CYP3A5 (cytochrome P450 family 3 subfamily A member 5) - Rat Genome Database

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Gene: CYP3A5 (cytochrome P450 family 3 subfamily A member 5) Homo sapiens
Analyze
Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
RGD ID: 1348646
HGNC Page HGNC:2638
Description: Enables estrogen 16-alpha-hydroxylase activity and retinoic acid 4-hydroxylase activity. Involved in several processes, including estrogen metabolic process; lipid hydroxylation; and retinoic acid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Biomarker of acute lymphoblastic leukemia and oral submucous fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: aryl hydrocarbon hydroxylase; CP35; CYPIIIA5; cytochrome P-450; cytochrome P450 3A5; cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450-PCN3; DKFZp686L16231; flavoprotein-linked monooxygenase; FLJ31317; microsomal monooxygenase; niphedipine oxidase; P450PCN3; P450PCN3.; PCN3; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CYP3A51P   CYP3A52P   CYP3A54P   CYP3AP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,648,194 - 99,679,996 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
CYP3A5Humanacute lymphoblastic leukemia disease_progressionIEP 11353796 RGD 
CYP3A5Humanacute lymphoblastic leukemia susceptibilityIAGP 11353805DNA:polymorphism: :RGD 
CYP3A5HumanB-lymphoblastic leukemia/lymphoma treatmentIAGP 11353807DNA:polymorphisms: :RGD 
CYP3A5HumanChemotherapy-Induced Febrile Neutropenia susceptibilityIAGP 11353804associated with breast neoplasm and DNA:polymorphism:splice junction:6986A>G (human)RGD 
CYP3A5Humanchronic myeloid leukemia susceptibilityIAGP 11353798DNA:polymorphism:intron :6986A>G (human)RGD 
CYP3A5Humanchronic myeloid leukemia treatmentIAGP 11353810DNA:SNP:: (rs776746) (human)RGD 
CYP3A5HumanDrug-Induced Leukopenia susceptibilityIAGP 11353800associated with Ovarian Neoplasms: DNA:polymorphism: :RGD 
CYP3A5HumanDrug-induced Neutropenia susceptibilityIAGP 11353800associated with Ovarian Neoplasms: DNA:polymorphism: :RGD 
CYP3A5HumanDrug-induced Neutropenia susceptibilityIAGP 11353804associated with breast neoplasm and DNA:polymorphism:splice junction:6986A>G (human)RGD 
CYP3A5Humanliver cirrhosis  ISOCyp3a9 (Rattus norvegicus)405820211mRNA:increased expression:liver (rat)RGD 
CYP3A5HumanMyeloid Leukemia, Chronic-Phase treatmentIAGP 11353797DNA:polymorphism:intron :6986A>G (human)RGD 
CYP3A5Humanoral submucous fibrosis  IEP 405847407mRNA:decreased expression:buccal mucosaRGD 
CYP3A5HumanPediatric Crohn's Disease  IEP 5685614mRNA:increased expression:duodenum:non-inflamed tissueRGD 
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CYP3A5Humanessential hypertension  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertension more ...ClinVarPMID:11279519 more ...
CYP3A5Humanessential hypertension  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: CYP3A5-related conditionClinVar 
CYP3A5Humanmyasthenia gravis  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: refractory myasthenia gravisClinVarPMID:11279519 more ...
CYP3A5Humanpleomorphic xanthoastrocytoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
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CYP3A5Humanautism spectrum disorder  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
CYP3A5Humanessential hypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
CYP3A5HumanExperimental Liver Cirrhosis  ISOCyp3a9 (Rattus norvegicus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
CYP3A5HumanExperimental Liver Cirrhosis  ISOCyp3a13 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980
CYP3A5Humankidney disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18408564 and PMID:20526235
CYP3A5Humannephrosis  ISOCyp3a9 (Rattus norvegicus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18725544
CYP3A5HumanProstatic Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:18306354
CYP3A5HumanReperfusion Injury  ISOCyp3a9 (Rattus norvegicus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22749977
CYP3A5Humanthrombosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16754899
CYP3A5Humantoxic encephalopathy  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:21225912
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CYP3A5Humanessential hypertension susceptibilityIAGP 7240710 OMIM 

