CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) Canis lupus familiaris
Analyze
Symbol: CYP3A4 (Ensembl: CYP3A26)
Name: cytochrome P450, family 3, subfamily A, polypeptide 4 (Ensembl:cytochrome P450 3A26)
RGD ID: 12169872
Description: ENCODES a protein that exhibits 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (ortholog); caffeine oxidase activity (ortholog); demethylase activity (ortholog); INVOLVED IN alkaloid catabolic process (ortholog); estrogen metabolic process (ortholog); lipid hydroxylation (ortholog); PARTICIPATES IN artemether pharmacokinetics pathway; axitinib pharmacokinetics pathway; caffeine pharmacokinetics pathway; ASSOCIATED WITH anxiety disorder (ortholog); Breast Neoplasms (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH midazolam; phenobarbital
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP3A12; cytochrome P450 3A12; cytochrome P450 CYP3A12
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
midazolam  (EXP)
phenobarbital  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
artemether pharmacokinetics pathway   (ISO)
axitinib pharmacokinetics pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
carbamazepine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway  (ISO)
clomipramine pharmacokinetics pathway  (ISO)
clopidogrel pharmacodynamics pathway  (ISO)
clopidogrel pharmacokinetics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacokinetics pathway  (ISO)
cyclophosphamide pharmacodynamics pathway  (ISO)
cyclophosphamide pharmacokinetics pathway  (ISO)
doxepin pharmacokinetics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fluoxetine pharmacokinetics pathway   (ISO)
gefitinib pharmacokinetics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
ifosfamide pharmacodynamics pathway  (ISO)
ifosfamide pharmacokinetics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
imipramine pharmacokinetics pathway  (ISO)
irinotecan pharmacodynamics pathway  (ISO)
irinotecan pharmacokinetics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lidocaine pharmacokinetics pathway   (ISO)
losartan pharmacokinetics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
mycophenolic acid pharmacokinetics pathway   (ISO)
nateglinide pharmacokinetics pathway  (ISO)
neviparine pharmacokinetics pathway   (ISO)
paracetamol pharmacokinetics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
prednisone pharmacodynamics pathway  (ISO)
prednisone pharmacokinetics pathway   (ISO)
repaglinide pharmacokinetics pathway   (ISO)
retinol metabolic pathway  (ISO)
sorafenib pharmacokinetics pathway   (ISO)
statin pharmacokinetics pathway   (ISO)
tamoxifen pharmacodynamics pathway   (ISO)
tamoxifen pharmacokinetics pathway  (ISO)
teniposide pharmacodynamics pathway  (ISO)
teniposide pharmacokinetics pathway  (ISO)
tramadol pharmacokinetics pathway  (ISO)
venlafaxine pharmacokinetics pathway  (ISO)
vinblastine pharmacodynamics pathway  (ISO)
vinorelbine pharmacodynamics pathway  (ISO)
vitamin A deficiency pathway   (ISO)
warfarin pharmacokinetics pathway  (ISO)

References
Additional References at PubMed
PMID:16446074   PMID:16971569   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CYP3A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBIUU_Cfam_GSD_1.0
CYP3A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,756,960 - 99,784,248 (-)EnsemblGRCh38hg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBINCBI36Build 36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
Cyp3a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,321,771 - 14,343,886 (-)NCBIGRCr8
mRatBN7.2129,207,978 - 9,230,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,009,578 - 10,031,654 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,632,755 - 10,654,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,656,186 - 9,678,268 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Celera1210,992,673 - 11,037,068 (-)NCBICelera
Cytogenetic Map12p11NCBI
CYP3A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,681,786 - 117,708,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,946,433 - 165,973,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,797,037 - 91,824,696 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,230,666 - 105,258,401 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,230,666 - 105,258,401 (-)Ensemblpanpan1.1panPan2
LOC103246766
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,297,566 - 13,330,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660702,940,765 - 2,971,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CYP3A4
673 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 6 6 6 1
Low 4 13 5 5 3 8 10 1
Below cutoff 5 3 1 6 9 5

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022419682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038478090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038478091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_536868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide DQ225113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_038478090   ⟹   XP_038334018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBI
RefSeq Acc Id: XM_038478091   ⟹   XP_038334019
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.169,696,608 - 9,720,690 (-)NCBI
RefSeq Acc Id: XM_038539354   ⟹   XP_038395282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBI
RefSeq Acc Id: XM_038539355   ⟹   XP_038395283
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,914,747 - 9,938,690 (-)NCBI
RefSeq Acc Id: XM_038603445   ⟹   XP_038459373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBI
RefSeq Acc Id: XM_038603446   ⟹   XP_038459374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.069,680,218 - 9,704,309 (-)NCBI
RefSeq Acc Id: XM_038668134   ⟹   XP_038524062
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
RefSeq Acc Id: XM_038668135   ⟹   XP_038524063
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBI
RefSeq Acc Id: XM_038668136   ⟹   XP_038524064
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.069,832,300 - 9,856,237 (-)NCBI
RefSeq Acc Id: XP_038334018   ⟸   XM_038478090
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038334019   ⟸   XM_038478091
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038459373   ⟸   XM_038603445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038459374   ⟸   XM_038603446
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038524063   ⟸   XM_038668135
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KP81 (UniProtKB/TrEMBL),   A0A8I3MQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524062   ⟸   XM_038668134
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KP81 (UniProtKB/TrEMBL),   A0A8I3MQC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038524064   ⟸   XM_038668136
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T0H6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395282   ⟸   XM_038539354
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SZA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395283   ⟸   XM_038539355
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T0H6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014877 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040017832 UniProtKB/TrEMBL
  ENSCAFG00845003103 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023714.5 UniProtKB/TrEMBL
  ENSCAFT00000070806.2 UniProtKB/TrEMBL
  ENSCAFT00000074667.2 UniProtKB/TrEMBL
  ENSCAFT00040033644.1 UniProtKB/TrEMBL
  ENSCAFT00040033679.1 UniProtKB/TrEMBL
  ENSCAFT00845005473.1 UniProtKB/TrEMBL
  ENSCAFT00845005563.1 UniProtKB/TrEMBL
  ENSCAFT00845005626.1 UniProtKB/TrEMBL
  ENSCAFT00845005662.1 UniProtKB/TrEMBL
  ENSCAFT00845005681 ENTREZGENE
  ENSCAFT00845005681.1 UniProtKB/TrEMBL
  ENSCAFT00845005689.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene CYP3A4 ENTREZGENE
PANTHER CYTOCHROME P450 3A4 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450II UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C0KP81 ENTREZGENE
  A0A8C0SZA0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0T0H6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MHC9_CANLF UniProtKB/TrEMBL
  A0A8I3MJ92_CANLF UniProtKB/TrEMBL
  A0A8I3MQC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUY1_CANLF UniProtKB/TrEMBL
  A0A8I3RSN4_CANLF UniProtKB/TrEMBL
  A0A8I3RSP1_CANLF UniProtKB/TrEMBL
  A0A8P0P4H0_CANLF UniProtKB/TrEMBL
  A0A8P0SJ43_CANLF UniProtKB/TrEMBL
  A0A8P0T288_CANLF UniProtKB/TrEMBL