GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp3a2 | increases expression | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | Corticosterone results in increased expression of CYP3A4 mRNA; Corticosterone results in increased expression of CYP3A4 protein | PMID:12072427 PMID:35301062 | Cyp3a2 | multiple interactions | ISO | CYP3A4 (Homo sapiens) | 6480464 | CTD | [Corticosterone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA; Corticosterone promotes the reaction [[NCOA1 protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]; Ketoconazole inhibits the reaction [Corticosterone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Ketoconazole inhibits the reaction [Corticosterone results in increased expression of CYP3A4 mRNA] | PMID:11581012 PMID:12072427 PMID:12851153 | |
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