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Gene: Btk (Bruton tyrosine kinase) Rattus norvegicus
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Symbol: Btk
Name: Bruton tyrosine kinase
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Localizes to the perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in X-linked agammaglobulinemia; agammaglobulinemia; isolated growth hormone deficiency type III; and mantle cell lymphoma. Orthologous to human BTK (Bruton tyrosine kinase); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH acrylamide; bisphenol A; cocaine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK
Orthologs:
Homo sapiens (human) : BTK (Bruton tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Btk (Bruton agammaglobulinemia tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btk (Bruton tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BTK (Bruton tyrosine kinase)
Canis lupus familiaris (dog) : BTK (Bruton tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btk (Bruton tyrosine kinase)
Sus scrofa (pig) : BTK (Bruton tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)Ensembl
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Btk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359683
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.