Cnr1 (cannabinoid receptor 1) - Rat Genome Database

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Gene: Cnr1 (cannabinoid receptor 1) Rattus norvegicus
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Symbol: Cnr1
Name: cannabinoid receptor 1
RGD ID: 2369
Description: Enables cannabinoid receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of acute inflammatory response; and regulation of secretion by cell. Located in membrane raft and plasma membrane. Used to study several diseases, including Parkinsonism; diabetic neuropathy; impotence; obesity; and peptic ulcer disease. Biomarker of obesity and status epilepticus. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (cannabinoid receptor 1); PARTICIPATES IN N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain-type cannabinoid receptor; Cannabinoid CB1 receptor; Cannabinoid CB1 receptor ; cannabinoid receptor 1 (brain); CB-R; CB1; CB1R; SKR6R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx550,575,033 - 50,597,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0552,174,251 - 52,196,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0552,110,881 - 52,132,920 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol use disorder  (IEP)
Alcohol Withdrawal Delirium  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
Ascites  (IMP)
attention deficit hyperactivity disorder  (ISO)
Binge-Eating Disorder  (ISO)
cannabis abuse  (ISO)
Catalepsy  (ISO)
cholestasis  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
developmental coordination disorder  (ISO)
diabetic neuropathy  (IDA)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Liver Cirrhosis  (ISO)
Fever  (IMP)
focal epilepsy  (IMP)
genetic disease  (ISO)
glucose intolerance  (ISO)
Hemorrhagic Shock  (IMP)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (IMP)
Hypotension  (IMP,ISO)
Hypothermia  (ISO)
impotence  (IMP)
Insulin Resistance  (IMP)
Intravenous Substance Abuse  (ISO)
liver cirrhosis  (ISO)
Memory Disorders  (ISO)
morphine dependence  (ISO)
movement disease  (ISO)
multiple sclerosis  (ISO)
Muscle Spasticity  (ISO)
Myocardial Reperfusion Injury  (IMP)
Nerve Degeneration  (IEP,ISO)
obesity  (IEP,IMP,ISO)
Pain  (IMP,ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
Parkinsonism  (IMP)
peptic ulcer disease  (IDA)
post-traumatic stress disorder  (ISO)
Reperfusion Injury  (IMP)
rhabdomyosarcoma  (ISO)
schizophrenia  (IDA,ISO)
Spinal Cord Injuries  (IEP)
status epilepticus  (IEP,ISO)
stress-related disorder  (IEP)
substance-related disorder  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
type 2 diabetes mellitus  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-arachidonoylglycerol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
Adb-fubinaca  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
AM-251  (EXP,ISO)
ammonium chloride  (EXP)
amphetamines  (ISO)
anandamide  (EXP,ISO)
arachidonyl-2'-chloroethylamide  (EXP,ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Bromazepam  (ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (EXP,ISO)
Cannabinol  (EXP)
capsaicin  (EXP,ISO)
carbazoles  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
choline  (ISO)
cisplatin  (ISO)
citalopram  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP,ISO)
cycloheximide  (ISO)
Cyclopamine  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
Delta(9)-tetrahydrocannabinolic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazepam  (ISO)
diazoxon  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichlorvos  (ISO)
dioxygen  (ISO)
diprotium oxide  (EXP)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fructose  (EXP)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
ghrelin  (EXP)
glucose  (EXP)
guanosine 5'-[gamma-thio]triphosphate  (ISO)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP)
imipramine  (EXP)
indazoles  (ISO)
indoles  (ISO)
indometacin  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP)
Methanandamide  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
morphine  (EXP,ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-oleoyldopamine  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
oxidopamine  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
palmitoyl ethanolamide  (EXP)
paracetamol  (EXP)
paraoxon  (ISO)
paraquat  (EXP)
parecoxib  (ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
phencyclidine  (ISO)
