Cyp3a2 (cytochrome P450, family 3, subfamily a, polypeptide 2) - Rat Genome Database

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Gene: Cyp3a2 (cytochrome P450, family 3, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
RGD ID: 708379
Description: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in oxidative demethylation and xenobiotic metabolic process. Predicted to be located in cytoplasm. Used to study alcohol dependence and anxiety disorder. Biomarker of cholestasis and end stage renal disease. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp3a11; CYPIIIA2; cytochrome P450 3A2; cytochrome P450, family 3, subfamily a, polypeptide 11; cytochrome P450-PCN2; cytochrome P450/6-beta-A; MGC108545; P450-PCN2; P450/6-beta-A; testosterone 6-beta-hydroxylase
RGD Orthologs
Human
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Cyp3a2em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,321,771 - 14,343,886 (-)NCBIGRCr8
mRatBN7.2129,207,978 - 9,230,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,009,578 - 10,031,654 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,632,755 - 10,654,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,656,186 - 9,678,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(E)-roxithromycin  (ISO)
(E)-thiamethoxam  (ISO)
(E,E)-germacrone  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,5-tetrachlorobenzene  (ISO)
1,2-dichloroethene  (EXP)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP,ISO)
1,4-dichlorobenzene  (ISO)
1,4-naphthoquinone  (ISO)
1,6-Dinitropyrene  (ISO)
1,8-cineole  (ISO)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-aminobenzotriazole  (ISO)
1-hydroxymidazolam  (ISO)
1-hydroxymidazolam beta-D-glucuronide  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (EXP)
13-cis-retinal  (ISO)
14,15-EET  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-indole  (ISO)
2'-deoxyguanosine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-hydroxychrysophanol  (ISO)
2-methyl-1H-indole  (ISO)
2-Naphthalenethiol  (ISO)
2-naphthol  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-(Methylthio)-1-propene  (EXP)
3-hydroxyquinine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-oxo-5beta-cholanic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4,4'-methanol-bisbenzonitrile  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-bromo-2-chlorophenol  (ISO)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (ISO)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (ISO)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxycyclophosphamide  (ISO)
4-hydroxymidazolam  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Ipomeanol  (ISO)
4-isopropylphenol  (ISO)
4beta-hydroxycholesterol  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5,6-dichlorobenzimidazole riboside  (ISO)
5,6-EET  (ISO)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-hydroxydiclofenac  (ISO)
5-Hydroxyflavone  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxyindole  (ISO)
6',7'-Dihydroxybergamottin  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-chrysenamine  (ISO)
6-Hydroxyflavone  (ISO)
6-Methylflavone  (ISO)
6alpha-methylprednisolone  (ISO)
6beta-hydroxycortisol  (ISO)
6beta-hydroxytestosterone  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
7-hydroxyflavone  (ISO)
8,9-EET  (ISO)
8-Epidiosbulbin E acetate  (ISO)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
9-hydroxyellipticine  (ISO)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
acalabrutinib  (ISO)
acenaphthylene  (ISO)
acetamide  (EXP)
acetochlor  (ISO)
