Penk (proenkephalin) - Rat Genome Database

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Gene: Penk (proenkephalin) Rattus norvegicus
Analyze
Symbol: Penk
Name: proenkephalin
RGD ID: 68946
Description: Predicted to enable opioid receptor binding activity. Involved in several processes, including cellular response to organic cyclic compound; general adaptation syndrome, behavioral process; and locomotory exploration behavior. Located in several cellular components, including cell body fiber; cytoplasmic vesicle lumen; and perikaryon. Used to study heroin dependence. Biomarker of Parkinson's disease; alcohol use disorder; dystonia; and spinal disease. Orthologous to human PENK (proenkephalin); INTERACTS WITH (S)-amphetamine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Enk; enkephalin; MGC93514; Penk-rs; Penk1; Penk2; preproenkephalin 2; preproenkephalin, related sequence; proenkephalin 1; proenkephalin 2; proenkephalin related sequence; proenkephalin, related sequence; proenkephalin-A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2517,183,799 - 17,189,160 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl517,183,806 - 17,189,129 (-)Ensembl
Rnor_6.0517,056,412 - 17,061,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl517,056,419 - 17,061,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,834,409 - 21,839,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,509,323 - 17,514,265 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1517,516,079 - 17,517,452 (-)NCBI
Celera516,529,164 - 16,534,106 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,7-dihydropurine-6-thione  (EXP)
3-nitropropanoic acid  (EXP)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
apomorphine  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
baclofen  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
Cuprizon  (EXP)
DDT  (EXP)
diazepam  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
fluoxetine  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
fonofos  (ISO)
formaldehyde  (EXP)
furan  (EXP)
haloperidol  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP)
Isradipine  (EXP)
istradefylline  (EXP)
kainic acid  (EXP)
medroxyprogesterone acetate  (ISO)
memantine  (EXP)
mercaptopurine  (EXP)
metformin  (EXP)
methamphetamine  (EXP)
Methanandamide  (EXP)
methylmercury chloride  (ISO)
metoprolol  (EXP)
morphine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (ISO)
pentobarbital  (EXP)
phenformin  (EXP)
phosphatidic acid  (EXP)
progesterone  (ISO)
propranolol  (EXP)
purine-6-thiol  (EXP)
reserpine  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
scopolamine  (EXP)
serotonin  (EXP)
SL-327  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone  (ISO)
thiopental  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
U69593  (EXP)
undecane  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
1. Alvarez-Fischer D, etal., Brain Res. 2012 Jun 29;1464:82-8. doi: 10.1016/j.brainres.2012.05.007. Epub 2012 May 15.
2. Berube P, etal., Physiol Behav. 2013 Oct 2;122:237-45. doi: 10.1016/j.physbeh.2013.04.009. Epub 2013 May 9.
3. Caffrey JL, etal., J Mol Cell Cardiol. 1994 Jun;26(6):701-11.
4. Chang GQ, etal., Alcohol Clin Exp Res. 2010 May;34(5):761-70. doi: 10.1111/j.1530-0277.2010.01148.x. Epub 2010 Feb 24.
5. Chang GQ, etal., Neuroscience. 2014 Sep 26;277:665-78. doi: 10.1016/j.neuroscience.2014.07.050. Epub 2014 Jul 30.
6. Chang GQ, etal., Physiol Behav. 2010 Oct 5;101(3):360-9. doi: 10.1016/j.physbeh.2010.06.005. Epub 2010 Jul 21.
7. Ciriello J, etal., Neuroscience. 2013 Oct 10;250:599-613. doi: 10.1016/j.neuroscience.2013.07.054. Epub 2013 Jul 30.
8. Corchero J, etal., J Psychopharmacol. 2002 Dec;16(4):283-9.
9. Cui X, Sheng Li Ke Xue Jin Zhan. 1995 Jul;26(3):230-2.
10. Ding YM, etal., Acta Pharmacol Sin. 2000 Oct;21(10):885-92.
11. Engstrom L, etal., J Comp Neurol 2003 Aug 4;462(4):450-61.
12. Farid WO, etal., PLoS One. 2012;7(12):e52812. doi: 10.1371/journal.pone.0052812. Epub 2012 Dec 26.
13. Fu ZF, etal., J Virol. 1993 Nov;67(11):6674-81.
14. Gao CJ, etal., Neuroscience. 2012 Jan 27;202:352-62. doi: 10.1016/j.neuroscience.2011.11.060. Epub 2011 Dec 21.
15. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Guo CQ, etal., Zhongguo Gu Shang. 2011 Aug;24(8):656-8.