Phenol, 5-(1,1-dimethylheptyl)-2-[(1r,3s)-3-hydroxycyclohexyl]-  (ISO)
phenylmercury acetate  (ISO)
piperidines  (ISO)
poly(I:C)  (EXP)
potassium atom  (EXP)
potassium chloride  (EXP)
pregabalin  (ISO)
pregnenolone  (ISO)
progesterone  (ISO)
pyrazoles  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quetiapine fumarate  (ISO)
reserpine  (EXP)
ricinoleic acid  (ISO)
rimonabant  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP)
SR 144528  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
topiramate  (ISO)
tribufos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
water  (EXP)
WIN 55212-2  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO,ISS)
axonal fasciculation  (ISO)
cannabinoid signaling pathway  (IDA,ISO)
G protein-coupled receptor signaling pathway  (IMP)
glucose homeostasis  (ISO)
learning or memory  (IMP)
maternal process involved in female pregnancy  (IEP)
memory  (IDA)
negative regulation of action potential  (IMP)
negative regulation of blood pressure  (IMP)
negative regulation of dopamine secretion  (IMP)
negative regulation of fatty acid beta-oxidation  (IMP)
negative regulation of mast cell activation  (IDA)
negative regulation of monoatomic ion transport  (IDA)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of serotonin secretion  (IMP)
positive regulation of acute inflammatory response to antigenic stimulus  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of fever generation  (IMP)
positive regulation of neuron projection development  (IDA)
regulation of feeding behavior  (IMP)
regulation of insulin secretion  (IMP)
regulation of lipid metabolic process  (IMP)
regulation of metabolic process  (IBA)
regulation of penile erection  (IMP)
regulation of presynaptic cytosolic calcium ion concentration  (ISO)
regulation of synaptic transmission, GABAergic  (IMP)
regulation of synaptic transmission, glutamatergic  (IMP)
response to cocaine  (IMP)
response to ethanol  (IMP)
response to lipopolysaccharide  (IMP)
response to nicotine  (IMP)
response to nutrient  (IEP)
retrograde trans-synaptic signaling by endocannabinoid  (ISO)
spermatogenesis  (IEP)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Baek J, etal., Neurosci Lett. 2009 Oct 16;464(1):71-3. Epub 2009 Aug 8.
2. Effects of rimonabant on the reinstatement of nicotine-conditioned place preference by drug priming in rats. Biala G, etal., Behav Brain Res. 2009 Sep 14;202(2):260-5. Epub 2009 Apr 8.
3. Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy. Bujalska M Pharmacology. 2008;82(3):193-200. Epub 2008 Sep 23.
4. Cannabinoid-mediated inhibition of inducible nitric oxide production by rat microglial cells: evidence for CB1 receptor participation. Cabral GA, etal., Adv Exp Med Biol 2001;493:207-14.
5. Expression of type-1 cannabinoid receptor during rat postnatal testicular development: possible involvement in adult leydig cell differentiation. Cacciola G, etal., Biol Reprod. 2008 Oct;79(4):758-65. Epub 2008 Jul 9.
6. Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia. Caraceni P, etal., Gut. 2009 Aug;58(8):1135-43. Epub 2009 Mar 11.
7. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Carriba P, etal., Neuropsychopharmacology. 2007 Nov;32(11):2249-59. Epub 2007 Mar 14.
8. Dual effect of anandamide on rat placenta nitric oxide synthesis. Cella M, etal., Placenta. 2008 Aug;29(8):699-707. Epub 2008 Jun 18.
9. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Clayton N, etal., Pain 2002 Apr;96(3):253-60.
10. Cannabinoid receptor gene (CNR1): association with i.v. drug use. Comings DE, etal., Mol Psychiatry 1997 Mar;2(2):161-8.
11. Food intake-independent effects of CB1 antagonism on glucose and lipid metabolism. Cota D, etal., Obesity (Silver Spring). 2009 Aug;17(8):1641-5. Epub 2009 Mar 26.
12. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
13. Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. De Filippis D, etal., Br J Pharmacol. 2008 Aug;154(8):1672-9. Epub 2008 Jun 16.
14. Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions. De March Z, etal., Neuroscience. 2008 Mar 27;152(3):734-40. doi: 10.1016/j.neuroscience.2007.11.044. Epub 2007 Dec 8.
15. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Deshpande LS, etal., Neurosci Lett. 2007 Jan 3;411(1):11-6. Epub 2006 Nov 15.
16. Type 1 diabetes alters brain cannabinoid receptor expression and phosphorylation status in rats. Diaz-Asensio C, etal., Horm Metab Res. 2008 Jul;40(7):454-8. Epub 2008 Mar 27.
17. Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis. Domenicali M, etal., Gastroenterology. 2009 Jul;137(1):341-9. Epub 2009 Jan 14.
18. The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation. Esposito G, etal., J Biol Chem 2002 Dec 27;277(52):50348-54.
19. Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Falenski KW, etal., Brain Res. 2009 Mar 25;1262:64-72. Epub 2009 Jan 31.
20. CB1 Receptor Blockade Decreases Ethanol Intake and Associated Neurochemical Changes in Fawn-Hooded Rats. Femenia T, etal., Alcohol Clin Exp Res. 2009 Oct 23.
21. Effects of the cannabinoid CB1 antagonist, rimonabant, on hepatic mitochondrial function in rats fed a high fat diet. Flamment M, etal., Am J Physiol Endocrinol Metab. 2009 Sep 1.
22. Anandamide-induced cell death: dual effects in primary rat decidual cell cultures. Fonseca BM, etal., Placenta. 2009 Aug;30(8):686-92. Epub 2009 Jun 27.
23. Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. Fonseca BM, etal., Reprod Biol Endocrinol. 2009 Oct 27;7:121.
24. Endogenous cannabinoids induce fever through the activation of CB1 receptors. Fraga D, etal., Br J Pharmacol. 2009 Aug;157(8):1494-501.
25. The endocannabinoid system is modulated in response to spinal cord injury in rats. Garcia-Ovejero D, etal., Neurobiol Dis. 2009 Jan;33(1):57-71. Epub 2008 Sep 30.
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Getty-Kaushik L, etal., Obesity (Silver Spring). 2009 Oct;17(10):1856-60. Epub 2009 Jul 30.
28. Anandamide improves the impaired nitric oxide-mediated neurogenic relaxation of the corpus cavernosum in diabetic rats: involvement of cannabinoid CB1 and vanilloid VR1 receptors. Ghasemi M, etal., BJU Int. 2007 Dec;100(6):1385-90. Epub 2007 Sep 10.
29. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
30. Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat. Haghparast A, etal., Neurosci Lett. 2009 Dec 18;467(1):43-7. Epub 2009 Oct 3.
31. Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain. Hama AT and Sagen J, Neuropharmacology. 2009 Dec 24.
32. Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats. Ho WS and Gardiner SM, Br J Pharmacol. 2009 Jan;156(1):94-104.
33. CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats. Hou LC, etal., Chin Med J (Engl). 2009 Apr 20;122(8):950-4.
34. Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding. Judge MK, etal., J Endocrinol. 2009 Nov;203(2):281-90. Epub 2009 Aug 13.
35. The CB(1) antagonist rimonabant is adjunctively therapeutic as well as monotherapeutic in an animal model of Parkinson's disease. Kelsey JE, etal., Behav Brain Res. 2009 Nov 5;203(2):304-7. Epub 2009 May 3.
36. Izvestiia Akademii nauk. Seriia biologicheskaia / Rossiiskaia akademiia nauk Lasukova OV, etal., Izv Akad Nauk Ser Biol. 2008 Jul-Aug;(4):471-8.
37. Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Leroy S, etal., Am J Med Genet 2001 Dec 8;105(8):749-52.
38. Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. Mahmud A, etal., Neuroscience. 2009 Sep 15;162(4):1202-11. Epub 2009 May 20.
39. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Marco EM, etal., Pharmacol Biochem Behav. 2017 Jan;152:68-80. doi: 10.1016/j.pbb.2016.11.005. Epub 2016 Nov 25.
40. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Matsuda LA, etal., Nature 1990 Aug 9;346(6284):561-4.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats. Mingorance C, etal., Obesity (Silver Spring). 2009 Jul;17(7):1340-7. Epub 2009 Feb 19.
43. Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission. Morera-Herreras T, etal., Synapse. 2010 Jan;64(1):20-9.
44. No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. Muller TD, etal., Mol Genet Metab. 2007 Apr;90(4):429-34. Epub 2007 Feb 8.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Niehaus JL, etal., Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.
47. D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry. O'Neill C, etal., J Neurochem. 2009 Feb;108(3):545-51.
48. Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. Oddi S, etal., Br J Pharmacol. 2012 Apr;165(8):2635-51. doi: 10.1111/j.1476-5381.2011.01658.x.
49. Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. Osborne KD, etal., ASN Neuro. 2009 Nov 11.
50. Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Pernia-Andrade AJ, etal., Science. 2009 Aug 7;325(5941):760-4.
51. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
52. The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat. Price TJ, etal., Neuroscience 2003;120(1):155-62.
53. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity. Pucci M, etal., Front Genet. 2019 Jun 14;10:523. doi: 10.3389/fgene.2019.00523. eCollection 2019.
54. Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB(1)-dopamine D(2) receptor mechanism. Rasmussen BA, etal., Brain Res. 2009 Jan 17.
55. Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats. Reich CG, etal., Behav Brain Res. 2009 Nov 5;203(2):264-9. Epub 2009 May 19.
56. GOA pipeline RGD automated data pipeline
57. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
59. Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat. Rizzo V, etal., Neurosci Lett. 2009 Sep 22;462(2):135-9. Epub 2009 Jul 10.
60. SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes. Rosenstock J, etal., Diabetes Care. 2008 Nov;31(11):2169-76. Epub 2008 Aug 4.
61. Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men. Russo P, etal., J Clin Endocrinol Metab. 2007 Jun;92(6):2382-6. Epub 2007 Apr 3.
62. Involvement of nitric oxide in the gastroprotective effect of ACEA, a selective cannabinoid CB1 receptor agonist, on aspirin-induced gastric ulceration. Rutkowska M and Fereniec-Golebiewska L, Pharmazie. 2009 Sep;64(9):595-7.
63. Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence. Schmidt LG, etal., Drug Alcohol Depend. 2002 Feb 1;65(3):221-4.
64. Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. Shim JY, etal., J Med Chem 2002 Mar 28;45(7):1447-59.
65. Cannabinoid self-administration attenuates PCP-induced schizophrenia-like symptoms in adult rats. Spano MS, etal., Eur Neuropsychopharmacol. 2009 Oct 22.
66. Integrated Cannabinoid CB1 Receptor Transmission within the Amygdala-Prefrontal Cortical Pathway Modulates Neuronal Plasticity and Emotional Memory Encoding. Tan H, etal., Cereb Cortex. 2009 Oct 30.
67. PALATABLE HIGH-ENERGY DIET DECREASES THE EXPRESSION OF CANNABINOID TYPE 1 RECEPTOR (CB1R) MRNA IN SPECIFIC BRAIN REGIONS IN RAT. Timofeeva E, etal., J Neuroendocrinol. 2009 Oct 6.
68. Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. Torres E, etal., J Neurochem. 2010 Jan 12.
69. New perspectives in the studies on endocannabinoid and cannabis: cannabinoid receptors and schizophrenia. Ujike H and Morita Y, J Pharmacol Sci. 2004 Dec;96(4):376-81.
70. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Villanueva A, etal., Shock. 2009 Dec;32(6):614-20.
71. Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system. Wang Q, etal., Stroke. 2009 Jun;40(6):2157-64. Epub 2009 Apr 16.
72. Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on food intake, body weight change, and pruritus in rats. Ward SJ, etal., Psychopharmacology (Berl). 2009 Sep;206(1):155-65. Epub 2009 Jul 3.
73. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Wilson RI and Nicoll RA, Nature 2001 Mar 29;410(6828):588-92.
74. Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1, 5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice. Wu CH, etal., J Med Chem. 2009 Jul 23;52(14):4496-510.
75. Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus. Zhang J, etal., Neurosci Lett. 2016 Sep 6;630:70-76. doi: 10.1016/j.neulet.2016.07.047. Epub 2016 Jul 25.
76. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. Zorina Y, etal., J Biol Chem. 2009 Oct 27.
Additional References at PubMed
PMID:7876112   PMID:8832654   PMID:11214319   PMID:11516401   PMID:11934799   PMID:12060783   PMID:12153749   PMID:12161251   PMID:12376184   PMID:12578907   PMID:12605905   PMID:12767117  
PMID:12895525   PMID:14499445   PMID:14614090   PMID:14648680   PMID:15033920   PMID:15193752   PMID:15229243   PMID:15450942   PMID:15451779   PMID:15604130   PMID:15657045   PMID:15686100  
PMID:15728830   PMID:15978014   PMID:16033894   PMID:16175569   PMID:16341592   PMID:16365309   PMID:16408587   PMID:16540577   PMID:16684876   PMID:16844297   PMID:16935424   PMID:17093402  
PMID:17113043   PMID:17182888   PMID:17222407   PMID:17286592   PMID:17320842   PMID:17355876   PMID:17415434   PMID:17419755   PMID:17442049   PMID:17494712   PMID:17507169   PMID:17545311  
PMID:17557913   PMID:17585904   PMID:17595216   PMID:17639288   PMID:17762511   PMID:17900568   PMID:17931662   PMID:17953657   PMID:17959701   PMID:17970731   PMID:18052990   PMID:18059440  
PMID:18063665   PMID:18222041   PMID:18336811   PMID:18342551   PMID:18400407   PMID:18407377   PMID:18469844   PMID:18469848   PMID:18472225   PMID:18487186   PMID:18554293   PMID:18554811  
PMID:18563836   PMID:18599027   PMID:18761332   PMID:18936914   PMID:18974922   PMID:19110037   PMID:19115376   PMID:19116182   PMID:19346272   PMID:19426726   PMID:19596404   PMID:19782066  
PMID:19819240   PMID:19945395   PMID:19961906   PMID:20026090   PMID:20074214   PMID:20081234   PMID:20097273   PMID:20211611   PMID:20378129   PMID:20430875   PMID:20451564   PMID:20512133  
PMID:20562021   PMID:20590567   PMID:20621146   PMID:20665820   PMID:20687106   PMID:20718743   PMID:20850463   PMID:20955176   PMID:20962221   PMID:20974221   PMID:21030483   PMID:21062287  
PMID:21123660   PMID:21173082   PMID:21183751   PMID:21251919   PMID:21414102   PMID:21439272   PMID:21452196   PMID:21486787   PMID:21514666   PMID:21646412   PMID:21693703   PMID:21733658  
PMID:21773721   PMID:21864979   PMID:21868092   PMID:22005165   PMID:22079489   PMID:22172925   PMID:22204950   PMID:22211674   PMID:22230885   PMID:22331883   PMID:22366450   PMID:22489809  
PMID:22504215   PMID:22508047   PMID:22521830   PMID:22532560   PMID:22656960   PMID:22683515   PMID:22715379   PMID:22722024   PMID:22787147   PMID:22791629   PMID:22798198   PMID:22872212  
PMID:22877648   PMID:22889888   PMID:22940464   PMID:23081739   PMID:23152849   PMID:23192660   PMID:23200786   PMID:23219970   PMID:23286559   PMID:23333674   PMID:23371449   PMID:23417606  
PMID:23454443   PMID:23620336   PMID:23636507   PMID:23738526   PMID:23902406   PMID:23902479   PMID:23911834   PMID:23937487   PMID:23943518   PMID:23954414   PMID:24005231   PMID:24041123  
PMID:24055403   PMID:24116178   PMID:24132958   PMID:24145047   PMID:24329778   PMID:24533119   PMID:24607231   PMID:24632810   PMID:24718372   PMID:24722948   PMID:24903921   PMID:24944910  
PMID:24945775   PMID:24949658   PMID:25031702   PMID:25081814   PMID:25273281   PMID:25296982   PMID:25422468   PMID:25446454   PMID:25474224   PMID:25510402   PMID:25533906   PMID:25595485  
PMID:25667928   PMID:25684344   PMID:25843413   PMID:25894754   PMID:26092203   PMID:26096126   PMID:26115586   PMID:26311003   PMID:26340366   PMID:26354043   PMID:26468198   PMID:26468265  
PMID:26470810   PMID:26475620   PMID:26478461   PMID:26497248   PMID:26572648   PMID:26681496   PMID:26724373   PMID:26778127   PMID:26880264   PMID:26969765   PMID:27062913   PMID:27157075  
PMID:27230434   PMID:27282634   PMID:27285468   PMID:27450568   PMID:27493155   PMID:27581068   PMID:27659492   PMID:27737762   PMID:27764673   PMID:27810514   PMID:27826249   PMID:27828947  
PMID:27935269   PMID:27984180   PMID:28082458   PMID:28108228   PMID:28356298   PMID:28431968   PMID:28492416   PMID:28593436   PMID:28599244   PMID:28665507   PMID:28734930   PMID:28837063  
PMID:28843453   PMID:28887229   PMID:29045576   PMID:29102876   PMID:29197803   PMID:29705007   PMID:29964164   PMID:30002493   PMID:31008528   PMID:31468622   PMID:31568767   PMID:31622603  
PMID:31625133   PMID:31637966   PMID:31697924   PMID:31711896   PMID:31898189   PMID:31919563   PMID:32259882   PMID:32320718   PMID:32428627   PMID:32483053   PMID:32510690   PMID:32857187  