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CYP3A5Human(+)-catechin multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
CYP3A5Human(+)-epicatechin-3-O-gallate multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
CYP3A5Human(+)-Tetrandrine increases glutathionylationEXP 6480464CYP3A5 protein results in increased glutathionylation of tetrandrineCTDPMID:21992520
CYP3A5Human(+)-Tetrandrine multiple interactionsEXP 6480464CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] more ...CTDPMID:26302866
CYP3A5Human(+)-Tetrandrine increases response to substanceEXP 6480464CYP3A5 protein results in increased susceptibility to tetrandrineCTDPMID:26302866
CYP3A5Human(-)-epigallocatechin 3-gallate multiple interactionsISOCyp3a13 (Mus musculus)6480464[Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of CYP3A13 mRNACTDPMID:25663641
CYP3A5Human(1->4)-beta-D-glucan multiple interactionsISOCyp3a13 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYP3A13 mRNACTDPMID:36331819
CYP3A5Human(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464alpha-Tocopherol inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]CTDPMID:31102695
CYP3A5Human(R,R,R)-alpha-tocopherol increases expressionISOCyp3a13 (Mus musculus)6480464alpha-Tocopherol results in increased expression of CYP3A13 mRNA and alpha-Tocopherol results in increased expression of CYP3A13 proteinCTDPMID:26102010
CYP3A5Human1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylationEXP 6480464CYP3A5 protein results in increased hydroxylation of 1 more ...CTDPMID:12167570
CYP3A5Human1,2-dichloroethane increases expressionISOCyp3a13 (Mus musculus)6480464ethylene dichloride results in increased expression of CYP3A13 mRNACTDPMID:28960355
CYP3A5Human1,2-dimethylhydrazine decreases expressionISOCyp3a13 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of CYP3A13 mRNACTDPMID:22206623
CYP3A5Human1,4-naphthoquinone increases abundanceEXP 6480464CYP3A5 protein results in increased abundance of 1 and 4-naphthoquinoneCTDPMID:16243959
CYP3A5Human1,8-cineole increases hydroxylationEXP 6480464CYP3A5 protein results in increased hydroxylation of EucalyptolCTDPMID:15715982
CYP3A5Human1-aminobenzotriazole multiple interactionsEXP 64804641-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]CTDPMID:24555085
CYP3A5Human1-hydroxymidazolam increases chemical synthesisEXP 6480464CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolamCTDPMID:18191104 and PMID:26958860
CYP3A5Human1-hydroxymidazolam multiple interactionsEXP 6480464[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]CTDPMID:34189909
CYP3A5Human1-naphthol increases abundanceEXP 6480464CYP3A5 protein results in increased abundance of 1-naphtholCTDPMID:16243959
CYP3A5Human1-naphthyl isothiocyanate decreases expressionISOCyp3a9 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of CYP3A9 mRNACTDPMID:25380136 and PMID:30723492
CYP3A5Human17alpha-ethynylestradiol increases hydroxylationEXP 6480464CYP3A5 protein results in increased hydroxylation of Ethinyl EstradiolCTDPMID:15304426

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Biological Process
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CYP3A5Humanaflatoxin metabolic process involved_inTAS 150520179 ReactomeReactome:R-HSA-5423646
CYP3A5Humanalkaloid catabolic process involved_inIDA 150520179 PMID:15039299BHF-UCLPMID:15039299
CYP3A5Humanestrogen metabolic process involved_inIDA 150520179 PMID:12865317UniProtPMID:12865317
CYP3A5Humanfemale pregnancy  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:12606633 and REF_RGD_ID:1299416
CYP3A5Humanlipid hydroxylation involved_inIDA 150520179 PMID:14559847BHF-UCLPMID:14559847
CYP3A5Humanlipid metabolic process involved_inIEAUniProtKB-KW:KW-0443150520179 UniProtGO_REF:0000043
CYP3A5Humanoxidative demethylation involved_inIBAPANTHER:PTN001548724 more ...150520179 GO_CentralGO_REF:0000033
CYP3A5Humanoxidative demethylation involved_inIDA 150520179 PMID:15039299BHF-UCLPMID:15039299
CYP3A5Humanpositive regulation of gene expression acts_upstream_of_or_withinISOMGI:37644869068941 PMID:18794335MGIPMID:18794335
CYP3A5Humanresponse to dexamethasone  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:8990268 and REF_RGD_ID:11353812
CYP3A5Humanresponse to estradiol  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:10570034 and REF_RGD_ID:11353816
CYP3A5Humanresponse to estrogen  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:9264551 and REF_RGD_ID:11353813
CYP3A5Humanresponse to ethanol  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:11046114 and REF_RGD_ID:11353817
CYP3A5Humanresponse to zinc ion  ISOCyp3a9 (Rattus norvegicus)9068941 RGDPMID:11705462 and REF_RGD_ID:11353814
CYP3A5Humanretinoic acid metabolic process involved_inIDA 150520179 PMID:11093772UniProtPMID:11093772
CYP3A5Humanretinol metabolic process involved_inIEAUniPathway:UPA00912150520179 UniProtGO_REF:0000041
CYP3A5Humansmall molecule metabolic process involved_inIEAARBA:ARBA00028529150520179 UniProtGO_REF:0000117
CYP3A5Humansteroid metabolic process involved_inTAS 150520179 PMID:2732228PINCPMID:2732228
CYP3A5Humansteroid metabolic process involved_inIBAPANTHER:PTN001548724 more ...150520179 GO_CentralGO_REF:0000033
CYP3A5Humansteroid metabolic process involved_inIEAUniProtKB-KW:KW-0753150520179 UniProtGO_REF:0000043
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Cellular Component