Acetyl tributyl citrate  (ISO)
aconitine  (ISO)
acrolein  (ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
adinazolam  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
aflatoxin Q1  (ISO)
ajmalicine  (ISO)
ajmaline  (ISO)
alachlor  (ISO)
albendazole  (EXP,ISO)
alcohol  (ISO)
aldrin  (ISO)
alectinib  (ISO)
alfacalcidol  (ISO)
alfentanil  (ISO)
all-trans-4-hydroxyretinoic acid  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
allyl alcohol  (EXP)
allyl isothiocyanate  (EXP,ISO)
allyl methyl disulfide  (ISO)
almotriptan  (ISO)
Aloe emodin  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-Hydroxyalprazolam  (ISO)
alpha-linolenic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-santonin  (ISO)
alpha-tocotrienol  (ISO)
alprazolam  (ISO)
Amaranth  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amoxapine  (ISO)
amphetamine  (ISO)
ampicillin  (EXP)
amprenavir  (ISO)
Ancriviroc  (ISO)
andrographolide  (ISO)
androst-4-ene-3,17-dione  (ISO)
aniline  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
Artemetin  (ISO)
Asiaticoside  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
Auriculasin  (ISO)
Avasimibe  (ISO)
axitinib  (ISO)
Azamulin  (ISO)
azithromycin  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
barbiturates  (ISO)
barnidipine  (ISO)
benfuracarb  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[c]phenanthrene  (ISO)
benzoic acid  (ISO)
benzphetamine  (ISO)
benzyl isothiocyanate  (EXP)
bepridil  (ISO)
berberine  (EXP,ISO)
bergomottin  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocotrienol  (ISO)
Betanin  (EXP)
bifenthrin  (ISO)
bifonazole  (ISO)
bilirubin IXalpha  (EXP,ISO)
bioresmethrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bosentan  (ISO)
Bromadiolone  (EXP)
bromfenac  (ISO)
bromocriptine  (ISO)
bromodichloromethane  (ISO)
Brotizolam  (ISO)
budesonide  (EXP,ISO)
bufalin  (ISO)
bufogenin  (ISO)
buprenorphine  (ISO)
buspirone  (ISO)
butachlor  (ISO)
butan-1-ol  (EXP)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (EXP,ISO)
cabozantinib  (ISO)
cafestol  (EXP)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (ISO)
carbaryl  (ISO)
carbendazim  (ISO)
carbofuran  (ISO)
carbosulfan  (ISO)
carfentanil  (ISO)
carmustine  (ISO)
Carnosol  (ISO)
carvedilol  (EXP)
cefaclor  (ISO)
cefadroxil  (ISO)
cerivastatin  (ISO)
cetirizine  (ISO)
CGP 52608  (ISO)
chelidonine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (ISO)
chitosan  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chlorfenvinfos  (ISO)
chlorfluazuron  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
chlorzoxazone  (EXP)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (EXP)
chrysin  (ISO)
chrysophanol  (ISO)
chrysosplenetin  (ISO)
cimetidine  (ISO)
cinitapride  (ISO)
Cinobufagin  (ISO)
ciprofibrate  (EXP)
ciprofloxacin  (ISO)
cisapride  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
citral  (ISO)
Citreorosein  (ISO)
clarithromycin  (ISO)
clemizole  (ISO)
climbazole  (EXP)
clindamycin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
clomiphene  (ISO)
clopidogrel  (ISO)
clothianidin  (ISO)
clotrimazole  (EXP,ISO)
clozapine  (ISO)
Clozapine N-oxide  (ISO)
cobalt dichloride  (ISO)
cobicistat  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
Columbin  (ISO)
cordycepin  (EXP)
corticosterone  (ISO)
cortisol  (EXP,ISO)
coumarin  (EXP)
crizotinib  (ISO)
Cryptotanshinone  (ISO)
curcumin  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP,ISO)
cyprodinil  (ISO)
cyproterone acetate  (ISO)
dabrafenib  (ISO)
daidzein  (EXP,ISO)
dapsone  (EXP,ISO)
dauricine  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
