CYP3A5 (cytochrome P450 family 3 subfamily A member 5) - Rat Genome Database

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Gene: CYP3A5 (cytochrome P450 family 3 subfamily A member 5) Homo sapiens
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Symbol: CYP3A5
Name: cytochrome P450 family 3 subfamily A member 5
RGD ID: 1348646
HGNC Page HGNC
Description: Enables estrogen 16-alpha-hydroxylase activity and retinoic acid 4-hydroxylase activity. Involved in several processes, including cellular hormone metabolic process; drug catabolic process; and lipid hydroxylation. Predicted to be located in endoplasmic reticulum membrane. Implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Biomarker of acute lymphoblastic leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; CP35; CYPIIIA5; cytochrome P-450; cytochrome P450 3A5; cytochrome P450 HLp2; cytochrome P450, family 3, subfamily A, polypeptide 5; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5; cytochrome P450-PCN3; DKFZp686L16231; flavoprotein-linked monooxygenase; FLJ31317; microsomal monooxygenase; niphedipine oxidase; P450PCN3; P450PCN3.; PCN3; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CYP3A51P   CYP3A52P   CYP3A54P   CYP3AP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl799,648,194 - 99,679,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (EXP,ISO)
(+)-artemisinin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-naphthoquinone  (EXP)
1,8-cineole  (EXP)
1-hydroxymidazolam  (EXP,ISO)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
1H-pyrazole  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-hydroxybutyric acid  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
4-hydroxymidazolam  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-hydroxydiclofenac  (EXP)
5-Hydroxythalidomide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
6beta-hydroxytestosterone  (EXP)
8-Br-cAMP  (EXP)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
aconitine  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (EXP)
alfentanil  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alpha-tocotrienol  (EXP)
alprazolam  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amlexanox  (ISO)
amlodipine  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
andrographolide  (ISO)
angelicin  (ISO)
antirheumatic drug  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
beclomethasone  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (ISO)
bergomottin  (ISO)
Besigomsin  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
brucine  (ISO)
budesonide  (EXP,ISO)
bupivacaine  (ISO)
buspirone  (EXP,ISO)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
canadine  (ISO)
cannabidiol  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
carbosulfan  (EXP)
carfentanil  (EXP)
carmustine  (EXP)
chlordecone  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
chlorzoxazone  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP)
citral  (EXP)
clobetasol  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
clopidogrel  (EXP)
clothianidin  (EXP)
clotrimazole  (EXP,ISO)
clozapine  (EXP)
Clozapine N-oxide  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisol  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cyproconazole  (ISO)
daidzein  (ISO)
decabromodiphenyl ether  (ISO)
Dechloroethylcyclophosphamide  (EXP)
dehydroepiandrosterone  (EXP)
dehydronifedipine  (ISO)
delta-tocotrienol  (EXP)
Deoxyschizandrin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
dextrorphan  (EXP)
Diallyl sulfide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
dihydroergotamine  (ISO)
diiodine  (ISO)
diltiazem  (EXP)
dimethyl sulfoxide  (EXP)
Diosbulbin B  (ISO)
diosgenin  (ISO)
diosmetin  (EXP)
Droloxifene  (EXP)
dronedarone  (EXP)
elemental selenium  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (EXP,ISO)
eplerenone  (EXP)
erythromycin A  (EXP)
erythromycin estolate  (ISO)
ethanol  (ISO)
etoposide  (EXP)
fenofibrate  (ISO)
fenthion  (EXP)
fimasartan  (EXP)
fipronil  (EXP,ISO)
flavonol  (EXP)
fluconazole  (ISO)
flunisolide  (EXP)
flunitrazepam  (EXP)
fluoxetine  (EXP)
fluticasone  (EXP)
fluvoxamine  (EXP)
fructose  (ISO)
fumonisin B1  (ISO)
gallocatechin  (ISO)
gefitinib  (EXP)
genistein  (ISO)
geranial  (EXP)
geraniol  (EXP)
glutathione  (EXP)
glycyrrhizinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
griseofulvin  (ISO)
guggulsterone  (ISO)
haloperidol  (EXP)
Heliotrine  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hydroquinone  (EXP)