17. Hildebrand B, etal., Brain Res. 1997 Jun 13;759(2):285-91.
18. Howells RD NIDA Res Monogr 1986;70:43-65.
19. Huang W, etal., Neurol Sci. 2011 Feb;32(1):53-8. doi: 10.1007/s10072-010-0387-1. Epub 2010 Aug 5.
20. Just L, etal., Cereb Cortex. 1999 Jun;9(4):332-9.
21. Just L, etal., J Mol Neurosci. 1998 Aug;11(1):57-66.
22. Karlsson O, etal., J Proteome Res. 2013 Apr 5;12(4):1678-90. doi: 10.1021/pr3010265. Epub 2013 Mar 5.
23. Kilpatrick DL, etal., Mol Cell Biol 1990 Jul;10(7):3717-26.
24. Kobylecki C, etal., J Neurochem. 2010 Jul;114(2):499-511. doi: 10.1111/j.1471-4159.2010.06776.x. Epub 2010 Apr 28.
25. Loh YP, etal., Ann N Y Acad Sci 2002 Oct;971:416-25.
26. Morganstern I, etal., Alcohol. 2012 Sep;46(6):559-68. doi: 10.1016/j.alcohol.2012.05.003. Epub 2012 Jun 14.
27. NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Ovadia H, etal., J Neuroimmunol. 1996 Aug;68(1-2):77-83.
29. Poulin JF, etal., Eur J Neurosci. 2013 Apr;37(8):1357-67. doi: 10.1111/ejn.12134. Epub 2013 Feb 1.
30. Poulin JF, etal., Stress. 2014 Jan;17(1):88-96. doi: 10.3109/10253890.2013.850669. Epub 2013 Oct 31.
31. Rao SM and Howells RD, Regul Pept 1992 Aug 13;40(3):397-408.
32. RGD automated data pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. RGD comprehensive gene curation
36. Rosen H, etal., J Biol Chem 1984 Nov 25;259(22):14309-13.
37. Rosen H, etal., Mol Endocrinol. 1995 Nov;9(11):1621-31.
38. Rosenberger J, etal., J Neurochem. 2001 Oct;79(1):35-44.
39. Rotsztejn WH, etal., Nature. 1978 Jul 20;274(5668):281-2.
40. Song DD, etal., Peptides. 1989 Nov-Dec;10(6):1239-46.
41. Szpirer C, etal., Transplant Proc 1999 May;31(3):1541-3
42. Tomasiewicz HC, etal., Biol Psychiatry. 2012 Nov 15;72(10):803-10. doi: 10.1016/j.biopsych.2012.04.026. Epub 2012 Jun 8.