PMID:32976819   PMID:33141426   PMID:33278598   PMID:33382401   PMID:33401515   PMID:33452429   PMID:33468648   PMID:33809047   PMID:34155271   PMID:34302891   PMID:34453219   PMID:35617998  
PMID:35864772   PMID:35908495   PMID:36270348   PMID:37085778  


Genomics

Comparative Map Data
Cnr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2548,408,543 - 48,436,099 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx550,575,033 - 50,597,155 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0552,174,251 - 52,196,375 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0552,110,881 - 52,132,920 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0549,307,584 - 49,333,064 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0553,878,619 - 53,904,013 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4550,427,173 - 50,445,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1550,427,351 - 50,445,650 (+)NCBI
Celera547,168,709 - 47,190,724 (+)NCBICelera
Cytogenetic Map5q21NCBI
CNR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38688,139,864 - 88,167,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl688,139,864 - 88,166,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37688,849,583 - 88,877,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36688,906,302 - 88,911,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 34688,906,301 - 88,911,775NCBI
Celera689,267,475 - 89,293,659 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef686,064,928 - 86,090,983 (-)NCBIHuRef
CHM1_1688,947,341 - 88,973,526 (-)NCBICHM1_1
T2T-CHM13v2.0689,348,358 - 89,375,841 (-)NCBIT2T-CHM13v2.0
Cnr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39433,923,171 - 33,948,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm39 Ensembl
GRCm38433,923,171 - 33,948,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl433,924,593 - 33,948,831 (+)EnsemblGRCm38mm10GRCm38
MGSCv37434,011,607 - 34,035,806 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36434,253,245 - 34,277,444 (+)NCBIMGSCv36mm8
Celera433,679,304 - 33,703,476 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map416.28NCBI
Cnr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541115,052,163 - 15,077,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541115,052,151 - 15,077,320 (-)NCBIChiLan1.0ChiLan1.0
CNR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16106,115,872 - 106,143,699 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0686,017,141 - 86,044,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1689,289,102 - 89,315,174 (-)NCBIpanpan1.1PanPan1.1panPan2
CNR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11247,537,240 - 47,560,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1247,509,583 - 47,560,983 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1247,344,588 - 47,368,064 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01248,342,012 - 48,365,459 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11247,639,694 - 47,663,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01247,561,070 - 47,584,546 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01247,752,753 - 47,776,234 (-)NCBIUU_Cfam_GSD_1.0
Cnr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494682,664,248 - 82,691,073 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365103,781,210 - 3,802,693 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365103,779,930 - 3,806,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl156,467,835 - 56,492,602 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1156,466,022 - 56,493,275 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,201,796 - 63,224,939 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CNR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11312,626,259 - 12,653,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1312,630,270 - 12,631,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040188,875,655 - 188,902,692 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247996,101,728 - 6,126,520 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247996,100,709 - 6,126,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnr1
81 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1184
