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Gene: Ncf2 (neutrophil cytosolic factor 2) Rattus norvegicus
Symbol: Ncf2
Name: neutrophil cytosolic factor 2
RGD ID: 1309424
Description: Predicted to have several functions, including Rac GTPase binding activity; protein C-terminus binding activity; and superoxide-generating NADPH oxidase activator activity. Involved in several processes, including response to hyperoxia; response to laminar fluid shear stress; and response to progesterone. Localizes to cytoplasm and membrane. Used to study proteinuria; renal fibrosis; and visual epilepsy. Biomarker of hypertension and obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal recessive chronic granulomatous disease cytochrome b-positive type II. Orthologous to human NCF2 (neutrophil cytosolic factor 2); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 17beta-estradiol; acetamide; aflatoxin B1.
Type: protein-coding
Also known as: LOC364018; NCF-2; neutrophil cytosol factor 2; neutrophil NADPH oxidase factor 2
Homo sapiens (human) : NCF2 (neutrophil cytosolic factor 2)  HGNC  Alliance
Mus musculus (house mouse) : Ncf2 (neutrophil cytosolic factor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ncf2 (neutrophil cytosolic factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NCF2 (neutrophil cytosolic factor 2)
Canis lupus familiaris (dog) : NCF2 (neutrophil cytosolic factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ncf2 (neutrophil cytosolic factor 2)
Sus scrofa (pig) : NCF2 (neutrophil cytosolic factor 2)
Chlorocebus sabaeus (African green monkey) : NCF2 (neutrophil cytosolic factor 2)
Heterocephalus glaber (naked mole-rat) : Ncf2 (neutrophil cytosolic factor 2)
more info ...
Allele / Splice: Ncf2em1Mcwi   Ncf2em4Mcwi  
Genetic Models: SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi SS-Nox4em2Ncf2em1Mcwi SS-Ncf2em1Mcwi-/- SS-Ncf2em4Mcwi SS-Ncf2em1Mcwi
Is Marker For: Strains:   SS.BN-(D13Rat151-D13Rat197)-Tg(Slc12a1-Ncf2-2A-Luc)26Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Celera1364,862,007 - 64,890,467 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ncf2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1309424
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.