  
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CYP3A5Humanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
CYP3A5Humanendoplasmic reticulum membrane located_inTAS 150520179 ReactomeReactome:R-HSA-156526 more ...
CYP3A5Humanendoplasmic reticulum membrane located_inIEAARBA:ARBA00028685150520179 UniProtGO_REF:0000117
CYP3A5Humanendoplasmic reticulum membrane located_inIEAUniRule:UR001528761150520179 UniProtGO_REF:0000104
CYP3A5Humanendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
CYP3A5Humanintracellular membrane-bounded organelle located_inTAS 150520179 PMID:2732228PINCPMID:2732228
CYP3A5Humanintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-0492150520179 UniProtGO_REF:0000043
CYP3A5Humanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043

Molecular Function
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CYP3A5Humanestrogen 16-alpha-hydroxylase activity enablesIDA 150520179 PMID:14559847BHF-UCLPMID:14559847
CYP3A5Humanestrogen 16-alpha-hydroxylase activity enablesIBAPANTHER:PTN000671091 more ...150520179 GO_CentralGO_REF:0000033
CYP3A5Humanestrogen 2-hydroxylase activity enablesIEARHEA:47208 and RHEA:47212150520179 RHEAGO_REF:0000116
CYP3A5Humanheme binding enablesIEAInterPro:IPR001128 more ...150520179 InterProGO_REF:0000002
CYP3A5Humanheme binding enablesIEAUniRule:UR001528761150520179 UniProtGO_REF:0000104
CYP3A5Humaniron ion binding enablesIEAUniRule:UR001528761150520179 UniProtGO_REF:0000104
CYP3A5Humaniron ion binding enablesIEAInterPro:IPR001128 more ...150520179 InterProGO_REF:0000002
CYP3A5Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
CYP3A5Humanmonooxygenase activity enablesISSUniProtKB:Q86SK3150520179 UniProtGO_REF:0000024
CYP3A5Humanmonooxygenase activity enablesIEAInterPro:IPR001128 more ...150520179 InterProGO_REF:0000002
CYP3A5Humanmonooxygenase activity enablesIEAUniProtKB-KW:KW-0503150520179 UniProtGO_REF:0000043
CYP3A5Humanmonooxygenase activity enablesTAS 150520179 PMID:2732228PINCPMID:2732228 more ...
CYP3A5Humanoxidoreductase activity enablesIEAUniProtKB-KW:KW-0560150520179 UniProtGO_REF:0000043
CYP3A5Humanoxidoreductase activity enablesIDA 150520179 PMID:15039299BHF-UCLPMID:15039299
CYP3A5Humanoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen enablesIEAInterPro:IPR001128 more ...150520179 InterProGO_REF:0000002
CYP3A5Humanoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAInterPro:IPR008072150520179 InterProGO_REF:0000002
CYP3A5Humanoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEARHEA:17149150520179 RHEAGO_REF:0000116
CYP3A5Humanoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen enablesIEAEC:1.14.14.1150520179 UniProtGO_REF:0000003
CYP3A5Humanoxygen binding enablesTAS 150520179 PMID:2732228PINCPMID:2732228
CYP3A5Humanprotein binding enablesIPIUniProtKB:P42858150520179 PMID:32814053IntActPMID:32814053
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RGD Manual Annotations


  
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CYP3A5Humanaxitinib pharmacokinetics pathway   TAS 6907361 RGD 
CYP3A5Humangefitinib pharmacokinetics pathway   TAS 5135288 RGD 
CYP3A5Humantamoxifen pharmacokinetics pathway   IDA 5129544 RGD 

Imported Annotations - SMPDB

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CYP3A5Humanartemether pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00651
CYP3A5Humancarbamazepine pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00634
CYP3A5Humanclopidogrel pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00260
CYP3A5Humanclopidogrel pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00610
CYP3A5Humanetoposide pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00442
CYP3A5Humanetoposide pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00601
CYP3A5Humanfluoxetine pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00426
CYP3A5Humanfluoxetine pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00646
CYP3A5Humanifosfamide pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00448
CYP3A5Humanifosfamide pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00605
CYP3A5Humanirinotecan pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00433
CYP3A5Humanirinotecan pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00600
CYP3A5Humanmycophenolic acid pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00652
CYP3A5Humanneviparine pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00642
CYP3A5Humanretinol metabolic pathway   EXP 10402751 SMPDBSMP:00074
CYP3A5Humantamoxifen pharmacodynamics pathway   EXP 10402751 SMPDBSMP:00471
CYP3A5Humantamoxifen pharmacokinetics pathway   EXP 10402751 SMPDBSMP:00606
CYP3A5Humanteniposide pharmacodynamics pathway  EXP 10402751 SMPDBSMP:00443
CYP3A5Humanteniposide pharmacokinetics pathway  EXP 10402751 SMPDBSMP:00602
CYP3A5Humanvitamin A deficiency pathway  EXP 10402751 SMPDBSMP:00336
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Imported Annotations - KEGG (archival)

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CYP3A5Humanlinoleic acid metabolic pathway  IEA 6907045 KEGGhsa:00591
CYP3A5Humanretinol metabolic pathway   IEA 6907045 KEGGhsa:00830
CYP3A5Humansteroid hormone biosynthetic pathway   IEA 6907045 KEGGhsa:00140
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CYP3A5HumanPositive methadone plasma/serum test exacerbatesIAGP 405849355DNA:SNP:intron: (rs776746)RGD 
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CYP3A5HumanPleomorphic xanthoastrocytoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358

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Reference Title
Reference Citation
1. Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy? Bedewy AM and El-Maghraby SM, Hematology. 2013 Jul;18(4):211-6. doi: 10.1179/1607845412Y.0000000067. Epub 2013 Jan 31.
2. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
3. Effects of liver fibrosis on verapamil pharmacokinetics in rats. Chen M, etal., Clin Exp Pharmacol Physiol. 2008 Mar;35(3):287-94. doi: 10.1111/j.1440-1681.2007.04826.x. Epub 2007 Oct 31.
4. Increased risk of vincristine neurotoxicity associated with low CYP3A5 expression genotype in children with acute lymphoblastic leukemia. Egbelakin A, etal., Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11.
5. Impact of inflammation on the duodenal mRNA expression of CYP3A and P-glycoprotein in children with Crohn's disease. Fakhoury M, etal., Inflamm Bowel Dis. 2006 Aug;12(8):745-9.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Impact of CYP3A5*3 and CYP2C8-HapC on paclitaxel/carboplatin-induced myelosuppression in patients with ovarian cancer. Green H, etal., J Pharm Sci. 2011 Oct;100(10):4205-9. doi: 10.1002/jps.22680. Epub 2011 Jun 23.
8. [Expression of CYP3A5 mRNA in children with acute leukemia]. Huang Z, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):549-54.
9. Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia. Kim DH, etal., Clin Cancer Res. 2009 Jul 15;15(14):4750-8. doi: 10.1158/1078-0432.CCR-09-0145. Epub 2009 Jul 7.
10. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
11. Combined Effect of CYP2B6 Genotype and Other Candidate Genes on a Steady-State Serum Concentration of Methadone in Opioid Maintenance Treatment. Kringen MK, etal., Ther Drug Monit. 2017 Oct;39(5):550-555. doi: 10.1097/FTD.0000000000000437.
12. Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment? Magliulo L, etal., Eur J Clin Pharmacol. 2011 Jan;67(1):47-54. Epub 2010 Oct 8.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Analysis of CYP3A5*3 and CYP3A5*6 gene polymorphisms in Indian chronic myeloid leukemia patients. Sailaja K, etal., Asian Pac J Cancer Prev. 2010;11(3):781-4.
18. CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcome. Silveira VS, etal., Mol Cell Biochem. 2012 May;364(1-2):217-23. doi: 10.1007/s11010-011-1220-8. Epub 2012 Jan 4.
19. Side effects after docetaxel treatment in Taiwanese breast cancer patients with CYP3A4, CYP3A5, and ABCB1 gene polymorphisms. Tsai SM, etal., Clin Chim Acta. 2009 Jun 27;404(2):160-5. doi: 10.1016/j.cca.2009.03.038. Epub 2009 Mar 28.
20. Clinical pharmacokinetics of tyrosine kinase inhibitors. van Erp NP, etal., Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5.
1 to 20 of 21 rows
1 to 10 of 63 rows
PMID:2732228   PMID:2802615   PMID:7750548   PMID:7811260   PMID:7883227   PMID:7894497   PMID:7895614   PMID:8004129   PMID:8125298   PMID:8569713   PMID:8619878   PMID:8619884  
PMID:8694864   PMID:8869826   PMID:8877031   PMID:8889549   PMID:8946469   PMID:9070608   PMID:9364212   PMID:9797707   PMID:9890157   PMID:10069460   PMID:10403825   PMID:11093772  
PMID:11137287   PMID:11266076   PMID:11279519   PMID:11502729   PMID:11726664   PMID:11740341   PMID:11809184   PMID:11836601   PMID:12042671   PMID:12202670   PMID:12242601   PMID:12324482  
PMID:12433824   PMID:12439220   PMID:12477932   PMID:12690205   PMID:12692107   PMID:12694732   PMID:12754175   PMID:12756511   PMID:12814460   PMID:12822676   PMID:12853948   PMID:12865317  
PMID:12893984   PMID:12960109   PMID:12966368   PMID:12969965   PMID:12975492   PMID:14504207   PMID:14515058   PMID:14515059   PMID:14559847   PMID:14647405   PMID:14676821   PMID:14702039  
PMID:14747421   PMID:14961555   PMID:15039299   PMID:15114431   PMID:15116055   PMID:15128046   PMID:15167702   PMID:15226679   PMID:15248218   PMID:15252010   PMID:15284534   PMID:15289787  
PMID:15319333   PMID:15385835   PMID:15454734   PMID:15469410   PMID:15489334   PMID:15502717   PMID:15548719   PMID:15592326   PMID:15596297   PMID:15596575   PMID:15622315   PMID:15632378  
PMID:15634941   PMID:15698606   PMID:15707415   PMID:15708542   PMID:15729180   PMID:15801936   PMID:15808586   PMID:15814280   PMID:15833928   PMID:15876487   PMID:15882469   PMID:15900215  
PMID:15900284   PMID:15919447   PMID:15931768   PMID:15952872   PMID:15961978   PMID:15978331   PMID:15981231   PMID:16004554   PMID:16024008   PMID:16086282   PMID:16116487   PMID:16141800  
PMID:16160620   PMID:16168193   PMID:16172230   PMID:16188140   PMID:16207150   PMID:16243813   PMID:16249748   PMID:16253141   PMID:16267764   PMID:16272171   PMID:16272955   PMID:16299241  
1 to 10 of 63 rows



