Cnr1 (cannabinoid receptor 1) - Rat Genome Database

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Gene: Cnr1 (cannabinoid receptor 1) Rattus norvegicus
Analyze
Symbol: Cnr1
Name: cannabinoid receptor 1
RGD ID: 2369
Description: Exhibits cannabinoid receptor activity. Involved in several processes, including positive regulation of acute inflammatory response; regulation of secretion by cell; and response to alkaloid. Localizes to membrane raft and plasma membrane. Colocalizes with intracellular membrane-bounded organelle. Used to study several diseases, including diabetic neuropathy; hypertension; impotence; obesity; and peptic ulcer disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1); PARTICIPATES IN N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: brain-type cannabinoid receptor; cannabinoid receptor 1 (brain); CB-R; CB1; SKR6R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBI
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (EXP,ISO)
ammonium chloride  (EXP)
amphetamines  (ISO)
anandamide  (EXP,ISO)
aripiprazole  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Bromazepam  (ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbazoles  (ISO)
chaetocin  (EXP)
chloroprene  (ISO)
chlorpyrifos-methyl  (ISO)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazepam  (ISO)
diazoxon  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichlorvos  (ISO)
dioxygen  (ISO)
diprotium oxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
gemcitabine  (ISO)
ghrelin  (EXP)
glucose  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
imipramine  (EXP)
indazoles  (ISO)
indoles  (ISO)
indometacin  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
Methanandamide  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylphenidate  (ISO)
morphine  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-oleoyldopamine  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
oxidopamine  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
palmitoyl ethanolamide  (EXP)
paracetamol  (EXP)
paraoxon  (ISO)
parecoxib  (ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
piperidines  (ISO)
poly(I:C)  (EXP)
potassium atom  (EXP)
potassium chloride  (EXP)
pregabalin  (ISO)
pregnenolone  (ISO)
progesterone  (ISO)
pyrazoles  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quetiapine fumarate  (ISO)
reserpine  (EXP)
ricinoleic acid  (ISO)
rimonabant  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topiramate  (ISO)
tribufos  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
water  (EXP)
WIN 55212-2  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO,ISS)
aging  (IMP)
axonal fasciculation  (ISO)
cannabinoid signaling pathway  (IBA,IDA,ISO)
G protein-coupled receptor signaling pathway  (IMP)
glucose homeostasis  (ISO)
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration  (IEA)
learning or memory  (IMP)
maternal process involved in female pregnancy  (IEP)
memory  (IDA)
negative regulation of action potential  (IMP)
negative regulation of blood pressure  (IMP)
negative regulation of dopamine secretion  (IMP)
negative regulation of fatty acid beta-oxidation  (IMP)
negative regulation of ion transport  (IDA)
negative regulation of mast cell activation  (IDA)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of serotonin secretion  (IMP)
positive regulation of acute inflammatory response to antigenic stimulus  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of fever generation  (IMP)
positive regulation of neuron projection development  (IDA)
regulation of feeding behavior  (IMP)
regulation of insulin secretion  (IMP)
regulation of lipid metabolic process  (IMP)
regulation of metabolic process  (IBA)
regulation of penile erection  (IMP)
regulation of synaptic transmission, GABAergic  (IMP)
regulation of synaptic transmission, glutamatergic  (IMP)
response to cocaine  (IMP)
response to ethanol  (IMP)
response to lipopolysaccharide  (IMP)
response to morphine  (IMP)
response to nicotine  (IMP)
response to nutrient  (IEP)
retrograde trans-synaptic signaling by endocannabinoid  (ISO)
sensory perception of pain  (IMP)
spermatogenesis  (IEP)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Baek J, etal., Neurosci Lett. 2009 Oct 16;464(1):71-3. Epub 2009 Aug 8.
2. Biala G, etal., Behav Brain Res. 2009 Sep 14;202(2):260-5. Epub 2009 Apr 8.
3. Bujalska M Pharmacology. 2008;82(3):193-200. Epub 2008 Sep 23.
4. Cabral GA, etal., Adv Exp Med Biol 2001;493:207-14.
5. Cacciola G, etal., Biol Reprod. 2008 Oct;79(4):758-65. Epub 2008 Jul 9.
6. Caraceni P, etal., Gut. 2009 Aug;58(8):1135-43. Epub 2009 Mar 11.
7. Carriba P, etal., Neuropsychopharmacology. 2007 Nov;32(11):2249-59. Epub 2007 Mar 14.
8. Cella M, etal., Placenta. 2008 Aug;29(8):699-707. Epub 2008 Jun 18.
9. Clayton N, etal., Pain 2002 Apr;96(3):253-60.
10. Comings DE, etal., Mol Psychiatry 1997 Mar;2(2):161-8.
11. Cota D, etal., Obesity (Silver Spring). 2009 Aug;17(8):1641-5. Epub 2009 Mar 26.
12. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
13. De Filippis D, etal., Br J Pharmacol. 2008 Aug;154(8):1672-9. Epub 2008 Jun 16.
14. De March Z, etal., Neuroscience. 2008 Mar 27;152(3):734-40. doi: 10.1016/j.neuroscience.2007.11.044. Epub 2007 Dec 8.
