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Gene: CYP3A5 (cytochrome P450 family 3 subfamily A member 5) Homo sapiens
Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
Description: Exhibits estrogen 16-alpha-hydroxylase activity and retinoic acid 4-hydroxylase activity. Involved in several processes, including cellular hormone metabolic process; lipid hydroxylation; and oxidative demethylation. Predicted to localize to the endoplasmic reticulum membrane and intracellular membrane-bounded organelle. Implicated in chronic myeloid leukemia; essential hypertension; precursor B lymphoblastic lymphoma/leukemia; and precursor lymphoblastic lymphoma/leukemia. Biomarker of precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; CP35; CYPIIIA5; cytochrome P-450; cytochrome P450 3A5; cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450-PCN3; DKFZp686L16231; flavoprotein-linked monooxygenase; FLJ31317; microsomal monooxygenase; niphedipine oxidase; P450PCN3; P450PCN3.; PCN3; xenobiotic monooxygenase
Related Pseudogenes: CYP3A51P   CYP3A52P   CYP3A54P   CYP3AP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl799,648,194 - 99,679,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,245,813 - 99,277,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,906 - 99,207,748 (-)NCBICHM1_1
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP3A5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348646
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.