CYP3A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,648,194 - 99,679,996 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
Cyp3a13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,891,195 - 137,923,872 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,891,194 - 137,919,881 (-)EnsemblGRCm39 Ensembl
GRCm385137,892,933 - 137,925,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,892,932 - 137,921,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,334,161 - 138,362,847 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,122,721 - 138,151,405 (-)NCBIMGSCv36mm8
Celera5134,879,058 - 134,907,700 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.89NCBI
Cyp3a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,919,955 - 21,960,160 (-)NCBIGRCr8
mRatBN7.21216,806,222 - 16,846,428 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,806,207 - 16,846,422 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,636,912 - 17,677,023 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,260,644 - 18,300,755 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01217,314,042 - 17,354,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Celera1218,744,706 - 18,784,438 (-)NCBICelera
Cytogenetic Map12q11NCBI
CYP3A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,505,661 - 117,538,312 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,770,036 - 165,802,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,621,561 - 91,654,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,123,437 - 105,155,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,123,437 - 105,155,322 (-)Ensemblpanpan1.1panPan2
CYP3A22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl36,615,343 - 6,822,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.136,617,256 - 6,665,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP3A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,473,649 - 13,517,905 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,491,483 - 13,519,507 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660702,792,815 - 2,818,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in CYP3A5
48 total Variants

1 to 10 of 76 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_000777.5(CYP3A5):c.219-237A>G single nucleotide variant Hypertension, salt-sensitive essential, susceptibility to [RCV000005370]|Tacrolimus response [RCV002292440]|refractory myasthenia gravis [RCV002227926] Chr7:99672916 [GRCh38]
Chr7:99270539 [GRCh37]
Chr7:7q22.1		 risk factor|association|drug response
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
NM_000777.5(CYP3A5):c.219-237= single nucleotide variant not provided [RCV000830072] Chr7:99672916 [GRCh38]
Chr7:99270539 [GRCh37]
Chr7:7q22.1		 benign|drug response
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
GRCh38/hg38 7q22.1(chr7:99195836-100348063)x3 copy number gain See cases [RCV000135630] Chr7:99195836..100348063 [GRCh38]
Chr7:98793459..99945686 [GRCh37]
Chr7:98631395..99783622 [NCBI36]
Chr7:7q22.1		 likely benign
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99643456-99913142)x3 copy number gain See cases [RCV000140269] Chr7:99643456..99913142 [GRCh38]
Chr7:99241079..99510765 [GRCh37]
Chr7:99079015..99348701 [NCBI36]
Chr7:7q22.1		 likely benign
1 to 10 of 76 rows