Hypaconitine  (EXP,ISO)
hyperforin  (EXP)
ifosfamide  (EXP)
imperatorin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
isoimperatorin  (ISO)
isopimpinellin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-ethionine  (ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lapatinib  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
luteolin  (EXP)
malathion  (EXP)
Meclizine  (EXP,ISO)
melatonin  (ISO)
mephenytoin  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methoxsalen  (ISO)
methoxychlor  (ISO)
midazolam  (EXP,ISO)
mifepristone  (EXP,ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
mycophenolic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-desmethylclozapine  (EXP)
N-Desmethyltamoxifen  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (ISO)
naphthalene  (EXP)
nefazodone  (EXP,ISO)
nelfinavir  (EXP)
nevirapine  (ISO)
nickel atom  (EXP)
nifedipine  (ISO)
nimesulide  (ISO)
Nonylphenol  (ISO)
nortriptyline  (EXP)
norverapamil  (EXP)
notoginsenoside R1  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
okadaic acid  (EXP,ISO)
oltipraz  (ISO)
omeprazole  (EXP,ISO)
ortho-Aminoazotoluene  (ISO)
Oxadiazon  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
parathion  (EXP)
PD 0325901  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phenacetin  (ISO)
phenanthrene  (ISO)
phencyclidine  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosphatidic acid  (ISO)
physostigmine  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prochloraz  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
pyrene  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP,ISO)
quinacrine  (EXP)
quinidine  (ISO)
rabeprazole  (EXP)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
riddelliine  (ISO)
rifampicin  (EXP,ISO)
rifaximin  (EXP,ISO)
risperidone  (EXP)
ritonavir  (EXP)
romidepsin  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
senecionine  (EXP,ISO)
Senkirkine  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
spironolactone  (ISO)
streptozocin  (ISO)
sulfaphenazole  (EXP)
sulforaphane  (ISO)
sulfoxaflor  (ISO)
tacrolimus hydrate  (EXP)
tamarixetin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
tebuconazole  (ISO)
tebufenozide  (ISO)
teniposide  (EXP)
Terfenadine  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetrahydrocurcumin  (ISO)
tetrodotoxin  (ISO)
thalidomide  (EXP)
thiacloprid  (EXP,ISO)
thioacetamide  (ISO)
thiophanate-methyl  (ISO)
Thiotepa  (EXP)
ticlopidine  (EXP)
titanium dioxide  (ISO)
toxaphene  (ISO)
trabectedin  (ISO)
trazodone  (EXP)
triadimefon  (ISO)
triamcinolone acetonide  (EXP)
trichostatin A  (EXP)
triclosan  (EXP,ISO)
triphenyl phosphate  (ISO)
Tris(1-aziridinyl)phosphine oxide  (EXP)
troglitazone  (EXP)
troleandomycin  (EXP)
undecane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP)
valsartan  (EXP)
verapamil  (EXP,ISO)
vincristine  (EXP)
vitamin E  (EXP,ISO)
voriconazole  (ISO)
warfarin  (EXP)
Wuweizisu C  (ISO)
zaragozic acid A  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (ISO)
zoledronic acid  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Bedewy AM and El-Maghraby SM, Hematology. 2013 Jul;18(4):211-6. doi: 10.1179/1607845412Y.0000000067. Epub 2013 Jan 31.
2. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
3. Egbelakin A, etal., Pediatr Blood Cancer. 2011 Mar;56(3):361-7. doi: 10.1002/pbc.22845. Epub 2010 Nov 11.
4. Fakhoury M, etal., Inflamm Bowel Dis. 2006 Aug;12(8):745-9.
5. GOA_HUMAN data from the GO Consortium
6. Green H, etal., J Pharm Sci. 2011 Oct;100(10):4205-9. doi: 10.1002/jps.22680. Epub 2011 Jun 23.
7. Huang Z, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jul;11(7):549-54.
8. Kim DH, etal., Clin Cancer Res. 2009 Jul 15;15(14):4750-8. doi: 10.1158/1078-0432.CCR-09-0145. Epub 2009 Jul 7.
9. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
10. Magliulo L, etal., Eur J Clin Pharmacol. 2011 Jan;67(1):47-54. Epub 2010 Oct 8.
11. OMIM Disease Annotation Pipeline
12. Pipeline to import KEGG annotations from KEGG into RGD
13. Pipeline to import SMPDB annotations from SMPDB into RGD
14. RGD automated import pipeline for gene-chemical interactions
15. Sailaja K, etal., Asian Pac J Cancer Prev. 2010;11(3):781-4.
16. Silveira VS, etal., Mol Cell Biochem. 2012 May;364(1-2):217-23. doi: 10.1007/s11010-011-1220-8. Epub 2012 Jan 4.
17. Tsai SM, etal., Clin Chim Acta. 2009 Jun 27;404(2):160-5. doi: 10.1016/j.cca.2009.03.038. Epub 2009 Mar 28.
18. van Erp NP, etal., Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5.
