CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) - Rat Genome Database

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Gene: CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) Canis lupus familiaris
Analyze
Symbol: CYP3A4
Name: cytochrome P450, family 3, subfamily A, polypeptide 4
RGD ID: 12169872
Description: ENCODES a protein that exhibits steroid hydroxylase activity; testosterone 6-beta-hydroxylase activity; 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (ortholog); INVOLVED IN hormone metabolic process; organic hydroxy compound metabolic process; progesterone metabolic process; PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; caffeine pharmacokinetics pathway; ASSOCIATED WITH anxiety disorder (ortholog); Breast Neoplasms (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH midazolam; phenobarbital
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP3A12; cytochrome P450 3A12; cytochrome P450 CYP3A12
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBI
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBI
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
midazolam  (EXP)
phenobarbital  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
artemether pharmacokinetics pathway  (ISO)
axitinib pharmacokinetics pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway  (ISO)
clomipramine pharmacokinetics pathway  (ISO)
clopidogrel pharmacodynamics pathway  (ISO)
clopidogrel pharmacokinetics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
doxepin pharmacokinetics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fluoxetine pharmacokinetics pathway  (ISO)
gefitinib pharmacokinetics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
imipramine pharmacokinetics pathway  (ISO)
irinotecan pharmacodynamics pathway  (ISO)
irinotecan pharmacokinetics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lidocaine pharmacokinetics pathway  (ISO)
losartan pharmacokinetics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
mycophenolic acid pharmacokinetics pathway  (ISO)
nateglinide pharmacokinetics pathway  (ISO)
neviparine pharmacokinetics pathway  (ISO)
paracetamol pharmacokinetics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
prednisone pharmacodynamics pathway  (ISO)
prednisone pharmacokinetics pathway  (ISO)
repaglinide pharmacokinetics pathway  (ISO)
retinol metabolic pathway  (ISO)
sorafenib pharmacokinetics pathway  (ISO)
statin pharmacokinetics pathway  (ISO)
tamoxifen pharmacodynamics pathway  (ISO)
tamoxifen pharmacokinetics pathway  (ISO)
teniposide pharmacodynamics pathway  (ISO)
teniposide pharmacokinetics pathway  (ISO)
tramadol pharmacokinetics pathway  (ISO)
venlafaxine pharmacokinetics pathway  (ISO)
vinblastine pharmacodynamics pathway  (ISO)
vinorelbine pharmacodynamics pathway  (ISO)
vitamin A deficiency pathway  (ISO)
warfarin pharmacokinetics pathway  (ISO)

References
Additional References at PubMed
PMID:16446074   PMID:16971569  


Genomics

Comparative Map Data
CYP3A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBI
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBI
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBI
CYP3A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl799,756,960 - 99,784,248 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBINCBI36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
Cyp3a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,207,986 - 9,230,038 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)Ensembl
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
CYP3A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17105,230,666 - 105,258,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,230,666 - 105,258,401 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0791,797,037 - 91,824,696 (-)NCBIMhudiblu_PPA_v0panPan3
LOC103246766
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,297,566 - 13,330,023 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660702,940,765 - 2,971,719 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 6 6 1
Low 4 13 5 5 3 8 10 1
Below cutoff 5 3 1 6 9 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022419682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038478090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038478091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_536868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide DQ225113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_038478090   ⟹   XP_038334018
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBI
RefSeq Acc Id: XM_038478091   ⟹   XP_038334019
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,696,608 - 9,720,690 (-)NCBI
RefSeq Acc Id: XM_038539354   ⟹   XP_038395282
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBI
RefSeq Acc Id: XM_038539355   ⟹   XP_038395283
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,914,747 - 9,938,690 (-)NCBI
RefSeq Acc Id: XM_038603445   ⟹   XP_038459373
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBI
RefSeq Acc Id: XM_038603446   ⟹   XP_038459374
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,680,218 - 9,704,309 (-)NCBI
RefSeq Acc Id: XM_038668134   ⟹   XP_038524062
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
RefSeq Acc Id: XM_038668135   ⟹   XP_038524063
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
RefSeq Acc Id: XM_038668136   ⟹   XP_038524064
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,856,237 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_038334018   ⟸   XM_038478090
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038334019   ⟸   XM_038478091
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459373   ⟸   XM_038603445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459374   ⟸   XM_038603446
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038524063   ⟸   XM_038668135
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524062   ⟸   XM_038668134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038524064   ⟸   XM_038668136
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038395282   ⟸   XM_038539354
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038395283   ⟸   XM_038539355
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014877 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845003103 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000021934 UniProtKB/TrEMBL
  ENSCAFP00000022014 UniProtKB/TrEMBL
  ENSCAFP00000044265 UniProtKB/TrEMBL
  ENSCAFP00000049540 UniProtKB/TrEMBL
  ENSCAFP00000051448 UniProtKB/TrEMBL
  ENSCAFP00000051896 UniProtKB/TrEMBL
  ENSCAFP00000055117 UniProtKB/TrEMBL
  ENSCAFP00000064544 UniProtKB/TrEMBL
  ENSCAFP00000066156 UniProtKB/TrEMBL
  ENSCAFP00845004507 ENTREZGENE
Ensembl Transcript ENSCAFT00000023623 UniProtKB/TrEMBL
  ENSCAFT00000023714 UniProtKB/TrEMBL
  ENSCAFT00000061904 UniProtKB/TrEMBL
  ENSCAFT00000068753 UniProtKB/TrEMBL
  ENSCAFT00000070806 UniProtKB/TrEMBL
  ENSCAFT00000074667 UniProtKB/TrEMBL
  ENSCAFT00000077891 UniProtKB/TrEMBL
  ENSCAFT00000085015 UniProtKB/TrEMBL
  ENSCAFT00000086581 UniProtKB/TrEMBL
  ENSCAFT00845005681 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene CYP3A4 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450II UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A5F4BR12_CANLF UniProtKB/TrEMBL
  A0A5F4C5K6_CANLF UniProtKB/TrEMBL
  A0A5F4CAY2_CANLF UniProtKB/TrEMBL
  A0A5F4CER1_CANLF UniProtKB/TrEMBL
  A0A5F4CNX4_CANLF UniProtKB/TrEMBL
  A0A5F4DCS3_CANLF UniProtKB/TrEMBL
  A0A5F4DI66_CANLF UniProtKB/TrEMBL
  F1PDL2_CANLF UniProtKB/TrEMBL
  F1PKT7_CANLF UniProtKB/TrEMBL