wu H, etal., Sci Rep. 2017 Mar 28;7(1):466. doi: 10.1038/s41598-017-00482-4. |
46. | RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. | Xu D, etal., J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6. |
47. | Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. | Yu PW, etal., Blood. 2004 Sep 1;104(5):1281-90. doi: 10.1182/blood-2003-09-3044. Epub 2004 May 13. |
48. | Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor. | Zhang C and Tian B, Int J Toxicol. 2020 May/Jun;39(3):232-240. doi: 10.1177/1091581820918511. |
49. | B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy. | Zhang L, etal., Clin Cancer Res. 2017 Aug 1;23(15):4212-4223. doi: 10.1158/1078-0432.CCR-16-2703. Epub 2017 Mar 27. |
PMID:7518558 | PMID:7565679 | PMID:7680896 | PMID:8630736 | PMID:10872802 | PMID:11007757 | PMID:11231015 | PMID:11577348 | PMID:11606584 | PMID:12235209 | PMID:14597404 | PMID:14657254 |
PMID:14734712 | PMID:15046600 | PMID:17020802 | PMID:17823121 | PMID:35129479 |
Btk (Rattus norvegicus - Norway rat) |
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BTK (Homo sapiens - human) |
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Btk (Mus musculus - house mouse) |
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Btk (Chinchilla lanigera - long-tailed chinchilla) |
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BTK (Pan paniscus - bonobo/pygmy chimpanzee) |
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BTK (Canis lupus familiaris - dog) |
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Btk (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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BTK (Sus scrofa - pig) |
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BTK (Chlorocebus sabaeus - green monkey) |
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Btk (Heterocephalus glaber - naked mole-rat) |
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Variants in Btk
223 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
DXGot170 |
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PMC24278P1 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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16 | 12 | 67 | 159 | 91 | 90 | 59 | 92 | 59 | 6 | 354 | 192 | 11 | 137 | 79 | 91 | 31 | 11 | 11 |
RefSeq Transcripts | NM_001007798 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039099952 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039099953 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039099954 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AY787790 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473969 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
FQ215667 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000077547 ⟹ ENSRNOP00000071684 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000086863 ⟹ ENSRNOP00000073875 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000109583 ⟹ ENSRNOP00000093229 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | NM_001007798 ⟹ NP_001007799 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039099952 ⟹ XP_038955880 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039099953 ⟹ XP_038955881 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_039099954 ⟹ XP_038955882 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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Protein RefSeqs | NP_001007799 | (Get FASTA) | NCBI Sequence Viewer |
XP_038955880 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038955881 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038955882 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAV52921 | (Get FASTA) | NCBI Sequence Viewer |
EDM07023 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000071684.2 | ||
ENSRNOP00000073875 | |||
ENSRNOP00000073875.2 | |||
ENSRNOP00000093229.1 |
