Eci1 (enoyl-CoA delta isomerase 1)

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Gene: Eci1 (enoyl-CoA delta isomerase 1) Rattus norvegicus

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Symbol:

Eci1

Name:

enoyl-CoA delta isomerase 1

RGD ID:

61892

Description:

Enables delta(3)-delta(2)-enoyl-CoA isomerase activity and identical protein binding activity. Involved in fatty acid beta-oxidation. Located in mitochondrion. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

3,2 trans-enoyl-coenyme A isomerase; 3,2-trans-enoyl-CoA isomerase; 3,2-trans-enoyl-CoA isomerase, mitochondrial; D3,D2-enoyl-CoA isomerase; Dci; delta(3),Delta(2)-enoyl-CoA isomerase; dodecenoyl-CoA isomerase; dodecenoyl-coenzyme A delta isomerase; dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase); dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase); dodecenoyl-Coenzyme A delta isomerase (32 trans-enoyl-Coenyme A isomerase); enoyl-CoA delta isomerase 1, mitochondrial; enoyl-Coenzyme A delta isomerase 1; MECI

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ECI1 (enoyl-CoA delta isomerase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Eci1 (enoyl-Coenzyme A delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Eci1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ECI1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ECI1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Eci1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ECI1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ECI1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eci1 (enoyl-CoA delta isomerase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Eci1 (enoyl-Coenzyme A delta isomerase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ECI1 (enoyl-CoA delta isomerase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	eci1 (enoyl-CoA delta isomerase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4592	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4594	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG4598	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	eci1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	13,961,250 - 13,974,595 (+)	NCBI		GRCr8
mRatBN7.2	10	13,456,715 - 13,470,061 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,456,563 - 13,470,061 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	18,203,212 - 18,216,533 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,692,057 - 17,705,378 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	13,191,242 - 13,204,563 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	13,797,573 - 13,810,918 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	13,797,562 - 13,810,913 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	13,614,559 - 13,627,904 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	13,683,000 - 13,697,179 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	13,682,988 - 13,697,174 (+)	NCBI
Celera	10	13,137,220 - 13,150,564 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 1 (ISO)

endometrial carcinoma (ISO)

epilepsy (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

alpha-hexachlorocyclohexane (EXP)

amiodarone (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bromobenzene (EXP)

buspirone (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (EXP)

captan (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumarin (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

diquat (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

ethanol (ISO)

fenofibrate (EXP,ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

gemfibrozil (EXP)

gentamycin (EXP)

indometacin (EXP)

inulin (ISO)

isotretinoin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

lamivudine (ISO)

leflunomide (EXP)

metformin (EXP)

methapyrilene (EXP)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

methylseleninic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (EXP)

Muraglitazar (EXP)

nefazodone (EXP)

nimesulide (EXP)

ochratoxin A (ISO)

omeprazole (EXP)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP,ISO)

phenformin (EXP)

phenobarbital (EXP)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

raloxifene (EXP)

resveratrol (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

sodium arsenite (EXP)

sodium dichromate (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

tamibarotene (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thiacloprid (ISO)

thioacetamide (EXP)

thiophanate-methyl (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP,ISO)

triphenyl phosphate (ISO)

troglitazone (EXP)

trovafloxacin (ISO)

ursodeoxycholic acid (EXP)

valdecoxib (EXP)

valproic acid (ISO)

zidovudine (ISO)

zinc atom (EXP)

zinc(0) (EXP)

ziram (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation (IBA,IDA,IEA,ISO,TAS)

Cellular Component

mitochondrial matrix (IEA)

mitochondrion (IBA,IDA,IEA,ISO)

Molecular Function

catalytic activity (IEA)

delta(3)-delta(2)-enoyl-CoA isomerase activity (IBA,IDA,IEA,ISO)

identical protein binding (IDA)

intramolecular oxidoreductase activity, transposing C=C bonds (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Domain swapping in the low-similarity isomerase/hydratase superfamily: the crystal structure of rat mitochondrial Delta3, Delta2-enoyl-CoA isomerase.	Hubbard PA, etal., Protein Sci. 2005 Jun;14(6):1545-55. Epub 2005 May 9.
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Mitochondrial 3-2trans-Enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of the key enzyme of unsaturated fatty acid beta-oxidation.	Muller-Newen G and Stoffel W, Biol Chem Hoppe Seyler 1991 Aug;372(8):613-24.
6.	Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA isomerase, 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase enzyme in rat liver. The proposed occurrence of isomerization and hydration in the same catalytic domain of the multifunctional enzyme.	Palosaari PM, etal., J Biol Chem 1991 Jun 15;266(17):10750-3.
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10.	Functional characterization of Delta3,Delta2-enoyl-CoA isomerases from rat liver.	Zhang D, etal., J Biol Chem. 2002 Mar 15;277(11):9127-32. Epub 2002 Jan 7.

