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Gene: CYP3A5 (cytochrome P450 family 3 subfamily A member 5) Pan paniscus

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Symbol:

CYP3A5

Name:

cytochrome P450 family 3 subfamily A member 5

RGD ID:

11997830

Description:

ENCODES a protein that exhibits estrogen 16-alpha-hydroxylase activity (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN female pregnancy (ortholog); response to dexamethasone (ortholog); response to estradiol (ortholog); PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; carbamazepine pharmacokinetics pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autism spectrum disorder (ortholog); B-lymphoblastic leukemia/lymphoma (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); intracellular membrane-bounded organelle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450 3A5; LOC100976333

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	117,505,661 - 117,538,312 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	165,770,036 - 165,802,947 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	91,621,561 - 91,654,164 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,123,437 - 105,155,322 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,123,437 - 105,155,322 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

autism spectrum disorder (ISO)

B-lymphoblastic leukemia/lymphoma (ISO)

Chemotherapy-Induced Febrile Neutropenia (ISO)

chronic myeloid leukemia (ISO)

Drug-Induced Leukopenia (ISO)

Drug-induced Neutropenia (ISO)

essential hypertension (ISO)

Experimental Liver Cirrhosis (ISO)

kidney disease (ISO)

liver cirrhosis (ISO)

myasthenia gravis (ISO)

Myeloid Leukemia, Chronic-Phase (ISO)

nephrosis (ISO)

oral submucous fibrosis (ISO)

Pediatric Crohn's Disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Prostatic Neoplasms (ISO)

Reperfusion Injury (ISO)

thrombosis (ISO)

toxic encephalopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alkaloid catabolic process (IEA)

estrogen metabolic process (IEA)

female pregnancy (ISO)

lipid hydroxylation (IEA)

oxidative demethylation (IEA)

response to dexamethasone (ISO)

response to estradiol (ISO)

response to estrogen (ISO)

response to ethanol (ISO)

response to zinc ion (ISO)

retinoic acid metabolic process (IEA)

steroid metabolic process (IEA)

xenobiotic catabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

Molecular Function

estrogen 16-alpha-hydroxylase activity (IEA)

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (IEA)

protein binding (ISO)

retinoic acid 4-hydroxylase activity (IEA)

testosterone 6-beta-hydroxylase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

artemether pharmacokinetics pathway (ISO)

axitinib pharmacokinetics pathway (ISO)

carbamazepine pharmacokinetics pathway (ISO)

clopidogrel pharmacodynamics pathway (ISO)

clopidogrel pharmacokinetics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

fluoxetine pharmacokinetics pathway (ISO)

gefitinib pharmacokinetics pathway (ISO)

ifosfamide pharmacodynamics pathway (ISO)

ifosfamide pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

mycophenolic acid pharmacokinetics pathway (ISO)

neviparine pharmacokinetics pathway (ISO)

retinol metabolic pathway (ISO)

tamoxifen pharmacodynamics pathway (ISO)

tamoxifen pharmacokinetics pathway (ISO)

teniposide pharmacodynamics pathway (ISO)

teniposide pharmacokinetics pathway (ISO)

vitamin A deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CYP3A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	117,505,661 - 117,538,312 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	165,770,036 - 165,802,947 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	91,621,561 - 91,654,164 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,123,437 - 105,155,322 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,123,437 - 105,155,322 (-)	Ensembl	panpan1.1		panPan2

CYP3A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	99,648,194 - 99,679,996 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	99,648,194 - 99,679,996 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	99,245,817 - 99,277,619 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,083,753 - 99,115,557 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	98,890,467 - 98,922,257	NCBI
Celera	7	93,980,042 - 94,011,861 (-)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	93,882,179 - 93,914,147 (-)	NCBI		HuRef
CHM1_1	7	99,175,907 - 99,207,720 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	100,887,521 - 100,919,516 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	98,605,608 - 98,637,429 (-)	NCBI

Cyp3a11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	145,791,417 - 145,816,664 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	145,791,236 - 145,816,774 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	145,854,607 - 145,879,854 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	145,854,426 - 145,879,964 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	146,666,183 - 146,691,430 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	146,158,841 - 146,184,088 (-)	NCBI		MGSCv36	mm8
Celera	5	143,836,316 - 143,861,583 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	85.17	NCBI

Cyp3a9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	21,919,955 - 21,960,160 (-)	NCBI		GRCr8
mRatBN7.2	12	16,806,222 - 16,846,428 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,806,207 - 16,846,422 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,636,912 - 17,677,023 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	18,260,644 - 18,300,755 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	17,314,042 - 17,354,154 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	19,074,288 - 19,114,491 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	19,074,583 - 19,114,399 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	21,132,926 - 21,173,248 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	17,164,384 - 17,204,589 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	17,153,354 - 17,193,208 (+)	NCBI
Celera	12	18,744,706 - 18,784,438 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

CYP3A22
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	6,615,343 - 6,822,817 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	6,617,256 - 6,665,179 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CYP3A5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	13,473,649 - 13,517,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	13,491,483 - 13,519,507 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666070	2,792,815 - 2,818,567 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003815709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008968739	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008968740	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054914 ⟹ ENSPPAP00000032048

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	105,123,437 - 105,155,322 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054923 ⟹ ENSPPAP00000032057

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	105,123,548 - 105,128,971 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000054927 ⟹ ENSPPAP00000032060

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	105,151,824 - 105,155,192 (-)	Ensembl

RefSeq Acc Id:

XM_003815709 ⟹ XP_003815757

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	117,505,661 - 117,538,291 (-)	NCBI
NHGRI_mPanPan1	7	165,770,036 - 165,802,947 (-)	NCBI
Mhudiblu_PPA_v0	7	91,621,561 - 91,653,840 (-)	NCBI
PanPan1.1	7	105,123,437 - 105,155,322 (-)	NCBI

Sequence:

show sequence

ATAAATCTTTCAGCAGCTTGGCTGAAGACTGCTGTGCAGGGCAGGGAAGCTCCAGGCAAACAGC
CCAGCAAACAGCAGCACTCAGCTAAAAGGAAGACTCACAGAAGACAGTTGAAGAAGGAAAGTGG
CGATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCT
CCTCTATCTATATGGGACCCGTACACATGGACTTTTTAAGAGACTGGGAATTCCAGGGCCCACA
CCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATCGTCAGGGTCTCTGGAAATTTGACACAGAGT
GCTATAAAAAGTATGGGAAAATGTGGGGAATGTATGATGGTCAACTCCCTGTGCTGGCCATCAC
AGATCCCGACATGATCAGAACAGTGCTAGTGAAAGAATGTTATTCTGTCTTCACAAATCGAAGG
TCTTTAGGCCCAGTGGGATTTATGAAAAGTGCCATCTCTTTAGCTGAGGATGAAGAATGGAAGA
GAATACGGTCATTGCTGTCTCCAACCTTCACCAGCGGAAAACTCAAGGAGATGTTCCCCATCAT
TGCCCAGTATGGAGATGTATTGGTGAGAAACTTGAGGCGGGAAGCAGAGAAAGGCAAGCCTGTC
ACCTTGAAAGACATCTTTGGGGCCTACAGCATGGATGTGATTACTGGCACATCATTTGGAGTGA
ACATCGACTCTCTCAACAATCCACAAGACCCCTTTGTGGAGAGCACTAAGAAGTTCCTAAAATT
TGGTTTCTTAGATCCATTATTTCTCTCAATAATACTCTTTCCATTCCTTACCCCAGTTTTTGAA
GCATTAAATGTCTCTCTGTTTCCAAAAGATACCATAAATTTTTTAAGTAAATCTGTAAACAGAA
TGAAGAAAAGTCGCCTCAACGACAAACAAAAGCACCGACTAGATTTCCTTCAGCTGATGATTGA
CTCCCAGAATTCGAAAGAAACTGAGTCCCACAAAGCTCTGTCTGATCTGGAGCTCGCAGCCCAG
TCAATAATCTTCATTTTTGCTGGCTATGAAACCACCAGCAGTGTTCTTTCCTTCACTTTATATG
AACTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAAAAGGAGATTGATGCAGTTTTGCCCAA
TAAGGCACCACCTACCTATGATGCCGTGGTACAGATGGAGTACCTTGACATGGTGGTGAATGAA
ACACTCAGATTATTCCCAGTTGCTATTAGACTTGAGAGGACCTGCAAGAAAGATGTTGAAATCA
ATGGGGTATTCATTCCCAAAGGGTCAATGGTGGTGATTCCAACTTATGCTCTTCACCATGACCC
AAAGTACTGGACAGAGCCTGAGGAGTTCCGCCCTGAAAGGTTCAGTAAGAAGAAGGACAGCATA
GATCCTTACATATACACACCTTTTGGAACTGGACCCAGAAACTGCATTGGCATGAGGTTTGCTC
TCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAGAACTTCTCCTTCAAACCTTGTAAAGA
AACACAGATCCCCTTGAAATTAGACACGCAAGGACTTCTTCAACCAGAAAAACCCATTGTTCTA
AAGGTGGATTCAAGAGATGGAACCCTAAGTGGAGAATGAGTTATTCTAAGGACTTCTACTTTGG
TCTTCAAGAAAGCTGTGCCCCAGAACACCAGAGATTTCAACTTAGTCAATAAAACCTTGAAATA
AAGATGGGCTTAATCTAAGGTA

