Nfatc2 (nuclear factor of activated T-cells 2) - Rat Genome Database
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Gene: Nfatc2 (nuclear factor of activated T-cells 2) Rattus norvegicus
Analyze
Symbol: Nfatc2
Name: nuclear factor of activated T-cells 2
RGD ID: 1307690
Description: Predicted to have several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphatase binding activity. Predicted to be involved in several processes, including calcineurin-NFAT signaling cascade; regulation of muscle cell differentiation; and regulation of transcription by RNA polymerase II. Localizes to cytosol and nucleus. Used to study pulmonary hypertension. Orthologous to human NFATC2 (nuclear factor of activated T cells 2); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH acetamide; amphetamine; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC311658; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Orthologs:
Homo sapiens (human) : NFATC2 (nuclear factor of activated T cells 2)  HGNC  Alliance
Mus musculus (house mouse) : Nfatc2 (nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfatc2 (nuclear factor of activated T cells 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NFATC2 (nuclear factor of activated T cells 2)
Canis lupus familiaris (dog) : NFATC2 (nuclear factor of activated T cells 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfatc2 (nuclear factor of activated T cells 2)
Sus scrofa (pig) : NFATC2 (nuclear factor of activated T cells 2)
Chlorocebus sabaeus (African green monkey) : NFATC2 (nuclear factor of activated T cells 2)
Heterocephalus glaber (naked mole-rat) : Nfatc2 (nuclear factor of activated T cells 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Celera3155,769,159 - 155,882,096 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
cytosol  (IBA,IDA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,ISO)
ribonucleoprotein complex  (ISO)
transcription regulator complex  (IBA,ISO)

References

Additional References at PubMed
PMID:7650004   PMID:8235597   PMID:8668213   PMID:8940147   PMID:8973343   PMID:10755616   PMID:11278367   PMID:12091710   PMID:12370307   PMID:12453415   PMID:12656674   PMID:12757709  
PMID:15319455   PMID:15790681   PMID:15857835   PMID:17875758   PMID:18319259   PMID:18676376   PMID:19561615   PMID:19752193   PMID:21295565   PMID:21709260   PMID:21871017   PMID:23123061  
PMID:23219532   PMID:23853098   PMID:24161931   PMID:24301466   PMID:25318679   PMID:26248042   PMID:27522126   PMID:28153703   PMID:28560440  


Genomics

Comparative Map Data
Nfatc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Celera3155,769,159 - 155,882,096 (-)NCBICelera
Cytogenetic Map3q42NCBI
NFATC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2051,386,957 - 51,562,831 (-)EnsemblGRCh38hg38GRCh38
GRCh382051,386,963 - 51,562,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372050,003,494 - 50,179,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362049,441,172 - 49,592,665 (-)NCBINCBI36hg18NCBI36
Build 342049,441,311 - 49,592,665NCBI
Celera2046,712,014 - 46,883,320 (-)NCBI
Cytogenetic Map20q13.2NCBI
HuRef2046,752,104 - 46,926,810 (-)NCBIHuRef
CHM1_12049,909,009 - 50,084,547 (-)NCBICHM1_1
Nfatc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,318,330 - 168,443,900 (-)NCBI
GRCm382168,476,410 - 168,601,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,476,410 - 168,601,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv372168,301,910 - 168,427,155 (-)NCBIGRCm37mm9NCBIm37
MGSCv362168,167,615 - 168,292,860 (-)NCBImm8
Celera2174,418,074 - 174,542,304 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.91NCBI
Nfatc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,035,876 - 7,153,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,035,876 - 7,153,199 (+)NCBIChiLan1.0ChiLan1.0
NFATC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12048,858,238 - 49,034,007 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,858,238 - 49,034,007 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02047,734,054 - 47,910,435 (-)NCBIMhudiblu_PPA_v0panPan3
NFATC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2437,609,561 - 37,771,132 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12437,606,977 - 37,734,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nfatc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365143,453,475 - 3,579,292 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,743,570 - 52,906,821 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,743,570 - 52,907,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21759,183,329 - 59,348,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl212,430,744 - 12,540,131 (+)Ensembl
ChlSab1.1212,412,935 - 12,585,275 (+)NCBI
Nfatc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247904,366,440 - 4,484,279 (+)NCBI

Position Markers
D3Rat141  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03165,368,814 - 165,369,047NCBIRnor6.0
Rnor_5.03171,508,982 - 171,509,215UniSTSRnor5.0
RGSC_v3.43159,783,634 - 159,783,868RGDRGSC3.4
RGSC_v3.43159,783,635 - 159,783,868UniSTSRGSC3.4
RGSC_v3.13159,689,670 - 159,689,904RGD
Celera3155,890,790 - 155,891,023UniSTS
Cytogenetic Map3q42UniSTS
SHRSP x BN Map378.8999RGD
SHRSP x BN Map378.8999UniSTS
D3Rat142  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03165,355,460 - 165,355,668NCBIRnor6.0
Rnor_5.03171,495,526 - 171,495,734UniSTSRnor5.0
RGSC_v3.43159,768,811 - 159,769,019UniSTSRGSC3.4
RGSC_v3.43159,768,810 - 159,769,019RGDRGSC3.4
RGSC_v3.13159,674,847 - 159,675,055RGD
Celera3155,877,270 - 155,877,494UniSTS
Cytogenetic Map3q42UniSTS
RH 3.4 Map31442.4RGD
RH 3.4 Map31442.4UniSTS
SHRSP x BN Map378.8999RGD
SHRSP x BN Map378.8999UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X155,795,871 - 155,797,528NCBIRnor6.0
Rnor_6.0X156,532,524 - 156,534,181NCBIRnor6.0
Rnor_5.01152,273,584 - 152,275,241UniSTSRnor5.0
Rnor_5.01151,515,195 - 151,516,852UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera1135,932,603 - 135,934,260UniSTS
Cytogenetic MapXq37UniSTS
Cytogenetic Map3q42UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03165,338,534 - 165,338,825NCBIRnor6.0
Rnor_5.03171,478,298 - 171,478,589UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera3155,860,462 - 155,860,753UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3148348517171467264Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3153918022177699992Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)3153412455170534769Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3156381661176418101Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153412455165355668Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:97
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000065615
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 3 43 34 18 17 18 8 11 63 35 33 11 8
Below cutoff 23 23 23 11 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07054634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07054635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07054636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01026593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000065615   ⟹   ENSRNOP00000059260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)Ensembl
RefSeq Acc Id: NM_001107805   ⟹   NP_001101275
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,245,238 - 165,360,292 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
RGSC_v3.43159,656,032 - 159,773,643 (-)RGD
Celera3155,769,159 - 155,882,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235653   ⟹   XP_006235715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,283,039 - 165,360,286 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762507   ⟹   XP_008760729
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,267,353 - 165,360,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591799   ⟹   XP_017447288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,241,750 - 165,360,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591800   ⟹   XP_017447289
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,251,717 - 165,360,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591801   ⟹   XP_017447290
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,267,353 - 165,374,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591802   ⟹   XP_017447291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,267,353 - 165,374,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591803   ⟹   XP_017447292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03165,283,039 - 165,374,644 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001101275   ⟸   NM_001107805
- UniProtKB: D4A0I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235715   ⟸   XM_006235653
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008760729   ⟸   XM_008762507
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447288   ⟸   XM_017591799
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447289   ⟸   XM_017591800
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017447290   ⟸   XM_017591801
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017447291   ⟸   XM_017591802
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017447292   ⟸   XM_017591803
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000059260   ⟸   ENSRNOT00000065615
Protein Domains
RHD

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307690 AgrOrtholog
Ensembl Genes ENSRNOG00000012175 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059260 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065615 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:311658 UniProtKB/TrEMBL
NCBI Gene 311658 ENTREZGENE
PANTHER NFAT UniProtKB/TrEMBL
Pfam RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Nfatc2 PhenoGen
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniGene Rn.17773 ENTREZGENE
  Rn.33679 ENTREZGENE
UniProt D4A0I8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nfatc2  nuclear factor of activated T-cells 2  Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2   Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED