Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) - Rat Genome Database

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Gene: Cyp3a23-3a1 (cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1) Rattus norvegicus
No known orthologs.
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
RGD ID: 628626
Description: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including aging; oxidative demethylation; and response to dexamethasone. Located in endoplasmic reticulum membrane. Biomarker of cholestasis and mental depression. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5); PARTICIPATES IN tamoxifen pharmacokinetics pathway; linoleic acid metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trichlorobenzene; 1,2-dichloroethene.
Type: protein-coding
Previously known as: AABR07035343.1; cDEX; CYP; Cyp3a1; CYP3A23; Cyp3a23/3a1; Cyp3a3; CYPIIIA1; cytochrome P-450; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1; cytochrome P450 3A1-like; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; Cytochrome P450, subfamily IIIA, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B; LOC100910877; MGC108757; P450 IIIA; P450-PCN1; RL33
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: Cyp3a23-3a1em1Myliu  
Genetic Models: SD-Cyp3a23/3a1em1Myliu,Cyp3a2em1Myliu
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2129,256,159 - 9,285,020 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,058,901 - 10,087,682 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01210,682,086 - 10,710,867 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0129,705,516 - 9,734,297 (-)NCBIRnor_WKY
Rnor_6.01211,053,888 - 11,082,742 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,145,742 - 13,174,596 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,567,120 - 9,595,974 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,596,712 - 9,625,890 (-)NCBI
Celera1211,063,015 - 11,090,937 (-)NCBICelera
RH 3.4 Map12117.0RGD
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichlorobenzene  (EXP)
1,2-dichloroethene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-methylcholanthrene  (EXP)
3-oxo-5beta-cholanic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (EXP)
4-nitrophenol  (EXP)
4-nonylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetonitrile  (EXP)
Acetyl tributyl citrate  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
alachlor  (EXP)
alkaloid  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-Hydroxyalprazolam  (EXP)
alprazolam  (EXP)
amiodarone  (EXP)
amitraz  (EXP)
amitriptyline  (EXP)
andrographolide  (EXP)
anthocyanin  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (EXP)
atorvastatin calcium  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzophenone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bilirubin IXalpha  (EXP)
bilobalide  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bitertanol  (EXP)
Bromadiolone  (EXP)
bromuconazole  (EXP)
calcitriol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carvedilol  (EXP)
chalcone  (EXP)
chenodeoxycholic acid  (EXP)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chlorpyrifos  (EXP)
chlorzoxazone  (EXP)
cholesterol  (EXP)
cholic acid  (EXP)
choline  (EXP)
ciprofibrate  (EXP)
ciprofloxacin  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
clomipramine  (EXP)
clothianidin  (EXP)
clotrimazole  (EXP)
cocaine  (EXP)
cordycepin  (EXP)
corticosterone  (EXP)
cortisol  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
dextromethorphan  (EXP)
Diallyl sulfide  (EXP)
dibenziodolium  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dicofol  (EXP)
diflubenzuron  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
diuron  (EXP)
enilconazole  (EXP)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP)
ethoxyquin  (EXP)
farnesol  (EXP)
felbamate  (EXP)
fenofibrate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
fipronil-sulfone  (EXP)
fluconazole  (EXP)
Furafylline  (EXP)
furan  (EXP)
gabapentin  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
Ginkgolide A  (EXP)
glafenine  (EXP)
glutathione  (EXP)
hexachlorobenzene  (EXP)
huperzine A  (EXP)
ifosfamide  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
isoniazide  (EXP)
ketamine  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
L-methionine  (EXP)
lactacystin  (EXP)
lamotrigine  (EXP)
Lasiocarpine  (EXP)
leflunomide  (EXP)
lithocholic acid  (EXP)
mangiferin  (EXP)
metazachlor  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP)
miconazole  (EXP)
midazolam  (EXP)
mifepristone  (EXP)
monocrotaline  (EXP)
Muraglitazar  (EXP)
musk xylene  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nelfinavir  (EXP)
nemorubicin  (EXP)
nevirapine  (EXP)
nicardipine  (EXP)
nifedipine  (EXP)
Nonylphenol  (EXP)
obeticholic acid  (EXP)
octamethylcyclotetrasiloxane  (EXP)
okadaic acid  (EXP)
oltipraz  (EXP)
omeprazole  (EXP)
oxycodone  (EXP)
paracetamol  (EXP)
Paraoxon-methyl  (EXP)
parathion-methyl  (EXP)
PCB138  (EXP)
pentachlorobenzene  (EXP)
pentachlorophenol  (EXP)
perfluorobutyric acid  (EXP)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (EXP)
phenytoin  (EXP)
phthalic acid  (EXP)
pioglitazone  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (EXP)
pravastatin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP)
pyrene  (EXP)
pyridine  (EXP)
rifampicin  (EXP)
ritonavir  (EXP)
rotenone  (EXP)
sodium arsenite  (EXP)
spironolactone  (EXP)
stilbene oxide  (EXP)
strychnine  (EXP)
Sudan III  (EXP)
sulfoxaflor  (EXP)
tamoxifen  (EXP)
taurocholic acid  (EXP)
tert-butyl ethyl ether  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thiacloprid  (EXP)
thioacetamide  (EXP)
toremifene  (EXP)
trabectedin  (EXP)
trans-1,2-dichloroethene  (EXP)
trans-chalcone  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (EXP)
trifluralin  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
troglitazone  (EXP)
troleandomycin  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP)
zaragozic acid A  (EXP)
zearalenone  (EXP)


References - curated
# Reference Title Reference Citation
1. Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis. Gabbia D, etal., World J Gastroenterol. 2017 Nov 14;23(42):7519-7530. doi: 10.3748/wjg.v23.i42.7519.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. Gonzalez FJ, etal., J Biol Chem 1985 Jun 25;260(12):7435-41.
4. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
5. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
6. Comparative study on nobiletin metabolism with liver microsomes from rats, Guinea pigs and hamsters and rat cytochrome p450. Koga N, etal., Biol Pharm Bull. 2007 Dec;30(12):2317-23.
7. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Kotsovolou O, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1075-84. Epub 2010 Jun 4.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2. Mei Q, etal., J Pharm Sci. 2004 Oct;93(10):2488-96.
10. Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. Nagata K, etal., Arch Biochem Biophys. 1999 Feb 15;362(2):242-53.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Profile of territrem metabolism and cytochrome P-450 3A expression in liver microsomes from Wistar rats of both genders as a function of age. Peng FC, etal., J Toxicol Environ Health A. 2005 Nov 12;68(21):1871-88.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. Effects of chronic exposure to cadmium on renal cytochrome P450-dependent monooxygenase system in rats. Plewka A, etal., Arch Toxicol. 2004 Apr;78(4):194-200. Epub 2003 Nov 1.
15. Selective downregulation of hepatic cytochrome P450 expression and activity in a rat model of inflammatory pain. Projean D, etal., Pharm Res. 2005 Jan;22(1):62-70.
16. Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices. Rekka E, etal., Biochem Pharmacol 2002 Aug 15;64(4):633-43.
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats. Ronis MJ, etal., Exp Biol Med (Maywood). 2006 Jan;231(1):60-9.
20. In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat. Souidi M, etal., Toxicology. 2005 Oct 15;214(1-2):113-22.
21. Induction of cytochrome P450 enzymes in rat liver by two conazoles, myclobutanil and triadimefon. Sun G, etal., Xenobiotica. 2007 Feb;37(2):180-93.
22. Critical amino-terminal segments in insertion of rat liver cytochrome P450 3A1 into the endoplasmic reticulum membrane. Van den Broek PJ, etal., Experientia 1996 Sep 15;52(9):851-5.
Additional References at PubMed
PMID:1298226   PMID:1372436   PMID:1417000   PMID:1731631   PMID:2398038   PMID:3875783   PMID:7528203   PMID:7681660   PMID:8274011   PMID:11901229   PMID:12477932   PMID:15979568  
PMID:16461430   PMID:19435144   PMID:19504095   PMID:19848203   PMID:20599767   PMID:22159698   PMID:22822673   PMID:23235327   PMID:23762486   PMID:24212381   PMID:25302309   PMID:25989892  
PMID:26900149   PMID:27899252   PMID:28532222   PMID:29381299   PMID:30811654   PMID:34461081  



Variants in Cyp3a23-3a1
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:139
Interacting mature miRNAs:156
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,255,993 - 9,256,161 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,772 - 11,703,939NCBIRnor6.0
Rnor_6.01211,053,723 - 11,053,890NCBIRnor6.0
Rnor_5.01213,145,577 - 13,145,744UniSTSRnor5.0
Rnor_5.01213,766,697 - 13,766,864UniSTSRnor5.0
RGSC_v3.4129,566,955 - 9,567,122UniSTSRGSC3.4
Celera1211,062,850 - 11,063,017UniSTS
Cytogenetic Map12p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,256,029 - 9,256,241 (+)MAPPERmRatBN7.2
Rnor_6.01211,703,808 - 11,704,019NCBIRnor6.0
Rnor_6.01211,053,759 - 11,053,970NCBIRnor6.0
Rnor_5.01213,766,733 - 13,766,944UniSTSRnor5.0
Rnor_5.01213,145,613 - 13,145,824UniSTSRnor5.0
RGSC_v3.4129,566,991 - 9,567,202UniSTSRGSC3.4
Celera1211,062,886 - 11,063,097UniSTS
RH 3.4 Map12102.2UniSTS
Cytogenetic Map12p11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,285,598 - 9,285,757 (+)MAPPERmRatBN7.2
Rnor_6.01211,733,681 - 11,733,839NCBIRnor6.0
Rnor_6.01211,083,321 - 11,083,479NCBIRnor6.0
Rnor_5.01213,796,606 - 13,796,764UniSTSRnor5.0
Rnor_5.01213,175,175 - 13,175,333UniSTSRnor5.0
RGSC_v3.4129,596,553 - 9,596,711UniSTSRGSC3.4
Celera1211,091,516 - 11,091,674UniSTS
RH 3.4 Map12117.0UniSTS
Cytogenetic Map12p11UniSTS