Additional References at PubMed
PMID:2732228   PMID:2802615   PMID:7750548   PMID:7811260   PMID:7883227   PMID:7894497   PMID:7895614   PMID:8004129   PMID:8125298   PMID:8569713   PMID:8619878   PMID:8619884  
PMID:8694864   PMID:8869826   PMID:8877031   PMID:8889549   PMID:8946469   PMID:9070608   PMID:9364212   PMID:9797707   PMID:9890157   PMID:10069460   PMID:10403825   PMID:11093772  
PMID:11137287   PMID:11266076   PMID:11279519   PMID:11502729   PMID:11726664   PMID:11740341   PMID:11809184   PMID:11836601   PMID:12042671   PMID:12202670   PMID:12242601   PMID:12324482  
PMID:12433824   PMID:12439220   PMID:12477932   PMID:12690205   PMID:12692107   PMID:12694732   PMID:12754175   PMID:12756511   PMID:12814460   PMID:12822676   PMID:12853948   PMID:12865317  
PMID:12893984   PMID:12960109   PMID:12966368   PMID:12969965   PMID:12975492   PMID:14504207   PMID:14515058   PMID:14515059   PMID:14559847   PMID:14647405   PMID:14676821   PMID:14702039  
PMID:14747421   PMID:14961555   PMID:15039299   PMID:15114431   PMID:15116055   PMID:15128046   PMID:15167702   PMID:15226679   PMID:15248218   PMID:15252010   PMID:15284534   PMID:15289787  
PMID:15319333   PMID:15385835   PMID:15454734   PMID:15469410   PMID:15489334   PMID:15502717   PMID:15548719   PMID:15592326   PMID:15596297   PMID:15596575   PMID:15622315   PMID:15632378  
PMID:15634941   PMID:15698606   PMID:15707415   PMID:15708542   PMID:15729180   PMID:15801936   PMID:15808586   PMID:15814280   PMID:15833928   PMID:15876487   PMID:15882469   PMID:15900215  
PMID:15900284   PMID:15919447   PMID:15931768   PMID:15952872   PMID:15961978   PMID:15978331   PMID:15981231   PMID:16004554   PMID:16024008   PMID:16086282   PMID:16116487   PMID:16141800  
PMID:16160620   PMID:16168193   PMID:16172230   PMID:16188140   PMID:16207150   PMID:16243813   PMID:16249748   PMID:16253141   PMID:16267764   PMID:16272171   PMID:16272955   PMID:16299241  
PMID:16306861   PMID:16314882   PMID:16321621   PMID:16338276   PMID:16361630   PMID:16421475   PMID:16424824   PMID:16442753   PMID:16513443   PMID:16584389   PMID:16595916   PMID:16612255  
PMID:16612333   PMID:16614106   PMID:16628701   PMID:16638864   PMID:16684709   PMID:16765145   PMID:16765147   PMID:16769602   PMID:16771603   PMID:16772608   PMID:16791115   PMID:16815317  
PMID:16822233   PMID:16827636   PMID:16842392   PMID:16847425   PMID:16906018   PMID:16906020   PMID:17015051   PMID:17032130   PMID:17042920   PMID:17047492   PMID:17048977   PMID:17049058  
PMID:17049128   PMID:17162466   PMID:17178265   PMID:17178267   PMID:17192506   PMID:17192769   PMID:17198275   PMID:17224914   PMID:17244352   PMID:17264302   PMID:17286792   PMID:17296590  
PMID:17329995   PMID:17339868   PMID:17352764   PMID:17358097   PMID:17363580   PMID:17372036   PMID:17373732   PMID:17377957   PMID:17391324   PMID:17395652   PMID:17425754   PMID:17430486  
PMID:17443134   PMID:17450472   PMID:17460031   PMID:17495880   PMID:17495881   PMID:17502835   PMID:17510208   PMID:17517050   PMID:17545536   PMID:17554244   PMID:17568575   PMID:17582393  
PMID:17605821   PMID:17615053   PMID:17635176   PMID:17635181   PMID:17635182   PMID:17691921   PMID:17700595   PMID:17701008   PMID:17761709   PMID:17827141   PMID:17851225   PMID:17875118  
PMID:17885626   PMID:17900275   PMID:17914095   PMID:17922881   PMID:17925548   PMID:17941052   PMID:17979504   PMID:17979523   PMID:17992026   PMID:18021343   PMID:18024866   PMID:18028890  
PMID:18058330   PMID:18192894   PMID:18211618   PMID:18212618   PMID:18214455   PMID:18221820   PMID:18223457   PMID:18240903   PMID:18248681   PMID:18294295   PMID:18300941   PMID:18306354  
PMID:18309947   PMID:18315786   PMID:18315894   PMID:18319058   PMID:18322448   PMID:18334918   PMID:18382661   PMID:18385010   PMID:18385991   PMID:18394438   PMID:18408564   PMID:18414696  
PMID:18429967   PMID:18443548   PMID:18490434   PMID:18496128   PMID:18496131   PMID:18502461   PMID:18509327   PMID:18509328   PMID:18509645   PMID:18518855   PMID:18551040   PMID:18566991  
PMID:18582803   PMID:18587567   PMID:18589174   PMID:18597650   PMID:18603015   PMID:18628519   PMID:18636247   PMID:18641551   PMID:18650247   PMID:18688081   PMID:18704002   PMID:18708991  
PMID:18727922   PMID:18752284   PMID:18930278   PMID:18936931   PMID:18978522   PMID:18979093   PMID:18981009   PMID:18989234   PMID:18996102   PMID:19005401   PMID:19005461   PMID:19010156  