Predicted Target Of
Summary Value
Count of predictions:2894
Count of miRNA genes:1141
Interacting mature miRNAs:1389
Transcripts:ENST00000222982, ENST00000339843, ENST00000343703, ENST00000439761, ENST00000456417, ENST00000461920, ENST00000463364, ENST00000463907, ENST00000466061, ENST00000469622, ENST00000469887, ENST00000473347, ENST00000480723, ENST00000481825, ENST00000488187, ENST00000489231
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597380186GWAS1476260_Hneutrophil count QTL GWAS1476260 (human)5e-10neutrophil quantity (VT:0000222)blood neutrophil count (CMO:0000030)79966869599668696Human
597481693GWAS1577767_Htacrolimus measurement QTL GWAS1577767 (human)1e-12tacrolimus measurement79967291699672917Human
597411738GWAS1507812_Hurinary metabolite measurement QTL GWAS1507812 (human)9e-30urinary metabolite measurement79967291699672917Human
596954390GWAS1073909_Hhypertension QTL GWAS1073909 (human)3e-08hypertension79966869599668696Human
597323166GWAS1419240_Hmethionine sulfone measurement QTL GWAS1419240 (human)2e-31methionine sulfone measurement79967669399676694Human
597349340GWAS1445414_Hblood metabolite measurement, X12063 measurement QTL GWAS1445414 (human)5e-50blood metabolite measurement, X12063 measurementblood metabolite measurement (CMO:0003699)79966869599668696Human
597526672GWAS1622746_Hmetabolonic lactone sulfate measurement QTL GWAS1622746 (human)6e-218metabolonic lactone sulfate measurement79967291699672917Human
597367817GWAS1463891_Htacrolimus measurement QTL GWAS1463891 (human)5e-35tacrolimus measurement79967291699672917Human
597407885GWAS1503959_Hmetabolite measurement QTL GWAS1503959 (human)5e-149metabolite measurement79967291699672917Human
597187202GWAS1283276_HX-17357 measurement QTL GWAS1283276 (human)2e-12X-17357 measurement79967669399676694Human

1 to 10 of 25 rows
D7S647  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,831 - 99,268,902UniSTSGRCh37
Celera794,003,066 - 94,003,137UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map7q21.1UniSTS
HuRef793,905,201 - 93,905,272UniSTS
CRA_TCAGchr7v2798,628,635 - 98,628,706UniSTS
Marshfield Genetic Map7112.32UniSTS
Marshfield Genetic Map7112.32RGD
Genethon Genetic Map7112.4UniSTS
Whitehead-YAC Contig Map7 UniSTS
SHGC-8697  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,251 - 99,268,350UniSTSGRCh37
Build 36799,106,187 - 99,106,286RGDNCBI36
Celera794,002,486 - 94,002,585RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,904,621 - 93,904,720UniSTS
CRA_TCAGchr7v2798,628,055 - 98,628,154UniSTS
GeneMap99-G3 RH Map74846.0UniSTS
RH123304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,258,197 - 99,258,489UniSTSGRCh37
Build 36799,096,133 - 99,096,425RGDNCBI36
Celera793,992,432 - 93,992,724RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,894,567 - 93,894,859UniSTS
CRA_TCAGchr7v2798,618,001 - 98,618,293UniSTS
TNG Radiation Hybrid Map742958.0UniSTS
D7S2874  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,361,364 - 99,361,528UniSTSGRCh37
GRCh37799,258,008 - 99,258,172UniSTSGRCh37
Build 36799,095,944 - 99,096,108RGDNCBI36
Celera793,992,243 - 93,992,407RGD
Celera794,095,609 - 94,095,773UniSTS
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,894,378 - 93,894,542UniSTS
HuRef793,997,792 - 93,997,956UniSTS
CRA_TCAGchr7v2798,617,812 - 98,617,976UniSTS
CRA_TCAGchr7v2798,721,177 - 98,721,341UniSTS
SHGC-1891  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,691 - 99,268,824UniSTSGRCh37
Build 36799,106,627 - 99,106,760RGDNCBI36
Celera794,002,926 - 94,003,059RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,905,061 - 93,905,194UniSTS
CRA_TCAGchr7v2798,628,495 - 98,628,628UniSTS
GeneMap99-G3 RH Map74864.0UniSTS
RH71343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,245,864 - 99,246,024UniSTSGRCh37
Build 36799,083,800 - 99,083,960RGDNCBI36
Celera793,980,093 - 93,980,253RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,882,230 - 93,882,390UniSTS
CRA_TCAGchr7v2798,605,659 - 98,605,819UniSTS
GeneMap99-GB4 RH Map7515.73UniSTS
RH45981  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,652 - 99,268,826UniSTSGRCh37
Build 36799,106,588 - 99,106,762RGDNCBI36
Celera794,002,887 - 94,003,061RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,905,022 - 93,905,196UniSTS
CRA_TCAGchr7v2798,628,456 - 98,628,630UniSTS
GeneMap99-GB4 RH Map7511.14UniSTS
D11S3059  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q24.3UniSTS
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map9q21.32UniSTS
Cytogenetic Map2p14UniSTS
D7S647  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2439 2788 2243 4952 1724 2347 5 622 1914 465 2267 7253 6420 52 3719 850 1739 1613 172


