Cyp3a18 (cytochrome P450, family 3, subfamily a, polypeptide 18) - Rat Genome Database

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Gene: Cyp3a18 (cytochrome P450, family 3, subfamily a, polypeptide 18) Rattus norvegicus
Analyze
Symbol: Cyp3a18
Name: cytochrome P450, family 3, subfamily a, polypeptide 18
RGD ID: 628709
Description: Enables testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; linoleic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPIIIA18; cytochrome P450 3A18; cytochrome P450(6)beta-2; cytochrome P450, 3a18; P450(6)beta-2
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,994,312 - 14,044,185 (+)NCBIGRCr8
mRatBN7.2128,880,509 - 8,930,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,678,389 - 9,728,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,301,584 - 10,351,575 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,325,028 - 9,375,015 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01210,636,294 - 10,684,273 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,738,271 - 12,787,784 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,086,752 - 9,136,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,116,679 - 9,166,534 (-)NCBI
Celera1210,707,212 - 10,757,562 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bosentan  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
dexamethasone  (EXP)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diuron  (EXP)
endosulfan  (EXP)
ethoxyquin  (EXP)
fipronil  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
Ginkgolide A  (EXP)
glafenine  (EXP)
methapyrilene  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
obeticholic acid  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
riddelliine  (EXP)
rotenone  (EXP)
senecionine  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triadimefon  (EXP)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP)
verapamil  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. Nagata K, etal., Pharmacogenetics 1996 Feb;6(1):103-11.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. A novel CYP3 gene from female rats. Strotkamp D, etal., Biochim Biophys Acta 1995 Feb 21;1260(3):341-4.
Additional References at PubMed
PMID:3259858   PMID:14559847   PMID:15039299   PMID:15256616   PMID:15327587   PMID:15546903   PMID:15680923   PMID:16401082   PMID:18356043   PMID:18446064   PMID:18619574   PMID:19219744  


Genomics

Comparative Map Data
Cyp3a18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81213,994,312 - 14,044,185 (+)NCBIGRCr8
mRatBN7.2128,880,509 - 8,930,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,678,389 - 9,728,392 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,301,584 - 10,351,575 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,325,028 - 9,375,015 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01210,636,294 - 10,684,273 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01212,738,271 - 12,787,784 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,086,752 - 9,136,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,116,679 - 9,166,534 (-)NCBI
Celera1210,707,212 - 10,757,562 (+)NCBICelera
Cytogenetic Map12p11NCBI
CYP3A43
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,828,013 - 99,866,093 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,828,013 - 99,866,093 (+)EnsemblGRCh38hg38GRCh38
GRCh37799,425,636 - 99,463,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,263,572 - 99,302,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,070,286 - 99,108,824NCBI
Celera794,159,885 - 94,198,421 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,061,564 - 94,099,614 (+)NCBIHuRef
CHM1_1799,355,683 - 99,393,889 (+)NCBICHM1_1
T2T-CHM13v2.07101,067,527 - 101,105,595 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,785,456 - 98,823,546 (+)NCBI
CYP3A43
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,746,741 - 117,785,619 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,011,375 - 166,050,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,862,437 - 91,903,033 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,296,111 - 105,335,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,296,111 - 105,335,958 (+)Ensemblpanpan1.1panPan2
CYP3A43
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,217,123 - 13,256,859 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2813,216,548 - 13,257,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,012,292 - 3,052,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cyp3a18
283 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000001285
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 2 7 4 4 2 9 2
Below cutoff 1 17 18 8 14 8 5 5 7 11 8 7 5

Sequence


RefSeq Acc Id: ENSRNOT00000001285   ⟹   ENSRNOP00000001285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,880,528 - 8,930,381 (+)Ensembl
Rnor_6.0 Ensembl1210,636,275 - 10,684,276 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075671   ⟹   ENSRNOP00000065082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1210,636,275 - 10,684,278 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107940   ⟹   ENSRNOP00000077873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl128,880,528 - 8,911,358 (+)Ensembl
RefSeq Acc Id: NM_145782   ⟹   NP_665725
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81213,994,312 - 14,044,184 (+)NCBI
mRatBN7.2128,880,509 - 8,930,381 (+)NCBI
Rnor_6.01210,636,294 - 10,684,273 (+)NCBI
Rnor_5.01212,738,271 - 12,787,784 (+)NCBI
RGSC_v3.4129,086,752 - 9,136,606 (-)RGD
Celera1210,707,212 - 10,757,562 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089108   ⟹   XP_038945036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,017,103 - 14,044,185 (+)NCBI
mRatBN7.2128,903,304 - 8,930,382 (+)NCBI
RefSeq Acc Id: NP_665725   ⟸   NM_145782
- UniProtKB: Q64581 (UniProtKB/Swiss-Prot),   G3V635 (UniProtKB/TrEMBL),   A6K1D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065082   ⟸   ENSRNOT00000075671
RefSeq Acc Id: ENSRNOP00000001285   ⟸   ENSRNOT00000001285
RefSeq Acc Id: XP_038945036   ⟸   XM_039089108
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000077873   ⟸   ENSRNOT00000107940

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64581-F1-model_v2 AlphaFold Q64581 1-497 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698409
Promoter ID:EPDNEW_R8934
Type:single initiation site
Name:Cyp3a18_1
Description:cytochrome P450, family 3, subfamily a, polypeptide 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01210,636,275 - 10,636,335EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628709 AgrOrtholog
BioCyc Gene G2FUF-20073 BioCyc
Ensembl Genes ENSRNOG00000000969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001285 ENTREZGENE
  ENSRNOT00000001285.6 UniProtKB/TrEMBL
  ENSRNOT00000107940.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252931 UniProtKB/Swiss-Prot
NCBI Gene 252931 ENTREZGENE
PANTHER CYTOCHROME P450 3A25-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP3A43 RGD
PhenoGen Cyp3a18 PhenoGen
PRINTS EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000969 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YC28_RAT UniProtKB/TrEMBL
  A6K1D6 ENTREZGENE, UniProtKB/TrEMBL
  CP3AI_RAT UniProtKB/Swiss-Prot
  G3V635 ENTREZGENE, UniProtKB/TrEMBL
  Q64581 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp3a18  cytochrome P450, family 3, subfamily a, polypeptide 18  Cyp3a18  cytochrome P450, 3a18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-02-27 Cyp3a18  cytochrome P450, 3a18      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is male-dominant 727620