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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a2
Name: cytochrome P450, family 3, subfamily a, polypeptide 2
Acc ID: CHEBI:3388
Term: carbamazepine-10,11-epoxide
Definition: An epoxide and metabolite of carbamazepine.
Chemical ID: MESH:C012227
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a2affects chemical synthesisISOCYP3A4 (Homo sapiens)6480464CTDCYP3A4 protein affects the chemical synthesis of carbamazepine epoxidePMID:15915352
Cyp3a2multiple interactionsISOCYP3A4 (Homo sapiens)6480464CTD[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide; Felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide]PMID:12606595 PMID:15915352
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