Gene: Btk (Bruton tyrosine kinase) Rattus norvegicus
Analyze
Symbol:
Btk
Name:
Bruton tyrosine kinase
Description:
Exhibits protein tyrosine kinase activity. Involved in several processes, including cellular response to molecule of fungal origin; histamine secretion by mast cell; and positive regulation of hypersensitivity. Localizes to the perinuclear region of cytoplasm. Used to study arthus reaction. Human ortholog(s) of this gene implicated in X-linked agammaglobulinemia; agammaglobulinemia; isolated growth hormone deficiency type III; and mantle cell lymphoma. Orthologous to human BTK (Bruton tyrosine kinase); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH acrylamide; bisphenol A; cocaine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
Bruton agammaglobulinemia tyrosine kinase; tyrosine-protein kinase BTK
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
BTK (Bruton tyrosine kinase) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):
Btk (Bruton agammaglobulinemia tyrosine kinase) HGNC
NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Btk (Bruton tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
BTK (Bruton tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
BTK (Bruton tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Btk (Bruton tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
BTK (Bruton tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
BTK (Bruton tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Btk (Bruton agammaglobulinemia tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
btk (Bruton agammaglobulinemia tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Btk29A
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 105,360,922 - 105,390,580 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 105,360,922 - 105,390,580 (-) Ensembl Rnor_5.0 X 105,250,666 - 105,279,934 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 121,998,935 - 122,030,289 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 122,072,367 - 122,103,722 (-) NCBI Celera X 98,764,036 - 98,794,122 (-) NCBI Celera Cytogenetic Map X q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia ClinVar PMID:10352268 Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:8162056 Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:11742281 more ... Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:11445810 more ... Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:28492532 Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:20529312 more ... Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:19039656 more ... Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:7849721 , PMID:7880320 Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar PMID:10092645 more ... Agammaglobulinemia, non-Bruton type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Agammaglobulinemia, non-Bruton type ClinVar autistic disorder ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 B-Cell Chronic Lymphocytic Leukemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: B-cell chronic lymphocytic leukemia ClinVar PMID:24869598 breast cancer ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Breast cancer ClinVar PMID:24869598 breast cancer ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Breast cancer ClinVar PMID:24869598 more ... Breast Neoplasms ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Breast cancer ClinVar PMID:24869598 Breast Neoplasms ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Breast tumor ClinVar PMID:24869598 more ... chronic lymphocytic leukemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Chronic lymphocytic leukemia ClinVar PMID:24869598 Hypogammaglobulinemia, X-Linked ISO RGD:1342660 8554872 ClinVar Annotator: match by null ClinVar PMID:8758136 isolated growth hormone deficiency ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Isolated Growth Hormone Deficiency ClinVar isolated growth hormone deficiency ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Isolated Growth Hormone Deficiency ClinVar PMID:12655572 more ... isolated growth hormone deficiency ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Isolated Growth Hormone Deficiency ClinVar PMID:24033266 more ... isolated growth hormone deficiency ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Isolated Growth Hormone Deficiency ClinVar PMID:28492532 isolated growth hormone deficiency ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Isolated Growth Hormone Deficiency ClinVar PMID:17045652 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:307200 ClinVar PMID:8013627 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:28492532 , PMID:9545398 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:28492532 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:28492532 , PMID:8834236 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11438999 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11445810 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:23335184 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:10737994 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11742281 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:10844531 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:15661032 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:19039656 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11438999 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:21520333 , PMID:28492532 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:28492532 , PMID:9445504 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:28492532 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11742281 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11742281 , PMID:28492532 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:12204007 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11472359 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:11472359 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:12217331 , PMID:28492532 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:20529312 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia with growth hormone deficiency ClinVar PMID:24033266 more ... isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by term: IGHD III ClinVar PMID:28492532 isolated growth hormone deficiency type III ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:307200 ClinVar PMID:7849697 syndromic X-linked intellectual disability Lubs type ISO RGD:1342660 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:10737994 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11445810 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11742281 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11809909 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11742281 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:10887125 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:24869598 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:25741868 , PMID:7678697 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:30627929 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:7678697 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:28492532 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11742281 , PMID:28492532 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11472359 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:11102984 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:12655572 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:19039656 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:24033266 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: AGAMMAGLOBULINEMIA, X-LINKED, TYPE 1 ClinVar PMID:28492532 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: X-linked agammaglobulinemia ClinVar PMID:17045652 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:11586956 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:11564824 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7880320 , PMID:8162056 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:12768435 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:10678660 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:15661032 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:8380905 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7849721 , PMID:7880320 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:8644706 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7849697 , PMID:7880320 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7880320 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:8162056 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7849697 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:10092645 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by term: Hypoagammaglobulinemia, X-linked ClinVar PMID:2896233 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:11555397 more ... X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:11809909 , PMID:12405164 X-linked agammaglobulinemia ISO RGD:1342660 8554872 ClinVar Annotator: match by OMIM:300755 ClinVar PMID:7849721
Gene-Chemical Interaction Annotations
