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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:223316
Term: (+)-artemisinin
Definition: A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.
Chemical ID: MESH:C031327
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the metabolism of artemisininPMID:12920490
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDartemisinin results in increased expression of CYP3A4 mRNAPMID:15761118 PMID:18332078
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNAPMID:17041008
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