Cyp3a25 (cytochrome P450, family 3, subfamily a, polypeptide 25) - Rat Genome Database

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Gene: Cyp3a25 (cytochrome P450, family 3, subfamily a, polypeptide 25) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
RGD ID: 734261
MGI Page MGI
Description: Predicted to enable retinoic acid 4-hydroxylase activity and steroid hydroxylase activity. Acts upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in liver and lung. Orthologous to human CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI327008; CYPIIIA25; cytochrome P450 3A25; cytochrome P450, 3a25
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395145,914,002 - 145,946,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5145,914,004 - 145,946,428 (-)EnsemblGRCm39 Ensembl
GRCm385145,977,192 - 146,009,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5145,977,194 - 146,009,618 (-)EnsemblGRCm38mm10GRCm38
MGSCv375146,788,770 - 146,821,194 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365146,281,451 - 146,313,842 (-)NCBIMGSCv36mm8
Celera5143,955,024 - 143,987,627 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map585.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11284050   PMID:12477932   PMID:12745259   PMID:14509827   PMID:14681479   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:21677750   PMID:21873635   PMID:23012479   PMID:27197076   PMID:32325033  


Genomics

Variants

.
Variants in Cyp3a25
732 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1371
Count of miRNA genes:501
Interacting mature miRNAs:592
Transcripts:ENSMUST00000068317, ENSMUST00000138870, ENSMUST00000145062, ENSMUST00000153808
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse

Markers in Region
AI327008  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385145,977,498 - 145,977,616UniSTSGRCm38
MGSCv375146,789,074 - 146,789,192UniSTSGRCm37
Celera5143,955,328 - 143,955,446UniSTS
Cytogenetic Map5G3UniSTS
cM Map585.0UniSTS
Whitehead/MRC_RH51742.88UniSTS
Cyp3a25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5G3UniSTS
cM Map585.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000068317   ⟹   ENSMUSP00000065585
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,914,006 - 145,946,427 (-)Ensembl
GRCm38.p6 Ensembl5145,977,196 - 146,009,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000138870   ⟹   ENSMUSP00000116077
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,914,376 - 145,946,408 (-)Ensembl
GRCm38.p6 Ensembl5145,977,566 - 146,009,598 (-)Ensembl
RefSeq Acc Id: ENSMUST00000145062   ⟹   ENSMUSP00000123615
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,914,004 - 145,946,428 (-)Ensembl
GRCm38.p6 Ensembl5145,977,194 - 146,009,618 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153808
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5145,921,767 - 145,928,453 (-)Ensembl
GRCm38.p6 Ensembl5145,984,957 - 145,991,643 (-)Ensembl
RefSeq Acc Id: NM_019792   ⟹   NP_062766
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395145,914,004 - 145,946,427 (-)NCBI
GRCm385145,977,194 - 146,009,617 (-)NCBI
MGSCv375146,788,770 - 146,821,194 (-)RGD
Celera5143,955,024 - 143,987,627 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_030782
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395145,914,004 - 145,946,428 (-)NCBI
GRCm385145,977,194 - 146,009,618 (-)NCBI
MGSCv375146,788,770 - 146,821,194 (-)RGD
Celera5143,955,024 - 143,987,627 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003955678
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395145,914,002 - 145,946,454 (-)NCBI
GRCm385145,977,192 - 146,009,644 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003955679
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395145,914,002 - 145,946,454 (-)NCBI
GRCm385145,977,192 - 146,009,644 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062766 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF15303 (Get FASTA)   NCBI Sequence Viewer  
  AAH28855 (Get FASTA)   NCBI Sequence Viewer  
  CAA72720 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000065585
  ENSMUSP00000065585.7
  ENSMUSP00000116077.2
  ENSMUSP00000123615.2
GenBank Protein O09158 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_062766   ⟸   NM_019792
- UniProtKB: O09158 (UniProtKB/Swiss-Prot),   Q9QXK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000123615   ⟸   ENSMUST00000145062
RefSeq Acc Id: ENSMUSP00000116077   ⟸   ENSMUST00000138870
RefSeq Acc Id: ENSMUSP00000065585   ⟸   ENSMUST00000068317

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09158-F1-model_v2 AlphaFold O09158 1-503 view protein structure

Promoters
RGD ID:6888764
Promoter ID:EPDNEW_M7833
Type:multiple initiation site
Name:Cyp3a25_1
Description:Mus musculus cytochrome P450, family 3, subfamily a, polypeptide25 , transcript variant 2, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385146,009,618 - 146,009,678EPDNEW
RGD ID:6837325
Promoter ID:MM_KWN:44850
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000061806
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365146,803,371 - 146,803,922 (-)MPROMDB
RGD ID:6837323
Promoter ID:MM_KWN:44851
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_019792,   NR_030782,   OTTMUST00000061805
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365146,820,821 - 146,821,321 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930638 AgrOrtholog
Ensembl Genes ENSMUSG00000029630 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068317 ENTREZGENE
  ENSMUST00000068317.13 UniProtKB/Swiss-Prot
  ENSMUST00000138870.2 UniProtKB/TrEMBL
  ENSMUST00000145062 ENTREZGENE
  ENSMUST00000145062.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56388 UniProtKB/Swiss-Prot
MGD MGI:1930638 ENTREZGENE
NCBI Gene 56388 ENTREZGENE
PANTHER CYTOCHROME P450 3A25-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP3A43 RGD
PhenoGen Cyp3a25 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CP3AP_MOUSE UniProtKB/Swiss-Prot
  D3Z707_MOUSE UniProtKB/TrEMBL
  D6RJM4_MOUSE UniProtKB/TrEMBL
  O09158 ENTREZGENE
  Q9QXK4 ENTREZGENE, UniProtKB/TrEMBL