Nfatc2 (nuclear factor of activated T-cells 2) - Rat Genome Database

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Gene: Nfatc2 (nuclear factor of activated T-cells 2) Rattus norvegicus
Analyze
Symbol: Nfatc2
Name: nuclear factor of activated T-cells 2
RGD ID: 1307690
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and phosphatase binding activity. Predicted to be involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of B cell proliferation; and regulation of gene expression. Predicted to act upstream of or within myotube cell development; positive regulation of myoblast fusion; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Used to study pulmonary hypertension. Orthologous to human NFATC2 (nuclear factor of activated T cells 2); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311658; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23157,195,970 - 157,328,640 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3157,198,872 - 157,328,325 (-)Ensembl
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Celera3155,769,159 - 155,882,096 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fisetin  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
harmine  (ISO)
hydralazine  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ionomycin  (ISO)
L-methionine  (ISO)
methanol  (ISO)
methapyrilene  (ISO)
methylisothiazolinone  (ISO)
Muscarine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
permethrin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
thapsigargin  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:7650004   PMID:8235597   PMID:8668213   PMID:8940147   PMID:8973343   PMID:10755616   PMID:11278367   PMID:12091710   PMID:12370307   PMID:12453415   PMID:12656674   PMID:12757709  
PMID:15319455   PMID:15790681   PMID:15857835   PMID:17875758   PMID:18319259   PMID:18676376   PMID:19561615   PMID:19752193   PMID:21295565   PMID:21709260   PMID:21871017   PMID:23123061  
PMID:23219532   PMID:23853098   PMID:24161931   PMID:24301466   PMID:25318679   PMID:26248042   PMID:27522126   PMID:28153703   PMID:28560440   PMID:33070779   PMID:33179105   PMID:34036377  


