Fez1 (fasciculation and elongation protein zeta 1) - Rat Genome Database

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Gene: Fez1 (fasciculation and elongation protein zeta 1) Rattus norvegicus
Analyze
Symbol: Fez1
Name: fasciculation and elongation protein zeta 1
RGD ID: 619708
Description: Enables protein N-terminus binding activity and protein kinase C binding activity. Involved in several processes, including hippocampus development; mitochondrion morphogenesis; and positive regulation of anterograde axonal transport of mitochondrion. Located in several cellular components, including dendrite; growth cone; and neuronal cell body. Colocalizes with mitochondrion. Biomarker of Parkinson's disease. Orthologous to human FEZ1 (fasciculation and elongation protein zeta 1); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fasciculation and elongation protein zeta 1 (zygin I); fasciculation and elongation protein zeta-1; MGC105385; protein kinase C-binding protein Zeta1; zygin I; zygin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2836,544,462 - 36,589,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl836,544,535 - 36,589,683 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx840,554,068 - 40,599,499 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0838,837,136 - 38,882,569 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0836,700,025 - 36,745,464 (+)NCBIRnor_WKY
Rnor_6.0839,305,128 - 39,350,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,305,128 - 39,350,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0839,307,579 - 39,353,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,078,328 - 38,123,983 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,087,093 - 38,132,749 (+)NCBI
Celera837,851,976 - 37,897,230 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
crocidolite asbestos  (ISO)
dibutyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
Mecamylamine  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
pentanal  (ISO)
phenylmercury acetate  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
tubocurarine  (ISO)
valproic acid  (ISO)
zinc sulfate  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells. Fujita T, etal., Biochem Biophys Res Commun. 2007 Sep 28;361(3):605-10. Epub 2007 Jul 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes. He J, etal., Mol Cell Biochem. 2009 May;325(1-2):159-67. Epub 2009 Feb 8.
5. Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain. Honda A, etal., Brain Res Mol Brain Res. 2004 Mar 17;122(1):89-92.
6. Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility. Ikuta J, etal., Biochem Biophys Res Commun. 2007 Feb 2;353(1):127-32. Epub 2006 Dec 6.
7. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. Kuroda S, etal., J Cell Biol 1999 Feb 8;144(3):403-11.
8. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
9. Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Lipska BK, etal., Hum Mol Genet. 2006 Apr 15;15(8):1245-58. Epub 2006 Mar 1.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Miyoshi K, etal., Mol Psychiatry. 2003 Jul;8(7):685-94.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Fasciculation and elongation protein zeta-1 (FEZ1) expression in reactive astrocytes in a rat model of Parkinson's disease. Sun YY, etal., Neuropathol Appl Neurobiol. 2014 Feb;40(2):164-76. doi: 10.1111/nan.12077.
Additional References at PubMed
PMID:12477932   PMID:15466860   PMID:15489334   PMID:15649943   PMID:15843383   PMID:15879557   PMID:19667186   PMID:25495476   PMID:27247180   PMID:31774489   PMID:33395696   PMID:33771901  


Genomics

Comparative Map Data
Fez1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2836,544,462 - 36,589,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl836,544,535 - 36,589,683 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx840,554,068 - 40,599,499 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0838,837,136 - 38,882,569 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0836,700,025 - 36,745,464 (+)NCBIRnor_WKY
Rnor_6.0839,305,128 - 39,350,270 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,305,128 - 39,350,270 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0839,307,579 - 39,353,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,078,328 - 38,123,983 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,087,093 - 38,132,749 (+)NCBI
Celera837,851,976 - 37,897,230 (-)NCBICelera
Cytogenetic Map8q21NCBI
FEZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,442,881 - 125,496,265 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11125,442,881 - 125,592,568 (-)EnsemblGRCh38hg38GRCh38
GRCh3711125,312,777 - 125,366,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,820,858 - 124,871,333 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411124,863,305 - 124,871,333NCBI
Celera11122,475,971 - 122,526,454 (-)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11121,257,207 - 121,307,713 (-)NCBIHuRef
CHM1_111125,201,870 - 125,252,371 (-)NCBICHM1_1
T2T-CHM13v2.011125,471,573 - 125,524,940 (-)NCBIT2T-CHM13v2.0
Fez1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39936,732,694 - 36,790,222 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl936,733,160 - 36,790,220 (+)EnsemblGRCm39 Ensembl
GRCm38936,821,398 - 36,878,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl936,821,864 - 36,878,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv37936,651,244 - 36,686,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36936,582,480 - 36,628,593 (+)NCBIMGSCv36mm8
Celera934,040,032 - 34,083,023 (+)NCBICelera
Cytogenetic Map9A4NCBI
Fez1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541226,477,301 - 26,531,354 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541226,477,995 - 26,530,686 (-)NCBIChiLan1.0ChiLan1.0
FEZ1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111124,186,241 - 124,236,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,182,901 - 124,236,403 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011120,272,187 - 120,322,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FEZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,001,927 - 9,044,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,001,989 - 9,044,332 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,045,434 - 9,088,812 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.058,940,817 - 8,984,967 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,940,786 - 8,984,968 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,012,637 - 9,056,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,982,968 - 9,026,843 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,019,529 - 9,062,951 (+)NCBIUU_Cfam_GSD_1.0
Fez1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947107,623,764 - 107,669,772 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,871,664 - 1,903,245 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367431,871,808 - 1,917,370 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FEZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl952,621,183 - 52,672,660 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1952,621,175 - 52,672,660 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2958,321,965 - 58,348,192 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103248766
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,617,835 - 116,668,601 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,617,714 - 116,668,574 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660439,401,860 - 9,506,604 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fez1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249271,469,025 - 1,512,790 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249271,470,218 - 1,512,780 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fez1
297 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:44
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000008285
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83084815440713225Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815442692818Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat

Markers in Region
D8Rat47  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,562,090 - 36,562,213 (+)MAPPERmRatBN7.2
Rnor_6.0839,322,676 - 39,322,798NCBIRnor6.0
Rnor_5.0839,325,280 - 39,325,402UniSTSRnor5.0
RGSC_v3.4838,096,366 - 38,096,488UniSTSRGSC3.4
RGSC_v3.4838,096,365 - 38,096,488RGDRGSC3.4
RGSC_v3.1838,105,132 - 38,105,254RGD
Celera837,879,500 - 37,879,622UniSTS
RH 3.4 Map8311.3RGD
RH 3.4 Map8311.3UniSTS
RH 2.0 Map8234.1RGD
SHRSP x BN Map827.82UniSTS
FHH x ACI Map828.0499RGD
Cytogenetic Map8q21UniSTS
D8Rat220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,562,099 - 36,562,212 (+)MAPPERmRatBN7.2
Rnor_6.0839,322,685 - 39,322,797NCBIRnor6.0
Rnor_5.0839,325,289 - 39,325,401UniSTSRnor5.0
RGSC_v3.4838,096,376 - 38,096,486RGDRGSC3.4
RGSC_v3.4838,096,375 - 38,096,487UniSTSRGSC3.4
RGSC_v3.1838,104,983 - 38,105,322RGD
Celera837,879,501 - 37,879,613UniSTS
SHRSP x BN Map827.75UniSTS
SHRSP x BN Map827.75RGD
FHH x ACI Map828.0499RGD
Cytogenetic Map8q21UniSTS
D8Rat218  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4838,096,366 - 38,096,488UniSTSRGSC3.4
RGSC_v3.1838,105,131 - 38,105,254RGD
Celera837,879,500 - 37,879,622UniSTS
RH 3.4 Map8311.3UniSTS
SHRSP x BN Map827.82RGD
D8Got318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,563,285 - 36,563,426 (+)MAPPERmRatBN7.2
Rnor_6.0839,323,871 - 39,324,011NCBIRnor6.0
Rnor_5.0839,326,475 - 39,326,615UniSTSRnor5.0
RGSC_v3.4838,097,561 - 38,097,701UniSTSRGSC3.4
RGSC_v3.41952,803,774 - 52,803,914UniSTSRGSC3.4
Celera837,878,287 - 37,878,427UniSTS
Cytogenetic Map8q21UniSTS
D11S3963E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2836,589,509 - 36,589,617 (+)MAPPERmRatBN7.2
Rnor_6.0839,350,097 - 39,350,204NCBIRnor6.0
Rnor_5.0839,353,139 - 39,353,246UniSTSRnor5.0
RGSC_v3.4838,123,810 - 38,123,917UniSTSRGSC3.4
Celera837,852,042 - 37,852,149UniSTS
Cytogenetic Map8q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 74 21
Low 2 39 37 21 16 21 8 11 20 20 11 8
Below cutoff 4 20 20 3 20 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008285   ⟹   ENSRNOP00000008285
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl836,544,535 - 36,589,683 (+)Ensembl
Rnor_6.0 Ensembl839,305,128 - 39,350,270 (+)Ensembl
RefSeq Acc Id: NM_031066   ⟹   NP_112328
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2836,544,535 - 36,589,683 (+)NCBI
Rnor_6.0839,305,128 - 39,350,270 (+)NCBI
Rnor_5.0839,307,579 - 39,353,313 (+)NCBI
RGSC_v3.4838,078,328 - 38,123,983 (+)RGD
Celera837,851,976 - 37,897,230 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082202   ⟹   XP_038938130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2836,544,462 - 36,589,684 (+)NCBI
RefSeq Acc Id: XM_039082203   ⟹   XP_038938131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2836,544,462 - 36,589,684 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112328   ⟸   NM_031066
- UniProtKB: Q62922 (UniProtKB/Swiss-Prot),   P97577 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008285   ⟸   ENSRNOT00000008285
RefSeq Acc Id: XP_038938130   ⟸   XM_039082202
- Peptide Label: isoform X1
- UniProtKB: Q62922 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038938131   ⟸   XM_039082203
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97577-F1-model_v2 AlphaFold P97577 1-393 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695855
Promoter ID:EPDNEW_R6380
Type:single initiation site
Name:Fez1_1
Description:fasciculation and elongation protein zeta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0839,305,084 - 39,305,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619708 AgrOrtholog
BioCyc Gene G2FUF-31100 BioCyc
Ensembl Genes ENSRNOG00000006075 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008285 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008285 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7314065 IMAGE-MGC_LOAD
InterPro FEZ UniProtKB/Swiss-Prot
  FEZ_1 UniProtKB/Swiss-Prot
KEGG Report rno:81730 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105385 IMAGE-MGC_LOAD
NCBI Gene 81730 ENTREZGENE
PANTHER PTHR12394 UniProtKB/Swiss-Prot
  PTHR12394:SF4 UniProtKB/Swiss-Prot
Pfam FEZ UniProtKB/Swiss-Prot
PharmGKB FEZ1 RGD
PhenoGen Fez1 PhenoGen
UniProt FEZ1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62922 ENTREZGENE
UniProt Secondary Q62922 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Fez1  fasciculation and elongation protein zeta 1  Fez1  fasciculation and elongation protein zeta 1 (zygin I)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fez1  fasciculation and elongation protein zeta 1 (zygin I)    protein kinase C-binding protein Zeta1  Name updated 1299863 APPROVED
2002-08-07 Fez1  protein kinase C-binding protein Zeta1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein present mainly in plasma membrane 728650
gene_expression mRNA expressed in brain in embryo and adult 728650
gene_physical_interaction interacts with N-terminal region (V1) of PKCzeta, and weakly with PKCepsilon 728650
gene_protein contains 393 aa residues 728650