Dechloroethylcyclophosphamide  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (EXP,ISO)
delta-tocotrienol  (ISO)
deoxycholic acid  (EXP,ISO)
Deoxyelephantopin  (ISO)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
Desethylchloroquine  (ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dextromethorphan  (ISO)
dextrorphan  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diflubenzuron  (ISO)
dihydroartemisinin  (ISO)
dihydroergotamine  (ISO)
diltiazem  (ISO)
dimemorfan  (ISO)
dimethocaine  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioleoyl phosphatidylcholine  (EXP,ISO)
diosmetin  (ISO)
dioxygen  (ISO)
diphenylamine  (ISO)
dipropyl disulfide  (EXP)
Dipropyl sulfide  (EXP)
diquat  (EXP)
disopyramide  (ISO)
disulfiram  (EXP,ISO)
Dithiopyr  (ISO)
diuron  (ISO)
domperidone  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
Droloxifene  (ISO)
dronedarone  (ISO)
Echimidine  (ISO)
econazole  (ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellipticine  (ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
endrin  (ISO)
enilconazole  (ISO)
eplerenone  (ISO)
epoxiconazole  (EXP,ISO)
Erdafitinib  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
erythrosin B  (ISO)
estazolam  (ISO)
estrone  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethion  (ISO)
eticlopride(1+)  (ISO)
etonogestrel  (ISO)
etoposide  (ISO)
etoricoxib  (ISO)
etoxazole  (ISO)
eupatilin  (ISO)
eupatorin  (ISO)
farnesol  (EXP,ISO)
farrerol  (ISO)
felbamate  (ISO)
felodipine  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenproporex  (ISO)
fentanyl  (ISO)
fenthion  (ISO)
fenvalerate  (ISO)
ferroheme b  (ISO)
fimasartan  (ISO)
fipronil  (EXP,ISO)
flavanone  (ISO)
flavone  (ISO)
flavonol  (ISO)
flucloxacillin  (ISO)
fluconazole  (ISO)
flucythrinate  (ISO)
fludioxonil  (ISO)
flunitrazepam  (ISO)
fluoren-9-one  (EXP)
fluorene  (EXP)
fluoxetine  (ISO)
fluphenazine  (ISO)
flusilazole  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutolanil  (ISO)
flutriafol  (EXP,ISO)
fluvalinate  (ISO)
fluvastatin  (ISO)
fluvoxamine  (ISO)
fluxapyroxad  (ISO)
fonofos  (ISO)
Fraxinellone  (ISO)
fulvestrant  (EXP)
Furafylline  (EXP)
furan  (EXP)
furathiocarb  (ISO)
fusidic acid  (ISO)
gadolinium trichloride  (EXP)
galangin  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gefitinib  (ISO)
Gelsemine  (ISO)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geranial  (ISO)
gestodene  (ISO)
gingerol  (ISO)
Ginkgolide A  (EXP,ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glimepiride  (ISO)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
Glycohyodeoxycholic acid  (ISO)
glycolithocholic acid  (ISO)
glycoursodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyoxal  (ISO)
granisetron  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
haloperidol  (ISO)
halothane  (ISO)
helenalin  (ISO)
Heliotrine  (ISO)
heme b  (ISO)
HET0016  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hexachlorobenzene  (EXP)
hexaflumuron  (ISO)
hexobarbital  (ISO)
huperzine A  (EXP)
hydrocortisone succinate  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxynefazodone  (ISO)
hyodeoxycholic acid  (ISO)
Hypaconitine  (ISO)
hyperforin  (ISO)
hypericin  (ISO)
iberin  (EXP)
ibrutinib  (ISO)
Icaritin  (ISO)
ifosfamide  (ISO)
iloperidone  (ISO)
imidacloprid  (ISO)
imidazoles  (ISO)
imipramine  (ISO)
indicine  (ISO)
indole-3-acetamide  (ISO)
indoline  (ISO)
indometacin  (ISO)
iprodione  (ISO)
irilone  (ISO)
irinotecan  (ISO)
iron(III) citrate  (ISO)
isobavachalcone  (EXP)
isocarbophos  (ISO)
isofenphos  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprothiolane  (ISO)
isoproturon  (ISO)
isorhamnetin  (ISO)
Isosafrole  (ISO)
isotretinoin  (ISO)
isoxazoles  (ISO)
Isradipine  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (EXP)
ketamine  (EXP,ISO)
ketoconazole  (EXP,ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lamotrigine  (ISO)
lansoprazole  (ISO)
lapatinib  (ISO)
laquinimod  (ISO)
Lasiocarpine  (EXP,ISO)
lead(0)  (ISO)
lefetamine  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
letrozole  (ISO)
Licochalcone A  (ISO)
lidocaine  (ISO)
Liensinine  (ISO)
limonene  (ISO)
limonin  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lopinavir  (ISO)
loratadine  (ISO)
lorlatinib  (ISO)
lovastatin  (ISO)
loxapine  (ISO)
luteolin  (ISO)
lycopene  (ISO)
madecassoside  (ISO)
malathion  (ISO)
Maleic hydrazide  (ISO)
mancozeb  (ISO)
mangiferin  (ISO)
Marrubiin  (ISO)
masitinib  (ISO)
Meclizine  (ISO)
Medazepam  (ISO)
medroxyprogesterone acetate  (ISO)
mefenamic acid  (ISO)
mefloquine  (ISO)
MeIQ  (ISO)
Melarsoprol  (ISO)
Mesaconitine  (ISO)
metazachlor  (ISO)
metformin  (ISO)
methadone  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methoxyflurane  (ISO)
metolachlor  (ISO)
metolazone  (ISO)
metoprolol  (ISO)
metronidazole  (EXP,ISO)
metyrapone  (ISO)
mevastatin  (ISO)
Mibefradil  (ISO)
miconazole  (ISO)
midazolam  (EXP,ISO)
mifepristone  (ISO)
Mitotane  (ISO)
Mitragynine  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (EXP,ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono-isopropyl-disopyramide  (ISO)
monobenzone  (ISO)
monocrotaline  (ISO)
monocrotophos  (ISO)
monoethylglycinexylidide  (ISO)
monosodium L-glutamate  (EXP)
moricizine  (ISO)
Muscone  (ISO)
musk xylene  (EXP)
mycophenolic acid  (ISO)
myricetin  (ISO)
myristicin  (ISO)
N'-Nitrosoanabasine  (ISO)
N,N-Didesmethyltamoxifen  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-(2,6-diethylphenyl)-2-chloroacetamide  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-desethylamiodarone  (ISO)
N-desmethylclozapine  (ISO)
N-Desmethyltamoxifen  (ISO)
N-Nitrosodi-n-propylamine  (ISO)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
nafcillin  (ISO)
naphthalene  (ISO)
naringin  (ISO)
nefazodone  (ISO)
Neferine  (ISO)
nelfinavir  (ISO)
nemorubicin  (EXP,ISO)
neobavaisoflavone  (EXP)
neomycin  (EXP)
nevirapine  (ISO)
nicardipine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nimetazepam  (ISO)
nitrazepam  (ISO)
nitrendipine  (ISO)
nobiletin  (ISO)
Norbuprenorphine  (ISO)
norcisapride  (ISO)
norcodeine  (ISO)
nordazepam  (ISO)
Norfluoxetine  (ISO)
Noroxycodone  (ISO)
nortriptyline  (ISO)
notoginsenoside R1  (ISO)
Notopterol  (ISO)
o-anisidine  (ISO)
o-toluidine  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octamethylcyclotetrasiloxane  (EXP)
ofloxacin  (ISO)
okadaic acid  (EXP,ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
Omeprazole sulfide  (ISO)
Ondansetron  (ISO)
organophosphorus compound  (ISO)
orlistat  (ISO)
Oxadiazon  (ISO)
oxatomide  (ISO)
oxiconazole  (ISO)
oxycodone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP,ISO)
Panaxytriol  (EXP,ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
paricalcitol  (ISO)
pazopanib  (ISO)
PD 0325901  (ISO)
pedalitin  (ISO)
penconazole  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perazine  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
Perhexiline maleate  (ISO)
permethrin  (ISO)
phenacetin  (EXP)
phencyclidine  (ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenoxymethylpenicillin  (ISO)
phenthoate  (ISO)