Count of miRNA genes:343
Interacting mature miRNAs:502
Transcripts:ENSRNOT00000010850
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat

Markers in Region
PMC166293P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,770 - 48,430,236 (+)MAPPERmRatBN7.2
Rnor_6.0549,328,781 - 49,329,246NCBIRnor6.0
Rnor_5.0553,899,733 - 53,900,198UniSTSRnor5.0
RGSC_v3.4550,445,069 - 50,445,534UniSTSRGSC3.4
Celera547,186,449 - 47,186,914UniSTS
Cytogenetic Map5q21UniSTS
BE120265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,431,724 - 48,431,883 (+)MAPPERmRatBN7.2
Rnor_6.0549,330,735 - 49,330,893NCBIRnor6.0
Rnor_5.0553,901,687 - 53,901,845UniSTSRnor5.0
RGSC_v3.4550,447,023 - 50,447,181UniSTSRGSC3.4
Celera547,188,403 - 47,188,561UniSTS
RH 3.4 Map5263.2UniSTS
Cytogenetic Map5q21UniSTS
BE121087  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,411,816 - 48,411,981 (+)MAPPERmRatBN7.2
Rnor_6.0549,310,827 - 49,310,991NCBIRnor6.0
Rnor_5.0553,881,779 - 53,881,943UniSTSRnor5.0
RGSC_v3.4550,426,970 - 50,427,134UniSTSRGSC3.4
Celera547,168,506 - 47,168,670UniSTS
RH 3.4 Map5264.1UniSTS
Cytogenetic Map5q21UniSTS
PMC123076P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,405 - 48,429,862 (+)MAPPERmRatBN7.2
Rnor_6.0549,328,416 - 49,328,872NCBIRnor6.0
Rnor_5.0553,899,368 - 53,899,824UniSTSRnor5.0
RGSC_v3.4550,444,704 - 50,445,160UniSTSRGSC3.4
Celera547,186,084 - 47,186,540UniSTS
Cytogenetic Map5q21UniSTS
Cnr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,429,933 - 48,430,116 (+)MAPPERmRatBN7.2
Rnor_6.0549,328,944 - 49,329,126NCBIRnor6.0
Rnor_5.0553,899,896 - 53,900,078UniSTSRnor5.0
RGSC_v3.4550,445,232 - 50,445,414UniSTSRGSC3.4
Celera547,186,612 - 47,186,794UniSTS
Cytogenetic Map5q21UniSTS
UniSTS:482606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2548,428,733 - 48,430,155 (+)MAPPERmRatBN7.2
Rnor_6.0549,327,744 - 49,329,165NCBIRnor6.0
Rnor_5.0553,898,696 - 53,900,117UniSTSRnor5.0
RGSC_v3.4550,444,032 - 50,445,453UniSTSRGSC3.4
Celera547,185,412 - 47,186,833UniSTS
Cytogenetic Map5q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 68 1 5 2
Low 3 4 2 12 2 2 2 6 34 31 9 2
Below cutoff 41 29 23 7 23 6 8 5 6

Sequence


RefSeq Acc Id: ENSRNOT00000010850   ⟹   ENSRNOP00000010850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl548,409,488 - 48,435,099 (+)Ensembl
Rnor_6.0 Ensembl549,311,030 - 49,333,056 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099728   ⟹   ENSRNOP00000081243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl548,410,316 - 48,435,099 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101534   ⟹   ENSRNOP00000085179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl548,409,293 - 48,435,099 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117169   ⟹   ENSRNOP00000079932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl548,408,574 - 48,435,099 (+)Ensembl
RefSeq Acc Id: NM_012784   ⟹   NP_036916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,412,020 - 48,434,054 (+)NCBI
Rnor_6.0549,311,030 - 49,333,056 (+)NCBI
Rnor_5.0553,878,619 - 53,904,013 (+)NCBI
RGSC_v3.4550,427,173 - 50,445,471 (+)RGD
Celera547,168,709 - 47,190,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237984   ⟹   XP_006238046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,410,417 - 48,434,054 (+)NCBI
Rnor_6.0549,309,049 - 49,333,064 (+)NCBI
Rnor_5.0553,878,619 - 53,904,013 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593151   ⟹   XP_017448640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,408,543 - 48,436,099 (+)NCBI
Rnor_6.0549,307,584 - 49,333,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109284   ⟹   XP_038965212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2548,408,853 - 48,436,099 (+)NCBI
RefSeq Acc Id: NP_036916   ⟸   NM_012784
- UniProtKB: P20272 (UniProtKB/Swiss-Prot),   A6IIL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238046   ⟸   XM_006237984
- Peptide Label: isoform X1
- UniProtKB: P20272 (UniProtKB/Swiss-Prot),   A6IIL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448640   ⟸   XM_017593151
- Peptide Label: isoform X1
- UniProtKB: P20272 (UniProtKB/Swiss-Prot),   A6IIL9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010850   ⟸   ENSRNOT00000010850
