CYP3A4 (cytochrome P450 family 3 subfamily A member 4) - Rat Genome Database
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Gene: CYP3A4 (cytochrome P450 family 3 subfamily A member 4) Homo sapiens
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
RGD ID: 1352962
Description: Exhibits several functions, including caffeine oxidase activity; iron ion binding activity; and monooxygenase activity. Involved in several processes, including cellular hormone metabolic process; exogenous drug catabolic process; and lipid hydroxylation. Localizes to cytoplasm. Implicated in familial Mediterranean fever.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole monooxygenase (sulfoxide-forming); albendazole sulfoxidase; cholesterol 25-hydroxylase; CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; cytochrome P450 3A3; cytochrome P450 3A4; cytochrome P450 HLp; cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450-PCN1; glucocorticoid-inducible P450; HLP; MGC126680; NF-25; nifedipine oxidase; P450-III, steroid inducible; P450C3; P450PCN1; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; VDDR3
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl799,756,960 - 99,784,248 (-)EnsemblGRCh38hg38GRCh38
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBINCBI36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP)
(+)-artemisinin  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (EXP)
(+)-trans-(S)-allethrin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-trans-epsilon-viniferin  (EXP)
(24S)-24-hydroxycholesterol  (EXP)
(3-phenoxyphenyl)methanol  (EXP)
(E)-roxithromycin  (EXP)
(E)-thiamethoxam  (EXP)
(R)-lipoic acid  (EXP)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
(Z)-ligustilide  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,3,5-tetrachlorobenzene  (EXP)
1,2-dichlorobenzene  (ISO)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP)
1,4-dichlorobenzene  (EXP)
1,4-naphthoquinone  (EXP)
1,6-Dinitropyrene  (EXP)
1,8-cineole  (EXP)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (EXP)
1-(3-chlorophenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
1-hydroxymidazolam  (EXP)
1-hydroxymidazolam beta-D-glucuronide  (EXP)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
13-cis-retinal  (EXP)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2'-deoxyguanosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxychrysophanol  (EXP)
2-methyl-1H-indole  (EXP)
2-naphthol  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-hydroxyquinine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (EXP)
4-bromo-2-chlorophenol  (EXP)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
4-hydroxycyclophosphamide  (EXP)
4-hydroxymidazolam  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-isopropylphenol  (EXP)
4beta-hydroxycholesterol  (EXP)
5,6-EET  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (EXP)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
5-hydroxydiclofenac  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxyindole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-chrysenamine  (EXP)
6-Hydroxyflavone  (EXP)
6alpha-methylprednisolone  (EXP)
6beta-hydroxycortisol  (EXP)
6beta-hydroxytestosterone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
7-hydroxyflavone  (EXP)
8,9-EET  (EXP)
9-cis-retinal  (EXP)
9-cis-retinoic acid  (EXP)
9-hydroxyellipticine  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (EXP)
acenaphthylene  (EXP)
acetamide  (ISO)
acetochlor  (EXP)
aconitine  (EXP)
acrolein  (EXP)
actinomycin D  (EXP)
adefovir pivoxil  (EXP)
adinazolam  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aflatoxin B1 exo-8,9-epoxide  (EXP)
Aflatoxin G1  (EXP)
aflatoxin M1  (EXP)
aflatoxin Q1  (EXP)
ajmalicine  (EXP)
ajmaline  (EXP)
alachlor  (EXP)
albendazole  (EXP,ISO)
alcohol  (EXP)
aldrin  (EXP)
alfacalcidol  (EXP)
alfentanil  (EXP)
all-trans-4-hydroxyretinoic acid  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
allyl isothiocyanate  (EXP,ISO)
allyl methyl disulfide  (EXP)
almotriptan  (EXP)
Aloe emodin  (EXP)
alpha-linolenic acid  (EXP)
alpha-naphthoflavone  (EXP)
alpha-santonin  (EXP)
alpha-tocotrienol  (EXP)
alprazolam  (EXP)
Amaranth  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amodiaquine  (EXP)
amoxapine  (EXP)
amphetamine  (EXP)
amprenavir  (EXP)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arachidonic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
Asiaticoside  (EXP)
aspartame  (ISO)
astemizole  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
axitinib  (EXP)
azithromycin  (EXP)
azoxystrobin  (EXP)
baicalein  (EXP)
barbiturates  (EXP)
barnidipine  (EXP)
benfuracarb  (EXP)
benidipine  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[c]phenanthrene  (EXP)
benzphetamine  (EXP)
bepridil  (EXP)
berberine  (EXP,ISO)
bergomottin  (EXP)
Besigomsin  (EXP)
beta-carboline  (EXP)
beta-carotene  (EXP)
beta-naphthoflavone  (EXP,ISO)
beta-tocotrienol  (EXP)
bifenthrin  (EXP)
bifonazole  (EXP)
bilirubin IXalpha  (EXP)
bioresmethrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bortezomib  (EXP)
bosentan  (EXP)
bromfenac  (EXP)
bromocriptine  (EXP)
bromodichloromethane  (EXP)
Brotizolam  (EXP)
budesonide  (EXP)
bufalin  (EXP)
bufogenin  (EXP)
buprenorphine  (EXP)
buspirone  (EXP)
butachlor  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cabozantinib  (EXP)
caffeine  (EXP)
calciol  (EXP)
calcitriol  (EXP)
camptothecin  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP)
captan  (EXP)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (EXP)
carbaryl  (EXP)
carbendazim  (EXP)
carbofuran  (EXP)
carbosulfan  (EXP)
carmustine  (EXP)
cefaclor  (EXP)
cefadroxil  (EXP)
cerivastatin  (EXP)
cetirizine  (EXP)
chelidonine  (EXP)
chenodeoxycholic acid  (EXP)
CHIR 99021  (EXP)
chitosan  (EXP)
chloramphenicol  (EXP)
chlordecone  (EXP)
chlorfenvinfos  (EXP)
chlorfluazuron  (EXP)
chloroquine  (EXP)
chlorpromazine  (EXP)
chlorpropham  (EXP)
chlorpyrifos  (EXP)
cholesterol  (EXP)
cholic acid  (EXP)
chrysin  (EXP)
chrysophanol  (EXP)
chrysosplenetin  (EXP)
cimetidine  (EXP)
cinitapride  (EXP)
Cinobufagin  (EXP)
ciprofloxacin  (EXP)
cisapride  (EXP)
cisplatin  (EXP)
citalopram  (EXP)
citral  (EXP)
Citreorosein  (EXP)
clarithromycin  (EXP)
clemizole  (EXP)
clindamycin  (EXP)
clobetasol  (EXP)
clofibric acid  (EXP)
Clofop  (EXP)
clomiphene  (EXP)
clopidogrel  (EXP)
clothianidin  (EXP)