PMID:19033450   PMID:19034006   PMID:19040121   PMID:19064572   PMID:19067682   PMID:19074750   PMID:19076156   PMID:19106083   PMID:19106084   PMID:19114346   PMID:19125240   PMID:19139162  
PMID:19141860   PMID:19205682   PMID:19225447   PMID:19228205   PMID:19228751   PMID:19229255   PMID:19239339   PMID:19258929   PMID:19289993   PMID:19290787   PMID:19290795   PMID:19337788  
PMID:19343046   PMID:19343327   PMID:19349540   PMID:19350405   PMID:19376366   PMID:19376514   PMID:19384171   PMID:19384264   PMID:19414505   PMID:19414633   PMID:19424794   PMID:19470925  
PMID:19474452   PMID:19506580   PMID:19516253   PMID:19523815   PMID:19538885   PMID:19545678   PMID:19546880   PMID:19576320   PMID:19591893   PMID:19593168   PMID:19636001   PMID:19644155  
PMID:19659438   PMID:19663817   PMID:19667110   PMID:19693007   PMID:19696793   PMID:19710077   PMID:19730841   PMID:19744012   PMID:19761365   PMID:19762492   PMID:19801957   PMID:19812606  
PMID:19817997   PMID:19823770   PMID:19842932   PMID:19855314   PMID:19865079   PMID:19881258   PMID:19904021   PMID:19907160   PMID:19913121   PMID:19916993   PMID:19925383   PMID:19934793  
PMID:19946748   PMID:20010459   PMID:20017669   PMID:20030680   PMID:20031551   PMID:20038391   PMID:20040338   PMID:20041908   PMID:20118548   PMID:20133509   PMID:20136364   PMID:20147896  
PMID:20160155   PMID:20172323   PMID:20173083   PMID:20179710   PMID:20207952   PMID:20212519   PMID:20214802   PMID:20218903   PMID:20231858   PMID:20235787   PMID:20332423   PMID:20345875  
PMID:20354687   PMID:20357698   PMID:20368718   PMID:20383212   PMID:20389299   PMID:20393454   PMID:20395213   PMID:20403997   PMID:20415563   PMID:20430047   PMID:20453000   PMID:20459744  
PMID:20479955   PMID:20490798   PMID:20514078   PMID:20526235   PMID:20529763   PMID:20530282   PMID:20565970   PMID:20588203   PMID:20596503   PMID:20602615   PMID:20615193   PMID:20617557  
PMID:20621111   PMID:20625352   PMID:20628086   PMID:20630055   PMID:20662624   PMID:20679960   PMID:20696882   PMID:20716514   PMID:20720558   PMID:20818295   PMID:20833683   PMID:20846929  
PMID:20860463   PMID:20873239   PMID:20881953   PMID:20959405   PMID:20959500   PMID:20970553   PMID:20970601   PMID:20970628   PMID:20970643   PMID:21047202   PMID:21072155   PMID:21072184  
PMID:21076384   PMID:21081028   PMID:21094057   PMID:21094796   PMID:21094797   PMID:21148251   PMID:21153923   PMID:21165655   PMID:21173786   PMID:21206424   PMID:21209234   PMID:21237140  
PMID:21265876   PMID:21380731   PMID:21389905   PMID:21418106   PMID:21434577   PMID:21436775   PMID:21493872   PMID:21513075   PMID:21519338   PMID:21544031   PMID:21644845   PMID:21677300  
PMID:21698374   PMID:21711429   PMID:21743379   PMID:21770725   PMID:21806386   PMID:21814220   PMID:21839244   PMID:21851254   PMID:21873635   PMID:21896346   PMID:21916909   PMID:21950641  
PMID:21988832   PMID:22007612   PMID:22022918   PMID:22096084   PMID:22210422   PMID:22214815   PMID:22277678   PMID:22292071   PMID:22304537   PMID:22369694   PMID:22511346   PMID:22610055  
PMID:22645092   PMID:22696420   PMID:22704849   PMID:22819265   PMID:22875663   PMID:22889968   PMID:22923690   PMID:22993851   PMID:23023417   PMID:23073208   PMID:23107770   PMID:23131698  
PMID:23143606   PMID:23143891   PMID:23146466   PMID:23146479   PMID:23149441   PMID:23223499   PMID:23320986   PMID:23354298   PMID:23364483   PMID:23385102   PMID:23432535   PMID:23459029  
PMID:23491640   PMID:23557865   PMID:23584898   PMID:23633119   PMID:23700791   PMID:23715232   PMID:23723360   PMID:23733010   PMID:23734777   PMID:23780963   PMID:23837476   PMID:23845965  
PMID:23863802   PMID:23873120   PMID:23900887   PMID:23951129   PMID:23984379   PMID:24024898   PMID:24033383   PMID:24085358   PMID:24088129   PMID:24135442   PMID:24168324   PMID:24301608  
PMID:24351870   PMID:24352002   PMID:24365989   PMID:24368493   PMID:24378577   PMID:24383873   PMID:24438215   PMID:24443221   PMID:24444408   PMID:24463861   PMID:24465960   PMID:24469018  
PMID:24484539   PMID:24535486   PMID:24593903   PMID:24682161   PMID:24691060   PMID:24699256   PMID:24739669   PMID:24816252   PMID:24875272   PMID:24911663   PMID:24989928   PMID:25014506  
PMID:25106522   PMID:25112801   PMID:25141896   PMID:25303300   PMID:25322286   PMID:25370902   PMID:25385241   PMID:25427746   PMID:25495409   PMID:25521359   PMID:25534367   PMID:25552922  
