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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2decreases expressionISOCYP3A4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CYP3A4 mRNAPMID:32234424
Cyp3a2increases expressionISOCYP3A4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CYP3A4 mRNAPMID:16545412 PMID:31096615
Cyp3a2increases metabolic processingISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein results in increased metabolism of Benzo(a)pyrenePMID:2509067
Cyp3a2increases methylationISOCYP3A4 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of CYP3A4 promoterPMID:27901495
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene; [Benzo(a)pyrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP3A4 protein results in increased metabolism of Benzo(a)pyrene] which results in increased chemical synthesis of benzo(a)pyrene 7,8-dihydrodiolPMID:23845848 PMID:2509067 PMID:27913846
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