43. Van Bockstaele EJ, etal., J Comp Neurol. 1995 Dec 18;363(3):423-38. doi: 10.1002/cne.903630307.
44. Wang Y, etal., Gene Ther. 2013 Jul;20(7):742-50. doi: 10.1038/gt.2012.90. Epub 2012 Dec 13.
45. Xu N, etal., J Pharm Biomed Anal. 2011 Apr 28;55(1):101-8. doi: 10.1016/j.jpba.2010.12.015. Epub 2010 Dec 21.
46. Yokoyama H, etal., Hum Gene Ther. 2013 Feb;24(2):170-80. doi: 10.1089/hum.2011.180. Epub 2013 Feb 14.
47. Yoshikawa K, etal., FEBS Lett 1989 Mar 27;246(1-2):193-6.
48. Yoshikawa K, etal., J Biol Chem 1984 Nov 25;259(22):14301-8.
Additional References at PubMed
PMID:6594709   PMID:8408077   PMID:8849726   PMID:11172058   PMID:12477932   PMID:12895518   PMID:14739357   PMID:15489334   PMID:15952166   PMID:18227978   PMID:19500224   PMID:20692550  
PMID:21125428   PMID:21171319   PMID:22725682   PMID:23000149   PMID:23012479   PMID:27072528   PMID:28423013   PMID:29169417   PMID:32184167  


Genomics

Comparative Map Data
Penk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2517,183,799 - 17,189,160 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl517,183,806 - 17,189,129 (-)Ensembl
Rnor_6.0517,056,412 - 17,061,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl517,056,419 - 17,061,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,834,409 - 21,839,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,509,323 - 17,514,265 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1517,516,079 - 17,517,452 (-)NCBI
Celera516,529,164 - 16,534,106 (-)NCBICelera
Cytogenetic Map5q12NCBI
PENK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl856,436,674 - 56,446,671 (-)EnsemblGRCh38hg38GRCh38
GRCh38856,440,957 - 56,446,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37857,353,516 - 57,359,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,516,070 - 57,521,143 (-)NCBINCBI36hg18NCBI36
Build 34857,516,069 - 57,521,143NCBI
Celera853,344,310 - 53,350,077 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,820,608 - 52,826,373 (-)NCBIHuRef
CHM1_1857,405,395 - 57,411,158 (-)NCBICHM1_1
Penk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3944,133,536 - 4,138,815 (-)NCBIGRCm39mm39
GRCm39 Ensembl44,133,531 - 4,138,819 (-)Ensembl
GRCm3844,133,536 - 4,138,815 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl44,133,531 - 4,138,819 (-)EnsemblGRCm38mm10GRCm38
MGSCv3744,060,683 - 4,065,592 (-)NCBIGRCm37mm9NCBIm37
MGSCv3644,060,683 - 4,065,592 (-)NCBImm8
Celera44,092,742 - 4,097,651 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.31NCBI
Penk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,426,017 - 15,426,685 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,425,712 - 15,426,685 (-)NCBIChiLan1.0ChiLan1.0
PENK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1850,234,170 - 50,239,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl850,234,170 - 50,239,949 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0852,864,388 - 52,870,144 (-)NCBIMhudiblu_PPA_v0panPan3
PENK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,757,543 - 7,763,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,757,857 - 7,762,398 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha298,069,914 - 8,075,462 (-)NCBI
ROS_Cfam_1.0297,832,106 - 7,837,657 (-)NCBI
UMICH_Zoey_3.1297,844,842 - 7,850,120 (-)NCBI
UNSW_CanFamBas_1.0297,975,639 - 7,980,923 (-)NCBI
UU_Cfam_GSD_1.0298,254,882 - 8,260,429 (-)NCBI
Penk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,763,745 - 71,769,230 (+)NCBI
SpeTri2.0NW_0049364963,016,247 - 3,021,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PENK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,525,555 - 75,561,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,525,497 - 75,530,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,444,889 - 82,449,745 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PENK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,458,113 - 52,463,933 (-)NCBI
ChlSab1.1 Ensembl852,457,904 - 52,463,859 (-)Ensembl
Vero_WHO_p1.0NW_02366603989,329,730 - 89,335,563 (+)NCBI
Penk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248863,595,485 - 3,613,117 (+)NCBI


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:270
Count of miRNA genes:184
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000011892
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 39 2 2 2 52 2 25
Low 3 4 26 10 13 10 6 6 22 26 16 10 6
Below cutoff 28 28 6 28 2 5 7 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011892   ⟹   ENSRNOP00000011892
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl517,183,806 - 17,189,129 (-)Ensembl
Rnor_6.0 Ensembl517,056,448 - 17,061,837 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089318   ⟹   ENSRNOP00000074581
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl517,056,419 - 17,061,361 (-)Ensembl
RefSeq Acc Id: NM_017139   ⟹   NP_058835