Additional References at PubMed

PMID:1543742	PMID:11916962	PMID:12865426	PMID:14651853	PMID:16952422	PMID:18614015	PMID:20833797	PMID:23376485	PMID:30053369

Genomics

Comparative Map Data

Eci1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	13,961,250 - 13,974,595 (+)	NCBI		GRCr8
mRatBN7.2	10	13,456,715 - 13,470,061 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	13,456,563 - 13,470,061 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	18,203,212 - 18,216,533 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	17,692,057 - 17,705,378 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	13,191,242 - 13,204,563 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	13,797,573 - 13,810,918 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	13,797,562 - 13,810,913 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	13,614,559 - 13,627,904 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	13,683,000 - 13,697,179 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	13,682,988 - 13,697,174 (+)	NCBI
Celera	10	13,137,220 - 13,150,564 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

ECI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	2,239,402 - 2,251,587 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	2,239,402 - 2,252,300 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	2,289,403 - 2,301,588 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	2,229,897 - 2,241,604 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	2,229,898 - 2,241,576	NCBI
Celera	16	2,504,294 - 2,516,030 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	2,215,959 - 2,227,648 (-)	NCBI		HuRef
CHM1_1	16	2,289,822 - 2,301,559 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	2,261,850 - 2,274,034 (-)	NCBI		T2T-CHM13v2.0

Eci1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	24,645,657 - 24,658,290 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	24,645,615 - 24,658,322 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	24,426,683 - 24,439,316 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	24,426,641 - 24,439,348 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	24,563,628 - 24,576,261 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	24,154,283 - 24,166,914 (+)	NCBI		MGSCv36	mm8
Celera	17	24,939,193 - 24,953,366 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.39	NCBI

Eci1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,010,412 - 15,027,014 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	15,010,412 - 15,027,014 (+)	NCBI	ChiLan1.0	ChiLan1.0

ECI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	2,741,784 - 2,753,362 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	6,522,684 - 6,534,247 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	1,097,165 - 1,108,726 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	2,339,864 - 2,351,221 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	2,339,864 - 2,351,385 (-)	Ensembl	panpan1.1		panPan2

ECI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	38,729,729 - 38,738,357 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	38,730,219 - 38,738,219 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	39,969,905 - 39,977,831 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	39,039,094 - 39,047,029 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	39,039,030 - 39,046,867 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	38,724,133 - 38,732,054 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	38,695,920 - 38,704,312 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	39,175,160 - 39,183,085 (+)	NCBI		UU_Cfam_GSD_1.0

Eci1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,902,157 - 104,914,806 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	1,794,670 - 1,807,299 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	1,794,673 - 1,807,306 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ECI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	39,750,742 - 39,758,516 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	39,750,742 - 39,758,516 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	42,422,314 - 42,425,576 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ECI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	2,135,042 - 2,147,246 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	2,135,129 - 2,147,109 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	28,910,452 - 28,924,540 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eci1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	53,458 - 66,946 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	53,174 - 66,986 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Eci1
58 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	45
Count of miRNA genes:	44
Interacting mature miRNAs:	45
Transcripts:	ENSRNOT00000011784
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
631660	Hcar1	Hepatocarcinoma resistance QTL 1	3.4	0.0001	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	10	6154182	15990232	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat

Markers in Region

RH138788

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,465,271 - 13,465,425 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	13,806,129 - 13,806,282	NCBI	Rnor6.0
Rnor_5.0	10	13,623,115 - 13,623,268	UniSTS	Rnor5.0
RGSC_v3.4	10	13,692,390 - 13,692,543	UniSTS	RGSC3.4
Celera	10	13,145,775 - 13,145,928	UniSTS
RH 3.4 Map	10	171.3	UniSTS
Cytogenetic Map	10	q12	UniSTS