phenylbutazone  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phosalone  (ISO)
phthalic acid  (EXP,ISO)
physcion  (ISO)
pimecrolimus  (ISO)
pimobendan  (ISO)
pinocembrin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (ISO)
PK-11195  (ISO)
poly(styrene)  (ISO)
polymyxin B2  (EXP)
pomalidomide  (ISO)
posaconazole  (ISO)
potassium bromate  (ISO)
potassium hexacyanoferrate(3-)  (ISO)
Pramiconazole  (ISO)
prednisolone  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Pretilachlor  (ISO)
primaquine  (ISO)
probenecid  (ISO)
prochloraz  (EXP,ISO)
procymidone  (ISO)
profenofos  (EXP,ISO)
progesterone  (ISO)
proguanil  (ISO)
propargite  (ISO)
propiconazole  (EXP,ISO)
propranolol  (ISO)
propyzamide  (ISO)
psoralidin  (EXP)
pyrantel  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (ISO)
pyridine  (EXP)
pyrimethanil  (ISO)
pyrimidin-2-amine  (ISO)
pyrrolidines  (EXP)
quercetin  (ISO)
quetiapine fumarate  (ISO)
quinacrine  (ISO)
quinidine  (ISO)
quinine  (ISO)
quinoxyfen  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
regorafenib  (ISO)
reserpic acid  (ISO)
reserpine  (ISO)
resveratrol  (ISO)
Retrorsine  (ISO)
riddelliine  (EXP,ISO)
rifabutin  (ISO)
rifampicin  (EXP,ISO)
rifapentine  (ISO)
rifaximin  (ISO)
risperidone  (ISO)
ritonavir  (ISO)
rivaroxaban  (ISO)
romidepsin  (ISO)
rose bengal  (ISO)
rubiarbonone C  (ISO)
Rutaevin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
saquinavir  (ISO)
saracatinib  (ISO)
satraplatin  (ISO)
secobarbital  (ISO)
selenium atom  (ISO)
semicarbazide  (EXP)
senecionine  (ISO)
seneciphylline  (ISO)
Senkirkine  (ISO)
sertraline  (ISO)
sevoflurane  (ISO)
Shikonin  (EXP,ISO)
sibutramine  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sinensetin  (ISO)
sirolimus  (ISO)
skatole  (ISO)
sodium arsenite  (ISO)
sodium cholate  (EXP,ISO)
sophoraflavanone B  (ISO)
sophoranone  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
styrene  (EXP)
Sudan I  (ISO)
Sudan III  (EXP)
sulconazole  (ISO)
sulfamethazine  (ISO)
sulfamethoxazole  (EXP)
sulfaphenazole  (ISO)
sulfinpyrazone  (ISO)
sulfisoxazole  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP,ISO)
tacrine  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamarixetin  (ISO)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (EXP)
taurodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
tebufenozide  (ISO)
telaprevir  (ISO)
telithromycin  (ISO)
Temazepam  (ISO)
teniposide  (ISO)
terbinafine  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
Territrem B  (EXP)
tert-butyl ethyl ether  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP,ISO)
tetramethrin  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thiabendazole  (ISO)
thiacloprid  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
Thiocoraline  (ISO)
thioridazine  (ISO)
Thiotepa  (ISO)
thiram  (ISO)
thyroxine  (ISO)
ticlopidine  (ISO)
tinidazole  (ISO)
tiratricol  (ISO)
tofacitinib  (ISO)
tolcapone  (ISO)
toluene  (EXP)
tolylfluanid  (ISO)
topiramate  (ISO)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP)
trans-cinnamic acid  (ISO)
transfluthrin  (EXP)
tranylcypromine  (ISO)
trazodone  (EXP,ISO)
triadimefon  (EXP,ISO)
triazolam  (ISO)
Tributyl citrate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
triflumuron  (ISO)
trifluridine  (ISO)
Triptolide  (EXP)
Tris(1-aziridinyl)phosphine oxide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
troleandomycin  (ISO)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vandetanib  (ISO)
vanoxerine dihydrochloride  (ISO)
veliparib  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
voriconazole  (ISO)
warfarin  (EXP,ISO)
