Rars1 (arginyl-tRNA synthetase 1)

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Gene: Rars1 (arginyl-tRNA synthetase 1) Rattus norvegicus

Analyze

Symbol:

Rars1

Name:

arginyl-tRNA synthetase 1

RGD ID:

1309215

Description:

Enables anion binding activity; arginine-tRNA ligase activity; and tRNA binding activity. Involved in arginyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

arginine--tRNA ligase; arginine--tRNA ligase, cytoplasmic; arginyl-tRNA synthetase; arginyl-tRNA synthetase, cytoplasmic; argRS; LOC287191; Rars

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RARS1 (arginyl-tRNA synthetase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rars (arginyl-tRNA synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rars1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RARS1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RARS1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rars1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RARS1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RARS1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rars1 (arginyl-tRNA synthetase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RARS1 (arginyl-tRNA synthetase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rars (arginyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rars (arginyl-tRNA synthetase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	ArgRS	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rars-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	20,270,744 - 20,295,192 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	20,270,483 - 20,295,196 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	25,021,858 - 25,046,283 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	24,510,383 - 24,534,811 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	19,994,537 - 20,018,847 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	20,633,630 - 20,658,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	20,633,632 - 20,658,100 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	20,505,807 - 20,530,334 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	20,721,170 - 20,745,484 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	20,722,223 - 20,746,536 (-)	NCBI
Celera	10	19,889,464 - 19,913,910 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypomyelinating leukodystrophy 9 (ISO)

immunodeficiency 40 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

casticin (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP)

chromium(6+) (ISO)

copper atom (ISO)

copper(0) (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

diuron (EXP)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flutamide (EXP)

gentamycin (EXP)

glyphosate (EXP)

hydrogen peroxide (ISO)

imidacloprid (EXP)

ivermectin (ISO)

lead diacetate (EXP)

lead(0) (ISO)

lead(2+) (ISO)

methylparaben (ISO)

nefazodone (EXP)

paracetamol (ISO)

paraquat (EXP)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

sodium dichromate (EXP)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP)

thiabendazole (EXP)

thioacetamide (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arginyl-tRNA aminoacylation (IBA,IDA,ISO)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (IDA,ISO)

cytoplasm (ISO)

cytosol (ISO)

cytosol (ISO,ISS)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

arginine binding (IDA)

arginine-tRNA ligase activity (IBA,IDA,ISO)

ATP binding (IDA)

protein binding (ISO)

tRNA binding (IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

aminoacyl-tRNA biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Physical and biochemical characterization of a purified arginyl-tRNA synthetase-lysyl-tRNA-synthetase complex from rat liver.	Van Dang C, etal., Biochemistry. 1982 Apr 13;21(8):1959-66.
9.	LysRS serves as a key signaling molecule in the immune response by regulating gene expression.	Yannay-Cohen N, etal., Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.

Additional References at PubMed

PMID:8889548	PMID:10791971	PMID:12060739	PMID:12477932	PMID:12947022	PMID:18614015	PMID:19056867	PMID:19131329	PMID:19289464	PMID:19946888	PMID:22871113	PMID:23376485
PMID:24710927	PMID:25288775	PMID:25468996

Genomics

Comparative Map Data

Rars1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	20,270,744 - 20,295,192 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	20,270,483 - 20,295,196 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	25,021,858 - 25,046,283 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	24,510,383 - 24,534,811 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	19,994,537 - 20,018,847 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	20,633,630 - 20,658,074 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	20,633,632 - 20,658,100 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	20,505,807 - 20,530,334 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	20,721,170 - 20,745,484 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	20,722,223 - 20,746,536 (-)	NCBI
Celera	10	19,889,464 - 19,913,910 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

RARS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	168,486,471 - 168,519,301 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	5	168,486,451 - 168,519,301 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	167,913,476 - 167,946,306 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	167,846,041 - 167,878,889 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	167,846,040 - 167,878,885	NCBI
Celera	5	163,948,808 - 163,981,683 (+)	NCBI		Celera
Cytogenetic Map	5	q34	NCBI
HuRef	5	163,012,238 - 163,045,058 (+)	NCBI		HuRef
CHM1_1	5	167,346,530 - 167,379,378 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	169,021,262 - 169,054,094 (+)	NCBI		T2T-CHM13v2.0