15. Deshpande LS, etal., Neurosci Lett. 2007 Jan 3;411(1):11-6. Epub 2006 Nov 15.
16. Diaz-Asensio C, etal., Horm Metab Res. 2008 Jul;40(7):454-8. Epub 2008 Mar 27.
17. Domenicali M, etal., Gastroenterology. 2009 Jul;137(1):341-9. Epub 2009 Jan 14.
18. Esposito G, etal., J Biol Chem 2002 Dec 27;277(52):50348-54.
19. Falenski KW, etal., Brain Res. 2009 Mar 25;1262:64-72. Epub 2009 Jan 31.
20. Femenia T, etal., Alcohol Clin Exp Res. 2009 Oct 23.
21. Flamment M, etal., Am J Physiol Endocrinol Metab. 2009 Sep 1.
22. Fonseca BM, etal., Placenta. 2009 Aug;30(8):686-92. Epub 2009 Jun 27.
23. Fonseca BM, etal., Reprod Biol Endocrinol. 2009 Oct 27;7:121.
24. Fraga D, etal., Br J Pharmacol. 2009 Aug;157(8):1494-501.
25. Garcia-Ovejero D, etal., Neurobiol Dis. 2009 Jan;33(1):57-71. Epub 2008 Sep 30.
26. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Getty-Kaushik L, etal., Obesity (Silver Spring). 2009 Oct;17(10):1856-60. Epub 2009 Jul 30.
28. Ghasemi M, etal., BJU Int. 2007 Dec;100(6):1385-90. Epub 2007 Sep 10.
29. GOA data from the GO Consortium
30. Haghparast A, etal., Neurosci Lett. 2009 Dec 18;467(1):43-7. Epub 2009 Oct 3.
31. Hama AT and Sagen J, Neuropharmacology. 2009 Dec 24.
32. Ho WS and Gardiner SM, Br J Pharmacol. 2009 Jan;156(1):94-104.
33. Hou LC, etal., Chin Med J (Engl). 2009 Apr 20;122(8):950-4.
34. Judge MK, etal., J Endocrinol. 2009 Nov;203(2):281-90. Epub 2009 Aug 13.
35. Kelsey JE, etal., Behav Brain Res. 2009 Nov 5;203(2):304-7. Epub 2009 May 3.
36. Lasukova OV, etal., Izv Akad Nauk Ser Biol. 2008 Jul-Aug;(4):471-8.
37. Leroy S, etal., Am J Med Genet 2001 Dec 8;105(8):749-52.
38. Mahmud A, etal., Neuroscience. 2009 Sep 15;162(4):1202-11. Epub 2009 May 20.
39. Matsuda LA, etal., Nature 1990 Aug 9;346(6284):561-4.
40. MGD data from the GO Consortium
41. Mingorance C, etal., Obesity (Silver Spring). 2009 Jul;17(7):1340-7. Epub 2009 Feb 19.
42. Morera-Herreras T, etal., Synapse. 2010 Jan;64(1):20-9.
43. Muller TD, etal., Mol Genet Metab. 2007 Apr;90(4):429-34. Epub 2007 Feb 8.
44. NCBI rat LocusLink and RefSeq merged data July 26, 2002
45. Niehaus JL, etal., Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.
46. O'Neill C, etal., J Neurochem. 2009 Feb;108(3):545-51.
47. Oddi S, etal., Br J Pharmacol. 2012 Apr;165(8):2635-51. doi: 10.1111/j.1476-5381.2011.01658.x.
48. Osborne KD, etal., ASN Neuro. 2009 Nov 11.
49. Pernia-Andrade AJ, etal., Science. 2009 Aug 7;325(5941):760-4.
50. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. Price TJ, etal., Neuroscience 2003;120(1):155-62.
52. Rasmussen BA, etal., Brain Res. 2009 Jan 17.
53. Reich CG, etal., Behav Brain Res. 2009 Nov 5;203(2):264-9. Epub 2009 May 19.
54. RGD automated data pipeline
55. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. RGD automated import pipeline for gene-chemical interactions
57. Rizzo V, etal., Neurosci Lett. 2009 Sep 22;462(2):135-9. Epub 2009 Jul 10.
58. Rosenstock J, etal., Diabetes Care. 2008 Nov;31(11):2169-76. Epub 2008 Aug 4.
59. Russo P, etal., J Clin Endocrinol Metab. 2007 Jun;92(6):2382-6. Epub 2007 Apr 3.
60. Rutkowska M and Fereniec-Golebiewska L, Pharmazie. 2009 Sep;64(9):595-7.
61. Schmidt LG, etal., Drug Alcohol Depend. 2002 Feb 1;65(3):221-4.
62. Shim JY, etal., J Med Chem 2002 Mar 28;45(7):1447-59.
63. Spano MS, etal., Eur Neuropsychopharmacol. 2009 Oct 22.
64. Tan H, etal., Cereb Cortex. 2009 Oct 30.
65. Timofeeva E, etal., J Neuroendocrinol. 2009 Oct 6.
66. Torres E, etal., J Neurochem. 2010 Jan 12.
67. Ujike H and Morita Y, J Pharmacol Sci. 2004 Dec;96(4):376-81.
68. Villanueva A, etal., Shock. 2009 Dec;32(6):614-20.
69. Wang Q, etal., Stroke. 2009 Jun;40(6):2157-64. Epub 2009 Apr 16.
70. Ward SJ, etal., Psychopharmacology (Berl). 2009 Sep;206(1):155-65. Epub 2009 Jul 3.
71. Wilson RI and Nicoll RA, Nature 2001 Mar 29;410(6828):588-92.
72. Wu CH, etal., J Med Chem. 2009 Jul 23;52(14):4496-510.
73. Zorina Y, etal., J Biol Chem. 2009 Oct 27.
Additional References at PubMed
PMID:7876112   PMID:8832654   PMID:11214319   PMID:11516401   PMID:11934799   PMID:12060783   PMID:12153749   PMID:12161251   PMID:12376184   PMID:12578907   PMID:12605905   PMID:12767117  
PMID:12895525   PMID:14499445   PMID:14614090   PMID:14648680   PMID:15033920   PMID:15193752   PMID:15229243   PMID:15450942   PMID:15451779   PMID:15604130   PMID:15657045   PMID:15686100  
PMID:15728830   PMID:15978014   PMID:16033894   PMID:16175569   PMID:16341592   PMID:16365309   PMID:16408587   PMID:16540577   PMID:16684876   PMID:16844297   PMID:16935424   PMID:17093402  
PMID:17113043   PMID:17182888   PMID:17222407   PMID:17286592   PMID:17320842   PMID:17355876   PMID:17415434   PMID:17419755   PMID:17442049   PMID:17494712   PMID:17507169   PMID:17545311  
PMID:17557913   PMID:17585904   PMID:17595216   PMID:17639288   PMID:17762511   PMID:17900568   PMID:17931662   PMID:17953657   PMID:17959701   PMID:17970731   PMID:18052990   PMID:18059440  
PMID:18063665   PMID:18222041   PMID:18336811   PMID:18342551   PMID:18400407   PMID:18407377   PMID:18469844   PMID:18469848   PMID:18472225   PMID:18487186   PMID:18554293   PMID:18554811  
PMID:18563836   PMID:18599027   PMID:18761332   PMID:18936914   PMID:18974922   PMID:19110037   PMID:19115376   PMID:19116182   PMID:19346272   PMID:19426726   PMID:19596404   PMID:19782066  
PMID:19819240   PMID:19945395   PMID:19961906   PMID:20026090   PMID:20074214   PMID:20081234   PMID:20097273   PMID:20211611   PMID:20378129   PMID:20430875   PMID:20451564   PMID:20512133  
PMID:20562021   PMID:20590567   PMID:20621146   PMID:20665820   PMID:20687106   PMID:20718743   PMID:20850463   PMID:20955176   PMID:20962221   PMID:20974221   PMID:21030483   PMID:21062287  
PMID:21123660   PMID:21173082   PMID:21183751   PMID:21251919   PMID:21414102   PMID:21439272   PMID:21452196   PMID:21486787   PMID:21514666   PMID:21646412   PMID:21693703   PMID:21733658  
PMID:21773721   PMID:21864979   PMID:21868092   PMID:22005165   PMID:22079489   PMID:22172925   PMID:22204950   PMID:22211674   PMID:22230885   PMID:22331883   PMID:22366450   PMID:22489809  
PMID:22504215   PMID:22508047   PMID:22521830   PMID:22532560   PMID:22656960   PMID:22683515   PMID:22715379   PMID:22722024   PMID:22787147   PMID:22791629   PMID:22798198   PMID:22872212  
PMID:22877648   PMID:22889888   PMID:22940464   PMID:23081739   PMID:23152849   PMID:23192660   PMID:23200786   PMID:23219970   PMID:23286559   PMID:23333674   PMID:23371449   PMID:23417606  
PMID:23454443   PMID:23620336   PMID:23636507   PMID:23738526   PMID:23902406   PMID:23902479   PMID:23911834   PMID:23937487   PMID:23943518   PMID:23954414   PMID:24005231   PMID:24041123  
PMID:24055403   PMID:24116178   PMID:24132958   PMID:24145047   PMID:24329778   PMID:24533119   PMID:24607231   PMID:24632810   PMID:24718372   PMID:24722948   PMID:24903921   PMID:24944910  
PMID:24945775   PMID:24949658   PMID:25031702   PMID:25081814   PMID:25273281   PMID:25296982   PMID:25422468   PMID:25446454   PMID:25474224   PMID:25510402   PMID:25533906   PMID:25595485  
PMID:25667928   PMID:25684344   PMID:25843413   PMID:25894754   PMID:26092203   PMID:26096126   PMID:26115586   PMID:26311003   PMID:26340366   PMID:26354043   PMID:26468198   PMID:26468265  
PMID:26470810   PMID:26475620   PMID:26478461   PMID:26497248   PMID:26572648   PMID:26681496   PMID:26724373   PMID:26778127   PMID:26880264   PMID:26969765   PMID:27062913   PMID:27157075  
PMID:27230434   PMID:27282634   PMID:27285468   PMID:27450568   PMID:27493155   PMID:27581068   PMID:27659492   PMID:27737762   PMID:27764673   PMID:27810514   PMID:27826249   PMID:27828947  
PMID:27935269   PMID:27984180   PMID:28082458   PMID:28108228   PMID:28356298   PMID:28431968   PMID:28492416   PMID:28593436   PMID:28599244   PMID:28665507   PMID:28734930   PMID:28837063  
PMID:28843453   PMID:28887229   PMID:29045576   PMID:29102876   PMID:29197803   PMID:29705007   PMID:29964164   PMID:30002493   PMID:31008528   PMID:31468622   PMID:31568767   PMID:31622603  
PMID:31697924   PMID:31919563   PMID:32259882   PMID:32857187   PMID:32976819   PMID:33401515   PMID:33809047  


Genomics

Comparative Map Data
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBI
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl688,139,864 - 88,166,359 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBI
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)Ensembl
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIGRCm37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBImm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1689,289,102 - 89,315,174 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0panPan3
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBI
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBI
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBI
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBI
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBI
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBI
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,466,027 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBI
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)Ensembl
Cnr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBI

Position Markers
PMC166293P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,770 - 48,430,236 (+)MAPPER
Rnor_6.0549,328,781 - 49,329,246NCBIRnor6.0
Rnor_5.0553,899,733 - 53,900,198UniSTSRnor5.0
RGSC_v3.4550,445,069 - 50,445,534UniSTSRGSC3.4
Celera547,186,449 - 47,186,914UniSTS
Cytogenetic Map5q21UniSTS
BE120265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,431,724 - 48,431,883 (+)MAPPER
Rnor_6.0549,330,735 - 49,330,893NCBIRnor6.0
Rnor_5.0553,901,687 - 53,901,845UniSTSRnor5.0
RGSC_v3.4550,447,023 - 50,447,181UniSTSRGSC3.4
Celera547,188,403 - 47,188,561UniSTS
RH 3.4 Map5263.2UniSTS
Cytogenetic Map5q21UniSTS
BE121087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,411,816 - 48,411,981 (+)MAPPER
Rnor_6.0549,310,827 - 49,310,991NCBIRnor6.0
Rnor_5.0553,881,779 - 53,881,943UniSTSRnor5.0
RGSC_v3.4550,426,970 - 50,427,134UniSTSRGSC3.4
Celera547,168,506 - 47,168,670UniSTS
RH 3.4 Map5264.1UniSTS
Cytogenetic Map5q21UniSTS
PMC123076P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,405 - 48,429,862 (+)MAPPER
Rnor_6.0549,328,416 - 49,328,872NCBIRnor6.0
Rnor_5.0553,899,368 - 53,899,824UniSTSRnor5.0
RGSC_v3.4550,444,704 - 50,445,160UniSTSRGSC3.4
Celera547,186,084 - 47,186,540UniSTS
Cytogenetic Map5q21UniSTS
Cnr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,933 - 48,430,116 (+)MAPPER
Rnor_6.0549,328,944 - 49,329,126NCBIRnor6.0
Rnor_5.0553,899,896 - 53,900,078UniSTSRnor5.0
RGSC_v3.4550,445,232 - 50,445,414UniSTSRGSC3.4
Celera547,186,612 - 47,186,794UniSTS
Cytogenetic Map5q21UniSTS
UniSTS:482606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,428,733 - 48,430,155 (+)MAPPER
Rnor_6.0549,327,744 - 49,329,165NCBIRnor6.0
Rnor_5.0553,898,696 - 53,900,117UniSTSRnor5.0
RGSC_v3.4550,444,032 - 50,445,453UniSTSRGSC3.4
Celera547,185,412 - 47,186,833UniSTS
Cytogenetic Map5q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5863228553632285Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51328888858288888Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51884791363847913Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52190436366904363Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52907889974078899Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52907889974078899Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52964166174641661Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52964166174641661Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53440240979402409Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53440240979402409Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53440240979402409Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53578875670742105Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54440427689432042Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54872203893587756Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1184
Count of miRNA genes:343
Interacting mature miRNAs:502
Transcripts:ENSRNOT00000010850
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 68 1 5 2
Low 3 4 2 12 2 2 2 6 34 31 9 2
Below cutoff 41 29 23 7 23 6 8 5 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010850   ⟹   ENSRNOP00000010850
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)Ensembl
RefSeq Acc Id: NM_012784   ⟹   NP_036916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,412,020 - 48,434,054 (+)NCBI
Rnor_6.0549,311,030 - 49,333,056 (+)NCBI
Rnor_5.0553,878,619 - 53,904,013 (+)NCBI
RGSC_v3.4550,427,173 - 50,445,471 (+)RGD
Celera547,168,709 - 47,190,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237984   ⟹   XP_006238046
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,410,417 - 48,434,054 (+)NCBI
Rnor_6.0549,309,049 - 49,333,064 (+)NCBI
Rnor_5.0553,878,619 - 53,904,013 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593151   ⟹   XP_017448640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,408,543 - 48,436,099 (+)NCBI
Rnor_6.0549,307,584 - 49,333,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109284   ⟹   XP_038965212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,408,853 - 48,436,099 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036916   ⟸   NM_012784
- UniProtKB: P20272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006238046   ⟸   XM_006237984
- Peptide Label: isoform X1
- UniProtKB: P20272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017448640   ⟸   XM_017593151
- Peptide Label: isoform X1
- UniProtKB: P20272 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010850   ⟸   ENSRNOT00000010850
RefSeq Acc Id: XP_038965212   ⟸   XM_039109284
- Peptide Label: isoform X1
Protein Domains
Cadherin   G_PROTEIN_RECEP_F1_2

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2369 AgrOrtholog
Ensembl Genes ENSRNOG00000008223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010850 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010850 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CBD UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Canbinoid_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25248 UniProtKB/Swiss-Prot
NCBI Gene 25248 ENTREZGENE
PANTHER PTHR22750:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin UniProtKB/TrEMBL
  Cadherin_tail UniProtKB/TrEMBL
PhenoGen Cnr1 PhenoGen
PIRSF Cnoid_rcpt_1 UniProtKB/Swiss-Prot
PRINTS CADHERIN UniProtKB/TrEMBL
  CANABINOID1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP SSF49313 UniProtKB/TrEMBL
UniProt CNR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q924V0_RAT UniProtKB/TrEMBL
  Q99NU2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-06 Cnr1  cannabinoid receptor 1  Cnr1  cannabinoid receptor 1 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-24 Cnr1  cannabinoid receptor 1 (brain)  Cnr1  cannabinoid receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-01 Cnr1  cannabinoid receptor 1  Cnr1  cannabinoid receptor 1 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cnr1  cannabinoid receptor 1 (brain)    cannabinoid receptor 1  Name updated 1299863 APPROVED
2002-06-10 Cnr1  Cannabinoid receptor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization expression is clustered at axon terminals on GABA-mediated inhibitory interneurons 1298773
gene_expression expressed on GABA (gamma-aminobutyric acid)-mediated inhibitory interneurons 1298773
gene_expression expressed in brain and neural cell lines 1298770
gene_function G-protein coupled receptor that inhibits adenylate cyclase activity (stereoselective and pertussis-toxin sensitive) 1298770
gene_process may participate in retrograde signaling by endocannabinoids 1298773
gene_process may mediate inhibition of nitric oxide synthesis upon treatment of microglial cells with cannabinoids 1298772
gene_process receptor for psychoactive cannabinoids likely involved in cannabinoid-induced effects on the central nervous system 1298770