Atr (ATR serine/threonine kinase) - Rat Genome Database

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Gene: Atr (ATR serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Atr
Name: ATR serine/threonine kinase
RGD ID: 1305796
Description: Predicted to enable MutLalpha complex binding activity; MutSalpha complex binding activity; and histone H2AXS139 kinase activity. Involved in response to arsenic-containing substance and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; XY body; and nucleus. Predicted to be part of ATR-ATRIP complex. Predicted to be active in nucleus and site of DNA damage. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic cancer. Orthologous to human ATR (ATR serine/threonine kinase); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH amphetamine; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ataxia telangiectasia and Rad3 related; ataxia telangiectasia and rad3 related-like; LOC300942; LOC685055; serine/threonine-protein kinase ATR; similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2896,426,704 - 96,524,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08103,673,578 - 103,770,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,123,798 - 103,222,597 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,936,342 - 101,014,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,002,130 - 101,034,333 (+)NCBI
Celera895,873,052 - 95,969,777 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aphidicolin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
flavanones  (ISO)
floxuridine  (ISO)
folic acid  (ISO)
gallic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydroxyurea  (ISO)
isocyanates  (ISO)
lovastatin  (EXP)
lutein  (ISO)
metformin  (ISO)
methoxsalen  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
motexafin gadolinium  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nicotine  (ISO)
nitenpyram  (ISO)
Nonidet P-40  (ISO)
O-methyleugenol  (ISO)
octamethylcyclotetrasiloxane  (ISO)
ouabain  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
yttrium chloride  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Andersson MK, etal., Oncogenesis. 2020 Jan 30;9(1):5. doi: 10.1038/s41389-020-0194-3.
2. ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. Fang Y, etal., EMBO J. 2004 Aug 4;23(15):3164-74. doi: 10.1038/sj.emboj.7600315. Epub 2004 Jul 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970. Hall AB, etal., Oncotarget. 2014 Jul 30;5(14):5674-85. doi: 10.18632/oncotarget.2158.
6. Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease . Katsel P, etal., PLoS One. 2013 Jul 5;8(7):e68361. doi: 10.1371/journal.pone.0068361. Print 2013.
7. Mutations in the ataxia telangiectasia and rad3-related-checkpoint kinase 1 DNA damage response axis in colon cancers. Lewis KA, etal., Genes Chromosomes Cancer. 2007 Dec;46(12):1061-8. doi: 10.1002/gcc.20486.
8. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18). Lu HF, etal., Neurochem Res. 2009 Aug;34(8):1491-7. Epub 2009 Mar 5.
9. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Murga M, etal., Nat Genet. 2009 Aug;41(8):891-8. doi: 10.1038/ng.420. Epub 2009 Jul 20.
10. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. O'Driscoll M, etal., Nat Genet. 2003 Apr;33(4):497-501. Epub 2003 Mar 17.
11. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. Okazaki T, etal., Clin Cancer Res. 2008 Apr 1;14(7):2042-8.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells. Wang M, etal., Cancer Biother Radiopharm. 2017 Aug;32(6):193-203. doi: 10.1089/cbr.2017.2212.
17. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. Watanabe R, etal., J Toxicol Pathol. 2017 Oct;30(4):333-337. doi: 10.1293/tox.2017-0020. Epub 2017 Jul 3.
Additional References at PubMed
PMID:9733515   PMID:9925639   PMID:10691732   PMID:12814551   PMID:12937170   PMID:14657349   PMID:15149599   PMID:15364958   PMID:15983387   PMID:16713580   PMID:18162465   PMID:18316482  
PMID:20639548   PMID:21829167   PMID:22549958   PMID:23039116   PMID:26586427   PMID:26586433   PMID:27723717   PMID:27723720  