RH141401

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	13,468,721 - 13,469,930 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	13,809,579 - 13,810,787	NCBI	Rnor6.0
Rnor_5.0	10	13,626,565 - 13,627,773	UniSTS	Rnor5.0
RGSC_v3.4	10	13,695,840 - 13,697,048	UniSTS	RGSC3.4
Celera	10	13,149,225 - 13,150,433	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

appendage

High

Medium

141

227

147

248

115

134

Low

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D00729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213384	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M61112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X61184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011784 ⟹ ENSRNOP00000011784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	13,457,120 - 13,470,061 (+)	Ensembl
Rnor_6.0 Ensembl	10	13,797,562 - 13,810,913 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083312 ⟹ ENSRNOP00000072341

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	13,456,563 - 13,470,060 (+)	Ensembl
Rnor_6.0 Ensembl	10	13,797,593 - 13,810,826 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119135 ⟹ ENSRNOP00000093771

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	13,456,563 - 13,470,060 (+)	Ensembl

RefSeq Acc Id:

NM_017306 ⟹ NP_059002

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	13,961,250 - 13,974,595 (+)	NCBI
mRatBN7.2	10	13,456,715 - 13,470,061 (+)	NCBI
Rnor_6.0	10	13,797,573 - 13,810,918 (+)	NCBI
Rnor_5.0	10	13,614,559 - 13,627,904 (+)	NCBI
RGSC_v3.4	10	13,683,000 - 13,697,179 (+)	RGD
Celera	10	13,137,220 - 13,150,564 (+)	RGD

Sequence:

show sequence

CCAAAATGGCGCTGGCTGCTGCGCGTCGCGTTCTGCTGCAGGCCGGATCCCGCCTCGGCCGCAG
GGGGGCCGTGGACGGCGCGCGGCGCTTCTCTAACAAGCGGGTGTTGGTGGAGAAGGAGGGCGAG
GCAGGAATCGCAGTGATGAAGTTCAAGAACCCTCCAGTGAATTCCCTCAGCTTGGAGTTTCTGA
CAGAGTTCGTCATCAGCCTGGAGAAGCTGGAAAATGACAAGAGCATCCGAGGTGTCATCCTCAC
TTCGGAGCGCCCGGGTATCTTCTCGGCTGGCCTGGACTTGATGGAGATGTATGGCCGGAACCCA
GCCCACTACGCTGAGTACTGGAAGGCTGTGCAGGAGCTGTGGCTGAGGCTCTACTTGTCCAACC
TGACCTTGATATCTGCCATCAATGGCGCCTCTCCAGCTGGAGGCTGCCTCATGGCTCTCACCTG
TGACTACAGGATAATGGCGGACAACCCCAAGTATACCATAGGATTGAATGAGAGCCTGCTGGGC
ATTGTTGCCCCCTTCTGGTTAAAAGACAACTACGTGAACACCATCGGGCACCGAGCAGCCGAGC
GTGCCCTTCAACTGGGGACGCTTTTCCCACCAGCAGAGGCCCTCAAGGTGGGTTTGGTGGATGA
GGTGGTACCTGAGGATCAGGTACACAGCAAGGCTCGCTCAGTGATGGCCAAGTGGTTCACCATT
CCGGACCATTCTCGGCAGCTGACGAAGAGCATGATGCGGAAGGCCACGGCGGACAACCTGATCA
AGCAGCGAGAGGCTGACATCCAGAACTTCACCAGTTTCATCTCCAGAGACTCCATCCAGAAGTC
CCTGCACGTGTACTTGGAAAAGCTCAAGCAAAAGAAGGGCTGACCTAAGGGTGCCACACGGGTG
TTTAGTTACACGTGCCTTCTAGGGACCCATGGTCCCAAGGATTATCAATAAGGTATTTTTCAAT
TTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_059002	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41073	(Get FASTA)	NCBI Sequence Viewer
	AAH78705	(Get FASTA)	NCBI Sequence Viewer
	BAA00629	(Get FASTA)	NCBI Sequence Viewer
	CAA43488	(Get FASTA)	NCBI Sequence Viewer
	EDM03825	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011784.3
	ENSRNOP00000072341.2
	ENSRNOP00000093771.1
	ENSRNOP00055038672
	ENSRNOP00060013410
	ENSRNOP00065012950
GenBank Protein	P23965	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_059002 ⟸ NM_017306
- Peptide Label:	precursor
- UniProtKB:	P23965 (UniProtKB/Swiss-Prot), Q68G41 (UniProtKB/TrEMBL), A0A8I6AJI3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALAAARRVLLQAGSRLGRRGAVDGARRFSNKRVLVEKEGEAGIAVMKFKNPPVNSLSLEFLTE FVISLEKLENDKSIRGVILTSERPGIFSAGLDLMEMYGRNPAHYAEYWKAVQELWLRLYLSNLT LISAINGASPAGGCLMALTCDYRIMADNPKYTIGLNESLLGIVAPFWLKDNYVNTIGHRAAERA LQLGTLFPPAEALKVGLVDEVVPEDQVHSKARSVMAKWFTIPDHSRQLTKSMMRKATADNLIKQ READIQNFTSFISRDSIQKSLHVYLEKLKQKKG hide sequence