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2517,183,806 - 17,188,748 (-)NCBI
Rnor_6.0517,056,419 - 17,061,361 (-)NCBI
Rnor_5.0521,834,409 - 21,839,759 (-)NCBI
RGSC_v3.4517,509,323 - 17,514,265 (-)RGD
Celera516,529,164 - 16,534,106 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237835   ⟹   XP_006237897
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2517,183,799 - 17,189,160 (-)NCBI
Rnor_6.0517,056,412 - 17,061,762 (-)NCBI
Rnor_5.0521,834,409 - 21,839,759 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058835   ⟸   NM_017139
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006237897   ⟸   XM_006237835
- Peptide Label: isoform X1
- UniProtKB: P04094 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011892   ⟸   ENSRNOT00000011892
RefSeq Acc Id: ENSRNOP00000074581   ⟸   ENSRNOT00000089318

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693550
Promoter ID:EPDNEW_R4075
Type:single initiation site
Name:Penk_2
Description:proenkephalin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4076  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0517,061,378 - 17,061,438EPDNEW
RGD ID:13693556
Promoter ID:EPDNEW_R4076
Type:multiple initiation site
Name:Penk_1
Description:proenkephalin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4075  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0517,061,738 - 17,061,798EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN-Lx/CubMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BUF/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
DA/OlaHsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
F344/Stm (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FXLE16/Stm (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/FarMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
HXB10/IpcvMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrcAek (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
M520/NRrrcMcwi (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MWF/Hsd (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/RijCrl (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (2020)
Visual CSV TAB Printer
Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (2019)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (2020)
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Sequenced By: MCW
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68946 AgrOrtholog
Ensembl Genes ENSRNOG00000008943 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000011892 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074581 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011892 UniProtKB/Swiss-Prot
  ENSRNOT00000089318 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112833 IMAGE-MGC_LOAD
InterPro Opioid_neupept UniProtKB/Swiss-Prot
  Proenkphlin_A UniProtKB/Swiss-Prot
KEGG Report rno:29237 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93514 IMAGE-MGC_LOAD
NCBI Gene 29237 ENTREZGENE
PANTHER PTHR11438 UniProtKB/Swiss-Prot
  PTHR11438:SF3 UniProtKB/Swiss-Prot
Pfam Opiods_neuropep UniProtKB/Swiss-Prot
PhenoGen Penk PhenoGen
PRINTS OPIOIDPRCRSR UniProtKB/Swiss-Prot
  PENKAPRCRSR UniProtKB/Swiss-Prot
PROSITE OPIOIDS_PRECURSOR UniProtKB/Swiss-Prot
UniProt P04094 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q53X05 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Penk  proenkephalin  Penk1  proenkephalin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-01 Penk1  proenkephalin 1  Penk-rs  preproenkephalin, related sequence  Data Merged 737654 APPROVED
2003-04-09 Penk1  proenkephalin 1      Symbol and Name updated 629477 APPROVED
2003-03-06 Penk1  proenkephalin 1  Penk  Proenkephalin  Data Merged 628472 PROVISIONAL
2002-06-10 Penk  Proenkephalin      Name updated 70585 PROVISIONAL
2002-06-10 Penk-rs  preproenkephalin, related sequence      Name updated 70584 APPROVED
2002-06-10 Penk1  preproenkephalin 1      Name updated 70586 APPROVED
2001-12-10 Penk-rs  proenkephalin, related sequence      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to dense-core granules of the regulated secretory pathway 1299170
gene_domains n-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing 61511
gene_expression expressed in bone, brain, breast, foreskin, germ cell, kidney, prostate, whole embryo, head-neck, lung, ovary, and testis 61511
gene_function precursor of the opiate neuropeptides M-enkephalin and L-enkephalin 61511
gene_physical_interaction binds to carboxypeptidase E (CPE)to effect its sorting in the regulated secretory pathway 1299170
gene_process plays a role in pain perception and responses to stress 61511
gene_process plays a role in a number of physiologic functions, including pain perception and responses to stress 61511
gene_product member of the opioids neuropeptides precursors family 61511
gene_protein 269 amino acids; 30.9 kDa 633675