1 to 30 of 47 rows
RefSeq Transcripts NG_007938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_033807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA076026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF280107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC383127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 47 rows

Ensembl Acc Id: ENST00000222982   ⟹   ENSP00000222982
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,648,194 - 99,679,996 (-)Ensembl
Ensembl Acc Id: ENST00000339843   ⟹   ENSP00000343074
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,648,200 - 99,679,998 (-)Ensembl
Ensembl Acc Id: ENST00000439761   ⟹   ENSP00000401269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,667,824 - 99,679,996 (-)Ensembl
Ensembl Acc Id: ENST00000456417   ⟹   ENSP00000415399
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,672,661 - 99,679,993 (-)Ensembl
Ensembl Acc Id: ENST00000461920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,648,198 - 99,679,988 (-)Ensembl
Ensembl Acc Id: ENST00000463364
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,660,219 - 99,679,966 (-)Ensembl
Ensembl Acc Id: ENST00000463907
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,670,910 - 99,679,996 (-)Ensembl
Ensembl Acc Id: ENST00000466061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,663,542 - 99,679,996 (-)Ensembl
Ensembl Acc Id: ENST00000469622
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,672,589 - 99,679,993 (-)Ensembl
Ensembl Acc Id: ENST00000469887
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,648,198 - 99,676,576 (-)Ensembl
Ensembl Acc Id: ENST00000473347
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,658,833 - 99,663,582 (-)Ensembl
Ensembl Acc Id: ENST00000480723
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,666,716 - 99,679,953 (-)Ensembl
Ensembl Acc Id: ENST00000481825
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,660,228 - 99,679,996 (-)Ensembl
Ensembl Acc Id: ENST00000488187
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,652,291 - 99,660,602 (-)Ensembl
Ensembl Acc Id: ENST00000489231
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,674,226 - 99,679,993 (-)Ensembl
Ensembl Acc Id: ENST00000646887   ⟹   ENSP00000496704
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,648,198 - 99,679,996 (-)Ensembl
RefSeq Acc Id: NM_000777   ⟹   NP_000768
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
Build 36799,083,753 - 99,115,542 (-)NCBI Archive
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,175,906 - 99,207,748 (-)NCBI
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001190484   ⟹   NP_001177413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,667,824 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,198,937 - 99,207,748 (-)NCBI
T2T-CHM13v2.07100,907,155 - 100,919,516 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001291829   ⟹   NP_001278758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
CHM1_1799,175,906 - 99,207,748 (-)NCBI
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291830   ⟹   NP_001278759
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
CHM1_1799,175,906 - 99,207,748 (-)NCBI
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBI
Sequence:
RefSeq Acc Id: NR_033807
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,175,906 - 99,207,748 (-)NCBI
T2T-CHM13v2.07100,887,521 - 100,919,516 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
1 to 30 of 31 rows
Protein RefSeqs NP_000768 (Get FASTA)   NCBI Sequence Viewer  
  NP_001177413 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278758 (Get FASTA)   NCBI Sequence Viewer  
  NP_001278759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02993 (Get FASTA)   NCBI Sequence Viewer  
  AAB00083 (Get FASTA)   NCBI Sequence Viewer  
  AAG32288 (Get FASTA)   NCBI Sequence Viewer  
  AAH33862 (Get FASTA)   NCBI Sequence Viewer  
  AAK73689 (Get FASTA)   NCBI Sequence Viewer  
  AAK73690 (Get FASTA)   NCBI Sequence Viewer  
  AAK73691 (Get FASTA)   NCBI Sequence Viewer  
  AAS02016 (Get FASTA)   NCBI Sequence Viewer  
  ABG25922 (Get FASTA)   NCBI Sequence Viewer  
  BAD96728 (Get FASTA)   NCBI Sequence Viewer  
  BAG36549 (Get FASTA)   NCBI Sequence Viewer  
  BAH12282 (Get FASTA)   NCBI Sequence Viewer  
  BAH12923 (Get FASTA)   NCBI Sequence Viewer  
  CAD97807 (Get FASTA)   NCBI Sequence Viewer  
  CCQ42992 (Get FASTA)   NCBI Sequence Viewer  
  EAL23868 (Get FASTA)   NCBI Sequence Viewer  
  EAW76638 (Get FASTA)   NCBI Sequence Viewer  
  EAW76639 (Get FASTA)   NCBI Sequence Viewer  
  EAW76640 (Get FASTA)   NCBI Sequence Viewer  
  EAW76641 (Get FASTA)   NCBI Sequence Viewer  
  EAW76642 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000222982
  ENSP00000222982.4
  ENSP00000401269
  ENSP00000401269.1
  ENSP00000496704.1
1 to 30 of 31 rows
RefSeq Acc Id: NP_000768   ⟸   NM_000777
- Peptide Label: isoform 1
- UniProtKB: Q75MV0 (UniProtKB/Swiss-Prot),   Q53WY8 (UniProtKB/Swiss-Prot),   B7Z5I7 (UniProtKB/Swiss-Prot),   A4D289 (UniProtKB/Swiss-Prot),   Q9HB56 (UniProtKB/Swiss-Prot),   P20815 (UniProtKB/Swiss-Prot),   B2R9K2 (UniProtKB/TrEMBL),   Q53GC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177413   ⟸   NM_001190484
- Peptide Label: isoform 2
- UniProtKB: P20815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278759   ⟸   NM_001291830
- Peptide Label: isoform 4 precursor
- UniProtKB: B7Z3P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278758   ⟸   NM_001291829
- Peptide Label: isoform 3
- Sequence:
Ensembl Acc Id: ENSP00000401269   ⟸   ENST00000439761