Rars
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	35,699,207 - 35,725,355 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	35,699,208 - 35,725,333 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	35,808,381 - 35,834,528 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	35,808,381 - 35,834,506 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	35,621,883 - 35,648,030 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	35,651,806 - 35,677,929 (-)	NCBI		MGSCv36	mm8
Celera	11	39,591,462 - 39,617,635 (-)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI

Rars1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	21,536,426 - 21,574,683 (+)	NCBI	ChiLan1.0	ChiLan1.0

RARS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	170,616,819 - 170,649,655 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	170,616,819 - 170,649,655 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	163,851,644 - 163,884,787 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

RARS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	43,237,499 - 43,260,738 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	43,237,499 - 43,260,677 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	43,193,938 - 43,217,200 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	43,659,249 - 43,682,521 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	43,650,992 - 43,682,460 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	43,428,969 - 43,452,203 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	43,623,543 - 43,646,768 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	44,129,367 - 44,152,642 (-)	NCBI		UU_Cfam_GSD_1.0

Rars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	97,268,905 - 97,302,352 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936622	884,423 - 918,650 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936622	884,324 - 917,964 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RARS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	55,373,727 - 55,412,112 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	55,373,739 - 55,412,076 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	59,959,187 - 59,972,120 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RARS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	70,711,435 - 70,746,000 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	70,711,016 - 70,745,884 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	7,934,274 - 7,970,520 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rars1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	21,487,847 - 21,535,797 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	21,487,847 - 21,535,487 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rars1
96 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	28
Count of miRNA genes:	21
Interacting mature miRNAs:	28
Transcripts:	ENSRNOT00000010252
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat

Markers in Region

RH141338

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	20,270,869 - 20,271,571 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	20,633,756 - 20,634,457	NCBI	Rnor6.0
Rnor_5.0	10	20,505,933 - 20,506,634	UniSTS	Rnor5.0
RGSC_v3.4	10	20,721,296 - 20,721,997	UniSTS	RGSC3.4
Celera	10	19,889,590 - 19,890,291	UniSTS
RH 3.4 Map	10	240.01	UniSTS
Cytogenetic Map	10	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161929	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF420005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB313613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF110623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000010252 ⟹ ENSRNOP00000010252

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	20,270,483 - 20,295,196 (-)	Ensembl
Rnor_6.0 Ensembl	10	20,633,632 - 20,658,100 (-)	Ensembl

RefSeq Acc Id:

NM_001105777 ⟹ NP_001099247

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	20,270,744 - 20,295,192 (-)	NCBI
Rnor_6.0	10	20,633,630 - 20,658,074 (-)	NCBI
Rnor_5.0	10	20,505,807 - 20,530,334 (-)	NCBI
RGSC_v3.4	10	20,721,170 - 20,745,484 (-)	RGD
Celera	10	19,889,464 - 19,913,910 (-)	RGD

Sequence:

