Btk (Bruton tyrosine kinase) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Btk (Bruton tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Btk
Name: Bruton tyrosine kinase
RGD ID: 1359683
Description: Enables protein tyrosine kinase activity. Involved in several processes, including positive regulation of gene expression; positive regulation of hypersensitivity; and regulation of B cell activation. Located in perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in agammaglobulinemia (multiple); isolated growth hormone deficiency type III; and lymphoma (multiple). Orthologous to human BTK (Bruton tyrosine kinase); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,397,016 - 99,436,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,907,749 - 102,946,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,410,180 - 100,449,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (IBA)
B cell affinity maturation  (ISO)
B cell receptor signaling pathway  (IBA,ISO)
cell maturation  (ISO)
cellular response to interleukin-7  (ISO)
cellular response to molecule of fungal origin  (IDA)
cellular response to reactive oxygen species  (IMP)
eosinophil homeostasis  (IMP)
histamine secretion by mast cell  (IMP)
intracellular signal transduction  (ISO)
monocyte proliferation  (IMP)
negative regulation of B cell activation  (IMP)
negative regulation of B cell proliferation  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of interleukin-10 production  (IMP)
negative regulation of leukocyte proliferation  (IMP)
neutrophil homeostasis  (IMP)
peptidyl-tyrosine autophosphorylation  (IMP)
phosphorylation  (IEA)
positive regulation of B cell proliferation  (IMP)
positive regulation of immunoglobulin production  (IMP)
positive regulation of interleukin-17A production  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of phagocytosis  (IMP)
positive regulation of synoviocyte proliferation  (IMP)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of type I hypersensitivity  (IMP)
positive regulation of type III hypersensitivity  (IMP)
protein autophosphorylation  (IDA)
proteoglycan catabolic process  (IMP)
response to lipopolysaccharide  (IMP)
response to organic substance  (IMP)
T cell receptor signaling pathway  (IBA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. Advani RH, etal., J Clin Oncol. 2013 Jan 1;31(1):88-94. doi: 10.1200/JCO.2012.42.7906. Epub 2012 Oct 8.
2. Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. Angst D, etal., J Med Chem. 2020 May 28;63(10):5102-5118. doi: 10.1021/acs.jmedchem.9b01916. Epub 2020 Mar 4.
3. Role of Bruton's Tyrosine Kinase in Stage III Colorectal Cancer. Basile D, etal., Cancers (Basel). 2019 Jun 24;11(6). pii: cancers11060880. doi: 10.3390/cancers11060880.
4. BTK Has Potential to Be a Prognostic Factor for Lung Adenocarcinoma and an Indicator for Tumor Microenvironment Remodeling: A Study Based on TCGA Data Mining. Bi KW, etal., Front Oncol. 2020 Apr 15;10:424. doi: 10.3389/fonc.2020.00424. eCollection 2020.
5. Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation,in-vitro proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model. Chu Y, etal., Oncoimmunology. 2018 Oct 11;8(1):e1512455. doi: 10.1080/2162402X.2018.1512455. eCollection 2019.
6. Bruton tyrosine kinase gene mutations in Argentina. Danielian S, etal., Hum Mutat. 2003 Apr;21(4):451.
7. Intracellular single-chain variable fragments directed to the Src homology 2 domains of Syk partially inhibit Fc epsilon RI signaling in the RBL-2H3 cell line. Dauvillier S, etal., J Immunol. 2002 Sep 1;169(5):2274-83. doi: 10.4049/jimmunol.169.5.2274.
8. Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia. de Porto AP, etal., Mol Med. 2019 Jan 15;25(1):3. doi: 10.1186/s10020-018-0069-7.
9. Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis. de Porto APNA, etal., Thromb Haemost. 2019 Jun;119(6):930-940. doi: 10.1055/s-0039-1681046. Epub 2019 Mar 14.
10. Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. de Weers M, etal., Hum Mol Genet. 1994 Jan;3(1):161-6.
11. Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury. Florence JM, etal., Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L52-L58. doi: 10.1152/ajplung.00047.2018. Epub 2018 Mar 8.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma. Giordano F, etal., J Exp Clin Cancer Res. 2019 Jun 14;38(1):260. doi: 10.1186/s13046-019-1199-7.
14. Evaluation of Experimental Infection with L. ( L.) Amazonensis in X-Linked Immunodeficient Mice. Gonzaga WFKM, etal., J Parasitol. 2017 Dec;103(6):708-717. doi: 10.1645/16-145. Epub 2017 Aug 7.
15. Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA). Heinonen JE, etal., FEBS Lett. 2002 Sep 11;527(1-3):274-8.
16. Nonreceptor tyrosine kinases ITK and BTK negatively regulate mast cell proinflammatory responses to lipopolysaccharide. Huang W, etal., J Allergy Clin Immunol. 2016 Apr;137(4):1197-205. doi: 10.1016/j.jaci.2015.08.056. Epub 2015 Nov 12.
17. The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. Köprülü AD, etal., PLoS One. 2013;8(3):e60476. doi: 10.1371/journal.pone.0060476. Epub 2013 Mar 27.
18. BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers. Lavitrano M, etal., J Pathol. 2020 Feb;250(2):134-147. doi: 10.1002/path.5347. Epub 2019 Dec 2.
19. Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling. Lindvall JM, etal., Immunol Rev 2005 Feb;203:200-15.
20. Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma. Lionakis MS, etal., Cancer Cell. 2017 Jun 12;31(6):833-843.e5. doi: 10.1016/j.ccell.2017.04.012. Epub 2017 May 25.
21. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. Liu L, etal., J Pharmacol Exp Ther. 2011 Jul;338(1):154-63. doi: 10.1124/jpet.111.181545. Epub 2011 Apr 26.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase. Moore ML, etal., J Virol. 2004 Jun;78(11):5584-90. doi: 10.1128/JVI.78.11.5584-5590.2004.
24. Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK. Ng YY, etal., Leukemia. 2010 Sep;24(9):1617-30. doi: 10.1038/leu.2010.140. Epub 2010 Jun 24.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion. Pinschewer DD, etal., Eur J Immunol. 1999 Sep;29(9):2981-7. doi: 10.1002/(SICI)1521-4141(199909)29:09<2981::AID-IMMU2981>3.0.CO;2-Y.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. PKC-interacting proteins: from function to pharmacology. Poole AW, etal., Trends Pharmacol Sci. 2004 Oct;25(10):528-35.
31. Purification of a major tyrosine kinase from RBL-2H3 cells phosphorylating Fc epsilon RI gamma-cytoplasmic domain and identification as the Btk tyrosine kinase. Price DJ, etal., Biochim Biophys Acta. 1995 Mar 16;1265(2-3):133-42.
32. Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Rawlings DJ, etal., Science. 1993 Jul 16;261(5119):358-61.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. Riccio LGC, etal., Hum Reprod. 2019 Jul 8;34(7):1225-1234. doi: 10.1093/humrep/dez071.
37. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Roschewski M, etal., Sci Immunol. 2020 Jun 5;5(48). pii: 5/48/eabd0110. doi: 10.1126/sciimmunol.abd0110. Epub 2020 Jun 5.
38. Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma. Sagiv-Barfi I, etal., Blood. 2015 Mar 26;125(13):2079-86. doi: 10.1182/blood-2014-08-593137. Epub 2015 Feb 6.
39. Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages. Shahan TA, etal., J Biol Chem. 2000 Apr 7;275(14):10175-81.
40. Development and pharmacological validation of novel methods of B cell activation in rat whole blood. Shin J, etal., J Pharmacol Toxicol Methods. 2015 Jan-Feb;71:61-7. doi: 10.1016/j.vascn.2014.12.006. Epub 2014 Dec 26.
41. Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. Stricker R, etal., Biochim Biophys Acta 2003 Sep 23;1651(1-2):102-15.
42. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. Strijbis K, etal., PLoS One. 2014 Nov 7;9(11):e112472. doi: 10.1371/journal.pone.0112472. eCollection 2014.
43. X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans Infection. Szymczak WA, etal., mBio. 2013 Jul 2;4(4). pii: mBio.00265-13. doi: 10.1128/mBio.00265-13.
44. Identification of the bruton tyrosine kinase (BTK) gene mutations in 20 Australian families with X-linked agammaglobulinemia (XLA). Velickovic M, etal., Hum Mutat. 2004 Apr;23(4):398-9.
45. Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model. Wu H, etal., Sci Rep. 2017 Mar 28;7(1):466. doi: 10.1038/s41598-017-00482-4.
46. RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodents. Xu D, etal., J Pharmacol Exp Ther. 2012 Apr;341(1):90-103. doi: 10.1124/jpet.111.187740. Epub 2012 Jan 6.
47. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Yu PW, etal., Blood. 2004 Sep 1;104(5):1281-90. doi: 10.1182/blood-2003-09-3044. Epub 2004 May 13.
48. Nonclinical Safety Assessment of Zanubrutinib: A Novel Irreversible BTK Inhibitor. Zhang C and Tian B, Int J Toxicol. 2020 May/Jun;39(3):232-240. doi: 10.1177/1091581820918511.
49. B-Cell Lymphoma Patient-Derived Xenograft Models Enable Drug Discovery and Are a Platform for Personalized Therapy. Zhang L, etal., Clin Cancer Res. 2017 Aug 1;23(15):4212-4223. doi: 10.1158/1078-0432.CCR-16-2703. Epub 2017 Mar 27.
Additional References at PubMed
PMID:7518558   PMID:7565679   PMID:7680896   PMID:8630736   PMID:10872802   PMID:11007757   PMID:11231015   PMID:11577348   PMID:11606584   PMID:12235209   PMID:14597404   PMID:14657254  
PMID:14734712   PMID:15046600   PMID:17020802   PMID:17823121   PMID:35129479  


Genomics

Comparative Map Data
Btk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,397,016 - 99,436,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,907,749 - 102,946,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,410,180 - 100,449,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
BTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,349,450 - 101,390,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,349,338 - 101,390,796 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,604,438 - 100,645,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,491,098 - 100,527,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,410,586 - 100,447,327NCBI
CeleraX101,123,894 - 101,160,669 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,410,583 - 90,447,505 (-)NCBIHuRef
CHM1_1X100,497,918 - 100,534,692 (-)NCBICHM1_1
T2T-CHM13v2.0X99,793,571 - 99,834,908 (-)NCBIT2T-CHM13v2.0
Btk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,443,083 - 133,484,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,443,085 - 133,484,319 (-)EnsemblGRCm39 Ensembl
GRCm38X134,542,334 - 134,583,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,542,336 - 134,583,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,076,880 - 131,117,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,888,761 - 129,929,466 (-)NCBIMGSCv36mm8
CeleraX117,421,885 - 117,462,725 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.18NCBI
Btk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,482,793 - 7,515,120 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,483,819 - 7,515,085 (-)NCBIChiLan1.0ChiLan1.0
BTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X100,952,265 - 100,989,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,551,874 - 90,588,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,684,017 - 100,720,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,684,017 - 100,725,187 (-)Ensemblpanpan1.1panPan2
BTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,270,952 - 75,302,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,270,979 - 75,302,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,691,359 - 76,723,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,691,367 - 76,723,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,255,464 - 74,287,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,915,885 - 75,947,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,678,325 - 75,710,045 (-)NCBIUU_Cfam_GSD_1.0
Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,007,672 - 63,045,710 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813429,224 - 463,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813429,400 - 467,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,981,515 - 83,014,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,981,512 - 83,014,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,690,569 - 89,727,420 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,609,796 - 14,647,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btk
215 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:93
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000043770
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
DXGot170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,732,291 - 97,732,486 (+)MAPPERmRatBN7.2
Rnor_6.0X105,370,050 - 105,370,241NCBIRnor6.0
Rnor_5.0X105,259,792 - 105,259,983UniSTSRnor5.0
RGSC_v3.4X122,008,431 - 122,008,625UniSTSRGSC3.4
CeleraX98,773,135 - 98,773,329UniSTS
Cytogenetic MapXq34UniSTS
PMC24278P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X97,753,197 - 97,753,330 (+)MAPPERmRatBN7.2
Rnor_6.0X105,390,420 - 105,390,552NCBIRnor6.0
Rnor_5.0X105,279,774 - 105,279,906UniSTSRnor5.0
RGSC_v3.4X122,030,129 - 122,030,261UniSTSRGSC3.4
CeleraX98,793,962 - 98,794,094UniSTS
Cytogenetic MapXq34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 14 10 15 10 4
Low 1 41 43 31 4 31 8 8 74 35 33 7 8
Below cutoff 2 3 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077547   ⟹   ENSRNOP00000071684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)Ensembl
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086863   ⟹   ENSRNOP00000073875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)Ensembl
Rnor_6.0 EnsemblX105,364,098 - 105,385,852 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109583   ⟹   ENSRNOP00000093229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)Ensembl
RefSeq Acc Id: NM_001007798   ⟹   NP_001007799
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,722,800 - 97,761,873 (-)NCBI
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBI
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBI
RGSC_v3.4X121,998,935 - 122,030,289 (-)RGD
CeleraX98,764,036 - 98,794,122 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099952   ⟹   XP_038955880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,722,796 - 97,761,890 (-)NCBI
RefSeq Acc Id: XM_039099953   ⟹   XP_038955881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,722,796 - 97,761,597 (-)NCBI
RefSeq Acc Id: XM_039099954   ⟹   XP_038955882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001007799   ⟸   NM_001007798
- UniProtKB: A0A0G2K6M9 (UniProtKB/TrEMBL),   Q5S255 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071684   ⟸   ENSRNOT00000077547
RefSeq Acc Id: ENSRNOP00000073875   ⟸   ENSRNOT00000086863
RefSeq Acc Id: XP_038955882   ⟸   XM_039099954
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6M9 (UniProtKB/TrEMBL),   Q5S255 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955880   ⟸   XM_039099952
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6M9 (UniProtKB/TrEMBL),   Q5S255 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955881   ⟸   XM_039099953
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K6M9 (UniProtKB/TrEMBL),   Q5S255 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093229   ⟸   ENSRNOT00000109583
Protein Domains
PH   Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K134-F1-model_v2 AlphaFold A0A0G2K134 1-662 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359683 AgrOrtholog
BioCyc Gene G2FUF-1682 BioCyc
Ensembl Genes ENSRNOG00000052407 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077547.2 UniProtKB/TrEMBL
  ENSRNOT00000086863 ENTREZGENE
  ENSRNOT00000086863.2 UniProtKB/TrEMBL
  ENSRNOT00000109583.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro BTK_SH3 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report rno:367901 UniProtKB/TrEMBL
NCBI Gene 367901 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE BTK UniProtKB/TrEMBL
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Btk PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052407 RatGTEx
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2K134_RAT UniProtKB/TrEMBL
  A0A0G2K6M9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJ90_RAT UniProtKB/TrEMBL
  A6IVF7_RAT UniProtKB/TrEMBL
  Q5S255 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-11 Btk  Bruton tyrosine kinase  Btk  Bruton agammaglobulinemia tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Btk  Bruton agammaglobulinemia tyrosine kinase      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Btk  Bruton agammaglobulinemia tyrosine kinase      Symbol and Name status set to provisional 70820 PROVISIONAL