Genomics

Comparative Map Data
Atr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2896,426,704 - 96,524,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.08103,673,578 - 103,770,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,123,798 - 103,222,597 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48100,936,342 - 101,014,881 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,002,130 - 101,034,333 (+)NCBI
Celera895,873,052 - 95,969,777 (+)NCBICelera
Cytogenetic Map8q31NCBI
ATR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383142,449,235 - 142,578,733 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3142,449,007 - 142,578,733 (-)EnsemblGRCh38hg38GRCh38
GRCh373142,168,077 - 142,297,575 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363143,650,767 - 143,780,358 (-)NCBINCBI36Build 36hg18NCBI36
Build 343143,650,777 - 143,780,349NCBI
Celera3140,574,471 - 140,721,117 (-)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3139,541,210 - 139,670,336 (-)NCBIHuRef
CHM1_13142,131,099 - 142,260,691 (-)NCBICHM1_1
T2T-CHM13v2.03145,196,519 - 145,326,002 (-)NCBIT2T-CHM13v2.0
Atr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39995,739,650 - 95,834,813 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl995,739,650 - 95,833,834 (+)EnsemblGRCm39 Ensembl
GRCm38995,857,597 - 95,953,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl995,857,597 - 95,951,781 (+)EnsemblGRCm38mm10GRCm38
MGSCv37995,758,016 - 95,852,063 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera995,424,018 - 95,518,128 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.27NCBI
Atr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555083,337,432 - 3,440,257 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555083,337,036 - 3,440,313 (+)NCBIChiLan1.0ChiLan1.0
ATR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan13140,365,083 - 140,494,866 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03139,482,606 - 139,612,274 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13147,074,993 - 147,204,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3147,075,185 - 147,196,261 (-)Ensemblpanpan1.1panPan2
ATR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12338,131,956 - 38,223,888 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2338,132,788 - 38,224,016 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2338,060,079 - 38,150,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02338,664,914 - 38,756,051 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2338,664,914 - 38,756,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12338,346,951 - 38,438,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02338,423,893 - 38,514,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02338,668,053 - 38,759,024 (-)NCBIUU_Cfam_GSD_1.0
Atr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560277,334,745 - 77,439,148 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365404,074,570 - 4,178,898 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365404,074,543 - 4,178,859 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1383,174,824 - 83,289,989 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11383,175,515 - 83,289,986 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,978,658 - 91,094,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,048,785 - 48,173,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,048,882 - 48,173,137 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604120,983,463 - 21,108,351 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473019,022,070 - 19,145,306 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473019,022,012 - 19,145,474 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atr
251 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:99
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000049967
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
AU047277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2896,429,963 - 96,430,158 (+)MAPPERmRatBN7.2
Rnor_6.08103,676,788 - 103,676,982NCBIRnor6.0
Rnor_5.08103,127,314 - 103,127,508UniSTSRnor5.0
RGSC_v3.48100,939,521 - 100,939,715UniSTSRGSC3.4
Celera895,876,262 - 95,876,454UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 20 6 15 6 36 21 40 8
Low 3 39 37 35 4 35 8 10 38 14 1 3 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049967   ⟹   ENSRNOP00000043760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl896,426,724 - 96,524,136 (+)Ensembl
Rnor_6.0 Ensembl8103,673,411 - 103,770,947 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097700   ⟹   ENSRNOP00000081218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl896,426,999 - 96,524,136 (+)Ensembl
RefSeq Acc Id: XM_003750561   ⟹   XP_003750609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2896,426,704 - 96,524,152 (+)NCBI
Rnor_6.08103,673,578 - 103,770,321 (+)NCBI
Rnor_5.08103,123,798 - 103,222,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243600   ⟹   XP_006243662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2896,426,930 - 96,524,152 (+)NCBI
Rnor_6.08103,673,684 - 103,770,886 (+)NCBI
Rnor_5.08103,123,798 - 103,222,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082561   ⟹   XP_038938489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2896,428,889 - 96,524,152 (+)NCBI
RefSeq Acc Id: XR_005488389
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2896,426,704 - 96,501,292 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003750609 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243662 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043760
  ENSRNOP00000043760.5
  ENSRNOP00000081218
  ENSRNOP00000081218.1
Reference Protein Sequences
RefSeq Acc Id: XP_003750609   ⟸   XM_003750561
- Peptide Label: isoform X1
- UniProtKB: D3Z822 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243662   ⟸   XM_006243600
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G5M3 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043760   ⟸   ENSRNOT00000049967
RefSeq Acc Id: XP_038938489   ⟸   XM_039082561
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G5M3 (UniProtKB/TrEMBL),   A6I268 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081218   ⟸   ENSRNOT00000097700
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z822-F1-model_v2 AlphaFold D3Z822 1-2636 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696197
Promoter ID:EPDNEW_R6713
Type:initiation region
Name:Atr_1
Description:ATR serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08103,673,551 - 103,673,611EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305796 AgrOrtholog
BioCyc Gene G2FUF-29472 BioCyc
Ensembl Genes ENSRNOG00000010027 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049967 ENTREZGENE
  ENSRNOT00000049967.6 UniProtKB/TrEMBL
  ENSRNOT00000097700 ENTREZGENE
  ENSRNOT00000097700.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_type_2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
KEGG Report rno:685055 UniProtKB/TrEMBL
NCBI Gene 685055 ENTREZGENE
PANTHER ATAXIA TELANGIECTASIA MUTATED ATM -RELATED UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ATR UniProtKB/TrEMBL
Pfam FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
PhenoGen Atr PhenoGen
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  HEAT_REPEAT UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010027 RatGTEx
SMART FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  UME UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I6G5M3 ENTREZGENE, UniProtKB/TrEMBL
  A6I268 ENTREZGENE, UniProtKB/TrEMBL
  D3Z822 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Atr  ATR serine/threonine kinase  Atr  ataxia telangiectasia and Rad3 related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Atr  ataxia telangiectasia and Rad3 related  LOC367198  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1591987 1643240 APPROVED
2013-05-24 Atr  ataxia telangiectasia and Rad3 related  LOC100365674  ataxia telangiectasia and rad3 related-like  Data merged from RGD:2318611 1643240 APPROVED
2010-05-05 LOC100365674  ataxia telangiectasia and rad3 related-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-03-24 Atr  ataxia telangiectasia and Rad3 related   LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1583247 737654 APPROVED
2008-04-30 Atr  ataxia telangiectasia and Rad3 related   Atr_predicted  ataxia telangiectasia and Rad3 related (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  LOC684113  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)  Data merged from RGD:1593937 1643240 APPROVED
2006-11-20 LOC684113  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC367198  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC685055  similar to Serine/threonine-protein kinase ATR (Ataxia telangiectasia and Rad3-related protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Atr_predicted  ataxia telangiectasia and Rad3 related (predicted)      Symbol and Name status set to approved 70820 APPROVED