hide sequence

RefSeq Acc Id:

XM_008968740 ⟹ XP_008966988

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	117,529,304 - 117,538,312 (-)	NCBI
NHGRI_mPanPan1	7	165,793,939 - 165,802,947 (-)	NCBI
Mhudiblu_PPA_v0	7	91,640,319 - 91,654,164 (-)	NCBI
PanPan1.1	7	105,146,976 - 105,155,322 (-)	NCBI

Sequence:

show sequence

ATAAATCTTTCAGCAGCTTGGCTGAAGACTGCTGTGCAGGGCAGGGAAGCTCCAGGCAAACAGC
CCAGCAAACAGCAGCACTCAGCTAAAAGGAAGACTCACAGAAGACAGTTGAAGAAGGAAAGTGG
CGATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCT
CCTCTATCTATATGGGACCCGTACACATGGACTTTTTAAGAGACTGGGAATTCCAGGGCCCACA
CCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATCGTCAGGGTCTCTGGAAATTTGACACAGAGT
GCTATAAAAAGTATGGGAAAATGTGGGGAATGTATGATGGTCAACTCCCTGTGCTGGCCATCAC
AGATCCCGACATGATCAGAACAGTGCTAGTGAAAGAATGTTATTCTGTCTTCACAAATCGAAGG
ATTTGTGCAACGACCAGCACCGTCAAGATGCAGACCCATTCCGTCACCATGTGGCTCCCTCCTG
CTGTCCTACAGTCACAACATGGAGTTTGTCTTTTTCTCTGACAGGTTCTATATCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003815757	(Get FASTA)	NCBI Sequence Viewer
	XP_008966988	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000032048
	ENSPPAP00000032048.1
	ENSPPAP00000032057.1
	ENSPPAP00000032060.1

RefSeq Acc Id:	XP_003815757 ⟸ XM_003815709
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9BZX8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTEC YKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKR IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN IDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRM KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYE LATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEIN GVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFAL MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE hide sequence

RefSeq Acc Id:	XP_008966988 ⟸ XM_008968740
- Peptide Label:	isoform X2
- Sequence:	show sequence MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTEC YKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVFTNRRICATTSTVKMQTHSVTMWLPPA VLQSQHGVCLFL hide sequence

Ensembl Acc Id:

ENSPPAP00000032057 ⟸ ENSPPAT00000054923

Ensembl Acc Id:

ENSPPAP00000032048 ⟸ ENSPPAT00000054914

Ensembl Acc Id:

ENSPPAP00000032060 ⟸ ENSPPAT00000054927

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038928	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054914.1	UniProtKB/TrEMBL
	ENSPPAT00000054923.1	UniProtKB/TrEMBL
	ENSPPAT00000054927.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_CYP3A	UniProtKB/TrEMBL
	Cyt_P450_E_grp-II	UniProtKB/TrEMBL
	Cyt_P450_E_grp-IV	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
	Cytochrome_P450_3A	UniProtKB/TrEMBL
KEGG Report	pps:100976333	UniProtKB/TrEMBL
NCBI Gene	LOC100976333	ENTREZGENE
PANTHER	CYTOCHROME P450 3A5	UniProtKB/TrEMBL
	CYTOCHROME P450 FAMILY 3	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450II	UniProtKB/TrEMBL
	EP450IICYP3A	UniProtKB/TrEMBL
	EP450IV	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A2R9BQW4_PANPA	UniProtKB/TrEMBL
	A0A2R9BRJ8_PANPA	UniProtKB/TrEMBL
	A0A2R9BZX8	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83023	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-25	CYP3A5	cytochrome P450 family 3 subfamily A member 5	LOC100976333	cytochrome P450 3A5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB