Cyp3a2 (cytochrome P450, family 3, subfamily a, polypeptide 2) - Rat Genome Database
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Gene: Cyp3a2 (cytochrome P450, family 3, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
RGD ID: 708379
Description: Exhibits demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in drug metabolic process and oxidative demethylation. Predicted to localize to endoplasmic reticulum membrane and integral component of membrane. Used to study anxiety disorder. Biomarker of cholestasis and end stage renal disease. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-alpha-tocopherol; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp3a11; CYPIIIA2; cytochrome P450 3A2; cytochrome P450, family 3, subfamily a, polypeptide 11; cytochrome P450-PCN2; cytochrome P450/6-beta-A; MGC108545; P450-PCN2; P450/6-beta-A; testosterone 6-beta-hydroxylase
Orthologs:
No known orthologs. homologs ...
Allele / Splice: Cyp3a2em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethene  (EXP)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-(Methylthio)-1-propene  (EXP)
3-methylcholanthrene  (EXP)
3-oxo-5beta-cholanic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
6beta-hydroxytestosterone  (EXP)
acetamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP)
albendazole  (EXP)
allethrin  (EXP)
allyl alcohol  (EXP)
allyl isothiocyanate  (EXP)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
anthocyanin  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atorvastatin calcium  (EXP)
benzyl isothiocyanate  (EXP)
berberine  (EXP)
beta-naphthoflavone  (EXP)
Betanin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
Bromadiolone  (EXP)
budesonide  (EXP)
butan-1-ol  (EXP)
cafestol  (EXP)
calcitriol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carvedilol  (EXP)
chenodeoxycholic acid  (EXP)
chlorpyrifos  (EXP)
chlorzoxazone  (EXP)
cholic acid  (EXP)
ciprofibrate  (EXP)
climbazole  (EXP)
clofibric acid  (EXP)
clotrimazole  (EXP)
cordycepin  (EXP)
cortisol  (EXP)
coumarin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cyproconazole  (EXP)
daidzein  (EXP)
dapsone  (EXP)
DDT  (EXP)
dehydroepiandrosterone sulfate  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
diallyl disulfide  (EXP)
Diallyl sulfide  (EXP)
dibenziodolium  (EXP)
diethyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dioleoyl phosphatidylcholine  (EXP)
dipropyl disulfide  (EXP)
diquat  (EXP)
disulfiram  (EXP)
epoxiconazole  (EXP)
ethambutol  (EXP)
ethanol  (EXP)
farnesol  (EXP)
fipronil  (EXP)
fluoren-9-one  (EXP)
fluorene  (EXP)
flutamide  (EXP)
fulvestrant  (EXP)
furan  (EXP)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
Ginkgolide A  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glutathione  (EXP)
hexachlorobenzene  (EXP)
huperzine A  (EXP)
iberin  (EXP)
indometacin  (EXP)
isobavachalcone  (EXP)
isoniazide  (EXP)
kahweol  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-methionine  (EXP)
Lasiocarpine  (EXP)
lithocholic acid  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP)
metronidazole  (EXP)
midazolam  (EXP)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (EXP)
mono(2-ethyl-5-oxohexyl) phthalate  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (EXP)
musk xylene  (EXP)
N-nitrosodiethylamine  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nemorubicin  (EXP)
neobavaisoflavone  (EXP)
neomycin  (EXP)
nicotinamide  (EXP)
nicotine  (EXP)
nifedipine  (EXP)
nimesulide  (EXP)
octamethylcyclotetrasiloxane  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
oxycodone  (EXP)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
PhIP  (EXP)
phthalic acid  (EXP)
pioglitazone  (EXP)
polymyxin B2  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
profenofos  (EXP)
propiconazole  (EXP)
psoralidin  (EXP)
pyrazinecarboxamide  (EXP)
pyridine  (EXP)
pyrrolidines  (EXP)
riddelliine  (EXP)
rifampicin  (EXP)
S-allylcysteine  (EXP)
semicarbazide  (EXP)
Shikonin  (EXP)
simvastatin  (EXP)
sodium cholate  (EXP)
styrene  (EXP)
Sudan III  (EXP)
sulfamethoxazole  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
tacrine  (EXP)
tamoxifen  (EXP)
taurocholic acid  (EXP)
tert-butyl ethyl ether  (EXP)
testosterone  (EXP)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP)
transfluthrin  (EXP)
trazodone  (EXP)
triadimefon  (EXP)
triclosan  (EXP)
Triptolide  (EXP)
troglitazone  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
vancomycin  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (EXP)
zearalenone  (EXP)
zidovudine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1417000   PMID:2043144   PMID:2398038   PMID:7681660   PMID:12477932   PMID:17366318   PMID:17431772   PMID:17505019   PMID:18826641   PMID:18845914   PMID:19435144   PMID:19504095  
PMID:20166883   PMID:21895978   PMID:22159698   PMID:23235327   PMID:23406751   PMID:25038063   PMID:25866300   PMID:26913515   PMID:28288489   PMID:28419964   PMID:28555194   PMID:29415952  


Genomics


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12111765163Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12122650917Rat
10450854Stl34Serum triglyceride level QTL 343.50.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)12122853017Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12123035872Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123758197Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12130749723Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12136919844Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12138334225Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)1215081045150810Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1215081045150810Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)1249257845492578Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12247568747475687Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12251344247513442Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12251344247513442Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12540609412355490Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12824960820590080Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12895459327911196Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12978983452716770Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121017588931975590Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)121025689031723732Rat


Genetic Models
This gene Cyp3a2 is modified in the following models/strains

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_153312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07035371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07035372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07035373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07035374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07035375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01071152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01071153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01071154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U09742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_153312   ⟹   NP_695224
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01211,641,500 - 11,677,818 (-)NCBI
Rnor_5.01213,719,927 - 13,740,743 (-)NCBI
RGSC_v3.4129,517,016 - 9,541,000 (-)RGD
Celera1210,992,673 - 11,037,068 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_695224   ⟸   NM_153312
- UniProtKB: P05183 (UniProtKB/Swiss-Prot)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708379 AgrOrtholog
Ensembl Genes ENSRNOG00000032560 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000068625 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087257 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7372112 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266682 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108545 IMAGE-MGC_LOAD
NCBI Gene 266682 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp3a2 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.225885 ENTREZGENE
UniProt A0A0G2JT98_RAT UniProtKB/TrEMBL
  CP3A2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5FVU5 UniProtKB/Swiss-Prot
  Q64629 UniProtKB/Swiss-Prot
  Q64672 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp3a2  cytochrome P450, family 3, subfamily a, polypeptide 2  Cyp3a11  cytochrome P450, family 3, subfamily a, polypeptide 11  Name updated 1299863 APPROVED
2004-09-10 Cyp3a11  cytochrome P450, family 3, subfamily a, polypeptide 11  Cyp3a2  testosterone 6-beta-hydroxylase  Symbol and Name updated 1299863 APPROVED