RefSeq Acc Id: XP_038965212   ⟸   XM_039109284
- Peptide Label: isoform X1
- UniProtKB: P20272 (UniProtKB/Swiss-Prot),   A6IIL9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079932   ⟸   ENSRNOT00000117169
RefSeq Acc Id: ENSRNOP00000085179   ⟸   ENSRNOT00000101534
RefSeq Acc Id: ENSRNOP00000081243   ⟸   ENSRNOT00000099728
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20272-F1-model_v2 AlphaFold P20272 1-473 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2369 AgrOrtholog
BioCyc Gene G2FUF-41673 BioCyc
Ensembl Genes ENSRNOG00000008223 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055016812 UniProtKB/Swiss-Prot
  ENSRNOG00060013854 UniProtKB/Swiss-Prot
  ENSRNOG00065004895 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010850.3 UniProtKB/Swiss-Prot
  ENSRNOT00000099728 ENTREZGENE
  ENSRNOT00000099728.1 UniProtKB/Swiss-Prot
  ENSRNOT00000101534 ENTREZGENE
  ENSRNOT00000101534.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117169 ENTREZGENE
  ENSRNOT00000117169.1 UniProtKB/Swiss-Prot
  ENSRNOT00055028545 UniProtKB/Swiss-Prot
  ENSRNOT00055028548 UniProtKB/Swiss-Prot
  ENSRNOT00055028551 UniProtKB/Swiss-Prot
  ENSRNOT00055028555 UniProtKB/Swiss-Prot
  ENSRNOT00060023667 UniProtKB/Swiss-Prot
  ENSRNOT00060023669 UniProtKB/Swiss-Prot
  ENSRNOT00060023671 UniProtKB/Swiss-Prot
  ENSRNOT00060023677 UniProtKB/Swiss-Prot
  ENSRNOT00065007116 UniProtKB/Swiss-Prot
  ENSRNOT00065007118 UniProtKB/Swiss-Prot
  ENSRNOT00065007119 UniProtKB/Swiss-Prot
  ENSRNOT00065007121 UniProtKB/Swiss-Prot
Gene3D-CATH Cadherins UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cadherin-like_dom UniProtKB/TrEMBL
  Cadherin-like_sf UniProtKB/TrEMBL
  Cadherin_CBD UniProtKB/TrEMBL
  Cadherin_CS UniProtKB/TrEMBL
  Canbinoid_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cnbnoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25248 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25248 ENTREZGENE
PANTHER CADHERIN-87A UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTOCADHERIN ALPHA-4 UniProtKB/TrEMBL
  PTHR22750:SF47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cadherin UniProtKB/TrEMBL
  Cadherin_tail UniProtKB/TrEMBL
PhenoGen Cnr1 PhenoGen
PIRSF Cnoid_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CADHERIN UniProtKB/TrEMBL
  CANABINOID1R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CANNABINOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CADHERIN_1 UniProtKB/TrEMBL
  CADHERIN_2 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008223 RatGTEx
  ENSRNOG00055016812 RatGTEx
  ENSRNOG00060013854 RatGTEx
  ENSRNOG00065004895 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00112 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49313 UniProtKB/TrEMBL
UniProt A6IIL9 ENTREZGENE, UniProtKB/TrEMBL
  CNR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q924V0_RAT UniProtKB/TrEMBL
  Q99NU2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-06 Cnr1  cannabinoid receptor 1  Cnr1  cannabinoid receptor 1 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-24 Cnr1  cannabinoid receptor 1 (brain)  Cnr1  cannabinoid receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-01 Cnr1  cannabinoid receptor 1  Cnr1  cannabinoid receptor 1 (brain)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cnr1  cannabinoid receptor 1 (brain)    cannabinoid receptor 1  Name updated 1299863 APPROVED
2002-06-10 Cnr1  Cannabinoid receptor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization expression is clustered at axon terminals on GABA-mediated inhibitory interneurons 1298773
gene_expression expressed on GABA (gamma-aminobutyric acid)-mediated inhibitory interneurons 1298773
gene_expression expressed in brain and neural cell lines 1298770
gene_function G-protein coupled receptor that inhibits adenylate cyclase activity (stereoselective and pertussis-toxin sensitive) 1298770
gene_process may participate in retrograde signaling by endocannabinoids 1298773
gene_process may mediate inhibition of nitric oxide synthesis upon treatment of microglial cells with cannabinoids 1298772
gene_process receptor for psychoactive cannabinoids likely involved in cannabinoid-induced effects on the central nervous system 1298770