GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | multiple interactions | EXP | | 6480464 | CTD | [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] | PMID:19501153 PMID:27919644 | Cyp3a2 | decreases activity | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Isoniazid results in decreased activity of CYP3A4 protein | PMID:15005856 PMID:15304522 | Cyp3a2 | increases response to substance | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | CYP3A4 protein results in increased susceptibility to Isoniazid | PMID:21540358 | | ||||||||||||||||||||||
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