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Gene: Ncf2 (neutrophil cytosolic factor 2) Rattus norvegicus
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Symbol: Ncf2
Name: neutrophil cytosolic factor 2
Description: Predicted to contribute to superoxide-generating NADPH oxidase activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Localizes to the cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal recessive chronic granulomatous disease cytochrome b-positive type II. Orthologous to human NCF2 (neutrophil cytosolic factor 2); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 17beta-estradiol; aflatoxin B1; AICA ribonucleotide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC364018; NCF-2; neutrophil cytosol factor 2; neutrophil NADPH oxidase factor 2
Orthologs:
Homo sapiens (human) : NCF2 (neutrophil cytosolic factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Ncf2 (neutrophil cytosolic factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf2 (neutrophil cytosolic factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF2 (neutrophil cytosolic factor 2)
Canis lupus familiaris (dog) : NCF2 (neutrophil cytosolic factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf2 (neutrophil cytosolic factor 2)
Sus scrofa (pig) : NCF2 (neutrophil cytosolic factor 2)
more info ...
Allele / Splice: Ncf2em1Mcwi   Ncf2em4Mcwi  
Genetic Models: SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi SS-Nox4em2Ncf2em1Mcwi SS-Ncf2em1Mcwi-/- SS-Ncf2em4Mcwi SS-Ncf2em1Mcwi
Is Marker For: Strains:   SS.BN-(D13Rat151-D13Rat197)-Tg(Slc12a1-Ncf2-2A-Luc)26Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Celera1364,862,007 - 64,890,467 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ncf2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309424
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.