RefSeq Acc Id: | NP_001007799 ⟸ NM_001007798 |
- UniProtKB: | A0A0G2K6M9 (UniProtKB/TrEMBL), Q5S255 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000071684 ⟸ ENSRNOT00000077547 |
Ensembl Acc Id: | ENSRNOP00000073875 ⟸ ENSRNOT00000086863 |
RefSeq Acc Id: | XP_038955882 ⟸ XM_039099954 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A0G2K6M9 (UniProtKB/TrEMBL), Q5S255 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038955880 ⟸ XM_039099952 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A0G2K6M9 (UniProtKB/TrEMBL), Q5S255 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_038955881 ⟸ XM_039099953 |
- Peptide Label: | isoform X1 |
- UniProtKB: | A0A0G2K6M9 (UniProtKB/TrEMBL), Q5S255 (UniProtKB/TrEMBL) |
Ensembl Acc Id: | ENSRNOP00000093229 ⟸ ENSRNOT00000109583 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-A0A0G2K134-F1-model_v2 | AlphaFold | A0A0G2K134 | 1-662 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
Database | Acc Id | Source(s) |
AGR Gene | RGD:1359683 | AgrOrtholog |
BioCyc Gene | G2FUF-1682 | BioCyc |
Ensembl Genes | ENSRNOG00000052407 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000077547.2 | UniProtKB/TrEMBL |
ENSRNOT00000086863 | ENTREZGENE | |
ENSRNOT00000086863.2 | UniProtKB/TrEMBL | |
ENSRNOT00000109583.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.30.29.30 | UniProtKB/TrEMBL |
3.30.505.10 | UniProtKB/TrEMBL | |
Phosphorylase Kinase, domain 1 | UniProtKB/TrEMBL | |
SH3 Domains | UniProtKB/TrEMBL | |
Transferase(Phosphotransferase) domain 1 | UniProtKB/TrEMBL | |
InterPro | BTK_SH3 | UniProtKB/TrEMBL |
Kinase-like_dom | UniProtKB/TrEMBL | |
Non-receptor_tyrosine_kinases | UniProtKB/TrEMBL | |
PH_type | UniProtKB/TrEMBL | |
Pleckstrin_homology | UniProtKB/TrEMBL | |
Prot_kinase_cat_dom | UniProtKB/TrEMBL | |
Protein_kinase_ATP_BS | UniProtKB/TrEMBL | |
Ser-Thr/Tyr-Pkinase | UniProtKB/TrEMBL | |
SH2 | UniProtKB/TrEMBL | |
SH2_dom_sf | UniProtKB/TrEMBL | |
SH3-like_dom | UniProtKB/TrEMBL | |
SH3_domain | UniProtKB/TrEMBL | |
Tyr_kinase_AS | UniProtKB/TrEMBL | |
Tyr_Pkinase_cat_dom | UniProtKB/TrEMBL | |
Znf_Btk_motif | UniProtKB/TrEMBL | |
KEGG Report | rno:367901 | UniProtKB/TrEMBL |
NCBI Gene | 367901 | ENTREZGENE |
PANTHER | TYROSINE-PROTEIN KINASE | UniProtKB/TrEMBL |
Pfam | BTK | UniProtKB/TrEMBL |
PF00169 | UniProtKB/TrEMBL | |
Pkinase_Tyr | UniProtKB/TrEMBL | |
SH2 | UniProtKB/TrEMBL | |
SH3_1 | UniProtKB/TrEMBL | |
PhenoGen | Btk | PhenoGen |
PRINTS | SH2DOMAIN | UniProtKB/TrEMBL |
SH3DOMAIN | UniProtKB/TrEMBL | |
TECBTKDOMAIN | UniProtKB/TrEMBL | |
TYRKINASE | UniProtKB/TrEMBL | |
PROSITE | PH_DOMAIN | UniProtKB/TrEMBL |
PROTEIN_KINASE_ATP | UniProtKB/TrEMBL | |
PROTEIN_KINASE_DOM | UniProtKB/TrEMBL | |
PROTEIN_KINASE_TYR | UniProtKB/TrEMBL | |
SH2 | UniProtKB/TrEMBL | |
SH3 | UniProtKB/TrEMBL | |
ZF_BTK | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000052407 | RatGTEx |
SMART | BTK | UniProtKB/TrEMBL |
SH2 | UniProtKB/TrEMBL | |
SH3 | UniProtKB/TrEMBL | |
SM00233 | UniProtKB/TrEMBL | |
TyrKc | UniProtKB/TrEMBL | |
Superfamily-SCOP | Kinase_like | UniProtKB/TrEMBL |
PH domain-like | UniProtKB/TrEMBL | |
SH3 | UniProtKB/TrEMBL | |
SSF55550 | UniProtKB/TrEMBL | |
UniProt | A0A0G2K134_RAT | UniProtKB/TrEMBL |
A0A0G2K6M9 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6AJ90_RAT | UniProtKB/TrEMBL | |
A6IVF7_RAT | UniProtKB/TrEMBL | |
Q5S255 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2016-01-11 | Btk | Bruton tyrosine kinase | Btk | Bruton agammaglobulinemia tyrosine kinase | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2006-03-30 | Btk | Bruton agammaglobulinemia tyrosine kinase | Symbol and Name status set to approved | 1299863 | APPROVED | ||
2005-07-29 | Btk | Bruton agammaglobulinemia tyrosine kinase | Symbol and Name status set to provisional | 70820 | PROVISIONAL |