xanthenes  (ISO)
yohimbine  (ISO)
zafirlukast  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)
zileuton  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
artemether pharmacokinetics pathway   (ISO)
axitinib pharmacokinetics pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway  (ISO)
clomipramine pharmacokinetics pathway  (ISO)
clopidogrel pharmacodynamics pathway  (ISO)
clopidogrel pharmacokinetics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
doxepin pharmacokinetics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fluoxetine pharmacokinetics pathway   (ISO)
gefitinib pharmacokinetics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
imipramine pharmacokinetics pathway  (ISO)
irinotecan pharmacodynamics pathway  (ISO)
irinotecan pharmacokinetics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lidocaine pharmacokinetics pathway  (ISO)
linoleic acid metabolic pathway   (IEA)
losartan pharmacokinetics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
mycophenolic acid pharmacokinetics pathway   (ISO)
nateglinide pharmacokinetics pathway  (ISO)
neviparine pharmacokinetics pathway   (ISO)
paracetamol pharmacokinetics pathway  (ISO)
phase I biotransformation pathway via cytochrome P450  (IEA)
phenytoin pharmacodynamics pathway  (ISO)
prednisone pharmacodynamics pathway  (ISO)
prednisone pharmacokinetics pathway   (ISO)
repaglinide pharmacokinetics pathway   (ISO)
retinol metabolic pathway  (IEA)
sorafenib pharmacokinetics pathway   (ISO)
statin pharmacokinetics pathway   (ISO)
steroid hormone biosynthetic pathway   (IEA)
tamoxifen pharmacodynamics pathway   (ISO)
tamoxifen pharmacokinetics pathway  (IDA)
teniposide pharmacodynamics pathway  (ISO)
teniposide pharmacokinetics pathway  (ISO)
tramadol pharmacokinetics pathway  (ISO)
venlafaxine pharmacokinetics pathway  (ISO)
vinblastine pharmacodynamics pathway  (ISO)
vinorelbine pharmacodynamics pathway  (ISO)
vitamin A deficiency pathway   (ISO)
warfarin pharmacokinetics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cytochrome P450 gene polymorphism and cancer. Agundez JA Curr Drug Metab. 2004 Jun;5(3):211-24.
2. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Aitken AE and Morgan ET, Drug Metab Dispos. 2007 Sep;35(9):1687-93. Epub 2007 Jun 18.
3. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation. Gonzalez FJ, etal., Mol Cell Biol 1986 Aug;6(8):2969-76.
6. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
7. Downregulation of intestinal cytochrome p450 in chronic renal failure. Leblond FA, etal., J Am Soc Nephrol. 2002 Jun;13(6):1579-85.
8. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Lytton SD, etal., Mol Pharmacol. 1999 Feb;55(2):223-33. doi: 10.1124/mol.55.2.223.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Structure of a gene and cDNA of a major constitutive form of testosterone 6 beta-hydroxylase (P450/6 beta A) encoding CYP3A2: comparison of the cDNA with P450PCN2. Miyata M, etal., Arch Biochem Biophys 1994 Nov 1;314(2):351-9.
11. Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear. Nishikawa H, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 May 9;31(4):926-31. Epub 2007 Feb 23.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices. Rekka E, etal., Biochem Pharmacol 2002 Aug 15;64(4):633-43.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. Yamada Y, etal., Stroke. 2008 Aug;39(8):2211-8. Epub 2008 Jun 19.
19. In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates. Zhao K, etal., J Pharm Pharmacol. 2012 Oct;64(10):1445-51. doi: 10.1111/j.2042-7158.2012.01516.x. Epub 2012 May 2.
Additional References at PubMed
PMID:1417000   PMID:2043144   PMID:2398038   PMID:7681660   PMID:10620362   PMID:12477932   PMID:17366318   PMID:17431772   PMID:17505019   PMID:18826641   PMID:18845914   PMID:19435144  
PMID:19504095   PMID:20166883   PMID:21895978   PMID:22159698   PMID:23235327   PMID:23406751   PMID:25038063   PMID:25866300   PMID:26913515   PMID:28288489   PMID:28419964   PMID:28555194  
PMID:29415952   PMID:34031539   PMID:34461081  


Genomics

Comparative Map Data
Cyp3a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,321,771 - 14,343,886 (-)NCBIGRCr8
mRatBN7.2129,207,978 - 9,230,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,009,578 - 10,031,654 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,632,755 - 10,654,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,656,186 - 9,678,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
CYP3A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,756,960 - 99,784,248 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBINCBI36Build 36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
CYP3A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,681,786 - 117,708,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,946,433 - 165,973,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,797,037 - 91,824,696 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,230,666 - 105,258,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,230,666 - 105,258,401 (-)Ensemblpanpan1.1panPan2
CYP3A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBIUU_Cfam_GSD_1.0
LOC103246766
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,297,566 - 13,330,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660702,940,765 - 2,971,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp3a2
235 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat


Genetic Models
This gene Cyp3a2 is modified in the following models/strains:
SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu    


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: NM_153312   ⟹   NP_695224
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,321,771 - 14,343,857 (-)NCBI
mRatBN7.2129,207,978 - 9,230,064 (-)NCBI
Rnor_6.01211,641,500 - 11,677,818 (-)NCBI
Rnor_5.01213,719,927 - 13,740,743 (-)NCBI
RGSC_v3.4129,517,016 - 9,541,000 (-)RGD
Celera1210,992,673 - 11,037,068 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271092   ⟹   XP_063127162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,321,779 - 14,343,886 (-)NCBI
RefSeq Acc Id: NP_695224   ⟸   NM_153312
- UniProtKB: Q64629 (UniProtKB/Swiss-Prot),   Q5FVU5 (UniProtKB/Swiss-Prot),   P05183 (UniProtKB/Swiss-Prot),   Q64672 (UniProtKB/Swiss-Prot),   A6K1D7 (UniProtKB/TrEMBL),   A0A8I6AL74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063127162   ⟸   XM_063271092
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL74 (UniProtKB/TrEMBL),   A0A0G2JT98 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05183-F1-model_v2 AlphaFold P05183 1-504 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708379 AgrOrtholog
BioCyc Gene G2FUF-20068 BioCyc
Ensembl Genes ENSRNOG00000032560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000062027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051244.2 UniProtKB/TrEMBL
  ENSRNOT00000071669.4 UniProtKB/TrEMBL
  ENSRNOT00000087257.2 UniProtKB/TrEMBL
  ENSRNOT00000099867.1 UniProtKB/TrEMBL
  ENSRNOT00000120620 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372112 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_P450_3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266682 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108545 IMAGE-MGC_LOAD
NCBI Gene 266682 ENTREZGENE
PANTHER CYTOCHROME P450 3A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp3a2 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032560 RatGTEx
  ENSRNOG00000062027 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JT98 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZZ45_RAT UniProtKB/TrEMBL
  A0A8I6AL74 ENTREZGENE, UniProtKB/TrEMBL
  A6K1D7 ENTREZGENE, UniProtKB/TrEMBL
  CP3A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVU5 ENTREZGENE
  Q64629 ENTREZGENE
  Q64672 ENTREZGENE
UniProt Secondary Q5FVU5 UniProtKB/Swiss-Prot
  Q64629 UniProtKB/Swiss-Prot
  Q64672 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp3a2  cytochrome P450, family 3, subfamily a, polypeptide 2  Cyp3a11  cytochrome P450, family 3, subfamily a, polypeptide 11  Name updated 1299863 APPROVED
2004-09-10 Cyp3a11  cytochrome P450, family 3, subfamily a, polypeptide 11  Cyp3a2  testosterone 6-beta-hydroxylase  Symbol and Name updated 1299863 APPROVED