Name Modeler Protein Id AA Range Protein Structure
AF-P20815-F1-model_v2 AlphaFold P20815 1-502 view protein structure

RGD ID:6805438
Promoter ID:HG_KWN:58838
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000222982,   ENST00000343703,   OTTHUMT00000345472,   OTTHUMT00000345473,   OTTHUMT00000345474,   OTTHUMT00000345475,   OTTHUMT00000345477,   OTTHUMT00000345479,   OTTHUMT00000345480,   OTTHUMT00000345481,   UC003URR.1,   UC003URT.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36799,115,171 - 99,115,671 (-)MPROMDB
RGD ID:6852116
Promoter ID:EP73864
Type:single initiation site
Name:HS_CYP3A5
Description:Cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide5.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36799,115,555 - 99,115,615EPD
RGD ID:7211247
Promoter ID:EPDNEW_H11369
Type:multiple initiation site
Name:CYP3A5_1
Description:cytochrome P450 family 3 subfamily A member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,679,996 - 99,680,056EPDNEW


1 to 40 of 54 rows
Database
Acc Id
Source(s)
COSMIC CYP3A5 COSMIC
Ensembl Genes ENSG00000106258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000222982 ENTREZGENE
  ENST00000222982.8 UniProtKB/Swiss-Prot
  ENST00000439761 ENTREZGENE
  ENST00000439761.3 UniProtKB/Swiss-Prot
  ENST00000461920 ENTREZGENE
  ENST00000469887 ENTREZGENE
  ENST00000646887.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
GTEx ENSG00000106258 GTEx
HGNC ID HGNC:2638 ENTREZGENE
Human Proteome Map CYP3A5 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
KEGG Report hsa:1577 UniProtKB/Swiss-Prot
NCBI Gene 1577 ENTREZGENE
OMIM 605325 OMIM
PANTHER CYTOCHROME P450 3A5 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A5 RGD, PharmGKB
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A4D289 ENTREZGENE
  B2R9K2 ENTREZGENE, UniProtKB/TrEMBL
  B7Z3P6 ENTREZGENE, UniProtKB/TrEMBL
  B7Z5I7 ENTREZGENE
  CP3A5_HUMAN UniProtKB/Swiss-Prot
  L8EC58_HUMAN UniProtKB/TrEMBL
  P20815 ENTREZGENE
  Q14V85_HUMAN UniProtKB/TrEMBL
  Q53GC3 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 54 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP3A5  cytochrome P450 family 3 subfamily A member 5    cytochrome P450, family 3, subfamily A, polypeptide 5  Symbol and/or name change 5135510 APPROVED