Ensembl Acc Id:

ENSRNOP00000011784 ⟸ ENSRNOT00000011784

Ensembl Acc Id:

ENSRNOP00000072341 ⟸ ENSRNOT00000083312

Ensembl Acc Id:

ENSRNOP00000093771 ⟸ ENSRNOT00000119135

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P23965-F1-model_v2	AlphaFold	P23965	1-289	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697010

Promoter ID:

EPDNEW_R7534

Type:

multiple initiation site

Name:

Eci1_1

Description:

enoyl-CoA delta isomerase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	13,797,558 - 13,797,618	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61892	AgrOrtholog
BioCyc Gene	G2FUF-25860	BioCyc
BioCyc Pathway	FAO-PWY [fatty acid beta-oxidation I (generic)]	BioCyc
	PWY-5137 [fatty acid beta-oxidation III (unsaturated, odd number)]	BioCyc
BioCyc Pathway Image	FAO-PWY	BioCyc
	PWY-5137	BioCyc
Ensembl Genes	ENSRNOG00000008843	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00055027196	UniProtKB/Swiss-Prot
	ENSRNOG00060010220	UniProtKB/Swiss-Prot
	ENSRNOG00065010437	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000011784.5	UniProtKB/TrEMBL
	ENSRNOT00000083312.2	UniProtKB/TrEMBL
	ENSRNOT00000119135.1	UniProtKB/TrEMBL
	ENSRNOT00055047054	UniProtKB/Swiss-Prot
	ENSRNOT00060017270	UniProtKB/Swiss-Prot
	ENSRNOT00065016911	UniProtKB/Swiss-Prot
Gene3D-CATH	6.10.250.170	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7129389	IMAGE-MGC_LOAD
InterPro	ClpP/crotonase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Enoyl-CoA_hyd/isom_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Enoyl-CoA_hydra/iso	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29740	UniProtKB/TrEMBL
MGC_CLONE	MGC:93116	IMAGE-MGC_LOAD
NCBI Gene	29740	ENTREZGENE
PANTHER	ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENOYL-COA HYDRATASE-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ECH_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Eci1	PhenoGen
PROSITE	ENOYL_COA_HYDRATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008843	RatGTEx
	ENSRNOG00055027196	RatGTEx
	ENSRNOG00060010220	RatGTEx
	ENSRNOG00065010437	RatGTEx
Superfamily-SCOP	SSF52096	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K2R2_RAT	UniProtKB/TrEMBL
	A0A8I6AJI3	ENTREZGENE, UniProtKB/TrEMBL
	ECI1_RAT	UniProtKB/Swiss-Prot
	F7FE51_RAT	UniProtKB/TrEMBL
	P23965	ENTREZGENE
	Q68G41	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-03	Eci1	enoyl-CoA delta isomerase 1	Eci1	enoyl-Coenzyme A delta isomerase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-03-17	Eci1	enoyl-Coenzyme A delta isomerase 1	Dci	dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Dci	dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)	Dci	dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-08	Dci	dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase)	Dci	dodecenoyl-coenzyme A delta isomerase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Dci	dodecenoyl-coenzyme A delta isomerase			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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