PMID:25590378   PMID:25594874   PMID:25649767   PMID:25673168   PMID:25730082   PMID:25778465   PMID:25825214   PMID:25857198   PMID:25869250   PMID:25894154   PMID:25916520   PMID:25930089  
PMID:25966085   PMID:25968921   PMID:25976223   PMID:26067485   PMID:26176181   PMID:26177012   PMID:26177348   PMID:26179145   PMID:26189776   PMID:26227094   PMID:26228923   PMID:26291084  
PMID:26316040   PMID:26421491   PMID:26450467   PMID:26458301   PMID:26485092   PMID:26507668   PMID:26521259   PMID:26615671   PMID:26634478   PMID:26635230   PMID:26651976   PMID:26654672  
PMID:26739429   PMID:26773964   PMID:26856541   PMID:26856709   PMID:26915847   PMID:26961113   PMID:27110018   PMID:27225724   PMID:27320564   PMID:27334520   PMID:27378609   PMID:27426203  
PMID:27503662   PMID:27511886   PMID:27649539   PMID:27717793   PMID:27790923   PMID:27841150   PMID:27885697   PMID:27926596   PMID:27977332   PMID:28044353   PMID:28049954   PMID:28094348  
PMID:28259948   PMID:28271256   PMID:28324194   PMID:28330783   PMID:28404946   PMID:28411281   PMID:28440407   PMID:28448186   PMID:28476838   PMID:28482130   PMID:28500872   PMID:28514442  
PMID:28533324   PMID:28540692   PMID:28605053   PMID:28678049   PMID:28697165   PMID:28704257   PMID:28736028   PMID:28872889   PMID:28891077   PMID:28941036   PMID:28945481   PMID:29115708  
PMID:29135906   PMID:29160300   PMID:29161757   PMID:29227563   PMID:29247736   PMID:29314799   PMID:29325225   PMID:29427770   PMID:29441922   PMID:29454235   PMID:29475834   PMID:29479969  
PMID:29491071   PMID:29535109   PMID:29539600   PMID:29550576   PMID:29611886   PMID:29615122   PMID:29970707   PMID:29991328   PMID:30021884   PMID:30040022   PMID:30045320   PMID:30119132  
PMID:30143489   PMID:30166405   PMID:30231963   PMID:30342278   PMID:30422888   PMID:30471066   PMID:30501698   PMID:30520827   PMID:30926609   PMID:30983501   PMID:31003147   PMID:31064695  
PMID:31124411   PMID:31124575   PMID:31128914   PMID:31309254   PMID:31322243   PMID:31588878   PMID:31588879   PMID:31690757   PMID:31710427   PMID:31849280   PMID:31880588   PMID:31902947  
PMID:32001245   PMID:32015456   PMID:32146629   PMID:32225074   PMID:32235678   PMID:32279544   PMID:32350633   PMID:32366712   PMID:32456253   PMID:32694731   PMID:32814053   PMID:33775687  
PMID:33952479  


Genomics

Comparative Map Data
CYP3A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl799,648,194 - 99,679,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38799,648,194 - 99,679,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37799,245,817 - 99,277,619 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,083,753 - 99,115,557 (-)NCBINCBI36hg18NCBI36
Build 34798,890,467 - 98,922,257NCBI
Celera793,980,042 - 94,011,861 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef793,882,179 - 93,914,147 (-)NCBIHuRef
CHM1_1799,175,907 - 99,207,720 (-)NCBICHM1_1
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)NCBI
Cyp3a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,791,417 - 145,816,664 (-)NCBIGRCm39mm39
GRCm39 Ensembl5145,791,236 - 145,816,774 (-)Ensembl
GRCm385145,854,607 - 145,879,854 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,854,426 - 145,879,964 (-)EnsemblGRCm38mm10GRCm38
MGSCv375146,666,183 - 146,691,430 (-)NCBIGRCm37mm9NCBIm37
MGSCv365146,158,841 - 146,184,088 (-)NCBImm8
Celera5143,836,316 - 143,861,583 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map585.17NCBI
Cyp3a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21216,806,222 - 16,846,428 (-)NCBI
Rnor_6.0 Ensembl1219,074,583 - 19,114,399 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01219,074,288 - 19,114,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01221,132,926 - 21,173,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41217,164,384 - 17,204,589 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11217,153,354 - 17,193,208 (+)NCBI
Celera1218,744,706 - 18,784,438 (-)NCBICelera
Cytogenetic Map12q11NCBI
CYP3A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17105,123,437 - 105,155,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,123,437 - 105,155,322 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0791,621,561 - 91,654,164 (-)NCBIMhudiblu_PPA_v0panPan3
CYP3A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,473,649 - 13,517,905 (+)NCBI
ChlSab1.1 Ensembl2813,491,483 - 13,519,507 (+)Ensembl
Vero_WHO_p1.0NW_0236660702,792,815 - 2,818,567 (-)NCBI

Position Markers
D7S647  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,831 - 99,268,902UniSTSGRCh37
Celera794,003,066 - 94,003,137UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map7q21.1UniSTS
HuRef793,905,201 - 93,905,272UniSTS
CRA_TCAGchr7v2798,628,635 - 98,628,706UniSTS
Marshfield Genetic Map7112.32UniSTS
Marshfield Genetic Map7112.32RGD
Genethon Genetic Map7112.4UniSTS
Whitehead-YAC Contig Map7 UniSTS
SHGC-8697  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,251 - 99,268,350UniSTSGRCh37
Build 36799,106,187 - 99,106,286RGDNCBI36
Celera794,002,486 - 94,002,585RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,904,621 - 93,904,720UniSTS
CRA_TCAGchr7v2798,628,055 - 98,628,154UniSTS
GeneMap99-G3 RH Map74846.0UniSTS
RH123304  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,258,197 - 99,258,489UniSTSGRCh37
Build 36799,096,133 - 99,096,425RGDNCBI36
Celera793,992,432 - 93,992,724RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,894,567 - 93,894,859UniSTS
CRA_TCAGchr7v2798,618,001 - 98,618,293UniSTS
TNG Radiation Hybrid Map742958.0UniSTS
D7S2874  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,361,364 - 99,361,528UniSTSGRCh37
GRCh37799,258,008 - 99,258,172UniSTSGRCh37
Build 36799,095,944 - 99,096,108RGDNCBI36
Celera793,992,243 - 93,992,407RGD
Celera794,095,609 - 94,095,773UniSTS
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,894,378 - 93,894,542UniSTS
HuRef793,997,792 - 93,997,956UniSTS
CRA_TCAGchr7v2798,617,812 - 98,617,976UniSTS
CRA_TCAGchr7v2798,721,177 - 98,721,341UniSTS
SHGC-1891  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,691 - 99,268,824UniSTSGRCh37
Build 36799,106,627 - 99,106,760RGDNCBI36
Celera794,002,926 - 94,003,059RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,905,061 - 93,905,194UniSTS
CRA_TCAGchr7v2798,628,495 - 98,628,628UniSTS
GeneMap99-G3 RH Map74864.0UniSTS
RH71343  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,245,864 - 99,246,024UniSTSGRCh37
Build 36799,083,800 - 99,083,960RGDNCBI36
Celera793,980,093 - 93,980,253RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,882,230 - 93,882,390UniSTS
CRA_TCAGchr7v2798,605,659 - 98,605,819UniSTS
GeneMap99-GB4 RH Map7515.73UniSTS
RH45981  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,268,652 - 99,268,826UniSTSGRCh37
Build 36799,106,588 - 99,106,762RGDNCBI36
Celera794,002,887 - 94,003,061RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,905,022 - 93,905,196UniSTS
CRA_TCAGchr7v2798,628,456 - 98,628,630UniSTS
GeneMap99-GB4 RH Map7511.14UniSTS
D11S3059  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q24.3UniSTS
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map9q21.32UniSTS
Cytogenetic Map2p14UniSTS
D7S647  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2894
Count of miRNA genes:1141
Interacting mature miRNAs:1389
Transcripts:ENST00000222982, ENST00000339843, ENST00000343703, ENST00000439761, ENST00000456417, ENST00000461920, ENST00000463364, ENST00000463907, ENST00000466061, ENST00000469622, ENST00000469887, ENST00000473347, ENST00000480723, ENST00000481825, ENST00000488187, ENST00000489231
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 798 3 612 455 139 430 1431 26 67 139 393 443 27 142 753
Low 1606 542 867 145 611 33 1792 1130 1361 244 809 903 126 1018 947 4
Below cutoff 35 2415 245 22 1164 2 1131 1032 2291 36 253 263 19 44 1088 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_007938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001291830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_033807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA076026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF280107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF355804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK055879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC383127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ680079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY120204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L26985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L35912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000222982   ⟹   ENSP00000222982
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,648,194 - 99,679,996 (-)Ensembl
RefSeq Acc Id: ENST00000339843   ⟹   ENSP00000343074
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,648,200 - 99,679,998 (-)Ensembl
RefSeq Acc Id: ENST00000439761   ⟹   ENSP00000401269
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,667,824 - 99,679,996 (-)Ensembl
RefSeq Acc Id: ENST00000456417   ⟹   ENSP00000415399
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,672,661 - 99,679,993 (-)Ensembl
RefSeq Acc Id: ENST00000461920
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,648,198 - 99,679,988 (-)Ensembl
RefSeq Acc Id: ENST00000463364
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,660,219 - 99,679,966 (-)Ensembl
RefSeq Acc Id: ENST00000463907
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,670,910 - 99,679,996 (-)Ensembl
RefSeq Acc Id: ENST00000466061
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,663,542 - 99,679,996 (-)Ensembl
RefSeq Acc Id: ENST00000469622
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,672,589 - 99,679,993 (-)Ensembl
RefSeq Acc Id: ENST00000469887
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,648,198 - 99,676,576 (-)Ensembl
RefSeq Acc Id: ENST00000473347
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,658,833 - 99,663,582 (-)Ensembl
RefSeq Acc Id: ENST00000480723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,666,716 - 99,679,953 (-)Ensembl
RefSeq Acc Id: ENST00000481825
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,660,228 - 99,679,996 (-)Ensembl
RefSeq Acc Id: ENST00000488187
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,652,291 - 99,660,602 (-)Ensembl
RefSeq Acc Id: ENST00000489231
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,674,226 - 99,679,993 (-)Ensembl
RefSeq Acc Id: ENST00000646887   ⟹   ENSP00000496704
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl799,648,198 - 99,679,996 (-)Ensembl
RefSeq Acc Id: NM_000777   ⟹   NP_000768
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
Build 36799,083,753 - 99,115,542 (-)NCBI Archive
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,175,906 - 99,207,748 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001190484   ⟹   NP_001177413
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,667,824 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,198,937 - 99,207,748 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001291829   ⟹   NP_001278758
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
CHM1_1799,175,906 - 99,207,748 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001291830   ⟹   NP_001278759
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
CHM1_1799,175,906 - 99,207,748 (-)NCBI
Sequence:
RefSeq Acc Id: NR_033807
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,648,194 - 99,679,996 (-)NCBI
GRCh37799,245,813 - 99,277,636 (-)NCBI
HuRef793,882,179 - 93,914,147 (-)ENTREZGENE
CHM1_1799,175,906 - 99,207,748 (-)NCBI
CRA_TCAGchr7v2798,605,608 - 98,637,429 (-)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000768   ⟸   NM_000777
- Peptide Label: isoform 1
- UniProtKB: P20815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177413   ⟸   NM_001190484
- Peptide Label: isoform 2
- UniProtKB: P20815 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001278759   ⟸   NM_001291830
- Peptide Label: isoform 4 precursor
- UniProtKB: B7Z3P6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001278758   ⟸   NM_001291829
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: ENSP00000401269   ⟸   ENST00000439761
RefSeq Acc Id: ENSP00000415399   ⟸   ENST00000456417
RefSeq Acc Id: ENSP00000343074   ⟸   ENST00000339843
RefSeq Acc Id: ENSP00000222982   ⟸   ENST00000222982
RefSeq Acc Id: ENSP00000496704   ⟸   ENST00000646887

Promoters
RGD ID:6805438
Promoter ID:HG_KWN:58838
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000222982,   ENST00000343703,   OTTHUMT00000345472,   OTTHUMT00000345473,   OTTHUMT00000345474,   OTTHUMT00000345475,   OTTHUMT00000345477,   OTTHUMT00000345479,   OTTHUMT00000345480,   OTTHUMT00000345481,   UC003URR.1,   UC003URT.2
Position:
Human AssemblyChrPosition (strand)Source
Build 36799,115,171 - 99,115,671 (-)MPROMDB
RGD ID:6852116
Promoter ID:EP73864
Type:single initiation site
Name:HS_CYP3A5
Description:Cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide5.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36799,115,555 - 99,115,615EPD
RGD ID:7211247
Promoter ID:EPDNEW_H11369
Type:multiple initiation site
Name:CYP3A5_1
Description:cytochrome P450 family 3 subfamily A member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,679,996 - 99,680,056EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
CYP3A5, 6986A-G single nucleotide variant Hypertension, salt-sensitive essential, susceptibility to [RCV000005370] Chr7:7q22.1 risk factor
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1
pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1
pathogenic
NM_000777.5(CYP3A5):c.219-237= single nucleotide variant cyclosporine response - Dosage, Metabolism/PK [RCV000211240]|not provided [RCV000830072]|sirolimus response - Dosage [RCV000211230]|sirolimus response - Metabolism/PK [RCV000660856]|tacrolimus response (donor genotype) - Dosage, Metabolism/PK [RCV000211322]|tacrolimus response (recipient genotype) - Dosage, Metabolism/PK [RCV000660855]|tacrolimus response - Efficacy [RCV000211409] Chr7:99672916 [GRCh38]
Chr7:99270539 [GRCh37]
Chr7:7q22.1
benign|drug response
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1
pathogenic|uncertain significance
GRCh38/hg38 7q22.1(chr7:99195836-100348063)x3 copy number gain See cases [RCV000135630] Chr7:99195836..100348063 [GRCh38]
Chr7:98793459..99945686 [GRCh37]
Chr7:98631395..99783622 [NCBI36]
Chr7:7q22.1
likely benign
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q22.1(chr7:99643456-99913142)x3 copy number gain See cases [RCV000140269] Chr7:99643456..99913142 [GRCh38]
Chr7:99241079..99510765 [GRCh37]
Chr7:99079015..99348701 [NCBI36]
Chr7:7q22.1
likely benign
NM_000777.5(CYP3A5):c.319-1630C>T single nucleotide variant appendicular lean mass relative to body height [RCV000167563] Chr7:99668695 [GRCh38]
Chr7:99266318 [GRCh37]
Chr7:99104254 [NCBI36]
Chr7:7q22.1
pathogenic|association
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split-hand/foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
Chr7:7q21.2-22.1
pathogenic
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
NM_000777.5(CYP3A5):c.1165C>T (p.Pro389Ser) single nucleotide variant Essential hypertension [RCV000709780] Chr7:99652641 [GRCh38]
Chr7:99250264 [GRCh37]
Chr7:7q22.1
not provided
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Speech-language disorder 1 [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q22.1(chr7:98758955-99368262)x1 copy number loss not provided [RCV000848016] Chr7:98758955..99368262 [GRCh37]
Chr7:7q22.1
uncertain significance
NM_000777.5(CYP3A5):c.1206C>T (p.His402=) single nucleotide variant not provided [RCV000931354] Chr7:99652600 [GRCh38]
Chr7:99250223 [GRCh37]
Chr7:7q22.1
likely benign
NM_000777.5(CYP3A5):c.1414-3T>C single nucleotide variant not provided [RCV000956509] Chr7:99648403 [GRCh38]
Chr7:99246026 [GRCh37]
Chr7:7q22.1
benign
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Robin sequence [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2638 AgrOrtholog
COSMIC CYP3A5 COSMIC
Ensembl Genes ENSG00000106258 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000222982 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000343074 UniProtKB/TrEMBL
  ENSP00000401269 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000415399 UniProtKB/TrEMBL
  ENSP00000496704 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000222982 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000339843 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000439761 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000456417 UniProtKB/TrEMBL
  ENST00000461920 ENTREZGENE
  ENST00000646887 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000106258 GTEx
HGNC ID HGNC:2638 ENTREZGENE
Human Proteome Map CYP3A5 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1577 UniProtKB/Swiss-Prot
NCBI Gene 1577 ENTREZGENE
OMIM 145500 OMIM
  605325 OMIM
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP3A5 RGD, PharmGKB
PRINTS EP450I UniProtKB/TrEMBL
  EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7Z3P6 ENTREZGENE, UniProtKB/TrEMBL
  CP3A5_HUMAN UniProtKB/Swiss-Prot
  L8EC58_HUMAN UniProtKB/TrEMBL
  P20815 ENTREZGENE
  Q14V85_HUMAN UniProtKB/TrEMBL
  Q7Z3N0_HUMAN UniProtKB/TrEMBL
  Q7Z446_HUMAN UniProtKB/TrEMBL
  Q7Z447_HUMAN UniProtKB/TrEMBL
  Q96RK6_HUMAN UniProtKB/TrEMBL
  Q96RK7_HUMAN UniProtKB/TrEMBL
  Q96RK8_HUMAN UniProtKB/TrEMBL
UniProt Secondary A4D289 UniProtKB/Swiss-Prot
  A6NDS0 UniProtKB/TrEMBL
  B7Z5I7 UniProtKB/Swiss-Prot
  Q53WY8 UniProtKB/Swiss-Prot
  Q75MV0 UniProtKB/Swiss-Prot
  Q9HB56 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP3A5  cytochrome P450 family 3 subfamily A member 5    cytochrome P450, family 3, subfamily A, polypeptide 5  Symbol and/or name change 5135510 APPROVED