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Gene: Scnn1b (sodium channel epithelial 1 subunit beta) Rattus norvegicus
Symbol: Scnn1b
Name: sodium channel epithelial 1 subunit beta
RGD ID: 3640
Description: Exhibits WW domain binding activity and ligand-gated sodium channel activity. Predicted to contribute to sodium channel activity. Involved in several processes, including regulation of sodium ion transport; response to hypoxia; and wound healing, spreading of epidermal cells. Localizes to apical plasma membrane and cell surface. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
Also known as: amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta; RNENACB; SCNEB; sodium channel epithelial 1 beta subunit; Sodium channel nonvoltage-gated 1 beta (epithelial); sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1 beta; sodium channel, nonvoltage-gated 1, beta; sodium channel, nonvoltage-gated, type I, beta
Homo sapiens (human) : SCNN1B (sodium channel epithelial 1 subunit beta)  HGNC  Alliance
Mus musculus (house mouse) : Scnn1b (sodium channel, nonvoltage-gated 1 beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scnn1b (sodium channel epithelial 1 beta subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SCNN1B (sodium channel epithelial 1 subunit beta)
Canis lupus familiaris (dog) : SCNN1B (sodium channel epithelial 1 subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scnn1b (sodium channel epithelial 1 subunit beta)
Sus scrofa (pig) : SCNN1B (sodium channel epithelial 1 subunit beta)
Chlorocebus sabaeus (African green monkey) : SCNN1B (sodium channel epithelial 1 subunit beta)
Heterocephalus glaber (naked mole-rat) : Scnn1b (sodium channel epithelial 1 subunit beta)
more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv  
QTLs:   Bp88  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01191,829,547 - 191,883,991 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,829,555 - 191,884,298 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01198,932,512 - 198,953,453 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41180,682,622 - 180,748,068 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11180,822,536 - 180,887,983 (+)NCBI
Celera1174,140,255 - 174,194,462 (+)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Scnn1b
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3640
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.