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Gene: Cyp3a2 (cytochrome P450, family 3, subfamily a, polypeptide 2) Rattus norvegicus
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Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Description: Exhibits demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in drug metabolic process and oxidative demethylation. Predicted to localize to the endoplasmic reticulum membrane. Used to study anxiety disorder. Biomarker of cholestasis and end stage renal failure. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; essential hypertension; precursor B lymphoblastic lymphoma/leukemia; and precursor lymphoblastic lymphoma/leukemia. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-alpha-tocopherol; (2-trans,6-trans)-farnesol; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cyp3a11; CYPIIIA2; cytochrome P450 3A2; cytochrome P450, family 3, subfamily a, polypeptide 11; cytochrome P450-PCN2; cytochrome P450/6-beta-A; MGC108545; P450-PCN2; P450/6-beta-A; testosterone 6-beta-hydroxylase
Orthologs:
No known orthologs. homologs ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

QTLs in Region (Rnor_6.0)

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Cyp3a2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708379
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.