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Gene: Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) Rattus norvegicus
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
RGD ID: 628626
Description: Exhibits demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to cadmium ion; and response to glucocorticoid. Localizes to endoplasmic reticulum membrane and intracellular membrane-bounded organelle. Biomarker of cholestasis and mental depression. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trichlorobenzene; 1,2-dichloroethene.
Type: protein-coding
Also known as: cDEX; CYP; Cyp3a1; CYP3A23; Cyp3a23/3a1; Cyp3a3; CYPIIIA1; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B; MGC108757; P450 IIIA; P450-PCN1; RL33
No known orthologs. homologs ...
Allele / Splice: Cyp3a23-3a1em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01211,053,888 - 11,082,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,145,742 - 13,174,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,567,120 - 9,595,974 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,596,712 - 9,625,890 (-)NCBI
Celera1211,063,015 - 11,090,937 (-)NCBICelera
Cytogenetic Map12p11NCBI
RH 3.4 Map12117.0RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cyp3a23-3a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628626
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.