show sequence

ATGTGAGTCGCTGACGAAAGGATGGACGGTCTGGTGGCTCAGTGCTCCGCGCGGTTGCTGCAGC
AGGAAAAGGAGATTAAATCTCTGACTGCTGAGATCGACCGGCTGAAGAACTGTAGTTACTTAGA
AGCTTCTCCAAGTTTGGAACAGTTACGAGAAGAAAATTTAAAATTGAAGTATAGGCTGAATATT
CTTCGAAGGAGTCTTCAGGCAGAAAGGAAAAGGCCGACTAAGAACATGATCAACATCAACAGTC
GCCTGCAGGAGCTCTTCGGCTGTGCCATTAAGGCTGCGTATCCAGACTTGGAGAACCCTCCCCT
GGTCGTAACACCAAGTCAGCAGCCCAAGTTTGGAGACTATCAATGTAATAGCGCCATGGGTATT
TCTCAGATGCTCAAGGCAAAGGAGCAGAAGGTTAGTCCTAGAGAAATTGCCGAAAACATTACCA
AACACCTGCCAAACAACGAGTACATCGACAGGGTTGAAATTGCGGGTCCCGGTTTCATCAATGT
GCACCTGAGAAAGGACTTTGTGTCAGAACAGTTAACCAATCTCCTAGTGAATGGAGTTCAACTA
CCTGTGCTTGGAGAAAATGAAAAGGTGATAGTTGACTTCTCCTCTCCCAACATAGCTAAGGAGA
TGCACGTTGGCCACCTCAGGTCAACCATCATAGGAGAAAGTATGAGCCGCCTCTTTGAGTTTGC
AGGATACAACGTGCTAAGGTTAAACCACGTAGGAGACTGGGGGACCCAGTTTGGCATGCTCATC
GCTCACCTGCAGGATAAGTTTCCAGATTATCTGACAGTTTCACCTCCTATTGGGGATCTTCAGG
CCTTTTATAAGGAATCTAAGAAGAGGTTTGATACCGAGGAGGAGTTTAAGAAGCGAGCCTATGA
GTGTGTTGTTTTGCTGCAGAGTAAAAACCCAGATATCATGAAAGCCTGGAATCTCATCTGTGAT
GTGTCCAGGGAAGAGTTTAATAAAATCTATGATGCACTGGACATCACTTTGATAGAAAGAGGAG
AATCCTTCTATCAAGATAGGATGAAGGATATTGTAAAGGAATTTGAAGATAAAGGGTTTGTGCA
GGTGGATGATGGCAGGAAAATTGTGTTCGTGCCTGGGTGTTCTGTACCATTAACAATAGTGAAA
TCAGATGGGGGCTACACTTACGACACCTCTGACCTGGCTGCCATCAAACAGAGGCTATTTGAAG
AAAAAGCAAATAAGATTATTTATGTGGTGGACAATGGACAAGCTACACACTTCCAGACAGTATT
TGCTGCTGCTCAAATGATTGGTTGGTATGACCCTAAAGTTACTCGAGTGGCCCACGTTGGATTT
GGTGTGGTCCTAGGAGAAGACAAGAAGAAATTTAAAACACGTTCAGGTGAAACTGTGCGCCTCA
TGGACCTGCTGGAAGAAGGACTGAGACGGTCCATGGACAAGCTGAAGGAGAAAGAGAGAGACAA
GGTCTTAACTGAAGAGGAGTTGAAGGCAGCTCAGACATCCGTTGCATATGGCTGCATCAAATAC
GCCGACCTTTCTCATAATCGCCTGAATGACTACGTCTTCTCCTTTGATAAGATGCTGGACGACA
GAGGGAACACAGCTGCCTACCTACTGTACGCCTTCACCAGAATCAGGTCCATTGCACGCCTGGC
CAATATCGATGAGGAAATGCTGCAGAGAGCAGCTCGGGAAACCAAGATCATTTTGGACCACGAG
AAGGAGTGGAAACTGGGACGGTGCATTTTACGGTTCCCCGAAATCCTACAGAAGATCTTAGATG
ACCTGTTTCTCCACACTCTGTGTGATTACATTTATGAGCTAGCAACCACTTTCACAGAGTTCTA
TGACAGCTGCTACTGTGTGGAGAAAGATCGGCAGACTGGGAAAGTGCTGAAGGTGAACATGTGG
CGGATGCTCCTGTGTGAAGCCGTAGCTGCTGTCATGGCCAAAGGCTTCGATATACTGGGAATAA
AGCCCGTCCAGAGGATGTAGCCCCCCAAGATCGGGGACTGTTTTTACCAAAGTAGACGTTACTA
CTGTTCGCTTTTTCAACAATCATGTGGACACAAATAGTAAAGGAATTTTCATAACTAAAAAAAA
AAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099247	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61929	(Get FASTA)	NCBI Sequence Viewer
	EDM04095	(Get FASTA)	NCBI Sequence Viewer
	EDM04096	(Get FASTA)	NCBI Sequence Viewer
	P40329	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099247 ⟸ NM_001105777

- UniProtKB:

B1WBX8 (UniProtKB/Swiss-Prot), P40329 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDGLVAQCSARLLQQEKEIKSLTAEIDRLKNCSYLEASPSLEQLREENLKLKYRLNILRRSLQA
ERKRPTKNMININSRLQELFGCAIKAAYPDLENPPLVVTPSQQPKFGDYQCNSAMGISQMLKAK
EQKVSPREIAENITKHLPNNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGVQLPVLGENE
KVIVDFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKF
PDYLTVSPPIGDLQAFYKESKKRFDTEEEFKKRAYECVVLLQSKNPDIMKAWNLICDVSREEFN
KIYDALDITLIERGESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPGCSVPLTIVKSDGGYTY
DTSDLAAIKQRLFEEKANKIIYVVDNGQATHFQTVFAAAQMIGWYDPKVTRVAHVGFGVVLGED
KKKFKTRSGETVRLMDLLEEGLRRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADLSHNR
LNDYVFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQRAARETKIILDHEKEWKLGR
CILRFPEILQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKVLKVNMWRMLLCEA
VAAVMAKGFDILGIKPVQRM

hide sequence

RefSeq Acc Id:

ENSRNOP00000010252 ⟸ ENSRNOT00000010252

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P40329-F1-model_v2	AlphaFold	P40329	1-660	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697103

Promoter ID:

EPDNEW_R7628

Type:

initiation region

Name:

Rars_1

Description:

arginyl-tRNA synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	20,658,074 - 20,658,134	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309215	AgrOrtholog
BioCyc Gene	G2FUF-25537	BioCyc
BioCyc Pathway	TRNA-CHARGING-PWY [tRNA charging]	BioCyc
Ensembl Genes	ENSRNOG00000007739	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000010252	ENTREZGENE
	ENSRNOP00000010252.4	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010252	ENTREZGENE
	ENSRNOT00000010252.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.1360.70	UniProtKB/Swiss-Prot
	3.40.50.620	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8375237	IMAGE-MGC_LOAD
InterPro	aa-tRNA-synth_I_CS	UniProtKB/Swiss-Prot
	Arg-tRNA-ligase	UniProtKB/Swiss-Prot
	Arg-tRNA-synth_N	UniProtKB/Swiss-Prot
	Arg-tRNA-synth_N_sf	UniProtKB/Swiss-Prot
	ArgRS_core	UniProtKB/Swiss-Prot
	DALR_anticod-bd	UniProtKB/Swiss-Prot
	Rossmann-like_a/b/a_fold	UniProtKB/Swiss-Prot
	tRNAsynth_Ia_anticodon-bd	UniProtKB/Swiss-Prot
KEGG Report	rno:287191	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187703	IMAGE-MGC_LOAD
NCBI Gene	287191	ENTREZGENE
PANTHER	ARGININE--TRNA LIGASE, CYTOPLASMIC	UniProtKB/Swiss-Prot
	PTHR11956	UniProtKB/Swiss-Prot
Pfam	Arg_tRNA_synt_N	UniProtKB/Swiss-Prot
	DALR_1	UniProtKB/Swiss-Prot
	tRNA-synt_1d	UniProtKB/Swiss-Prot
PhenoGen	Rars1	PhenoGen
PRINTS	TRNASYNTHARG	UniProtKB/Swiss-Prot
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/Swiss-Prot
SMART	Arg_tRNA_synt_N	UniProtKB/Swiss-Prot
	DALR_1	UniProtKB/Swiss-Prot
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/Swiss-Prot
	SSF47323	UniProtKB/Swiss-Prot
	SSF55190	UniProtKB/Swiss-Prot
TIGRFAMs	argS	UniProtKB/Swiss-Prot
UniProt	B1WBX8	ENTREZGENE
	P40329	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	B1WBX8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-09	Rars1	arginyl-tRNA synthetase 1	Rars	arginyl-tRNA synthetase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Rars	arginyl-tRNA synthetase	Rars_predicted	arginyl-tRNA synthetase (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rars_predicted	arginyl-tRNA synthetase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)