Genetic Models
This gene Cyp3a23-3a1 is modified in the following models/strains


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4 4 4
Medium 20 20 20 1
Low 2 16 13 1 13 2 2 2 4 3 2
Below cutoff 2 7 12 3 3 13 8 15 5 3


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051244   ⟹   ENSRNOP00000041138
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Rnor_6.0 Ensembl1211,703,598 - 11,733,099 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087257   ⟹   ENSRNOP00000068625
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099867   ⟹   ENSRNOP00000094020
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,207,980 - 9,230,043 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100533   ⟹   ENSRNOP00000082425
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,285,030 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104663   ⟹   ENSRNOP00000084206
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118926   ⟹   ENSRNOP00000088335
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,282,915 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119539   ⟹   ENSRNOP00000087895
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl129,254,475 - 9,283,058 (-)Ensembl
RefSeq Acc Id: NM_013105   ⟹   NP_037237
Rat AssemblyChrPosition (strand)Source
mRatBN7.2129,256,159 - 9,285,020 (-)NCBI
Rnor_6.01211,053,888 - 11,082,742 (-)NCBI
Rnor_5.01213,145,742 - 13,174,596 (-)NCBI
RGSC_v3.4129,567,120 - 9,595,974 (-)RGD
Celera1211,063,015 - 11,090,937 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_037237   ⟸   NM_013105
- UniProtKB: Q06884 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068625   ⟸   ENSRNOT00000087257
RefSeq Acc Id: ENSRNOP00000041138   ⟸   ENSRNOT00000051244
RefSeq Acc Id: ENSRNOP00000084206   ⟸   ENSRNOT00000104663
RefSeq Acc Id: ENSRNOP00000082425   ⟸   ENSRNOT00000100533
RefSeq Acc Id: ENSRNOP00000088335   ⟸   ENSRNOT00000118926
RefSeq Acc Id: ENSRNOP00000087895   ⟸   ENSRNOT00000119539
RefSeq Acc Id: ENSRNOP00000094020   ⟸   ENSRNOT00000099867

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04800-F1-model_v2 AlphaFold P04800 1-504 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628626 AgrOrtholog
BioCyc Gene G2FUF-20067 BioCyc
Ensembl Genes ENSRNOG00000032560 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000062027 UniProtKB/TrEMBL
  ENSRNOG00000067532 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041138.2 UniProtKB/TrEMBL
  ENSRNOP00000068625.2 UniProtKB/TrEMBL
  ENSRNOP00000082425.1 UniProtKB/TrEMBL
  ENSRNOP00000084206.1 UniProtKB/TrEMBL
  ENSRNOP00000084956.1 UniProtKB/TrEMBL
  ENSRNOP00000087895.1 UniProtKB/TrEMBL
  ENSRNOP00000088335.1 UniProtKB/TrEMBL
  ENSRNOP00000094020.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051244.2 UniProtKB/TrEMBL
  ENSRNOT00000071669.4 UniProtKB/TrEMBL
  ENSRNOT00000087257.2 UniProtKB/TrEMBL
  ENSRNOT00000099867.1 UniProtKB/TrEMBL
  ENSRNOT00000100533.1 UniProtKB/TrEMBL
  ENSRNOT00000104663.1 UniProtKB/TrEMBL
  ENSRNOT00000118926.1 UniProtKB/TrEMBL
  ENSRNOT00000119539.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25642 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp3a23-3a1 PhenoGen
  EP450II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205966
UniProt A0A0G2JT98_RAT UniProtKB/TrEMBL
  CP3A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64580 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  AABR07035343.1    Data Merged 737654 PROVISIONAL
2021-03-09 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  LOC100910877  cytochrome P450 3A1-like  Data Merged 737654 PROVISIONAL
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1  Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Name changed 629549 APPROVED
2020-04-16 Cyp3a23-3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol changed 629549 APPROVED
2019-11-08 AABR07035343.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-07-05 LOC100910877  cytochrome P450 3A1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-08 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Data Merged 737654 APPROVED
2007-09-21 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Symbol and Name updated 1299863 APPROVED
2007-09-21 Cyp3a23/3a1_retired  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1_retired  Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Symbol and Name updated 1299863 PROVISIONAL
2007-07-06 Cyp3a23/3a1  cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1  Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3  Name updated 1299863 APPROVED
2005-09-08 Cyp3a1  cytochrome P450, family 3, subfamily a, polypeptide 1  Cyp3A1  cytochrome P-450PCN (PNCN inducible)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-02-27 Cyp3A1  cytochrome P-450PCN (PNCN inducible)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-11-06 Cyp3a3  cytochrome P450, subfamily 3A, polypeptide 3    Cytochrome P450, subfamily IIIA, polypeptide 3  Name updated 625702 APPROVED
2002-06-10 Cyp3a3  Cytochrome P450, subfamily IIIA, polypeptide 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs induced strongly by pregnenolone 16 alpha-carbonitrile and dexamethasone (DEX) and weakly by phenobarbital (PB) and triacetyloleandomycin 1298860
gene_expression expressed in liver 1298860