Cyp3a59 (cytochrome P450, family 3, subfamily a, polypeptide 59) - Rat Genome Database

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Gene: Cyp3a59 (cytochrome P450, family 3, subfamily a, polypeptide 59) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
RGD ID: 2294005
MGI Page MGI
Description: Predicted to enable retinoic acid 4-hydroxylase activity and steroid hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Orthologous to human CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A7 (cytochrome P450 family 3 subfamily A member 7).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome P450, subfamily 3A, polypeptide 59; ENSMUSG00000061292
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395146,016,018 - 146,051,788 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5146,016,067 - 146,050,097 (+)EnsemblGRCm39 Ensembl
GRCm385146,079,208 - 146,114,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5146,079,257 - 146,113,287 (+)EnsemblGRCm38mm10GRCm38
MGSCv375146,890,834 - 146,924,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365146,890,834 - 146,924,861 (+)NCBIMGSCv36mm8
Celera5144,054,053 - 144,087,616 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map585.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17975676   PMID:21677750   PMID:21873635   PMID:23125282  


Genomics

Variants

.
Variants in Cyp3a59
891 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:110
Interacting mature miRNAs:110
Transcripts:ENSMUST00000035571
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035571   ⟹   ENSMUSP00000049494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5146,016,077 - 146,050,095 (+)Ensembl
GRCm38.p6 Ensembl5146,079,267 - 146,113,285 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199212   ⟹   ENSMUSP00000142591
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5146,016,067 - 146,050,097 (+)Ensembl
GRCm38.p6 Ensembl5146,079,257 - 146,113,287 (+)Ensembl
RefSeq Acc Id: NM_001105160   ⟹   NP_001098630
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,016,068 - 146,050,095 (+)NCBI
GRCm385146,079,258 - 146,113,285 (+)NCBI
Celera5144,054,053 - 144,087,616 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030254003   ⟹   XP_030109863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,016,025 - 146,051,788 (+)NCBI
GRCm385146,079,215 - 146,114,978 (+)NCBI
Sequence:
RefSeq Acc Id: XR_868673
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395146,016,018 - 146,045,936 (+)NCBI
GRCm385146,079,208 - 146,109,126 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001098630 (Get FASTA)   NCBI Sequence Viewer  
  XP_030109863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000049494
  ENSMUSP00000049494.9
  ENSMUSP00000142591.2
Reference Protein Sequences
RefSeq Acc Id: NP_001098630   ⟸   NM_001105160
- UniProtKB: D3Z2W7 (UniProtKB/TrEMBL),   Q9QXK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030109863   ⟸   XM_030254003
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000142591   ⟸   ENSMUST00000199212
RefSeq Acc Id: ENSMUSP00000049494   ⟸   ENSMUST00000035571

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z2W7-F1-model_v2 AlphaFold D3Z2W7 1-503 view protein structure

Promoters
RGD ID:6888766
Promoter ID:EPDNEW_M7834
Type:multiple initiation site
Name:Cyp3a59_1
Description:Mus musculus cytochrome P450, family 3, subfamily a, polypeptide59 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385146,079,257 - 146,079,317EPDNEW
RGD ID:6837336
Promoter ID:MM_KWN:44852
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001105160
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365146,890,696 - 146,891,196 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3769707 AgrOrtholog
Ensembl Genes ENSMUSG00000061292 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035571 ENTREZGENE
  ENSMUST00000035571.10 UniProtKB/TrEMBL
  ENSMUST00000199212.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report mmu:100041449 UniProtKB/TrEMBL
MGD MGI:3769707 ENTREZGENE
NCBI Gene 100041449 ENTREZGENE
PANTHER CYTOCHROME P450 3A25-RELATED UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp3a59 PhenoGen
PRINTS EP450II UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2JE14_MOUSE UniProtKB/TrEMBL
  D3Z2W7 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXK4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-17 Cyp3a59  cytochrome P450, family 3, subfamily a, polypeptide 59  ENSMUSG00000061292  predicted gene, ENSMUSG00000061292  Symbol and/or name change 5135510 APPROVED