Genomics

Comparative Map Data
Nfatc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23157,195,970 - 157,328,640 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl3157,198,872 - 157,328,325 (-)Ensembl
Rnor_6.03165,241,750 - 165,374,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03171,380,993 - 171,514,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43159,656,032 - 159,773,643 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13159,560,378 - 159,679,702 (-)NCBI
Celera3155,769,159 - 155,882,096 (-)NCBICelera
Cytogenetic Map3q42NCBI
NFATC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382051,386,963 - 51,562,839 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2051,386,957 - 51,562,831 (-)EnsemblGRCh38hg38GRCh38
GRCh372050,003,500 - 50,179,378 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362049,441,172 - 49,592,665 (-)NCBINCBI36hg18NCBI36
Build 342049,441,311 - 49,592,665NCBI
Celera2046,712,014 - 46,883,320 (-)NCBI
Cytogenetic Map20q13.2NCBI
HuRef2046,752,104 - 46,926,810 (-)NCBIHuRef
CHM1_12049,909,009 - 50,084,547 (-)NCBICHM1_1
T2T-CHM13v2.02053,157,543 - 53,333,581 (-)NCBI
Nfatc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392168,318,330 - 168,443,900 (-)NCBIGRCm39mm39
GRCm39 Ensembl2168,318,330 - 168,443,577 (-)Ensembl
GRCm382168,476,410 - 168,601,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2168,476,410 - 168,601,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv372168,301,910 - 168,427,155 (-)NCBIGRCm37mm9NCBIm37
MGSCv362168,167,615 - 168,292,860 (-)NCBImm8
Celera2174,418,074 - 174,542,304 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map288.91NCBI
Nfatc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554457,035,876 - 7,153,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554457,035,876 - 7,153,199 (+)NCBIChiLan1.0ChiLan1.0
NFATC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12048,858,238 - 49,034,007 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2048,858,238 - 49,034,007 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02047,734,054 - 47,910,435 (-)NCBIMhudiblu_PPA_v0panPan3
NFATC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12437,606,977 - 37,734,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2437,609,561 - 37,771,132 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2436,848,834 - 36,994,081 (-)NCBI
ROS_Cfam_1.02438,316,651 - 38,461,824 (-)NCBI
ROS_Cfam_1.0 Ensembl2438,320,200 - 38,479,698 (-)Ensembl
UMICH_Zoey_3.12437,552,559 - 37,697,657 (-)NCBI
UNSW_CanFamBas_1.02437,686,199 - 37,831,205 (-)NCBI
UU_Cfam_GSD_1.02438,231,487 - 38,376,716 (-)NCBI
LOC101976824
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640188,030,736 - 188,129,333 (+)NCBI
SpeTri2.0NW_0049365143,453,475 - 3,579,292 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1752,743,570 - 52,906,821 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11752,743,570 - 52,907,373 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21759,183,329 - 59,348,705 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1212,412,935 - 12,585,275 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl212,430,744 - 12,540,131 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605060,814,273 - 60,985,872 (+)NCBIVero_WHO_p1.0
Nfatc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247904,366,406 - 4,484,432 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247904,366,440 - 4,484,279 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D3Rat141  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23157,322,804 - 157,323,038 (+)MAPPERmRatBN7.2
Rnor_6.03165,368,814 - 165,369,047NCBIRnor6.0
Rnor_5.03171,508,982 - 171,509,215UniSTSRnor5.0
RGSC_v3.43159,783,634 - 159,783,868RGDRGSC3.4
RGSC_v3.43159,783,635 - 159,783,868UniSTSRGSC3.4
RGSC_v3.13159,689,670 - 159,689,904RGD
Celera3155,890,790 - 155,891,023UniSTS
SHRSP x BN Map378.8999RGD
SHRSP x BN Map378.8999UniSTS
Cytogenetic Map3q42UniSTS
D3Rat142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23157,309,278 - 157,309,487 (+)MAPPERmRatBN7.2
Rnor_6.03165,355,460 - 165,355,668NCBIRnor6.0
Rnor_5.03171,495,526 - 171,495,734UniSTSRnor5.0
RGSC_v3.43159,768,810 - 159,769,019RGDRGSC3.4
RGSC_v3.43159,768,811 - 159,769,019UniSTSRGSC3.4
RGSC_v3.13159,674,847 - 159,675,055RGD
Celera3155,877,270 - 155,877,494UniSTS
RH 3.4 Map31442.4UniSTS
RH 3.4 Map31442.4RGD
SHRSP x BN Map378.8999UniSTS
SHRSP x BN Map378.8999RGD
Cytogenetic Map3q42UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,960,823 - 151,962,481 (-)MAPPERmRatBN7.2
Rnor_6.0X156,532,524 - 156,534,181NCBIRnor6.0
Rnor_6.0X155,795,871 - 155,797,528NCBIRnor6.0
Rnor_5.01151,515,195 - 151,516,852UniSTSRnor5.0
Rnor_5.01152,273,584 - 152,275,241UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera1135,932,603 - 135,934,260UniSTS
Cytogenetic MapXq37UniSTS
Cytogenetic Map3q42UniSTS
Nfatc2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23157,292,345 - 157,292,637 (+)MAPPERmRatBN7.2
Rnor_6.03165,338,534 - 165,338,825NCBIRnor6.0
Rnor_5.03171,478,298 - 171,478,589UniSTSRnor5.0
RGSC_v3.43159,751,583 - 159,751,874UniSTSRGSC3.4
Celera3155,860,462 - 155,860,753UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:97
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000065615
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 3 43 34 18 17 18 8 11 63 35 33 11 8
Below cutoff 23 23 23 11 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065615   ⟹   ENSRNOP00000059260
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,199,459 - 157,314,117 (-)Ensembl
Rnor_6.0 Ensembl3165,245,238 - 165,360,292 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102500   ⟹   ENSRNOP00000078664
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,198,872 - 157,314,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103552   ⟹   ENSRNOP00000082665
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,237,889 - 157,328,325 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105625   ⟹   ENSRNOP00000096538
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,237,889 - 157,314,117 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110172   ⟹   ENSRNOP00000086352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3157,223,642 - 157,314,117 (-)Ensembl
RefSeq Acc Id: NM_001107805   ⟹   NP_001101275
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,199,459 - 157,314,117 (-)NCBI
Rnor_6.03165,245,238 - 165,360,292 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
RGSC_v3.43159,656,032 - 159,773,643 (-)RGD
Celera3155,769,159 - 155,882,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235653   ⟹   XP_006235715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,237,235 - 157,314,245 (-)NCBI
Rnor_6.03165,283,039 - 165,360,286 (-)NCBI
Rnor_5.03171,380,993 - 171,514,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591799   ⟹   XP_017447288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,195,970 - 157,314,245 (-)NCBI
Rnor_6.03165,241,750 - 165,360,286 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591803   ⟹   XP_017447292
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,237,235 - 157,328,640 (-)NCBI
Rnor_6.03165,283,039 - 165,374,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105142   ⟹   XP_038961070
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,195,970 - 157,328,640 (-)NCBI
RefSeq Acc Id: XM_039105143   ⟹   XP_038961071
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,195,970 - 157,328,640 (-)NCBI
RefSeq Acc Id: XM_039105144   ⟹   XP_038961072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23157,195,970 - 157,314,025 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101275   ⟸   NM_001107805
- UniProtKB: D4A0I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235715   ⟸   XM_006235653
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017447288   ⟸   XM_017591799
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447292   ⟸   XM_017591803
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000059260   ⟸   ENSRNOT00000065615
RefSeq Acc Id: XP_038961071   ⟸   XM_039105143
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038961070   ⟸   XM_039105142
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038961072   ⟸   XM_039105144
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000078664   ⟸   ENSRNOT00000102500
RefSeq Acc Id: ENSRNOP00000096538   ⟸   ENSRNOT00000105625
RefSeq Acc Id: ENSRNOP00000082665   ⟸   ENSRNOT00000103552
RefSeq Acc Id: ENSRNOP00000086352   ⟸   ENSRNOT00000110172
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0I8-F1-model_v2 AlphaFold D4A0I8 1-931 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307690 AgrOrtholog
BioCyc Gene G2FUF-46697 BioCyc
Ensembl Genes ENSRNOG00000012175 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000059260 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000078664 ENTREZGENE
  ENSRNOP00000082665 ENTREZGENE
  ENSRNOP00000096538 ENTREZGENE
Ensembl Transcript ENSRNOT00000065615 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000102500 ENTREZGENE
  ENSRNOT00000103552 ENTREZGENE
  ENSRNOT00000105625 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report rno:311658 UniProtKB/TrEMBL
NCBI Gene 311658 ENTREZGENE
PANTHER NFAT UniProtKB/TrEMBL
Pfam RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
PhenoGen Nfatc2 PhenoGen
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt D4A0I8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Nfatc2  nuclear factor of activated T-cells 2  Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nfatc2  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2   Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nfatc2_predicted  nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED